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The formula and other properties ascribed to andrographolide, C20H30O5, by Gorter have been confirmed. The presence of a methylenedioxy group has been proved. Tri­acetylandrographolide of Gorter could not be prepared. Hydrolysis of andrographolide gave two isomeric acids, C30H32O6, one of which is probably identical with the known andrographolic acid. Iodine chloride indicated one double bond, but the catalytic hydro­genation of the bitter principle gave a dihydro derivative different from an isomeric dihy­droandrographolide obtained by the action of stannous chloride.

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