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Hypophyseo-adrenal and hypophyseo-thyroid systems were studied in 102 patients aged 16-55 (88 males and 14 females) who suffered from hemorrhagic fever with renal syndrome. Measurements of serum levels of ACTH, hydrocortisone, TTH, T3 and T4 recorded supernormal concentrations of ACTH, hydrocortisone and TTH against subnormal concentrations of T3 and T4 in oliguric and polyuric periods of the disease. In convalescence TTH, T3 and T4 returned to normal levels, while ACTH and hydrocortisone were lower than in controls. It is inferred that in hemorrhagic fever with renal syndrome the activity of the system hypophysis-adrenals in convalescence is declined, whereas hypophysis-thyroid interaction is disturbed at the height of the disease.

Altogether 38 patients (33 men and 5 women) suffering from grave and moderate hemorrhagic fever with nephrotic syndrome (HFNS) were examined. The hemolysate aggregation test and ADP were employed to explore the aggregation ability of platelets in those patients. Besides, measurements were made of the activity of the 3rd platelet factor in the plasma and serotonin content in each platelet. A considerable rise of the aggregation activity of platelets was established to take place in the oligoanuric and polyuric periods of HFNS. At the same time the increase in the blood of the 3rd platelet factor and lowering of serotonin in each platelet were noted. The role of platelet hyperaggregation in the pathogenesis of HFNS is discussed. The conclusion is made that such patients were in a prethrombotic state in the oligoanuric and to a lesser degree in the polyuric periods.

As many as 56 patients with associated hemorrhagic fever and the renal syndrome were examined for vascular permeability, microcirculation and blood plasma histamine, serotonin, kallikrein and prekallikrein. In all the disease periods, the majority of the patients (n-52) demonstrated a rise of vascular permeability for protein and liquid part of the plasma, with this being marked in particular in the oligoanuric period. Besides, significant perivascular and intravascular changes in microcirculation were noted in the oligoanuric and polyuric disease periods. It was established during examination of biologically active substances that the greatest shifts were experienced by the kinin system. Sometimes the content of kallikrein surpassed the control values more than 7-fold. Less pronounced changes were seen in blood plasma serotonin and histamine. A direct correlation was established between vascular permeability, microcirculation and the content of all biologically active substances explored by the authors. The strongest correlation was found to exist between the above parameters and the kinin system of blood plasma.

A basal value of antidiuretic activity (ADA) of the plasma was determined in 79 HFRS patients and stimulated activity using the insulin tolerance test in 24 persons. A decrease in the plasma ADA was observed in the acute period of disease. The insulin tolerance test did not cause a statistically significant increment of the plasma ADA in the HFRS patients.