1. The Anti-depressant Effect of Nelumbinis Semen on Rats Under Chronic Mild Stress Induced Depression-like Symptoms
- Author
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Hyun Choi, Dongwon Shin, Jung-Hwan Yun, Hwa-Jin Lee, Minkyu Shin, Moochang Hong, Dong-Won Yoon, Sang Moon Lee, Chongwoon Cho, Jung-Wan Oh, Seong-Kyu Park, Moonkyu Kang, and Hyunsu Bae
- Subjects
Male ,Light ,Traditional medicine ,Depression ,business.industry ,Hypericum perforatum ,General Medicine ,Pharmacology ,Nelumbinis Semen ,Rats ,Rats, Sprague-Dawley ,Disease Models, Animal ,Complementary and alternative medicine ,Mild stress ,Asian country ,Animals ,Medicine ,Antidepressant ,Anti depressant ,business ,Stress, Psychological ,Depression (differential diagnoses) ,Drugs, Chinese Herbal ,Behavioural despair test - Abstract
Nelumbinis Semen is a well-known traditional herbal medicine frequently used in treatment of depression in many Asian countries. In this study, its anti-depression effects in rats were investigated by comparing the test results of those treated with Nelumbinis Semen to those treated with other herbal anti-depressants, including Rehmanniae Radix Preparat, Corni Fructus, Lycii Fructus, Pinelliae Rhizoma and Hypericum Perforatum. In order to induce depression-like symptoms, the animals were placed under chronic mild stress in the form of overnight illumination for 2 consecutive days. They were treated with the respective herbal extract and forced swimming tests were conducted afterwards. The anti-depression effects of each extract were then evaluated based on a measured index, which consisted of struggling time, first latency and first rest duration. These test results show that Nelumbinis Semen provides greater anti-depression effects than the other herbal extracts. Specifically, only the rats treated with Nelumbinis Semen showed significant increases in struggling time (43.9%, p
- Published
- 2005
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