1. Protective effect of extracorporeal membrane pulmonary oxygenation combined with cardiopulmonary resuscitation on post-resuscitation lung injury
- Author
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Xiao-Li Yuan, Ji-Yang Ling, Yun Zhang, Bo Liu, Yong Liang, Qiang Zhang, and Chunsheng Li
- Subjects
Lung ,business.industry ,medicine.medical_treatment ,Oxygenation ,Lung injury ,Pulmonary edema ,medicine.disease ,Extracorporeal ,medicine.anatomical_structure ,Anesthesia ,Emergency Medicine ,Extracorporeal membrane oxygenation ,Medicine ,Original Article ,Extracorporeal cardiopulmonary resuscitation ,Cardiopulmonary resuscitation ,business - Abstract
BACKGROUND: Cardiac arrest (CA) is a critical condition that is a concern to healthcare workers. Comparative studies on extracorporeal cardiopulmonary resuscitation (ECPR) and conventional cardiopulmonary resuscitation (CCPR) technologies have shown that ECPR is superior to CCPR. However, there is a lack of studies that compare the protective effects of these two resuscitative methods on organs. Therefore, we aim to perform experiments in swine models of ventricular fibrillation-induced CA to study whether the early application of ECPR has advantages over CCPR in the lung injury and to explore the protective mechanism of ECPR on the post-resuscitation pulmonary injury. METHODS: Sixteen male swine were randomized to CCPR (CCPR; n=8; CCPR alone) and ECPR (ECPR; n=8; extracorporeal membrane oxygenation with CCPR) groups, with the restoration of spontaneous circulation at 6 hours as an endpoint. RESULTS: For the two groups, the survival rates between the two groups were not statistically significant (P>0.05), the blood and lung biomarkers were statistically significant (P
- Published
- 2021