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Sepsis is extremely common amongst critically ill patients and requires early diagnosis. Hence, identifying a biomarker that could acknowledge sepsis at its prior stage is of vital significance. Immature platelets are a percentage of circulating platelets that contain RNA and is a newer parameter that is measured using automated hematology analyzers in diagnosing sepsis. This review article discusses 10 articles that reveal the role of immature platelet fraction in predicting the onset of sepsis and its relationship with mortality in sepsis. Literature search was done using PubMed, Scopus and Google Scholar and words like platelet indices and immature platelet fraction were typed in the search bar. The aim of this review article is to present a precise form of data that talk about immature platelet fraction (IPF) and its association with the severity and mortality of sepsis. Five out of 10 articles suggest that immature platelet fraction can predict the onset of sepsis and eight out of 10 articles suggest that increased IPF values are associated with high mortality.

Objective: To evaluate the Bolton ratio in the Maratha population in Pune with near ideal occlusion. Materials and Methods: Fifty study casts were made from impression obtained from patients (25 males and 25 females) aged between 15 and 30 years visiting the Department of Orthodontics and Dentofacial Orthopedics at Sinhgad Dental College and Hospital, Pune. The mesiodistal widths of all maxillary and mandibular teeth from right first molar to left first molar were measured with a digital caliper to calculate the Bolton ratio. The readings were then used to compute the anterior and total Bolton ratios. t-test was used for the statistical analysis. Results: The mean overall and anterior ratios were found to be 92.73 and 80.48 with standard deviation of 2.69 and 2.86, respectively. The range of overall ratio was 81.91–96.75, and the range of anterior ratio was 74.75–86.45. The values obtained from this study indicated that there was a statistically significant difference between the overall and anterior ratios of Maratha and Caucasian participants. Conclusion: It can be suggested that new values should be obtained for the Maratha population as the values were found to be significantly different from the Bolton values obtained for Caucasian population. Hence, population-specific standards are necessary to be formed for clinical assessment.