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Masson’s tumor is a benign intravascular lesion of proliferating endothelial cells that accounts for 2% of vascular and subcutaneous lesions. It manifests clinically as a bluish swelling, resembling a mucocele or hemangioma. Intravascular papillary endothelial hyperplasia (IPEH) was coined by Clearkin and Enzinger in 1976 to describe reactive vascular expansion, following traumatic vascular stasis mimicking angiosarcoma. Clinically, this condition manifests as a bluish enlargement resembling a mucocele or hemangioma. We reported a rare case of IPEH located on the upper lip in an 18-year-old female. A diagnosis of IPEH was reported based on the histopathological findings of papillary proliferating endothelial cells with engorged red blood cells. There was no evidence of recurrence after 6 months of follow-up.

Introduction: Oral intravascular papillary endothelial hyperplasia (IPEH) is a rare entity with only 105 cases reported so far. Labial and buccal mucosa are the commonly affected sites. These sites are coincidently subjected to continuous minor trauma, which led the researchers to opine that IPEH could have a traumatic etiology with a further role of fibroblast growth factors. Clinical Presentation: We report a case of IPEH of right buccal mucosa in a 35 years old South Indian male who clinically presented as mucocele. Histopathologically, multiple lesions were found. Immunohistochemical and histochemical findings have also been presented. Discussion: The case is supported by a plausible mechanism involved in the pathogenesis. Thus, IPEH must be included in the clinical differential diagnosis of oral mucoceles and hemangioma. Take-away Lessons: Being a reactive lesion, it does not require extensive treatment. Clinicians and histopathologists must be aware of this uncommon yet benign condition for appropriate therapy.

Masson hemangioma is a rare benign vascular tumor characterized by intravascular papillary endothelial hyperplasia (IPEH). Numerous case reports have described lesions in the digits, neck, oral cavity, and intracranially. IPEH involving primary brachial artery aneurysm is extremely rare, with only a handful of reported cases. We present a 43-year-old female with a true distal brachial artery aneurysm who presented with a painful pulsatile mass in the antecubital region. She underwent aneurysm resection and end-to-end repair with a saphenous vein graft. Histology confirmed the diagnosis of IPEH with characteristic features of papillary hyperplasia within the intravascular thrombus.

Masson's hemangioma (MH), also known as intravascular papillary endothelial hyperplasia, is a rare benign vascular tumor. Histopathology helps to confirm the diagnosis, wherein a papillary proliferation of thin-walled capillaries is almost always associated with thrombus formation in the lumen of a vessel. We report the case of a 48-year-old female with a purple-colored swelling over the right thigh that was diagnosed as MH with the help of histopathological examination. Dermoscopy was also done, and the findings were reported.

In this case report, we present a case of a 47-year-old man with sinusoidal hemangioma with secondary intravascular papillary endothelial hyperplasia arising in the subcutaneous tissue. To the best of our knowledge, there are only two cases of sinusoidal hemangioma with secondary intravascular papillary endothelial hyperplasia reported till date, both of which were intramuscular hemangiomas. These are rare entities that also have overlapping histomorphological features with that of various other vascular tumors making histopathological diagnosis troublesome at times. Careful histopathological examination aided by immunohistochemical studies in difficult cases is essential to avoid these diagnostic pitfalls.

Intravascular papillary endothelial hyperplasia (IPEH) is a rare cause of orbital mass which can affect healthy individuals of any age/sex/race/region. It usually requires a histopathological examination, characterized by the appearance of papillary proliferation of vascular endothelial cells within the lumen of the blood vessel, for the final diagnosis. One should be aware that this is a highly vascular lesion which can cause excessive intraoperative bleeding and incomplete removal can lead to recurrences. IPEH of the orbit/eyelid has been reported in few parts of the world as isolated case reports but none from India so far.

Intravascular papillary endothelial hyperplasia (IPEH) is an unusual reactive lesion of vascular origin, which rarely occurs in the oral cavity. Pathogenetically, is it divided into true, mixed and extra-vascular types. We report a case of extra-vascular IPEH of the lower lip in 54-year-old female patient. Patient gives history of trauma 4 months back with lesion developing at the site to trauma. The lesion was 3 cm × 4 cm in size with soft to firm in consistency. Histologically, it is characterized by an exuberant papillary endothelial cell proliferation toward the lumen of an enlarged blood vessel from the area of an organizing thrombus. The lesion was surgically excised under local anesthesia. The patient was followed for 1-year with no evidence of recurrence. This paper discusses the various aspects of IPEH of the oral cavity such as pathogenesis, clinical features, histopathology treatment, and prognosis.

Intravascular papillary endothelial hyperplasia (Masson′s tumor) is a benign lesion of the skin and subcutaneous tissue consisting of a reactive proliferation of endothelial cells with papillary formations related to a thrombus. It poses a diagnostic challenge as the clinical signs and symptoms are nonspecific and may mimic a soft tissue sarcoma. The diagnosis is based on histopathology. Here we report two cases of Masson′s hemangioma occurring on the upper lip and on the left hand.

An otherwise healthy 19-year-old female patient had painless swelling in her left buccal mucosa. No precipitating factors were identified. Pathological analysis demonstrated the mass to be a Masson′s hemangioma, a papillary proliferation of thin-walled capillaries intimately associated with thrombus. A very rare tumor occurring in oral cavity with only 80 cases being published in literature until date.