Introduction: The benefits of bilateral laparoscopic adrenalectomy in patients with Cushing's syndrome and pheochromocytoma associated with multiple endocrine neoplasia (MEN) have been published only in very few articles. Our aim is to analyze the results in these patients. Materials and Methods: From May 2003 to Jul 2007 fourteen patients had undergone bilateral single stage laparoscopic adrenalectomy. Patient's demographics, indications, operative details, complications, hospital stay and convalescence were analyzed retrospectively. Results: The median age group was 34 years (11-65) including 9 women and 5 men. The indications for bilateral adrenalectomy were refractory Cushing.s disease (n = 6), Ectopic ACTH dependant cushings syndrome (n = 4), and bilateral pheochromocytoma (n = 4) including three patients with MEN syndrome. A mean of 53 months elapsed between onset of symptoms and adrenalectomy. All procedures were completed laparoscopic approach without any conversion. One patient needed terminal hand assist in view of large size of the tumour. The mean hospital stay was 7.7 days (range, 3-15 days). The mean operative time and blood loss were 193 min (range 90-270) and 71 ml (30-100) respectively. Mean size of the adrenal gland was 5.9 cm (range, 4-9 cm). Three procedures were done by retroperitoneoscopic approach and all were on the right side. Three patients (21%) experienced postoperative complications such as adrenal crisis, chyluria and pleural effusion. All the patients received postoperative steroid replacement and appropriate follow-up assessment with an endocrinologist. Hypertension resolved in 3 out of 4 pheochromocytoma patients. Conclusion: Laparoscopic bilateral adrenalectomy is safe and effective option with minimal morbidity for this subset of patients. Although patients should be monitored closely in the immediate postoperative period, most are discharged with glucocorticoid and mineralocorticoid replacement in long term follow up. [ABSTRACT FROM AUTHOR]