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Introduction: The simultaneous achievement of endometrial and ovarian cancer by a cancerous process is not a rare phenomenon. In the absence of molecular biology, it is a true diagnostic challenge: Is it a double primary or metastatic form? Purpose of Our Work: The objective of this study was to evaluate the prevalence of the association of synchronous carcinomas of the ovary and endometrium, the epidemiological, clinical, histological and evolving profiles. Materials and Methods: This is a retrospective study conducted at the Regional Oncology Center Hassan II between 2005 and 2012. We analyzed the clinical folders of patients with synchronous carcinoma of the ovary and endometrium in terms of epidemiological, clinical, histological and evolutionarily profiles. Results: 11 cases have been collected during this period (8% of ovarian cancers and 17% of the endometrium cancers). The average age of patients was 51 years. 46% of patients were nulliparous and 54% in pre menopause. The most frequent reason for consultation was the abdominal pelvic pain in 6 patients followed by spontaneous bleeding in five cases. Ten patients were treated by radical hysterectomy without adnexal consevation. The omentectomy was performed in eight patients. Four patients underwent a pelvic lymphadenectomy. Adjuvant chemotherapy was conducted in eight cases and adjuvant radiation in two cases. Pathological examination showed histological correlation of endometrial and ovarian tumors in 10 patients with a dominance of endometroid carcinoma. According to Scully and Ulbright criteria, five patients had endometrial cancer with metastasis to the ovary, five patients had ovarian cancer with metastasis to the endometrium and one patient had two independent primary tumors. At the end of treatment, nine patients were in good control. With a median follow of 60 months, one patient developed an isolated metastasis and three patients a pelvic recurrence and metastasis. Conclusion: Our study is limited by the small number of patients. However, it seems that women with synchronous carcinomas of endometrium and ovary had clinical (younger age, pre-menopausal status and nulliparity) and histological (dominance of endometroid type) characteristic suggesting that hormonal factors may explain the development of synchronous carcinomas of endometrium and ovary. [ABSTRACT FROM AUTHOR]

Introduction: Breast cancer in men is an uncommon disease, accounting for approximately 1% of all breast cancer cases. The aim of our study is to investigate the epidemiological and clinical aspects, the pathological features and results of treatment of this rare entity in the Eastern Region of Morocco. Materials and Methods: This is a retrospective study conducted at the Oncology Center of Oujda between January 2006 and December 2013. We analyzed the clinical records of male patients with breast cancer. In each case, the following features were studied: age, family history, circumstances of discovery, histological and immunohistochemical data, treatment and the evolutionary profile. Results: 25 cases have been collected over this period (0.5% of all breast cancers). The average age of patients was 62,5ans. 4 patients had a family history of breast cancer (16% of cases). The nodule sub-nipple as circumstance of discovery was the most frequent (68%); 15 patients consulted beyond to 3 months (60%). Mammography ± ultrasound were performed in 19 patients (76%). After staging, five patients had metastatic disease (20%). Twenty-three patients underwent surgical treatment (92% of cases). It was a radical Halsted mastectomy for 19 patients (82.6%) and Patey for 4 patients (17.4%). The mean histological tumor size was 3.5cm. 65% were classified as pT1T2 and 35% pT3T4. The only histological type was invasive ductal carcinoma (100% of cases), grade II (SBR) in 95% of cases. 81% of patients had axillary lymph node involvement. Hormone receptors were positive in 88% and HER2 test negative in 83% of cases. 80% of patients with no metastatic disease had an adjuvant chemotherapy and 90% had an adjuvant radiotherapy and tamoxifen. After a mean of 60 months, 40% of patients with no metastatic disease were kept in control, 40% had a local ± metastatic recurrence after a mean of 33 months and 20% were lost to follow up. Conclusion: Breast cancer in men is rare. The histo-biological profile looks identical to breast cancer of women but locally advanced forms are more frequent. Surgical treatment is based on the Halsted radical mastectomy and adjuvant treatment is similar to that of the woman. The prognosis is related to molecular characteristics, early diagnosis and treatment in a multidisciplinary collaboration. [ABSTRACT FROM AUTHOR]