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Purpose: To report a case of marked regression of drusen and a pigment epithelial detachment (PED) with visual improvements after pars plana vitrectomy (PPV)., Methods: A 67-year-old man noticed gradual visual deterioration to 20/80 due to macular soft drusen and a PED. A posterior vitreous detachment (PVD) was not present in the affected eye., Results: PPV was performed to create a PVD, and there was marked regression of drusen and a PED with visual improvement to 20/30. Vision was maintained at the final examination 30 months after surgery., Conclusion: Vitrectomy may be considered for treatment of macular drusen and prevention of choroidal neovascularization.