1. B-cell lymphocyte kinase polymorphisms rs13277113, rs2736340, and rs4840568 and risk of autoimmune diseases
- Author
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Zeng, Chang, Fang, Cheng, Weng, Hong, Xu, Xiaoqing, Wu, Tianyang, and Li, Wenhua
- Subjects
Racial Groups ,autoimmune disease ,Polymorphism, Single Nucleotide ,polymorphism ,Autoimmune Diseases ,meta-analysis ,Observational Studies as Topic ,src-Family Kinases ,Gene Frequency ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,Odds Ratio ,Humans ,Lupus Erythematosus, Systemic ,Genetic Predisposition to Disease ,B-cell lymphocyte kinase ,BLK ,Systematic Review and Meta-Analysis ,Research Article - Abstract
Supplemental Digital Content is available in the text, Background: B-cell lymphocyte kinase (BLK) is an inhibitor of B cells that has an important influence on several autoimmune diseases, but there is a lack of comprehensive analysis of its association with autoimmune diseases. Hence, it is meaningful to conduct a comprehensive analysis. Methods: A systematic literature search was performed on the PubMed, ScienceDirect, and Web of Science databases up to June 30, 2016. The data were extracted and quality-assessed before conducting the meta-analysis. The odds ratios (ORs) and 95% confidence intervals (95% CIs) were assessed with the STATA version 12.0 software. Subgroup and sensitivity analysis were conducted to explore potential sources of heterogeneity. Results: Altogether, 33 studies with 68,874 cases and 90,684 controls, 24 studies with 31,095 cases and 39,077 controls for rs13277113, 21 studies with 26,388 cases and 40,635 controls for rs2736340, and 4 studies with 11,391 cases and 10,972 controls for rs4840568 were included in this meta-analysis. The results revealed that the BLK rs13277113 and rs2736340 polymorphisms increased the risk of autoimmune diseases in the total analysis (A vs G: OR = 1.33, 95% CI = 1.27–1.39, P
- Published
- 2017