1. Pathogenesis of hepatic fibrosis and the role of cytokines.
- Author
-
Lissoos TW and Davis BH
- Subjects
- Cell Division physiology, Humans, Liver metabolism, Liver ultrastructure, Liver Cirrhosis metabolism, Liver Cirrhosis pathology, Collagen metabolism, Extracellular Matrix metabolism, Liver pathology, Liver Cirrhosis etiology, Platelet-Derived Growth Factor physiology, Transforming Growth Factor beta physiology
- Abstract
No definitive therapy exists for the treatment of hepatic fibrosis and cirrhosis. Recent evidence suggests that hepatic lipocytes (Ito cells, fat storage cells, or stellate cells of the liver) are responsible for much of the collagen hypersecretion and nodule formation that occurs during hepatic fibrosis and cirrhosis. This review describes the cellular mechanisms of hepatic fibrogenesis emphasizing new experimental data about cytokines or growth factors to suggest potential avenues of future therapeutic design.
- Published
- 1992
- Full Text
- View/download PDF