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Background: Negative pressure pulmonary is a non-cardiogenic pulmonary oedema that can occur after reliving of upper airway obstruction. It is life threatening clinical scenario developed due to increase intrathoracic pressure during marked inspiratory effort against a closed glottis., Case Presentation: A successful adenotonsillectomy was done for a healthy 12-year-old, 33 kg male patient and transferred to post-anaesthesia care unit. In the unit the patient developed signs and symptoms of negative pressure pulmonary oedema so he was treated with diuretics and oxygen while restricting fluid. However, the dyspnoea was persisted so he was transferred to ICU., Clinical Discussion: This case report shows the development of negative pressure pulmonary oedema after adenotonsillectomy. In this report the clinical presentation, diagnosis, treatment, prevention and prognosis of negative pressure pulmonary oedema after adenotonsillectomy was discussed in detail with citing updated evidences., Conclusions: Post-extubation pulmonary oedema can occur after reliving of chronic air obstruction. Usually it occur within 5 min after reliving the obstruction but it can occur at any time. All healthcare professionals must be knowledgeable about clinical presentation and managements of negative pressure pulmonary oedema., Competing Interests: There was no any conflict of interest.Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article, (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)