1. A randomized open-label study of the impact of quetiapine versus risperidone on sexual functioning.
- Author
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Knegtering R, Castelein S, Bous H, Van Der Linde J, Bruggeman R, Kluiter H, and van den Bosch RJ
- Subjects
- Adolescent, Adult, Dibenzothiazepines administration & dosage, Dibenzothiazepines therapeutic use, Drug Administration Schedule, Female, Humans, Male, Prolactin blood, Psychotic Disorders physiopathology, Quetiapine Fumarate, Risperidone administration & dosage, Risperidone therapeutic use, Schizophrenia physiopathology, Sexual Dysfunctions, Psychological chemically induced, Surveys and Questionnaires, Testosterone blood, Treatment Outcome, Dibenzothiazepines adverse effects, Risperidone adverse effects, Sexual Dysfunctions, Psychological drug therapy
- Abstract
Objective: To compare sexual functioning in patients treated with quetiapine or risperidone., Methods: This open-label study included patients with schizophrenia or a related psychotic illness who were randomized to quetiapine (200-1200 mg/d) or risperidone (1-6 mg/d) for 6 weeks. Sexual dysfunction was assessed by a semistructured interview, the Antipsychotics and Sexual Functioning Questionnaire (ASFQ), based upon the Utvalg for Kliniske Undersogelser (UKU)., Results: Four of 25 quetiapine-treated patients (16%) and 12 of 24 risperidone-treated patients (50%) reported sexual dysfunction (chi 2 = 6.4; df = 1; P = 0.006) on the ASFQ. Six patients (11.7%; 4 on risperidone, 2 on quetiapine) spontaneously reported sexual dysfunction. The mean+/-SD dose was 580+/-224 mg/d for quetiapine and 3.2 +/- 1.3 mg/d for risperidone. Mean +/- SD prolactin levels in quetiapine- and risperidone-treated patients were 13.8 +/- 17.9 and 57.7 +/- 39.7 ng/mL, respectively., Conclusion: Sexual dysfunction was less common in patients treated with quetiapine than with risperidone. Direct questioning about sexual functioning is necessary to avoid underestimating the frequency of sexual side effects in patients with schizophrenia and related psychotic disorders.
- Published
- 2004
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