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1. Stereodivergent total synthesis of Δ9-tetrahydrocannabinols.

Author

Schafroth MA, Zuccarello G, Krautwald S, Sarlah D, and Carreira EM

Subjects
Dronabinol chemistry, Stereoisomerism, Dronabinol chemical synthesis
Abstract

All four stereoisomers of Δ(9)-tetrahydrocannabinol (Δ(9)-THC) were synthesized in concise fashion using stereodivergent dual catalysis. Thus, following identical synthetic sequences and applying identical reaction conditions to the same set of starting materials, selective access to the four stereoisomers of THC was achieved in five steps., (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Published
2014
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