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Secondary trastuzumab resistance represents an evolutionary adaptation of HER2-positive breast cancer during anti-HER2 treatment. Most current studies have tended to prioritize HER2 and its associated signaling pathways, often overlooking broader but seemingly less relevant cellular processes, along with their associated genetic and epigenetic mechanisms. Here, transcriptome data is not only characterized but also examined epigenomic and 3D genome architecture information in both trastuzumab-sensitive and secondary-resistant breast cancer cells. The findings reveal that the global metabolic reprogramming associated with trastuzumab resistance may stem from genome-wide alterations in both histone modifications and chromatin structure. Specifically, the transcriptional activities of key genes involved in lipid metabolism appear to be regulated by variant promoter H3K27me3 and H3K4me3 modifications, as well as promoter-enhancer interactions. These discoveries offer valuable insights into how cancer cells adapt to anti-tumor drugs and have the potential to impact future diagnostic and treatment strategies., (© 2024 The Authors. Advanced Science published by Wiley‐VCH GmbH.)

Monolithic perovskite/silicon tandem solar cells have been attracted much attention in recent years. Despite their high performances, the stability issue of perovskite-based devices is recognized as one of the key challenges to realize industrial application. When comes to the perovskite top subcell, the interface between perovskite and electron transporting layers (usually C 60 ) significantly affects the device efficiency as well as the stability due to their poor adhesion. Here, different from the conventional interfacial passivation using metal fluorides, a hybrid intermediate layer is proposed-PMMA functionalized with ionic liquid (IL)-is introduced at the perovskite/C 60 interface. The application of PMMA essentially improves the interfacial stability due to its strong hydrophobicity, while adding IL relieves the charge accumulation between PMMA and the perovskite. Thus, an optimal wide-bandgap perovskite solar cells achieves power conversion efficiency of 20.62%. These cells are further integrated as top subcells with silicon bottom cells in a monolithic tandem structure, presenting an optimized PCE up to 27.51%. More importantly, such monolithic perovskite/silicon cells exhibit superior stability by maintaining 90% of initial efficiency after 1200 h under continuous illumination., (© 2023 Wiley‐VCH GmbH.)

Wide-bandgap metal halide perovskites have demonstrated promise in multijunction photovoltaic (PV) cells. However, photoinduced phase segregation and the resultant low open-circuit voltage (V oc ) have greatly limited the PV performance of perovskite-based multijunction devices. Here, a alloying strategy is reported to achieve uniform distribution of triple cations and halides in wide-bandgap perovskites by doping Rb + and Cl - with small ionic radii, which effectively suppresses halide phase segregation while promoting the homogenization of surface potential. Based on this strategy, a V oc of 1.33 V is obtained from single-junction perovskite solar cells, and a V OC approaching 3.0 V and a power conversion efficiency of 25.0% (obtained from reverse scan direction, certified efficiency: 24.19%) on an 1.04 cm 2 photoactive area can be achieved in a perovskite/perovskite/c-Si triple-junction tandem cell, where the certification efficiency is by far the greatest performance of perovskite-based triple-junction tandem solar cells. This work overcomes the performance deadlock of perovskite-based triple-junction tandem cells by setting a materials-by-design paradigm., (© 2024 Wiley‐VCH GmbH.)

Perovskite/silicon tandem solar cells are promising avenues for achieving high-performance photovoltaics with low costs. However, the highest certified efficiency of perovskite/silicon tandem devices based on economically matured silicon heterojunction technology (SHJ) with fully textured wafer is only 25.2% due to incompatibility between the limitation of fabrication technology which is not compatible with the production-line silicon wafer. Here, a molecular-level nanotechnology is developed by designing NiO x /2PACz ([2-(9H-carbazol-9-yl) ethyl]phosphonic acid) as an ultrathin hybrid hole transport layer (HTL) above indium tin oxide (ITO) recombination junction, to serve as a vital pivot for achieving a conformal deposition of high-quality perovskite layer on top. The NiO x interlayer facilitates a uniform self-assembly of 2PACz molecules onto the fully textured surface, thus avoiding direct contact between ITO and perovskite top-cell for a minimal shunt loss. As a result of such interfacial engineering, the fully textured perovskite/silicon tandem cells obtain a certified efficiency of 28.84% on a 1.2-cm 2 masked area, which is the highest performance to date based on the fully textured, production-line compatible SHJ. This work advances commercially promising photovoltaics with high performance and low costs by adopting a meticulously designed HTL/perovskite interface., (© 2022 Wiley-VCH GmbH.)

Halide perovskites have shown superior potentials in flexible photovoltaics due to their soft and high power-to-weight nature. However, interfacial residual stress and lattice mismatch due to the large deformation of flexible substrates have greatly limited the performance of flexible perovskite solar cells (F-PSCs). Here, ammonium formate (HCOONH 4 ) is used as a pre-buried additive in electron transport layer (ETL) to realize a bottom-up infiltration process for an in situ, integral modification of ETL, perovskite layer, and their interface. The HCOONH 4 treatment leads to an enhanced electron extraction in ETL, relaxed residual strain and micro-strain in perovskite film, along with reduced defect densities within these layers. As a result, a top power conversion efficiency of 22.37% and a certified 21.9% on F-PSCs are achieved, representing the highest performance reported so far. This work links the critical connection between multilayer mechanics/defect profiles of ETL-perovskite structure and device performance, thus providing meaningful scientific direction to further narrowing the efficiency gap between F-PSCs and rigid-substrate counterparts., (© 2022 Wiley-VCH GmbH.)

Layered halide perovskites (LHPs) with crystallographically 2D structures have gained increasing interest for photovoltaic applications due to their superior chemical stability and intriguing anisotropic properties, which are in contrast to their conventional 3D perovskite counterparts. The most frequently studied LHPs are Ruddlesden-Popper (RP) phases, which suffer from a carrier-transport bottleneck due to the van der Waals gap associated with their intrinsic organic interlayer structures. To address this issue, Dion-Jacobson (DJ) and alternating-cation-interlayer (ACI) LHPs have rapidly emerged, which exhibit unique structural and (opto)electronic characteristics that may resemble those of the 3D counterparts owing to the eliminated or reduced van der Waals gap. Improved photophysical properties have been achieved in DJ and ACI LHPs, leading towards better photovoltaic performance. Here we provide a comprehensive discussion on the merits and promises of DJ and ACI LHPs from a chemistry perspective. Then, we review recent progress on the synthesis and tailoring of DJ and ACI LHP crystals and thin films, as well as their optoelectronic properties and photovoltaic performance. Finally, we discuss possible pathways to overcome critical challenges to realize the full potential of DJ and ACI LHPs for high-performance solar cells and beyond., (© 2021 Wiley-VCH GmbH.)

The chemical stabilities of hybrid perovskite materials demand further improvement toward long-term and large-scale photovoltaic applications. Herein, the enhanced chemical stability of CH 3 NH 3 PbI 3 is reported by doping the divalent anion Se 2- in the form of PbSe in precursor solutions to enhance the hydrogen-bonding-like interactions between the organic cations and the inorganic framework. As a result, in 100% humidity at 40 °C, the 10% w/w PbSe-doped CH 3 NH 3 PbI 3 films exhibited >140-fold stability improvement over pristine CH 3 NH 3 PbI 3 films. As the PbSe-doped CH 3 NH 3 PbI 3 films maintained the perovskite structure, a top efficiency of 10.4% with 70% retention after 700 h aging in ambient air is achieved with an unencapsulated 10% w/w PbSe:MAPbI 3 -based cell. As a bonus, the incorporated Se 2- also effectively suppresses iodine diffusion, leading to enhanced chemical stability of the silver electrodes., (© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Two pseudohalide thiocyanate ions (SCN(-) ) have been used to replace two iodides in CH3 NH3 PbI3 , and the resulting perovskite material was used as the active material in solar cells. In accelerated stability tests, the CH3 NH3 Pb(SCN)2 I perovskite films were shown to be superior to the conventional CH3 NH3 PbI3 films as no significant degradation was observed after the film had been exposed to air with a relative humidity of 95 % for over four hours, whereas CH3 NH3 PbI3 films degraded in less than 1.5 hours. Solar cells based on CH3 NH3 Pb(SCN)2 I thin films exhibited an efficiency of 8.3 %, which is comparable to that of CH3 NH3 PbI3 based cells fabricated in the same way., (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)