1. Capillary electrophoresis-electrospraymass spectrometry in peptide analysis and peptidomics
- Author
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Miguel Herrero, Frantisek Foret, Elena Ibanez, and Alejandro Cifuentes
- Subjects
Peptide analysis ,Proteomics ,Spectrometry, Mass, Electrospray Ionization ,Proteomics methods ,Chromatography ,Electrospray mass spectrometry ,Chemistry ,Clinical Biochemistry ,Protein Array Analysis ,Electrophoresis, Capillary ,Equipment Design ,Mass spectrometry ,Silicon Dioxide ,Biochemistry ,Capillary electrophoresis–mass spectrometry ,Analytical Chemistry ,Electrophoresis, Microchip ,Capillary electrophoresis ,proteomics ,peptides ,Animals ,Humans ,Capillary electrophoresis-mass spectrometry ,Peptides - Abstract
In the present work, an exhaustive review of the main developments and applications of CEMS for peptide analysis is given. This review includes the use of different CE separation modes, MS analyzers, capillary coatings, preconcentration techniques, on-chip applications as well as other different multidimensional strategies for peptide analysis. Key applications are critically discussed and relevant works published from January 2000 to May 2007 are summarized including information concerning the type of sample, CE-MS parameters as well as some figures of merit of the different CE-MS procedures developed for peptide analysis and peptidomics., This study was supported by ProjectsAGL2005-05320-C02-01 Ciencia) and S-505/AGR-0153 (ALIBIRD, Comunidad de Madrid). M. H. would like to thank the Spanish Education and Science Ministry (MEC) for a post-doctoral fellowship.
- Published
- 2008