1. Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: results from a prospective, randomized sham-controlled trial.
- Author
-
Mueller J, Skogseid IM, Benecke R, Kupsch A, Trottenberg T, Poewe W, Schneider GH, Eisner W, Wolters A, Müller JU, Deuschl G, Pinsker MO, Roeste GK, Vollmer-Haase J, Brentrup A, Krause M, Tronnier V, Schnitzler A, Voges J, Nikkhah G, Vesper J, Naumann M, and Volkmann J
- Subjects
- Adult, Depressive Disorder diagnosis, Depressive Disorder psychology, Disability Evaluation, Double-Blind Method, Dystonia diagnosis, Female, Humans, Male, Placebos, Prospective Studies, Severity of Illness Index, Surveys and Questionnaires, Deep Brain Stimulation methods, Dystonia physiopathology, Dystonia therapy, Globus Pallidus physiopathology, Quality of Life psychology
- Abstract
As part of the first randomized, sham-stimulation controlled trial on deep brain stimulation (DBS) in primary segmental or generalized dystonia, health-related quality of life (HRQoL) was assessed by SF-36. After the 3-month sham-controlled phase, significant HRQoL improvement occurred only in the active-stimulation group. The open-label extension phase resulted in a significant improvement in all SF-36 domains following 6 months of neurostimulation. These results demonstrate a favorable impact of DBS on HRQoL in primary dystonia., (2007 Movement Disorder Society)
- Published
- 2008
- Full Text
- View/download PDF