1. Characterization of hepatitis delta virus strains spreading in Abuja, Nigeria.
- Author
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Ifeorah IM, Faleye TOC, Bakarey AS, Adewumi OM, Gerber A, Le Gal F, Adeniji JA, Gordien E, and Onyemelukwe NF
- Subjects
- Coinfection, Female, Genotype, Hepatitis Antibodies, Hepatitis Delta Virus classification, Humans, Male, Nigeria epidemiology, Phylogeny, Prevalence, RNA, Viral, Sequence Analysis, DNA, Viral Load, Hepatitis D epidemiology, Hepatitis D virology, Hepatitis Delta Virus genetics
- Abstract
Hepatitis delta virus (HDV) is responsible for the most severe form of liver disease in humans. So far, eight genotypes (HDV-1 to -8) have been individualized worldwide. Little is known about HDV strains that spread in Nigeria. HDV genotyping was performed in 15 anti-HDV positive samples from a cohort of 306 hepatitis B virus (HBV)-infected patients in Abuja (Nigeria). Phylogenetic analyses revealed 90% were HDV-1, two among them clustering with European/Asian HDV-1, the remaining one being HDV-6. It was also found that two members of a couple superinfected with the same HDV strain, were enveloped by two different HBV strains of genotype E., (© 2019 Wiley Periodicals, Inc.)
- Published
- 2019
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