1. Functions of transforming growth factor‐β isoforms in the nervous system.
- Author
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Unsicker, Klaus and Strelau, Jens
- Subjects
- *
TRANSFORMING growth factors-beta , *CELL proliferation - Abstract
This review briefly describes the cellular distribution and documented roles of the transforming growth factor (TGF)-β isoforms TGF-β2 and -β3 in the central and peripheral nervous system. TGF-β2 and -β3 are coexpressed in developing radial glial and mature astroglial and Schwann cells, as well as in subpopulations of differentiated neurons, most prominently in cortical, hippocampal, and brainstem/spinal cord motor neurons. In vitro studies have suggested a number of potential, physiologically relevant functions for TGF-βs including regulation of astroglial cell proliferation, expression of adhesion molecules, survival promoting roles for neurons in combination with established neurotrophic factors, and differentiative actions on neurons. [ABSTRACT FROM AUTHOR]
- Published
- 2000
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