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Cancer vaccines represent a promising form of immunotherapy employed in the treatment of cancer. However, their efficiency in eliciting immune responses is limited, and satisfactory results have yet to be achieved. Optimizing adjuvants and antigens is an important approach to promoting the anti‐tumor efficacy of cancer vaccines. Here, a novel nanoadjuvant (LNP/siRNA) designed to silence T‐cell immunoglobulin and mucin‐domain containing‐3 (TIM3) and activate Toll‐like receptors (TLRs) is presented. The LNP/siRNA demonstrates significant potential in promoting dendritic cell (DC) maturation and enhancing the anti‐tumor response. Furthermore, desialylated cancer cell membrane is utilized as antigens, providing a variety of tumor antigens for DCs and enhancing their function. Additionally, they are integrated to create a core‐shell structured nanovaccine (dClip‐LNP/siRNA) through coextrusion, which collectively enhances the cross‐presentation ability of DCs, thus achieving a dual enhancement strategy. The dClip‐LNP/siRNA significantly silences TIM3 expression in DCs and promotes antigen presentation by DCs. Besides, dClip‐LNP/siRNA significantly promotes the activation of T cells in lymph nodes and induces robust and durable anti‐tumor immunity in tumor sites to eliminate established B16‐OVA tumors, prevent tumor occurrence, and suppress tumor lung metastasis. The dClip‐LNP/siRNA is also suitable for combination with adoptive OT‐I cell therapy to enhance cancer immunotherapy. The dClip‐LNP/siRNA represents a robust vaccine platform for personalized cancer immunotherapy. [ABSTRACT FROM AUTHOR]

Global human‐induced warming has intensified water circulation in the atmospheric environment and altered the streamflow generation regime. The VIC hydrological model approach for impact assessment of climate change and human activities mainly focuses on variations in streamflow, but ignores other critical flooding characteristics induced by extreme streamflow, especially bivariate flooding characteristics. In this work, the copula functions are employed to structure the flooding risk under the shared socioeconomic pathway (SSP) across the Yellow River basin (YRB). This is based on the multi‐model ensemble (MME) and Delta downscaling outputs (Delta‐MME) of the CMIP6 global climate models (GCMs), as well as the flooding characteristics simulated by VIC hydrological model. Compared to the reference period (1995–2014), Delta‐MME reveals a significant warming and humidifying trend under three SSPs over the YRB. Despite uncertainties originating from climate variables and hydrological model, multiple findings underscore the substantial influence of climate change on the flooding generation regime in YRB. This includes: (a) an increase in the streamflow under all SSPs; (b) a larger flooding peak (Q) and volume (W) under SSP585, with Q and W at the Huayuankou hydrologic station (HYK) increasing by 52.7% and 44.8%, respectively; (c) an advancement in the bivariate flooding risk, particularly in SSP585 where flooding co‐occurrence return period at HYK may be more than 50 times earlier. This study underscores that the urgent need to enhance social resilience to climate change in the YRB. Plain Language Summary: The YRB, as the second‐longest river in China, is confronted with the threat of catastrophic flooding hazards. The CMIP6, representing the latest climate prediction products, was developed by Earth System Grid Federation. This research aims to propose a novel perspective for predicting future flooding risks along the YRB under all SSPs. The findings of this research could hold great potential for informing mitigation and adaptation policies regarding flooding hazards in the YRB. Key Points: The VIC hydrologic model is employed to simulate flooding magnitude to climate change over the Yellow River basinFlooding magnitude over the Yellow River basin become more fluctuating under three SSPsFuture return period levels for flooding peak and volume have reduced significantly from the historical period, with the co‐occurrence return period being more prominent than the joint return period [ABSTRACT FROM AUTHOR]

Growing evidence indicates that circular RNAs (circRNAs) are promising biomarkers, as they play significant roles in the development of various cancers. The circular RNA MYLK (circMYLK) has been reported to be involved in the development of malignant tumours, including liver, prostate and bladder cancers. Nevertheless, the biological function of circMYLK in renal cell carcinoma (RCC) remains unclear. In this study, we observed that circMYLK is notably up‐regulated in RCC. Increased circMYLK expression led to a larger tumour size, distant metastasis and poor prognosis of RCC patients. Moreover, circMYLK silencing repressed RCC growth and metastasis in vitro and in vivo. Mechanistically, circMYLK can capture miR‐513a‐5p to facilitate VEGFC expression and further promote the tumorigenesis of RCC cells. In summary, our findings demonstrate that circMYLK has an oncogenic role in RCC growth and metastasis by modulating miR‐513a‐5p/VEGFC signalling. Thus, circMYLK has potential as a diagnostic biomarker and therapeutic target in the treatment of RCC. [ABSTRACT FROM AUTHOR]