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Ionic liquids (ILs) are promising solvents for separating aromatics from fuel oils. However, studies for separate polycyclic aromatics with ILs are rare and insufficient, and the impact of solute structure on extraction performance still needs to be determined. In this work, we use 1‐ethyl‐3‐methylimidazolium bis([trifluoromethyl]sulfonyl)imide ([EMIM][NTF2]) as an extractant to separate 1‐methylnaphthalene, quinoline, and benzothiophene from dodecane mixtures. Liquid–liquid equilibrium experiments identified the optimal operating conditions. Nine solute molecules, including five alkanes and four aromatic hydrocarbons, were used to study the relationship between extraction performance and solute structure. Molecular dynamics simulation and quantum chemistry calculations gave a deep insight and reasonable interpretation of the structure‐performance relationship at the molecular level. An industrial‐scale extraction process was proposed. The IL can be easily regenerated using heptane as a back‐extractive solvent. A high‐purity fuel oil with aromatic content below 0.5 wt% is obtained after 8‐stage extraction. [ABSTRACT FROM AUTHOR]

N‐heterocyclic carbene catalysis has been developed as a versatile method for the enantioselective synthesis of complex organic molecules in organic chemistry. Merging of N‐heterocyclic carbene catalysis with transition metal catalysis holds the potential to achieve unprecedented transformations with broad substrate scope and excellent stereoselectivity, which are unfeasible with individual catalyst. Thus, this dual catalysis has attracted increasing attention, and numerous elegant dual catalytic systems have been established. In this review, we summarize the recent achievements of dual NHC/transition metal catalysis, including the reaction design, mechanistic studies and practical applications. [ABSTRACT FROM AUTHOR]

Integration of solar cell and secondary battery cannot only promote solar energy application but also improve the electrochemical performance of battery. Lithium–sulfur battery (LSB) is an ideal candidate for photoassisted batteries owing to its high theoretical capacity. Unfortunately, the researches related the combination of solar energy and LSB are relatively lacking. Herein, a freestanding photoelectrode is developed for photoassisted lithium–sulfur battery (PALSB) by constructing a heterogeneous structured Au@N‐TiO2 on carbon cloths (Au@N‐TiO2/CC), which combines multiple advantages. The Au@N‐TiO2/CC photoelectrode can produce the photoelectrons to facilitate sulfur reduction during discharge process, while generating holes to accelerate sulfur evolution during charge process, improving the kinetics of electrochemical reactions. Meanwhile, Au@N–TiO2/CC can work as an electrocatalyst to promote the conversion of intermediate polysulfides during charge/discharge process, mitigating induced side reactions. Benefiting from the synergistic effect of electrocatalysis and photocatalysis, PALSB assembled with an Au@N‐TiO2/CC photoelectrode obtains ultrahigh specific capacity, excellent rate performance, and outstanding cycling performance. What is more, the Au@N‐TiO2/CC assembled PALSB can be directly charged under light illumination. This work not only expands the application of solar energy but also provides a new insight to develop advanced LSBs. [ABSTRACT FROM AUTHOR]

Polysulfides shuttle and lithium dendrites growth greatly restricts the practical application of lithium–sulfur batteries (LSBs). A rational designed separator combined polysulfide catalyst and lithium regulator can achieve the effect of killing two birds with one stone. Herein, organic–inorganic hybrid materials are designed to construct a complementary interface for LSBs. Specially, two kinds of covalent organic frameworks (COF) with different pore size are in situ grown on the MXene surface by forming Ti–N bond. The high electronic conductivity and abundant surface functional groups of MXene allow it to work as a catalyst to effectively accelerate the polysulfides conversion, while COF can be used as an ion calibrator to guide homogeneous lithium deposition. As expected, the MXene@COF (MCOF) integrated separator realizes complementary advantages that enable a Li||Li symmetric cell to achieve a surprisingly stable lithium plating/stripping process up to 4750 h at 10 mA cm−2. Furthermore, the assembled LSBs exhibit high capacities of 584/563 mAh g−1 at 3 C and low‐capacity decay rates of 0.042%/0.048% per cycle after 1000 cycles at 1 C. This work proposes a strategy of complementary advantages based on the MXene and COF composites in the interface layer, which is of great significance for the separator construction of high‐performance LSBs. [ABSTRACT FROM AUTHOR]

A process of simultaneous desulfurization and dehydration of flue gas with ionic liquid was explored. The selection of ionic liquid was completed based on COSMO‐SAC model. Random forest (RF) and one‐dimensional convolutional neural network were trained for the prediction of CO2 and SO2 solubility. A feature selection method is designed to remove verbose descriptors. The feature importance was analyzed by SHAP analysis. Quantum chemistry calculation and molecular dynamics (MD) simulation were used to investigate the type and position of intermolecular forces. The results show that the R2 coefficients of the two prediction models for CO2 and SO2 test sets reach 0.981 and 0.983. [EMIM][SCN] was selected as the optimal solvent, and the interaction with SO2 is mainly electrostatic and orbital interaction, while the interaction with H2O is strong hydrogen bond. [ABSTRACT FROM AUTHOR]

DNA damage plays a significant role in the tumorigenesis and progression of the disease. Abnormal DNA repair affects the therapy and prognosis of cancer. In this study, it is demonstrated that the deubiquitinase USP25 promotes non‐homologous end joining (NHEJ), which in turn contributes to chemoresistance in cancer. It is shown that USP25 deubiquitinates SHLD2 at the K64 site, which enhances its binding with REV7 and promotes NHEJ. Furthermore, USP25 deficiency impairs NHEJ‐mediated DNA repair and reduces class switch recombination (CSR) in USP25‐deficient mice. USP25 is overexpressed in a subset of colon cancers. Depletion of USP25 sensitizes colon cancer cells to IR, 5‐Fu, and cisplatin. TRIM25 is also identified, an E3 ligase, as the enzyme responsible for degrading USP25. Downregulation of TRIM25 leads to an increase in USP25 levels, which in turn induces chemoresistance in colon cancer cells. Finally, a peptide that disrupts the USP25‐SHLD2 interaction is successfully identified, impairing NHEJ and increasing sensitivity to chemotherapy in PDX model. Overall, these findings reveal USP25 as a critical effector of SHLD2 in regulating the NHEJ repair pathway and suggest its potential as a therapeutic target for cancer therapy. [ABSTRACT FROM AUTHOR]

Electrolyte design is indeed a highly effective strategy to improve battery performance. However, identifying the intermolecular interaction in electrolyte solvation structure is rarely reported in potassium‐ion batteries. Herein, it is discovered that a solvent‐solvent intermolecular interaction can be formed when introducing the cyclopentylmethyl ether (CPME) solvent into the commonly used 1,2‐dimethoxyethane (DME)‐based electrolytes. Such interaction is not only analyzed by 2D 1H‐1H correlation spectroscopy for the first time but also found that it can weaken the K+‐DME interaction significantly, consequently enabling a reversible K+ (de‐)intercalation within the graphite. By employing this strategy without using any fluorine‐based solvent, a new fluorine‐free and low‐concentration ether‐based electrolyte is designed, which is not only compatible with graphite but also facilitates the design of high‐energy‐density and safe potassium ion sulfur batteries. A novel molecular interfacial model is further presented to analyze the interfacial behaviors of K+‐solvent‐anion complexes on the electrode surface that are affected by intermolecular interactions, elucidating the reasons behind the superior electrolyte compatibility and graphite electrode performance at the molecular scale. This work sheds some light on the critical role of solvent–solvent interactions in electrolyte design for potassium‐ion batteries and provides valuable insights for engineering and enhancing the performance of electrolytes and batteries. [ABSTRACT FROM AUTHOR]

Electrolytes have recently regained significant attention in rechargeable batteries due to the discovery that the electrolyte microstructures play a determinant role in battery performance. By adjusting the compositions of electrolytes to cater to various functionalities, such as high‐voltage, fast‐charging, wide‐temperature operation, and non‐flammable features, a diverse range of batteries can be developed to adapt to different environmental working conditions. Nevertheless, elucidating the electrolyte microstructures and understanding the associated electrode interfacial behaviors remain challenging. These challenges arise from the interdisciplinary nature of the research, encompassing subjects such as solution chemistry, interface chemistry, electrochemistry, and organic chemistry. This topic holds particular significance because solution chemistry and solution‐solid interface chemistry are ubiquitous in daily lives, yet their behaviors remain unclear due to their inherent complexity, dynamic nature, and rapid variability. In this context, electrolyte and electrolyte‐electrode interface research are used as an illustrative example and summarize their progress from six key perspectives of graphic, quantitation, visualization, standardization, digitization, and intelligence. It is aimed to provide a multi‐faceted understanding of electrolyte microstructures and their behaviors on the electrode interface. This comprehensive approach enables the effective design of electrolytes and enhances the accuracy of predicting battery performance, servicing the development of solution and solution‐solid interface. [ABSTRACT FROM AUTHOR]

A series of BaLaAl3O7 : xEu3+ nanophosphors have been prepared by the high‐temperature solid state reaction method. The XRD and SEM characterization results present that there exists a slight influence on the crystal structure and the average particle size of the nanophosphors while the Eu3+ ions are doped into the matrix. The intense and narrow red photoluminescence spectra have been measured under the ultraviolet excitation and there are two optimal Eu3+ concentrations of 0.8 and 12 mol %, respectively, and the intensity of the former is stronger than that of the latter. Furthermore, the mechanoluminescence phenomena with the same color are also observed when the samples are scratched with a pen. The calculated results based on the measurements of thermoluminescence spectra reveal that the total initial concentration of trapped carriers of BaLaAl3O7 : 12Eu3+ nanophosphors is larger than that of BaLaAl3O7 : 0.8Eu3+ sample, which causes the change trend of ML intensity to be opposite to that of PL intensity even though both have the same Eu3+ doping concentrations. [ABSTRACT FROM AUTHOR]

The production of acetylene (C2H2) via calcium carbide method is an industrial process commonly used in the production of polyvinyl chloride resin. The dehydration of C2H2 is one crucial aspect. In this work, a novel approach based on ionic liquid (IL) separation was explored. Thermodynamic properties of the IL were predicted using the COSMO‐SAC model to screen for an appropriate absorbent. The loss of C2H2 and dehydration performance of IL during dehydration were measured by solubility experiment and laboratory‐scale absorption experiment. Quantum chemistry (QC) calculations and molecular dynamics (MD) simulations were utilized to explore the mechanism of the C2H2 dehydration process. [EMIM][Tf2N] was selected as the final absorbent to achieve highly selective dehydration with low C2H2 losses. Anions play a leading role in the dehydration process, and the dehydration effect mainly depends on hydrogen bonds. This work provides guidance for the rational design of a new absorbent for C2H2. [ABSTRACT FROM AUTHOR]

The upper Müllerian duct (MD) is patterned and specified into two morphologically and functionally distinct organs, the oviduct and uterus. It is known that this regionalization process is instructed by inductive signals from the adjacent mesenchyme. However, the interaction landscape between epithelium and mesenchyme during upper MD development remains largely unknown. Here, we performed single‐cell transcriptomic profiling of mouse neonatal oviducts and uteri at the initiation of MD epithelial differentiation (postnatal day 3). We identified major cell types including epithelium, mesenchyme, pericytes, mesothelium, endothelium, and immune cells in both organs with established markers. Moreover, we uncovered region‐specific epithelial and mesenchymal subpopulations and then deduced region‐specific ligand‐receptor pairs mediating mesenchymal‐epithelial interactions along the craniocaudal axis. Unexpectedly, we discovered a mesenchymal subpopulation marked by neurofilaments with specific localizations at the mesometrial pole of both the neonatal oviduct and uterus. Lastly, we analyzed and revealed organ‐specific signature genes of pericytes and mesothelial cells. Taken together, our study enriches our knowledge of upper MD development, and provides a manageable list of potential genes, pathways, and region‐specific cell subtypes for future functional studies. [ABSTRACT FROM AUTHOR]

Lithium‐ion batteries (LIBs) have gained widespread attention due to their numerous advantages, including high energy density, prolonged cycle life, and environmental friendliness. Nevertheless, their electrochemical performance deteriorates rapidly under extreme temperature conditions, accompanied by a series of safety issues. Electrolyte optimization has emerged as a crucial and feasible strategy to expand the operational temperature range of LIBs. This review comprehensively summarizes the challenges, advances, and characterization methodologies of electrolytes at both subzero and elevated temperatures. Initially, it discusses the degradation mechanisms of different types of electrolytes at extreme temperatures, integrates recent advances, and offers insights into future research directions. Subsequently, various experimental techniques are systematically presented to evaluate the fundamental physical properties, stability, and dynamic behaviors of electrolytes in non‐ambient environments. Finally, it also provides relevant computational methods across the electronic, molecular, and macroscopic scales, and explores the application of high‐throughput techniques in this field. This review offers valuable guidance for breaking the working temperature limits of electrolytes and promoting the development of next‐generation LIBs. [ABSTRACT FROM AUTHOR]

We describe a small population of remarkable plants found in Shuangjiang County, SW Yunnan, as Tuberowithania pengiana gen. & sp. nov., a unique genus within the subtribe Withaninae, tribe Physalideae of the Solanaceae family. The new genus and species feature a distinctive combination of morphological traits, including a large clumped tuberous root, urceolate and densely pubescent dark purplish flowers, densely pubescent purplish filaments, and yellowish‐white, ovoid berries snugly covered by 10‐ribbed accrescent calyx. Molecular phylogenetic analysis, based on a combined matrix of four DNA markers (nrITS, trnL‐F, waxy, LFY), revealed that T. pengiana is deeply nested within the subtribe Withaninae. It forms a sister relationship with Archiphysalis chamaesarachoides, although with weak support. [ABSTRACT FROM AUTHOR]

The mpox outbreak has subdued with fewer reported cases at the present in high‐income countries. It is known that mpox virus (MPXV) infection has been epidemic for more than 50 years in African countries. The ancestral MPXV strain has changed into multiple clades, indicating the ongoing evolution of MPXV, which reflects the historical neglect of mpox in Africa, especially after smallpox eradication, and bestows the danger of more severe mpox epidemics in the future. It is thus imperative to continue the development of mpox diagnostics and treatments so we can be prepared in the event of a new mpox epidemic. In this study, we have developed an MPXV detection tool that leverages the recombinase‐aid amplification assay by integrating lateral flow strips (RAA‐LF) and one‐step sample DNA preparation, with visible readout, no need of laboratory instrument, and ready for field deployment. The detection limit reaches 10 copies per reaction. The performance of our RAA‐FL assay in diagnosing mpox clinical samples is on par with that of the quantitative polymerase chain reaction (PCR) assay. Taken together, we have developed a point‐of‐care RAA‐LF method of high accuracy and sensitivity, readily deployable for field detection of MPXV. This diagnostic tool is expected to improve and accelerate field‐ and self‐diagnosis, allow timely isolation and treatment, reduce the spread of MPXV, thus effectively mitigate MPXV outbreak in the future. [ABSTRACT FROM AUTHOR]

This letter presents a design method of resistance reactance hybrid continuous power amplifier based on reconfigurable devices and CG2H40010F. The power amplifier combines resistive‐reactive inverse F‐class power amplifier (RRIFPA), resistive‐reactive J‐class power amplifier (RRJPA), and resistive‐reactive F class power amplifier (RRFPA). We utilize the principle of low‐pass filters to control the impedance of multi‐frequency harmonics, and use the reconfigurable device SMP1345‐079LF to expand the bandwidth of the power amplifier. This article designs and produces a 1–4 GHz broadband power amplifier. The simulation and measurement results show that within the entire frequency range of 1–4 GHz, the Drain efficiency is between 53.6 and 72.1% $ \% $, the output power is between 40.1 and 42.6 dBm, the gain is between 10.1 and 12.6 dB, and the relative bandwidth is up to 120% $ \% $. [ABSTRACT FROM AUTHOR]

The purpose of this research is to investigate the influence of placement of drainage channels and non‐drainage channels in obese women on post‐caesarean delivery. Documents were retrieved from four databases, such as PubMed and Embase. This study was not limited in time, language, or geography. This trial was conducted using either a cohort or a randomized, controlled study to compare the efficacy of placement of drain in caesarean delivery channel in obese women with or without drain for post‐operative wound complications. The study excluded those who were restricted to those who were not overweight. The main results were the wound infection, the bleeding of the wound and the dehiscence. The risk of bias was evaluated by two authors with a risk‐of‐bias tool for nonrandomized intervention trials. The meta‐analyses only included those that were considered to have a low‐to‐medium risk of bias. The data were pooled with a random‐effects model to determine the relative risk and 95% confidence interval (CI). The quality of the evidence in the selection of results was evaluated. Of 329 related trials, eight were eligible for inclusion. There were 1868 cases of obesity who received C‐section. Among them, there were 451 cases of drain and 1417 cases of non‐drain. No statistical significance was found in the rate of post‐operation infection of the post‐operation between non‐drain or drain treatment of obesity patients (OR, 0.8; 95% CI: 0.48–1.33; p = 0.39). Compared with those with non‐drain, there was a reduction in the risk of haematoma after drain (OR, 0.34; 95% CI: 0.20–0.58; p < 0.0001). The results showed that there were no significant differences in the influence of drainage and non‐drainage on the post‐operative dehiscence of the patients with obesity (OR, 0.84; 95% CI: 0.15–4.70; p = 0.85). The results showed that there were no statistically different effects on the rate of post‐operation wound infection and dehiscence after operation, but the rate of haematoma during drain operation was lower. [ABSTRACT FROM AUTHOR]

We report a photochemical bismuth vanadate (BiVO4) sensing material, which possesses a large proportion of (110) and (011) facets combined with the additional (111) facets, for the selective detection of ultra‐low concentration hydrogen sulfide (H2S) driven by visible light. Specifically, the obtained octadecahedron BiVO4 (Octa‐BiVO4) performs a high response value (67) and short response time (47.4 s) to 100 ppm H2S with good stability for nearly 100 days, as well as undisturbedness by moist air. With the combination of experimental and theoretical calculation results, the adsorption and carrier transfer behaviors of H2S molecules on the Octa‐BiVO4 crystal surface are investigated. By adjusting the ratio of different crystal facets and controlling the facets with characteristic adsorption, we achieve improved anisotropic photoinduced carrier separation and high selectivity for a specific gas. Furthermore, this facial facet engineering can be extended to the synthesis of other sensing materials, offering huge opportunities for fundamental research and technological applications. [ABSTRACT FROM AUTHOR]

Binder plays a pivotal role in the development of lithium‐ion batteries as it must be used to adhere electrode materials on current collectors tightly to guarantee stability. Then, many binder molecules have been designed to enhance the adhesion capability, and conductivity, and/or form a robust solid electrolyte interphase layer for better performance. However, the binder effect on the lithium‐ion (i.e., Li+) de‐solvation on the electrode surface has never been reported before. Herein, it is reported that the binder can influence the Li+ (de‐)solvation process significantly, where its functional group can serve as a probe to detect the dynamic Li+ (de‐)solvation process. It is discovered that different binder functional groups (e.g., *─COO− versus *─F) can affect the Li+‐solvent arrangement on the electrode surface, leading to different degrees of side‐reactions, rate capabilities, and/or the tolerance against Li+‐solvent co‐insertion for the graphite anode, such as in the propylene carbonate‐based electrolyte. A molecular interfacial model related to the electrolyte component's behaviors and binder functional group is proposed to interpret the varied electrode performance. This discovery opens a new avenue for studying the interactions between the binder and electrolyte solvation structure, in turn helping to understand electrode performances underlying the micro‐structures. [ABSTRACT FROM AUTHOR]

The seed morphology of 40 taxa within the genus Hypericum (Hypericaceae) from China, representing 9 sections of the genus, was examined using both Light and Scanning Electron Microscopy to evaluate the taxonomic relevance of macro‐ and micro‐morphological features. Details articulating variation in seed size, color, shape, appendages, and seed coat ornamentation are described, illustrated, and compared, and their taxonomic importance is discussed. Seeds were generally brown in color and cylindric‐ellipsoid to prolonged cylindric in shape. Seed size displayed wide variation, ranging from 0.37–1.91 mm in length and 0.12–0.75 mm in width. Seed appendages were observed as a characteristic morphological feature. Seed surface ornamentation has high phenotypic plasticity, and four types (reticulate, foveolate, papillose, and ribbed) can be recognized. In general, seed color and shape have limited taxonomic significance. However, some other features represent informative characters that can be used efficiently in distinguishing the studied taxa at the section and/or species levels. The findings illustrate that considerable taxonomic knowledge can be obtained by investigating the seed features of Hypericum, and the use of Scanning Electron Microscopy can reveal inconspicuous morphological affinities among species and play a role in taxonomic and systematic studies of the genus Hypericum. Research Highlights: Macro‐ and micro‐morphological features of seeds of 40 Hypericum taxa from China were examined using Light and Scanning Electron Microscopy, providing the first broad study regarding seed morphology for Hypericum from China.Details and variations of seed size, shape, color, surface ornamentation, and appendages are fully presented.Seed features and their variation have important taxonomic significance at the section and/or species levels within Hypericum. [ABSTRACT FROM AUTHOR]

Image collection strategies and ground control points (GCPs) are of particular importance for uncrewed aerial vehicle combined with Structure‐from‐Motion (UAV–SfM) photogrammetry, and the generalization of their effects has proved elusive. This study designed various photogrammetric scenarios to investigate the effects of image collection strategies, ground control quantity, and their interaction on digital elevation model (DEM) errors and their spatial structure in high‐relief terrain. The results of 1.77 × 105 UAV–SfM scenarios provide insights for improving UAV–SfM practices. A high image capture angle (20–40°) enhances camera calibration quality decreasing the magnitude and spatial correlation of errors. High camera inclination reduces the sensitivity of mean and standard deviation of error to flying height but not the spatial correlation of error. Including additional data (e.g. supplemented convergent images; images captured at multiple flying heights) has only a minor effect if imagery is highly inclined. GCPs provide more effective constraints than image collection strategies. The mean error and standard error decline quickly with a small number of GCPs and then become stable in all scenarios, but the spatial correlation of error can be further improved with increasing GCPs. However, the effects of GCP quantity do interact with image collection strategies. High camera inclination reduces requirements for GCPs, whilst strategies combining different flying heights and image orientations have little effect on necessary GCP quantity. The distribution of GCPs still affects the errors, but the effect of GCP distribution becomes less important with an increase in the number of GCPs. Finally, we show that UAV–SfM photogrammetric quality assessment should routinely assess the spatial dependence of error using a statistic like Moran's I. [ABSTRACT FROM AUTHOR]

Nuclear industry spent fuel reprocessing and some radioactive contamination sites often involve high acidity and salinity environments. Currently developed and reported sorbents in 99TcO4− sequestration from the nuclear waste are unstable and show low adsorption efficiency in harsh conditions. To address this issue, we developed a post‐synthetic modification strategy by grafting imidazole‐based ionic liquids (ILs) onto the backbone of covalent organic framework (COF) via vinyl polymerization. The resultant COF‐polyILs sorbent exhibits fast adsorption kinetics (<5 min) and good sorption capacity (388 mg g−1) for ReO4− (a nonradioactive surrogate of 99TcO4−). Outstandingly, COF‐polyILs composite shows superior ReO4− removal even under highly acidic conditions and in the presence of excess competing ions of Hanford low‐level radioactive waste stream, benefiting from the stable covalent bonds between the COF and polyILs, mass of imidazole rings, and hydrophobic pores in COF. [ABSTRACT FROM AUTHOR]

The service life of soluble lead flow batteries can be extended by periodic addition of H2O2, especially when it failed. However in first few cycles after H2O2 treatment, its coulombic efficiency is very low. To clarify it, the properties of electrode and electrolyte, and cycle performance have been systematically analyzed. It has been found that the negative/positive electrode reactions have serious overpotentials during early charging due to oxygen, which are produced and dissolved into the electrolyte during H2O2 treatment. With increasing the cycle number, the polarization degree decreases to the normal level of the battery. To solve it, oxygen is removed using argon after H2O2 treatment. The flow cell is normally recovered in the cycling performance. The average coulomb efficiency is 94.5±5.8 % for 500 times. After H2O2 treatment and oxygen removal, it exhibits a good cycling performance at the average coulomb efficiency of 93.9±4.2 % for another 500 times. [ABSTRACT FROM AUTHOR]

Shape memory polymers (SMP) and its composites (SMPC) have gained popularity for their potential in intelligent structures fields. Developing a reliable mechanical model to accurately describe mechanical behavior of its intelligent structures is important for both theory and practice. This paper presents a novel mechanical model for describing the mechanical behavior of short glass fiber/polyurethane (GF/PU) composite beams, based on a constitutive model of SMP and incorporating principles from composite mechanics theory, the Hamiltonian principle and Euler–Bernoulli beam theory. The model includes kinematic equations and material parameter equations. Based on the constitutive equations of SMP, coupled with Euler–Bernoulli beam theory and Hamilton's principle, the kinematic equations of GF/PU composite beam are established. Additionally, a correction factor was proposed and employed to modify the material parameter equation of SMP, which was then combined with the mechanics theory of composite materials to establish a material parameter equation for composite beams. Taking a simply supported beam as an example, we solve the model using Fourier method and simulate and analyze the material parameters properties, static and viscous mechanical behaviors properties, and shape memory behavior properties of the GF/PU composite beam. The results show that the GF volume fraction, temperature correction coefficient, regularization parameter, and contact parameter have a significant impact on the material parameters of GF/PU composite materials and the material parameters of composite beams have important effects on their mechanical properties. By adjusting material parameters, ideal mechanical properties can be obtained for the GF/PU composite beam. This study provides a theoretical foundation for intelligent beam design and analysis based on SMP and SMPC. Highlights: A novel viscoelastic mechanical model for GF/PU composite beam is proposed.Effect of composite components on GF/PU composite is studied.Kinematic equations based on Hamiltonian principle is established.Material parameter equation including corrected parameter is established. [ABSTRACT FROM AUTHOR]

Background: Aflatoxin B1 (AFB1) is strongly carcinogenic and has been classified as a class I carcinogenic compound by the International Agency for Research on Cancer. AFB1 is widely contaminated in wheat, peanuts, corn and other crops and their products, posing a great threat to human health. Objective: To establish a rapid, safe and accurate fluorescent aptasensor for sensitive detection of AFB1 in food. Methods: In this study, single‐stranded DNA (S1) labeled with black hole quencher BHQ1 and carboxyfluorescein FAM at both ends was used as a signal probe. Nucleic acid exonuclease III (EXO‐III) was introduced as a signal amplification strategy. The basic principle is to exploit the fluorescence resonance energy transfer (FRET) effect generated between FAM and BHQ1. The fluorescent signal change of FAM in the presence or absence of the target is used for the quantitative detection of AFB1. And on this basis, the factors affecting the sensitivity of the sensor are explored in depth. Results: Under optimal experimental conditions, the sensor showed a good linear relationship between LgCAFB1 and relative fluorescence intensity in the range of 0.05‐500 ng/mL. The detection limit was as low as 18.2 pg/mL. In particular, the best performance of the aptasensor was achieved when the ratio of cDNA to Apt was 1.2 and the amount of EXO‐III was 25 U. Conclusions: The combination of MBs, dual‐labeled S1 probes and Exo‐III was used to develop an accurate and sensitive fluorescent aptasensor for AFB1 detection. The developed aptasensor has satisfied recovery and selectivity in AFB1 detection of corn flour and wine samples, indicating that the designed aptasensor has the potential to be used in detecting AFB1 of food samples. [ABSTRACT FROM AUTHOR]

Achieving thermoreversible adhesion between hydrogel and living tissues in a facile way is challenging. Existing strategies bring difficulty to the chemical design and synthesis of hydrogels. Herein, an approach to achieve tough thermoreversible tissue adhesion with hydrogel is proposed, which uses a polymer solution with heat‐induced sol‐gel transition as the interfacial polymer matrix, with no chemical design required for the hydrogel network. When the interfacial polymer matrix is introduced to the interface of the hydrogel and living tissues, it can gelate in situ within the substrate networks under a temperature stimulus, and topologically entangle with the preexisting networks of the substrates, which generates a strong adhesion. By triggering with another temperature stimulus, the newly formed network dissociates to realize an easy detachment. Thermoreversible adhesion is demonstrated between polyacrylamide hydrogel and various porcine tissues as examples, and the mechanism of this adhesion strategy is studied by varying various influence factors. A theoretical model that can fit and predict the effects of different parameters on the adhesion energies is also established. This adhesion strategy based on topological entanglement among a thermoreversible polymer system and the substrates may broaden the achieving methods of thermoreversible tissue adhesion. [ABSTRACT FROM AUTHOR]

Aims: Epilepsy is a common symptom in diffuse lower‐grade glioma (DLGG). The specific role of white matter (WM) alteration in patients with glioma‐related epilepsy (GRE) is largely unknown. This study aims to investigate the reorganization of WM tracts and changes in structural networks related to GRE. Methods: Diffusion‐weighted images were collected from 70 patients with left frontal DLGG (GRE = 33, non‐GRE = 37) and 41 healthy controls (HC). Tractometry with TractSeg was applied to segment tracts and quantify fractional anisotropy (FA) along each tract. Structural network was constructed using constrained spherical deconvolution and probabilistic tractography. FA and network properties were compared among three groups. Results: Compared with HC, both GRE and non‐GRE showed decreased FA in contralateral inferior fronto‐occipital fasciculus, superior longitudinal fasciculus II and arcuate fasciculus, increased nodal efficiency in contralateral nodes of frontal–parietal and limbic networks, whereas decreased degree centrality and betweenness centrality in nodes of dorsal temporal lobe and rostral middle frontal gyrus (rMFG). Additionally, when compared GRE with non‐GRE, increased FA in contralateral corticospinal tract (CST) and lower betweenness centrality in paracentral lobule (PCL) in GRE (all p < 0.05 after Bonferroni correction). Conclusion: This study indicates that patients with left frontal DLGG exhibit complex WM reorganization, and the altered regions mainly concentrated in the language, frontal–parietal and limbic networks. Moreover, the preserved integrity in contralateral CST and server decreased nodal betweenness in PCL may be potential neuroimaging markers underlying the occurrence of presurgical seizures of GRE. [ABSTRACT FROM AUTHOR]

A novel fitting method of obtaining the anisotropic complex moduli of fibers based on the complex moduli of matrix and composites is presented. The complex longitudinal, transverse and in‐plane shear moduli of the unidirectional T700 carbon fiber reinforced epoxy resin composite and the complex modulus of its matrix are measured using dynamic mechanical analysis. The predicted properties of the composite are calculated using the generalized method of cells (GMC). The complex axial, transverse and axial shear moduli of the carbon fibers are obtained by minimizing the sum of the squares of the modules of the difference between the test properties and predicted properties. Finally, the results of the experiment, finite element analysis, and GMC are compared. The results show that the complex axial and transverse moduli of the carbon fibers can be accurately evaluated, while the complex axial shear modulus cannot be accurately determined. [ABSTRACT FROM AUTHOR]

Fine particulate matter (PM2.5) has been a global environmental problem threatening public health in recent years. PM2.5 exposure was associated with an increased risk of neurodegenerative diseases related to neuronal apoptosis. Ferroptosis is a nonapoptotic form of programmed the cell death, characterized by excess iron‐dependent lipid peroxidation products. Whether PM2.5 could induce ferroptosis in cells and thus be involved in its neurotoxicity is unknown. In this study, we found that PM2.5 induced endoplasmic reticulum stress, apoptosis, autophagy, and ferroptosis in neuroblastoma human neuroblastoma cells (SH‐SY5Y). Interestingly, ferroptosis was the predominant form of mortality in the presence of high doses of PM2.5 exposure. In addition, the endoplasmic reticulum stress inhibitor 4‐phenylbutyric acid (4‐PBA) inhibited PM2.5‐induced cellular autophagy, apoptosis, and ferroptosis. Autophagy inhibitors chloroquine (CQ) alleviated PM2.5‐induced ferroptosis but did not reverse apoptosis. We also found that inhibition of both endoplasmic reticulum stress and autophagy reversed the PM2.5‐induced increase in the expression level of cytophagy nuclear receptor coactivator 4 (NCOA4). Our results suggested that PM2.5‐induced ferroptosis in SH‐SY5Y cells was autophagy‐dependent ferroptosis due to endoplasmic reticulum stress, which might be associated with the elevation of iron content caused by NCOA4‐mediated ferritin autophagy. PM2.5‐induced ferroptosis in SH‐SY5Y cells is an autophagy dependent ferroptosis due to endoplasmic reticulum stress, which may be related to the elevated iron content caused by NCOA4‐mediated ferritin autophagy. [ABSTRACT FROM AUTHOR]

The topological system of lakes and streams is the basis for deriving a multitude of patterns and processes in hydrology, geomorphology and ecology. Flow direction is key to constructing a lake‐stream topological system. However, lakes and streams are important hydrological objects that should be considered since they are linked during the process of material and energy transportation. Therefore, a flow direction algorithm that can clearly express the topological relationship of lakes and streams, was proposed here. Lakes and streams were taken as the hydrological objects in stream networks and coupled into a flow direction algorithm. A topological system was established based on the proposed algorithms. Six areas on the Tibetan Plateau were chosen as sample areas with the MERIT digital elevation model (DEM) as the DEM data source. Streams derived from flow direction data in the HydroSHEDS data set (HYDROSTREAMS) and MERIT hydro data set (MERITSTREAMS), as well as streams derived from flow direction results of the D‐infinity algorithm and priority‐flood algorithm were compared with streams derived from the proposed algorithm. The topological relationship between streams and lakes was clearly expressed by the proposed algorithm. In lake areas, the proposed algorithm showed better performance, and no parallel streams were found. In nonlake areas, the stream networks derived from these algorithms were stable. The proposed algorithm offers an opportunity to treat lakes and streams differently during simulation, thus adding to the authenticity of the simulation. Key Points: A novel flow direction algorithm considering the characteristics of lake‐stream is proposed to construct a lake‐stream topological systemThe proposed flow direction model exhibits good robustness, considering the errors in lake areas in digital elevation modelsThe constructed lake‐stream topological system can be applied in both endorheic and exorheic basins worldwide [ABSTRACT FROM AUTHOR]

Resonance‐enhanced emission (REE) effect was discovered and lead to a novel dye family of hydrostyryl pyridinium derivatives in our recent work. Herein, the REE effect was employed to design a red and near‐infrared dual‐state emissive fluorophore family of SW−OH−NO2 derivatives which were easily synthesized by coupling an electron‐withdrawing group (W) onto nitro(hydroxyl)styryl (S−OH−NO2) through a C=C double bond as π‐bridge. The deprotonation of a phenolic hydroxyl group promoted by a nitro group and the electron‐withdrawing group (W) on the other side of the π‐bridge triggered resonance, resulting in significantly red‐shifted emission. All the resultant SW−OH−NO2 compounds showed excellent dual‐state emission behavior. Remarkably, hydrostyryl quinolinium (SQ−OH−NO2) is one of the smallest NIR emitter molecular skeleton (λem=725 nm, MW<400) and showed dual‐state emission characteristics and obvious viscosity‐depended fluorescent behaviors. In addition to constructing electron donor‐acceptor structures and prolonging π‐bridges, the REE effect promises a reliable strategy toward novel fluorophores with small size, long emissive wavelength, and dual‐emission characteristics, and importantly, feasible industrial manufactures and applications due to their easy and low‐cost synthesis strategy. [ABSTRACT FROM AUTHOR]

Distributed in Central Asia, Metastachydium (Lamiaceae) is a poorly understood and rare monotypic genus, with few collections known. The systematic position of this enigmatic genus within Lamiaceae has remained unresolved due to its poor representation in herbaria and coincident lack of available materials for molecular phylogenetic analysis. Facilitated by some recent collections, we performed Bayesian inference and maximum likelihood analyses, using an 80‐protein‐coding plastid‐gene dataset of Lamioideae, to infer the systematic placement of Metastachydium at the tribal level within Lamioideae. In addition, we used an 8‐plastid‐DNA‐region dataset as well as the nuclear ribosomal internal transcribed spacer to determine the phylogenetic affinities of Metastachydium. All phylogenetic analyses agree that Metastachydium is a member of Phlomideae and deeply nested within the genus Phlomoides, suggesting the need to expand the latter to include Metastachydium. Hence, a new combination, Phlomoides sagittata comb. nov., is proposed, and we present the first available photographs and an amended morphological description of P. sagittata. In addition, the infrageneric circumscription of Phlomoides is not supported, as most sections and subsections are not monophyletic. Hybridization and incomplete lineage sorting, following rapid diversification within Phlomoides, seem to be the source of incongruence between the nuclear and plastid tree topologies. [ABSTRACT FROM AUTHOR]

Aim: To investigate the status and influencing factors of health information literacy in patients with intermediate‐stage chronic kidney disease (CKD). Design: A prospective clinical study. Methods: We used a CKD health information literacy questionnaire to survey 130 patients with intermediate‐stage CKD and valuate their health needs and health knowledge. We performed the study in strict accordance with the Guidelines for Clinical Trial Protocols. We registered the study in the Chinese Clinical Trial Registration Center (registration No. ChiCTR2100053103; approval No. K56‐1). Results: The overall health information literacy of CKD was relatively low. Low education level, advanced age and unemployment were influencing factors. The scores of assessment ability, literacy awareness, application ability, integration ability and CKD health knowledge reserve were relatively low. The generalized linear model showed that the older the men, the lower their health information literacy. [ABSTRACT FROM AUTHOR]

A method was established for the separation and determination of triadimefon and its metabolite triadimenol enantiomer residues in major complementary fruit puree for infants and young children (banana puree, pineapple puree, and grape puree) by supercritical fluid chromatography. After the samples were extracted with acetonitrile and purified with a solid phase extraction cartridge, Acquity Trefoil CEL2 chiral chromatographic column was adopted for separation, and gradient elution was conducted at the flow rate of 1.0 ml/min under the mobile phase of supercritical carbon dioxide ‐ 0.5% ammonia methanol, the detection wavelength was 220 nm and quantification was conducted with the external standard method. The limits of quantitation of triadimefon and triadimenol enantiomers were both 0.05 mg/kg, the linear ranges were 0.5–50 mg/L, and the linear correlation coefficients were greater than 0.9993. The recoveries in the spiked samples at 0.05, 0.2, and 3.0 mg/kg were from 80.1 to 106%, and the relative standard deviation reached 3.3–7.6%. The method is efficient, rapid, reproducible, and environmentally friendly, enabling accurate analysis of pesticide enantiomers, which can detect the enantiomer residues of triadimefon and its metabolite triadimenol in major complementary fruit puree for infants and young children. [ABSTRACT FROM AUTHOR]

In this paper, we present a nonlinear strong positivity‐preserving finite volume (FV) scheme on tetrahedral meshes for nonstationary convection–diffusion equations with general right‐hand term, whose exact solution is assumed to be non‐negative, while the right‐hand term is allowed to be negative. A nonlinearization technique, which can be regarded as a correction of the linear scheme, is used to the discretization of both the diffusion and convection terms. Moreover, we impose nonlinear correction for the right‐hand term if it is a sink. The resulting scheme is cell‐centered and locally conservative, and has a fixed stencil. And in the construction of the scheme, it is unnecessary to assume that auxiliary unknowns are non‐negative. Besides, the existence of a solution and the strong positivity‐preserving property for the nonlinear system are proved. Finally, the numerical examples are presented to show the positivity of the new scheme and the second‐order convergence rate for the solution. [ABSTRACT FROM AUTHOR]

Objective: To systematically evaluate the development of Machine Learning (ML) models and compare their diagnostic accuracy for the classification of Middle Ear Disorders (MED) using Tympanic Membrane (TM) images. Methods: PubMed, EMBASE, CINAHL, and CENTRAL were searched up until November 30, 2021. Studies on the development of ML approaches for diagnosing MED using TM images were selected according to the inclusion criteria. PRISMA guidelines were followed with study design, analysis method, and outcomes extracted. Sensitivity, specificity, and area under the curve (AUC) were used to summarize the performance metrics of the meta‐analysis. Risk of Bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies‐2 tool in combination with the Prediction Model Risk of Bias Assessment Tool. Results: Sixteen studies were included, encompassing 20254 TM images (7025 normal TM and 13229 MED). The sample size ranged from 45 to 6066 per study. The accuracy of the 25 included ML approaches ranged from 76.00% to 98.26%. Eleven studies (68.8%) were rated as having a low risk of bias, with the reference standard as the major domain of high risk of bias (37.5%). Sensitivity and specificity were 93% (95% CI, 90%–95%) and 85% (95% CI, 82%–88%), respectively. The AUC of total TM images was 94% (95% CI, 91%–96%). The greater AUC was found using otoendoscopic images than otoscopic images. Conclusions: ML approaches perform robustly in distinguishing between normal ears and MED, however, it is proposed that a standardized TM image acquisition and annotation protocol should be developed. Level of Evidence: NA Laryngoscope, 133:732–741, 2023 [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of large vestibular aqueduct syndrome (LVAS) on middle ear sound transmission using wideband absorbance immittance (WAI). Methods: WAI results from young adult LVAS patients and normal adults were compared. Results: Averaged energy absorbance (EA) at ambient and peak pressure in the LVAS group showed differences to the normal group. Under ambient pressure, the average EA of the LVAS group was significantly higher than the normal group at frequencies 472–866 Hz and 6169–8000 Hz (p <.05) and lower at frequencies 1122–2520 Hz (p <.05). Under peak pressure, absorbance was increased at frequencies 515–728, 841, and 6169–8000 Hz (p <.05) and decreased at 1122–1374 Hz and 1587–2448 Hz (p <.05). An investigation into the effect of external auditory canal pressure on EA across frequencies in the pressure–frequency domain, showed that EA differed significantly in the low‐frequency region of 707and 1000 Hz from 0 to 200 daPa and 500 Hz at 50 daPa (p <.05). There was also a significant difference in EA between the two groups at 8000 Hz (p <.05) in the pressure range −200–300 daPa. Conclusion: WAI is a valuable tool to measure the effect of LVAS on middle ear sound transmission. LVAS has a significant effect on EA at low and mid frequencies under ambient pressure, while the frequencies affected are mainly at low frequencies when positive pressure is presented. Level of Evidence: Level 3a. [ABSTRACT FROM AUTHOR]

Temperature fluctuation is one of the most important factors in climate change, and research into its effects on organisms is increasing. Nonetheless, few studies have addressed its effects on insects and particularly on the parental generation. We therefore simulated temperature amplitudes (± 0, 4, 6, 8, 10°C) for a mean environmental temperature of 25°C and studied their immediate and maternal effects on a global pest, the diamondback moth Plutella xylostella (Lepidoptera: Plutellidae), focusing on adult longevity and fecundity and egg development and survivorship in the next generation. Relative to constant temperature, moderate amplitudes (4 and 6°C) did not affect the adults, whereas 8 and 10°C amplitudes hindered adult longevity and fecundity, but significantly increased the proportional of early fecundity after each treatment. Temperature amplitude 10°C inhibited development of Day 2 and Day 3 laid eggs. These findings show that temperature amplitude affects both the maternal and offspring phenotype and indicate that the influence of temperature amplitude on diamondback moth population models requires further research. [ABSTRACT FROM AUTHOR]

Objectives: Ruxolitinib, a Janus kinase (JAK) 1/2 inhibitor, demonstrates efficacy for treating steroid‐resistant acute graft‐versus‐host disease (SR‐aGVHD) following allogeneic stem cell transplantation (allo‐HSCT). Myeloid‐derived suppressor cells (MDSCs) have a protective effect on aGVHD via suppressing T cell function. However, the precise features and mechanism of JAK inhibitor‐mediated immune modulation on MDSCs subsets remain poorly understood. Methods: A total of 74 SR‐aGVHD patients treated with allo‐HSCT and ruxolitinib were enrolled in the present study. The alterations of MDSC and regulatory T cell (Treg) populations were monitored during ruxolitinib treatment in responders and nonresponders. A mouse model of aGVHD was used to evaluate the immunosuppressive activity of MDSCs and related signalling pathways in response to ruxolitinib administration in vivo and in vitro. Results: Patients with SR‐aGVHD who received ruxolitinib treatment achieved satisfactory outcomes. Elevation proportions of MDSCs before treatment, especially polymorphonuclear‐MDSCs (PMN‐MDSCs) were better to reflect the response to ruxolitinib than those in Tregs. In the mouse model of aGVHD, the administration of ruxolitinib resulted in the expansion and functional enhancement of PMN‐MDSCs and the effects could be partially reversed by an anti‐Gr‐1 antibody in vivo. Ruxolitinib treatment significantly elevated the suppressive function of PMN‐MDSCs through reactive oxygen species (ROS) production by Nox2 upregulation as well as bypassing the activated MAPK/NF‐κB signalling pathway. Additionally, ex vivo experiments demonstrated that ruxolitinib prevented the differentiation of mature myeloid cells and promoted the accumulation of MDSCs by inhibiting STAT5. Conclusions: Ruxolitinib enhances PMN‐MDSCs functions through JAK/STAT and ROS‐MAPK/NF‐κB signalling pathways. Monitoring frequencies and functions of MDSCs can help evaluate treatment responses to ruxolitinib. [ABSTRACT FROM AUTHOR]

The "toe syndactyly, telecanthus and anogenital and renal malformations" (STAR) syndrome is a rare X‐linked dominant inherited kidney ciliopathy caused by CCNQ gene mutations. Here, we investigated the genotype and phenotype in the first two twin sisters with a novel tail extension CCNQ variant in Asia. Genetic variants of the pedigree were screened using whole‐exome sequence analysis and validated by direct Sanger sequencing. The genetic function was investigated through cultured cells and zebrafish embryos transfected with mutant. The proband is suffered from end‐stage renal disease, telecanthus, scoliosis, anal atresia, bilateral hydronephrosis pyeloureter dilation and hearing loss, while her twin sister had milder phenotypes. A novel heterozygous variant c.502_518delinsA (p.Val168SerfsTer173) in CCNQ gene was identified in the twins and their asymptomatic mosaic mother. The concurrent deletion of 17 bases and insertion of one base variant led to the loss of 5 amino acids, subsequently caused a 96 more amino acids tail extension delaying the appearance of stop codon. The loss‐of‐function variant of CCNQ not only led to the impaired expression of cyclin M but also increased the binding affinity of CDK10‐cyclin M complex, which is different from the previous study. The research expanded the genotypic and phenotypic spectrum of STAR syndrome. [ABSTRACT FROM AUTHOR]

We performed a meta‐analysis to evaluate the effect of platelet‐rich plasma vs standard management for the treatment of diabetic foot ulcer wounds. A systematic literature search up to March 2022 was performed and 1435 subjects with diabetic foot ulcer wounds at the baseline of the studies; 723 of them were treated with platelet‐rich plasma, and 712 used control. Odds ratio (OR) with 95% confidence intervals (CIs) was calculated to assess the effect of platelet‐rich plasma vs standard management for the treatment of diabetic foot ulcer wounds using the dichotomous method with a random or fixed‐effect model. The use of autologous platelet‐rich plasma resulted in significantly higher complete‐healed diabetic foot ulcer wounds compared with control (OR, 1.95; 95% CI, 1.49‐2.56, P < 0.001). The use of allogeneic platelet‐rich plasma resulted in significantly higher complete‐healed diabetic foot ulcer wounds compared with control (OR, 6.19; 95% CI, 2.32‐16.56, P < 0.001). The use of autologous and allogeneic platelet‐rich plasma resulted in significantly higher complete‐healed diabetic foot ulcer wounds compared with control. Though, the analysis of outcomes should be with caution because of the low number of studies in certain comparisons, for example, allogeneic platelet‐rich plasma compared with control. [ABSTRACT FROM AUTHOR]

It is a pressing need, but still challenging to explore the structure and function of membrane proteins (MPs). One of the main obstacles is the limited availability of matched detergents for the handling of specific MPs. We describe herein the design of new detergents by incorporation of a transition linker between the hydrophilic head and the hydrophobic tail. This design allows a gradual change of hydrophobicity between the outside and inside of micelles, in contrast to the abrupt switch in conventional detergents. Notably, many of these detergents assembled into micelles in while retaining low critical micelle concentrations. Meanwhile, thermal stabilizing evaluation identified superior detergents for representative MPs, including G protein‐coupled receptors and a transporter protein. Among them, further improved the NMR study of MPs. We anticipate these that results will encourage future detergent expansion through new remodeling on the traditional detergent scaffold. [ABSTRACT FROM AUTHOR]

The coupling mechanism of the Tianshan Orogenic Belt (TOB) and the basins on its sides (Junggar, Turpan–Hami, Tarim, Yili, etc.) since the Late Mesozoic was complex and multi‐levelled. Based on gravity, magnetism, Moho discontinuity, and lithospheric velocity structure of the TOB, together with the structural and sedimentary data of the basins, a model is proposed to reflect the influence of the basin–orogen coupling on the regional source–sink processes of sandstone‐type uranium mineralization since the Late Mesozoic. Generally, there are four main stages of tectonic movements that have changed the coupling mechanism of basin and orogeny: including the Early Yanshanian Movement, the Late Yanshanian Movement, the Middle Himalayan Movement, and the Late Himalayan Movement. These four movements together controlled the mineralization of the sandstone‐type uranium deposits in the TOB together. The mineralization of sandstone‐type uranium deposits in the TOB can be divided into three metallogenic stages: the ore‐bearing formation stage (T‐J2), the tectonic reversal‐related metallogenic stage (J3‐N1), and the epigenetic regenerating ore‐preserving stage (N2‐Q). The tectonic reversal‐related metallogenic stage can be subsequently divided into three sub‐stages: the pre‐metallogenic stage (J3), the sub‐metallogenic stage (K), and the main metallogenic stage (E‐N1). The associated uplift led to the deformation of the mineralized strata in the basins, while the reducing agent migration along faults enhanced the reduction environment within the strata, which affected the enrichment and distribution of the uranium mineralization in the strata. Meanwhile, the recharge and the change of flow state of groundwater also contributed to the later transformation and mineralization. The intra‐continental subduction caused deep lithospheric buckling and depression in the TOB, accompanied by local‐scale mantle convection, which accounts for both tectonic and geodynamic settings for the regional basin–orogen coupling mechanism. In addition, the far‐field effect of the India–Eurasian collision also provided the driving force for the sandstone‐type uranium mineralization in the TOB. [ABSTRACT FROM AUTHOR]