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The influence of El Niño‐Southern Oscillation (ENSO) on the North Tropical Atlantic (NTA) sea surface temperature (SST) is well‐documented in boreal spring, yet it manifests greater complexity in winter. Distinct from El Niño, La Niña has a statistically significant impact on winter NTA SST, which is primarily contributed by the re‐occurring (i.e., second and third years of multi‐year) La Niña events. Despite similar atmospheric forcing, prominent SST anomalies are observed in the NTA during the re‐occurring La Niña winters but not in the first‐year La Niña winters, mainly due to different initial states associated with previous tropical Pacific forcing. Targeted pacemaker experiments well reproduce the robust impacts of re‐occurring La Niña events on the wintertime NTA SST, highlighting the crucial impact of ENSO cycle complexity in its inter‐basin linkages. Plain Language Summary: The El Niño‐Southern Oscillation (ENSO) significantly influences the sea surface temperature (SST) in the North Tropical Atlantic (NTA), particularly as ENSO events decay during boreal spring. However, during winter when ENSO reaches its peak, the NTA SST anomalies exhibit strong uncertainty. While no marked SST anomalies are observed in the NTA during El Niño winters, prominent SST anomalies can often be found in the NTA during La Niña winters. The significant La Niña‐related SST anomalies in the NTA are primarily contributed by the second and third years of multi‐year La Niña events, rather than the first‐year La Niña events. The SST difference between the first‐year and re‐occurring La Niña winters can be attributed to the SST initial state in the NTA, which is related to the preceding forcing from the tropical Pacific. By incorporating this initial state, we can more accurately reconstruct the NTA SST anomalies during La Niña winters. Targeted pacemaker experiments corroborate the significant role of re‐occurring La Niña events in influencing wintertime NTA SST. Key Points: La Niña usually has stronger impacts on winter NTA SST than El Niño, primarily contributed by re‐occurring La Niña eventsDifferent NTA SST anomalies during the first‐year and re‐occurring La Niña can be well understood by considering the NTA initial stateTargeted pacemaker experiments confirm the important effect of re‐occurring La Niña on the NTA SST [ABSTRACT FROM AUTHOR]

Atmospheric variability associated with the winter North Pacific Oscillation (NPO), preceding El Niño‐Southern Oscillation (ENSO) events by about 1 year, is driven mainly by the tropical Pacific sea surface temperature (SST) anomalies but may also affect the subsequent ENSO. To isolate the latter, we conduct an idealized hindcast experiment using a climate model MIROC6, in which the NPO‐related surface heat flux and wind stress anomalies are overridden over the North Pacific. The ENSO evolution can be overall reproduced without the NPO forcing, confirming the predominant intrinsic predictability arising from the tropical coupled dynamics. However, the extratropical atmospheric forcing associated with the NPO, when it reaches three standard deviations, can enhance the ENSO development by about 29.6%, contrasting with limited effects of the moderate NPO forcing. La Niña events exhibit much less sensitivity to the NPO forcing compared to El Niño events, possibly due to asymmetric patterns of the simulated NPO. Plain Language Summary: The winter North Pacific Oscillation (NPO), manifesting as a meridional dipole structure in sea level pressure over the North Pacific, is suggested to play a role in the subsequent El Niño‐Southern Oscillation (ENSO) development. Recent studies demonstrate that the preceding winter NPO signal mainly originates from the tropical Pacific SST forcing, making it challenging to isolate its specific impact on ENSO. In this study, we design a series of "overriding" experiments to decouple the tropical and extratropical Pacific processes based on the MIROC6 model. It is found that the ENSO evolution can be reproduced when excluding the NPO forcing, suggesting that the ENSO events is primarily driven by internal dynamics within the tropics. While the moderate NPO forcing has minor effects on the ENSO events, the exceptionally strong NPO forcing can further amplify the ENSO development. This study underscores that while NPO‐related extratropical variabilities do affect ENSO, their impact, especially under moderate conditions, should not overshadow the intrinsic predictability from the tropics. Key Points: The El Niño‐Southern Oscillation (ENSO) development is primarily driven by internal dynamics within tropicsThe NPO forcing of the extreme rather than moderate amplitude can significantly amplify the ENSO developmentDevelopment of El Niño events are more sensitive to the NPO forcing compared to La Niña events [ABSTRACT FROM AUTHOR]

Automatic segmentation of the fundus retinal vessels and accurate classification of the arterial and venous vessels play an important role in clinical diagnosis. This article proposes a fundus retinal vascular segmentation and arteriovenous classification network that combines the adversarial training and attention mechanism to address the issues of fundus retinal arteriovenous classification error and ambiguous segmentation of fine blood vessels. It consists of three core components: discriminator, generator, and segmenter. In order to address the domain shift issue, U‐Net is employed as a discriminator, and data samples for arterial and venous vessels are generated with a generator using an unsupervised domain adaption (UDA) approach. The classification of retinal arterial and venous vessels (A/V) as well as the segmentation of fine vessels is improved by adding a self‐attention mechanism to improve attention to vessel edge features and the terminal fine vessels. Non‐strided convolution and non‐pooled downsampling methods are also used to avoid losing fine‐grained information and learning less effective feature representations. The performance of multi‐class blood vessel segmentation is as follows, per test results on the DRIVE dataset: F1‐score (F1) has a value of 0.7496 and an accuracy of 0.9820. The accuracy of A/V categorization has increased by 1.35% when compared to AU‐Net. The outcomes demonstrate that by enhancing the baseline U‐Net, the strategy we suggested enhances the automated classification and segmentation of blood vessels. [ABSTRACT FROM AUTHOR]

Key Clinical Message: Cholecystolithiasis combined with choledocholithiasis represents a prevalent disease. At present, regarding the management of the common bile duct (CBD), T‐tube drainage (TTD) and primary duct closure (PDC) emerge as two prominent approaches for biliary tract repair after laparoscopic CBD exploration (LCBDE). Here, retrospective analysis was conducted on the clinical records of 157 patients who underwent LCBDE at our hospital between January 2019 and January 2022. All patients were categorized into the PDC group or the TTD group based on the chosen CBD treatment approach. A comparative assessment was made across demographic factors, preoperative conditions, surgical particulars, and postoperative complications. The results showed that PDC is recommended for patients with a limited number of small stones, particularly when the CBD is in the 10–15 mm diameter range. [ABSTRACT FROM AUTHOR]

The article focuses on the innovative Zman-seq technology, which integrates time stamps into single-cell transcriptomics to track immune cell dynamics over extended periods. It enables a deeper understanding of temporal changes in immune responses, revealing insights into immune cell differentiation and function, particularly in cancer research and therapeutic interventions.

Globally, significant attention is given to the cultivation and evaluation of Mathematical Higher‐Order Thinking Skills (MHOTS). This study aims to address the gap in developing and validating suitable MHOTS structures for high school students. In this study, 53 items were determined by experts in the field of mathematics education and scale development. The study group of this study consists of 654 students educated at the high school level. We decided to split the samples randomly in two by designating a random half as exploratory factor analysis (EFA) and the other half as confirmatory factor analysis (CFA). EFA was used to confirm a robust "four‐dimensional, nine‐factor" measurement structure, encompassing four key dimensions, namely mathematical critical thinking, mathematical creative thinking, mathematical problem‐solving, and mathematical metacognitive skills. The scale's quality was assessed through a retest using CFA and the structural validity was evaluated through CFA and correlation analysis. The criterion validity of the scale was also examined using math scores. The results from the double validity analysis showed that the scale had a reasonable and valid structure. The findings established the MHOTS for high school students as a reliable and valid instrument for measuring the level of MHOTS among high school students. This newly developed scale holds promise as an effective tool to assess and enhance mathematical higher‐order thinking in the student population. Practitioner points: MHOTS encompasses four key dimensions, namely mathematical critical thinking, mathematical creative thinking, mathematical problem‐solving, and mathematical metacognitive skills.We utilized exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) to assess the reliability and validity of H‐MHOTS.H‐MHOTS is a reliable and valid instrument for measuring the level of MHOTS among high school students. [ABSTRACT FROM AUTHOR]

Summary: Potato (Solanum tuberosum) is the fourth largest food crop in the world. Late blight, caused by oomycete Phytophthora infestans, is the most devastating disease threatening potato production. Previous research has shown that StRFP1, a potato Arabidopsis Tóxicos en Levadura (ATL) family protein, positively regulates late blight resistance via its E3 ligase activity. However, the underlying mechanism is unknown.Here, we reveal that StRFP1 is associated with the plasma membrane (PM) and undergoes constitutive endocytic trafficking. Its PM localization is essential for inhibiting P. infestans colonization. Through in vivo and in vitro assays, we investigated that StRFP1 interacts with two sugar transporters StSWEET10c and StSWEET11 at the PM.Overexpression (OE) of StSWEET10c or StSWEET11 enhances P. infestans colonization. Both StSWEET10c and StSWEET11 exhibit sucrose transport ability in yeast, and OE of StSWEET10c leads to an increased sucrose content in the apoplastic fluid of potato leaves. StRFP1 ubiquitinates StSWEET10c and StSWEET11 to promote their degradation.We illustrate a novel mechanism by which a potato ATL protein enhances disease resistance by degrading susceptibility (S) factors, such as Sugars Will Eventually be Exported Transporters (SWEETs). This offers a potential strategy for improving disease resistance by utilizing host positive immune regulators to neutralize S factors. [ABSTRACT FROM AUTHOR]

Lesion segmentation is a fundamental task in medical image processing, often facing the challenge of subtle lesions. It is important to detect these lesions, even though they can be difficult to identify. Convolutional neural networks, an effective method in medical image processing, often ignore the relationship between lesions, leading to topological errors during training. To tackle topological errors, move is made from pixel‐level to hypergraph representations. Hypergraphs can model lesions as vertices connected by hyperedges, capturing the topology between lesions. This paper introduces a novel dynamic hypergraph learning strategy called DHLS. DHLS allows for the dynamic construction of hypergraphs contingent upon input vertex variations. A hypergraph global‐aware segmentation network, termed HGSNet, is further proposed. HGSNet can capture the key high‐order structure information, which is able to enhance global topology expression. Additionally, a composite loss function is introduced. The function emphasizes the global aspect and the boundary of segmentation regions. The experimental setup compared HGSNet with other advanced models on medical image datasets from various organs. The results demonstrate that HGSNet outperforms other models and achieves state‐of‐the‐art performance on three public datasets. [ABSTRACT FROM AUTHOR]

Extreme El Niño events have outsized global impacts and control the El Niño Southern Oscillation (ENSO) warm/cold phases asymmetries. Yet, a consensus regarding the relative contributions of atmospheric and oceanic nonlinearities to their genesis remains elusive. Here, we isolate the contribution of oceanic nonlinearities by conducting paired experiments forced with opposite wind stress anomalies in an oceanic general circulation model, which realistically simulates extreme El Niño events and oceanic nonlinearities thought to contribute to ENSO skewness (Tropical Instability Waves (TIWs), Nonlinear Dynamical Heating (NDH)). Our findings indicate a weak contribution of oceanic nonlinearities to extreme El Niño events in the eastern Pacific, owing to compensatory effects between lateral (NDH and TIWs) and vertical processes. These results hold across different vertical mixing schemes and modifications of the upper‐ocean heat budget mixed layer criterion. Our study reinforces previous research underscoring the pivotal role of atmospheric nonlinearities in shaping extreme El Niño events. Plain Language Summary: The El Niño‐Southern Oscillation (ENSO) is the primary driver of year‐to‐year climate variations in the tropics and beyond. Originating from air‐sea interactions in the tropical Pacific, ENSO oscillates between warm (El Niño) and cold (La Niña) phases, modulating sea surface temperature in the central and eastern equatorial Pacific. Occasionally, El Niño events intensify into "super" El Niño events, causing widespread impacts globally. Utilizing a state‐of‐the‐art oceanic model, our research challenges previous results suggesting a strong oceanic contribution to the amplitude difference between "normal" and "super" El Niño events. Instead, our findings reveal that potential oceanic influences on "super" El Niño events tend to offset each other. This is consistent with recent research highlighting the crucial role of atmospheric processes in the transformation from a "normal" to a "super" El Niño. Key Points: A state‐of‐the‐art ocean model reproduces extreme El Niño events and the corresponding nonlinear oceanic processes realisticallyContributions from oceanic nonlinearities are isolated using paired simulations forced by opposite wind stress anomaliesEffects of oceanic nonlinearities on extreme El Niño events are small, due to compensation between lateral and vertical processes [ABSTRACT FROM AUTHOR]

Meroterpenoids of the ochraceopones family featuring a linear tetracyclic scaffold exhibit exceptional antiviral and anti‐inflammatory activities. The biosynthetic pathway and chemical logic to generate this linear tetracycle, however, remain unknown. In this study, we identified and characterized all biosynthetic enzymes to afford ochraceopones and elucidated the complete biosynthetic pathway. We demonstrated that the linear tetracyclic scaffold of ochraceopones was derived from an angular tetracyclic precursor. A multifunctional cytochrome P450 OchH was validated to catalyze the free‐radical‐initiated carbon‐carbon bond cleavage of the angular tetracycle. Then, a new carbon‐carbon bond was verified to be constructed using a new aldolase OchL, which catalyzes an intramolecular aldol reaction to form the linear tetracycle. This carbon‐carbon bond fragmentation and aldol reaction cascade features an unprecedented strategy for converting a common angular tetracycle to a distinctive linear tetracyclic scaffold in meroterpenoid biosynthesis. [ABSTRACT FROM AUTHOR]

The article describes the case of a 58-year old female diagnosed with a rare combination of correct transposition of the great arteries and isolated levocardia. It describes the position of the heart chambers and abnormal spatial relationship of the great arteries, including the right and left atrium, right ventricle and pulmonary artery, verified by transthoracic echocardiography, Color Doppler flow imaging, cardiac magnetic resonance imaging, echocardiography and cardiac segmental analysis.

The engineering of anode‐electrolyte interphase for highly reversible and dendrite‐free Zn plating‐stripping continues to pose a significant challenge in the progression of aqueous Zn‐ion batteries (AZIBs). In this study, a novel approach is introduced that involves the design of a hierarchical carbon nanotube (CNT)‐based host through functionalization with cetyltrimethylammonium cations (CTA+). This hierarchical host enables dynamically switchable repulsive shielding to regulate Zn plating. The CNT scaffold, featured with high flexibility and conductivity, facilitates expandable accommodation of continuous Zn plating. Concurrently, the entangled CTA+ cations, acting as manipulators to form switchable repulsive shields, dynamically suppress the growth of Zn dendrites, and result in uniform Zn plating within cationic CNT (C‐CNT) hosts. The cationic shielding effect is further elucidated through density functional theory calculations. By incorporating the self‐adaptive C‐CNT host, Zn symmetric cells exhibit an impressively stable cycling lifespan exceeding 6500 h at 1 mA·cm−2 and achieve a cumulative capacity of 6000 mAh·cm−2 at 4 mA·cm−2. Full batteries, by coupling the C‐CNT@Zn anode and MnO2 cathode, demonstrate an 88% capacity retention after 2000 cycles at 2 A·g−1. The design of the self‐adaptive C‐CNT host offers a promising approach in electrode‐electrolyte interphase engineering toward the practical applications of Zn‐based energy storage systems. [ABSTRACT FROM AUTHOR]

Introduction: Chimeric antigen receptor (CAR) T cell therapy has markedly improved the prognosis of patients with diffuse large B‐cell lymphoma (DLBCL). The relative positioning of tumor lesions in lymphoma varies among patients, manifesting as either aggregation (clumped together) or dissemination (spread throughout the body). Prognostic significance of factors indicating the relative positioning of tumor lesions in CAR T cell therapy remains underexplored. For aggregation, prior research proposed the tumor volume surface ratio (TVSR), linking it to prognosis in chemotherapy. Regarding dissemination, indicators such as disease stage or extranodal involvement, commonly used in clinical practice, have not demonstrated prognostic significance in CAR T cell therapy. This study aims to analyze current indicators of tumor aggregation or dissemination and introduce a novel indicator to assess the prognostic value of tumor lesions' relative positioning in DLBCL patients undergoing CAR T cell therapy. Methods: This retrospective study included 42 patients receiving CAR T cell therapy. Lesion image information was obtained from the last PET/CT scan prior to CAR T cell infusion, including total metabolic tumor volume, total tumor surface, diameter of lymphoma masses, and the sites of tumor lesions. We evaluated TVSR and bulky disease as descriptors of tumor aggregation. We refined existing indicators, stage III&IV and >1 site extranodal involvement, to distill a new indicator, termed 'extra stage', to better represent tumor dissemination. The study examined the prognostic significance of tumor aggregation and dissemination. Results: Our findings indicate that TVSR, while prognostically valuable in chemotherapy, lacks practical prognostic value in CAR T cell therapy. Conversely, bulky disease emerged as an optimal prognostic indicator of tumor aggregation. Both bulky disease and extra stage were associated with poor prognosis and exhibiting synergistic prognostic impact in CAR T cell therapy. Conclusions: Overall, the relative positioning of tumor lesions significantly influences the prognosis of patients with DLBCL receiving CAR T cell therapy. The ideal scenario involves tumors with minimal dissemination and no aggregation. The relative positioning of tumor lesions is associated with the prognosis of patients with DLBCL receiving CAR T cell therapy.The tumor lesion with limited dissemination and no aggregation is the most ideal. [ABSTRACT FROM AUTHOR]

While the prominent influence of El Niño‐Southern Oscillation (ENSO) on the Indian Ocean Oscillation (IOD) is widely recognized, intricate relationships between them are often invoked that introduce challenges into seasonal predictions. Previous studies have shown that different flavors of El Niño exhibit distinct associations with the IOD. In this study, we demonstrate that La Niña's teleconnection to the IOD is primarily controlled by its longitudinal position. Westward‐displaced La Niña events tend to produce stronger negative convection anomalies in the central Pacific and more pronounced Walk Circulation anomalies, thereby triggering strong negative IOD events. In contrast, eastward‐displaced La Niña events are usually accompanied by feeble convection response due to the excessively cold conditions in the cold tongue, yielding insignificant IOD response. The pivotal role of La Niña's longitudinal position on the IOD's response is realistically reproduced by targeted pacemaker experiments, providing new insights into inter‐basin climate connections. Plain Language Summary: The tropical Indian Ocean usually witnesses a dipolar pattern of sea surface temperature (SST) anomalies, which is commonly referred to as the Indian Ocean Dipole (IOD). The IOD phenomenon has received much attention due to its profound global impacts, yet its seasonal prediction remains a large challenge for the climate community. The year‐to‐year variability of IOD has usually been linked to the El Niño–Southern Oscillation (ENSO), the predominant interannual climate variability in the tropical Pacific. The relationship between El Niño (i.e., warm phase of ENSO) and the intensity of IOD has been demonstrated in previous studies, which is shown to be dependent on the different El Niño flavors. In this study, we show that the longitudinal position of negative SST anomalies during La Niña events (i.e., cold phase of ENSO) in shaping their connection with IOD. Different from westward‐displaced La Niña events that can drive robust negative IOD events, eastward‐displaced La Niña events do not yield significant IOD anomalies due to the excessively cold conditions prevalent in the eastern Pacific cold tongue region. We highlight the importance of La Niña's longitudinal position in its teleconnection to other ocean basins and the associated regional climate anomalies. Key Points: The La Niña's regulation of Indian Ocean Oscillation (IOD) mainly depends on the La Niña longitudinal positionThe westward‐displaced La Niña events produce significant Walker Circulation anomalies, triggering robust negative IOD eventThe importance of La Niña longitudinal position on the IOD's response can be evidenced by the targeted pacemaker experiments [ABSTRACT FROM AUTHOR]

This study examines whether board social networks are associated with executive trading profitability. Using a sample of US public firms with a history of executive trading from years 2000 to 2015, we find robust evidence that the profitability of executive trading is significantly lower in firms with higher levels of board social networks. The evidence is consistent with our view that board social networks effectively curb executives' private information advantage over outsiders, thus leading to a lower level of managerial rent‐seeking. Our research has policy implications for regulators concerned about the role of corporate board in capital markets. [ABSTRACT FROM AUTHOR]

The Pacific Meridional Mode (PMM) has long been associated with extra‐tropical air‐sea coupling processes, which are thought to influence the development of El Niño‐Southern Oscillation (ENSO). Here we show that the PMM on seasonal to interannual timescales is closely associated with a newly proposed tropical mode known as the ENSO Combination mode (C‐mode), which arises from the nonlinear interaction between ENSO and the background annual cycle in the deep tropics. The PMM exhibits a remarkable resemblance with the C‐mode in atmospheric patterns, spectral characteristics, and local impacts. Based on a simple Hasselmann‐type model, we further demonstrate that the C‐mode‐related atmospheric anomalies can effectively drive PMM‐like sea surface temperature anomalies. As the C‐mode captures seasonally modulated ENSO characteristics, the seasonal‐to‐interannual PMM variability could naturally establish a connection with ENSO, thereby offering an alternative explanation for the observed relationship between PMM and ENSO. Plain Language Summary: Previous studies demonstrated that the Pacific Meridional Mode (PMM) is driven by the extratropical climate systems, which can impact the development of El Niño‐Southern Oscillation (ENSO) events in the tropics. In our study, we establish a close connection between the PMM on seasonal‐to‐interannual timescales and a tropical atmospheric mode arising from the nonlinear interaction between ENSO and the background annual cycle (the ENSO Combination mode, C‐mode). The C‐mode closely resembles the PMM in terms of atmospheric patterns and spectral characteristics. We further demonstrate that the C‐mode could drive a PMM‐like SST pattern in the tropical Pacific. Consequently, we suggest that the PMM on seasonal‐to‐interannual timescales has tropical origins, thereby offering an alternative explanation for the relationship between the conventional PMM index and the mature phase of ENSO. Key Points: The spatiotemporal features of Pacific Meridional Mode (PMM) on seasonal‐to‐interannual timescales exhibit a remarkable resemblance with those of the tropical combination modeC‐mode‐related atmospheric anomalies are capable of inducing PMM‐like sea surface temperature changes in the tropical PacificEl Niño‐Southern Oscillation (ENSO)'s interaction with the annual cycle manifests in PMM‐related air‐sea conditions, which explains the observed ENSO‐PMM linkage [ABSTRACT FROM AUTHOR]

Non‐fullerene acceptors have shown great promise for organic solar cells (OSCs). However, challenges in achieving high efficiency molecular system with conformational unicity and effective molecular stacking remain. In this study, we present a new design of non‐fused tetrathiophene acceptor R4T‐1 via employing the encapsulation of tetrathiophene with macrocyclic ring. The single crystal structure analysis reveals that cyclic alkyl side chains can perfectly encapsulate the central part of molecule and generate a conformational stable and planar molecular backbone. Whereas, the control 4T‐5 without the encapsulation restriction displays cis‐ and twisted conformation. As a result, R4T‐1 based OSCs achieved an outstanding power conversion efficiency (PCE) exceeding 15.10 % with a high short‐circuit current density (Jsc) of 25.48 mA/cm2, which is significantly improved by ≈30 % in relative to that of the control. Our findings demonstrate that the macrocyclic encapsulation strategy could assist fully non‐fused electron acceptors (FNEAs) to achieve a high photovoltaic performance and pave a new way for FNEAs design. [ABSTRACT FROM AUTHOR]

Regio‐ and chemoselective C−H activation at multi‐positions of a single molecule is fascinating but chemically challenging. The homologous cytochrome P450 enzymes IkaD and CftA catalyze multiple C−H oxidations on the same polycyclic tetramate macrolactam (PoTeM) ikarugamycin, with distinct regio‐ and chemoselectivity. Herein we provide mechanistic understanding of their functional differences by solving crystal structures of IkaD and CftA in complex with ikarugamycin and unnatural substrates. Distinct conformations of the F/G region in IkaD and CftA are found to differentiate the orientation of PoTeM substrates, by causing different binding patterns with polar moieties to determine site selection, oxidation order, and chemoselectivity. Fine‐tuning the polar subpocket altered the regioselectivity of IkaD, indicating that substrate re‐orientation by mutating residues distal to the oxidation site could serve as an important method in future engineering of P450 enzymes. [ABSTRACT FROM AUTHOR]

Aging is accompanied by a decreased DNA repair capacity, which might contribute to age‐associated functional decline in multiple tissues. Disruption in hormone signaling, associated with reproductive organ dysfunction, is an early event of age‐related tissue degeneration, but whether it impacts DNA repair in nonreproductive organs remains elusive. Using skin fibroblasts derived from healthy donors with a broad age range, we show here that the downregulation of expression of XRCC4, a factor involved in nonhomologous end‐joining (NHEJ) repair, which is the dominant pathway to repair somatic double‐strand breaks, is mediated through transcriptional mechanisms. We show that the androgen receptor (AR), whose expression is also reduced during aging, directly binds to and enhances the activity of the XRCC4 promoter, facilitating XRCC4 transcription and thus stabilizing the genome. We also demonstrate that dihydrotestosterone (DHT), a powerful AR agonist, restores XRCC4 expression and stabilizes the genome in different models of cellular aging. Moreover, DHT treatment reverses senescence‐associated phenotypes, opening a potential avenue to aging interventions in the future. Synopsis: Age‐related downregulation of the androgen receptor leads to decreased XRCC4 transcription, contributing to genome instability. Activation of androgen signaling increases XRCC4 expression to stabilize the genome and counteract senescence.In young individuals, relatively high levels of AR maintain an active transcription state of XRCC4, thereby promoting NHEJ repair and genomic stability.In aged individuals, reduced AR expression contributes to declined XRCC4 promoter activity, XRCC4 mRNA level, and NHEJ capacity, causing genomic instability and cellular senescence.Reactivation of androgen signaling with DHT rescues XRCC4 expression, reverses genomic instability and alleviates the onset of cellular senescence. [ABSTRACT FROM AUTHOR]

Lung cancer is the leading killer among all types of cancer globally. As a key factor, epithelial‐mesenchymal transition (EMT) plays a crucial role in pathological fibrosis and lung cancer metastasis. This study endeavors to investigate the effect of blue light at specific wavelengths of 405 nm and 415 nm (54 J/cm2) on EMT induced by TGF‐β1 in A549 cells. The results revealed that the blue light irradiation reduced the morphological characteristics of EMT in the A549 cells, and cell‐to‐cell connections were weakened significantly. Molecular analysis showed upregulation of epithelial marker E‐cadherin and downregulation of EMT marker vimentin. Additionally, exposure to blue light irradiation at 405 nm and 415 nm significantly decelerated the ability of invasion and migration. Moreover, cell viability was also investigated. Based on these findings, blue light can serve as a useful therapeutic option for inhibiting EMT in cases of lung cancer and fibrotic lung disease. [ABSTRACT FROM AUTHOR]

Comprehensive Summary: Solar‐driven cross‐coupling reactions by dual nickel/photocatalysis under mild conditions have received considerable attention. However, the existing photo/nickel dual catalytic cross‐coupling reactions require the addition of expensive photosensitizers and organic ligands, and the catalytic activity is inadequate. Herein, we report a nickel single‐atom heterogeneous catalyst supported on mesoporous carbon nitride for photocatalytic C—O coupling reaction between 4‐bromobenzonitrile and ethanol, affording 4‐ethoxybenzonitrile in excellent yield compared to a semi‐heterogeneous catalytic system. The catalytic system exhibits a broad substrate scope including ketones, aldehydes, esters, and amides. This work presents a simple and cost‐effective strategy for anchoring metal single atoms onto carbon nitride, providing a new platform for enabling high‐performance photocatalytic production of aryl ether compounds. [ABSTRACT FROM AUTHOR]

This paper aims to study the forecasting capabilities of several models under the Markov regime‐switching (MRS) and the extreme value theory (EVT) frameworks applied to daily electricity prices in the New Zealand electricity market. The MRS models in this study include up to five regimes, with time‐varying transition probabilities and incorporation of external market variables. We apply Hamilton's filter with maximum likelihood estimation for parameter estimation. The EVT peaks‐over‐threshold (EVT‐PoT) framework is also considered, and its relationship to the MRS class of models is discussed. We generate out‐of‐sample forecasts under various market scenarios. The MRS models are able to replicate real price densities under stable market conditions. The EVT‐PoT model performs well despite its lack of complexity compared to the MRS framework. We attribute this to the usage of the generalized Pareto distribution to model price extremities. [ABSTRACT FROM AUTHOR]

Biomass with abundant reproducible carbon resource holds great promise as an intriguing substitute for fossil fuels in the manufacture of high‐value‐added chemicals and fuels. Photocatalytic biomass valorization using inexhaustible solar energy enables to accurately break desired chemical bonds or selectively functionalize particular groups, thus emerging as an extremely creative and low carbon cost strategy for relieving the dilemma of the global energy. Quantum dots (QDs) are an outstandingly dynamic class of semiconductor photocatalysts because of their unique properties, which have achieved significant successes in various photocatalytic applications including biomass valorization. In this review, the current development rational design for QDs photocatalytic biomass valorization effectively is highlighted, focusing on the principles of tuning their particle size, structure, and surface properties, with special emphasis on the effect of the ligands for selectively broken chemical bonds (C─O, C─C) of biomass. Finally, the present issues and possibilities within that exciting field are described. [ABSTRACT FROM AUTHOR]

Most nonalcoholic steatohepatitis (NASH) patients develop severe fibrosis through extracellular matrix (ECM) accumulation, which can lead to hepatocellular carcinoma (HCC). Fibroblast growth factor 9 (FGF9) is involved in serial types of cancer; however, the specific role of FGF9 in NASH‐driven HCC is not fully understood. This study finds that FGF9 is increased in patients with NASH‐associated HCC. Furthermore, NASH‐driven HCC mice models by feeding wildtype mice with high‐fat/high‐cholesterol (HFHC) diet and low dose carbon tetrachloride (CCl4) treatment is established; and identified that hepatic FGF9 is increased; with severe fibrosis. Additionally, AAV‐mediated knockdown of FGF9 reduced the hepatic tumor burden of NASH‐driven HCC mice models. Hepatocyte‐specific FGF9 transgenic mice (FGF9Alb) fed with a HFHC diet without CCl4 treatment exhibited an increased hepatic ECM and tumor burden. However, XAV‐939 treatment blocked ECM accumulation and NASH‐driven HCC in FGF9Alb mice fed with HFHC diet. Molecular mechanism studies show that FGF9 stimulated the expression of ECM related genes in a β‐catenin dependent manner; and FGF9 exerts its effect on β‐catenin stability via the ERK1/2‐GSK‐3β signaling pathway. In summary, the data provides evidence for the critical role of FGF9 in NASH‐driven HCC pathogenesis; wherein it promotes the tumors formation through the ECM pathway. [ABSTRACT FROM AUTHOR]

Post‐infectious irritable bowel syndrome (PI‐IBS) occurs after acute infectious diarrhea, and dysbiosis can be involved in its pathogenesis. Here, the role of chlorogenic acid (CGA) is investigated, a natural compound with several pharmacological properties, in alleviating PI‐IBS in rats. It is elucidated that the gut microbiota plays a key role in PI‐IBS pathogenesis and that rectal administration of CGA alleviated PI‐IBS by modulating the gut microbiota and its metabolites. CGA supplementation significantly increased fecal Bacteroides acidifaciens abundance and glycine levels. Glycine structurally altered B. acidifaciens extracellular vesicles (EVs) and enriched functional proteins in the EVs; glycine‐induced EVs alleviated PI‐IBS by reducing inflammation and hypersensitivity of the intestinal viscera and maintaining mucosal barrier function. Moreover, B. acidifaciens EVs are enriched in the brain tissue. Thus, CGA mediates the mitigation of PI‐IBS through the gut microbiota and its metabolites. This study proposes a novel mechanism of signal exchange between the gut microenvironment and the host. [ABSTRACT FROM AUTHOR]

Micro‐/nanorobots (mn‐robots), inspired by the versatile mechanisms found in natural microorganisms, show great potential in enabling innovative bio‐applications. The 3D‐printed magnetic mn‐robots are substantially advanced to swim in vivo and to carry and release therapeutic agents in a controlled manner. To understand the state of the art of such robots and identify their development trend, this article presents a comprehensive and systematic review of the recent works on development of magnetic robots and their applications in biomedical engineering, with a particular focus on targeted therapeutic delivery. The developments in materials, fabrications, actuations, and applications with design for magnetic mn‐robots are reviewed, and it is aimed to discover the limitations of the existing works and to identify the knowledge gap, thereby deriving future research directions on developing magnetic mn‐robots, especially for their applications in targeted therapeutic delivery. [ABSTRACT FROM AUTHOR]

The electrocatalytic CO2 reduction reaction (CO2RR) has been considered a promising route toward carbon neutrality and renewable energy conversion. At present, most bismuth (Bi) based electrocatalysts are adopted to reduce CO2 to formate (HCOOH). However, the mechanism of different Bi nanostructures on the electrocatalytic performance requires more detailed exposition. Herein, a combined chemical replacement and electrochemical reduction process is reported to realize in situ morphology reconstruction from Bi@Bi2O3 nanodendrites (Bi@Bi2O3‐NDs) to Bi nanoflowers (Bi‐NFs). The Bi@Bi2O3‐NDs are proven to undergo a two‐step transformation process to form Bi‐NFs, aided by Bi2O2CO3 as the intermediate in KHCO3 solution. Extensive surface reconstruction of Bi@Bi2O3‐NDs renders the realization of tailored Bi‐NFs electrocatalyst that maximize the number of exposed active sites and active component (Bi0), which is conducive to the adsorption and activation of CO2 and accelerated electron transfer process. The as‐prepared Bi‐NFs exhibit a Faradaic efficiency (FEformate) of 92.3% at −0.9 V versus RHE and a high partial current density of 28.5 mA cm−2 at −1.05 V versus RHE for the electroreduction of CO2 to HCOOH. Moreover, the reaction mechanism is comprehensively investigated by in situ Raman analysis, which confirms that *OCHO is a key intermediate for the formation of HCOOH. [ABSTRACT FROM AUTHOR]

Background: Pulsed field ablation (PFA) has been increasingly used to cut off the delivery of abnormal electrical signals in the treatment of cardiac arrhythmias. A successful cut off requires forming a layer of transmural damage on the heart wall, and this layer depends on the depth of ablation by PFA. Purpose: This study aims to propose a novel polarity configuration of PFA to increase the ablation depth in the treatment of cardiac arrhythmias. Method: A novel polarity configuration was designed for a multi‐electrode system, where the number of electrodes is greater than two. The polarity configuration in such multi‐electrode system is called the paired‐electrode interlaced configuration (PIC). The existing configuration called the single‐electrode interlaced configuration (SIC) was used to compare with the PIC. To both the SIC and PIC, a full‐SIC or a full‐PIC is called when all electrodes (anode, cathode) in a catheter is used otherwise partial‐SIC or partial‐PIC is called. By the comparison between the full‐SIC and full‐PIC, the benefit of the PIC was exhibited as opposed to the SIC, but an extra ablation step was added in the PIC in order to form a continuous ablation zone. The other comparative study was taken between a partial‐PIC and a partial‐SIC with the same number of ablation step. In this study, a rabbit model was built by infusing 0.4% saline solution (at 37°C) into the rabbit's abdominal cavity which surrounds the liver. This model was considered as a biometric environment of the heart, namely cardiac‐mimetic model (CMM). Result: The experimental results have shown that the full‐PIC is superior to the full‐SIC in the ablation depth, specifically in both the maximum (4.14 ± 0.55 mm vs. 3.35 ± 0.26 mm, p < 0.01) and the minimum (3.18 ± 0.29 mm vs. 2.76 ± 0.28 mm, p < 0.05), and in the ablation width, specifically only in the maximum (8.27 ± 0.76 mm vs. 7.09 ± 0.51 mm, p = 0.019) under an identical ablation time (i.e., 5 s). It is noted that the minimum ablation width did not show a significant difference between the full‐PIC and full‐SIC (specifically, 5.61 ± 0.86 mm vs. 4.67 ± 0.73 mm, p = 0.069). Considering the lethal electric field threshold (LEFT) to be 600 V/cm for liver tissues, the maximum and minimum ablation depth generated by the full‐PIC was found larger than that by the full‐SIC (3.90 vs. 3.52 mm, and 3.03 vs. 2.48 mm, respectively) in the simulation. Meanwhile, similar experiment results by comparing the partial‐PIC and partial‐SIC have been obtained, which shows a significant increase in both the maximum ablation depth (4.81 ± 0.87 mm vs. 3.30 ± 0.73 mm, p < 0.001) and the maximum ablation width (8.19 ± 0.85 mm vs. 6.47 ± 1.13 mm, p = 0.001). Conclusions: (1) The electric field in the PIC is concentrated around the pair of electrodes, and the pattern of the field is a significant factor in the energy delivery along the direction of the depth. (2) The increase of the ablation depth can significantly expand the range of the tissue on the heart, where the PFA can apply, and can therefore readily form a layer of transmural damage on the heart wall at positions at which the wall is thicker. [ABSTRACT FROM AUTHOR]

As a promising candidate for next‐generation energy storage devices, Zn metal battery excels with their good safety, high specific capacity, and economic attractiveness. However, it still suffers from a narrow electrochemical window, notorious dendrite formation, and sluggish Zn ion transfer. Aqueous electrolyte engineering has been regarded as an effective way to improve these. It is shown that by adding sodium polystyrene sulfonate (PSS) polymers into a dilute 1 m Zn(OTf)2 aqueous electrolyte, compact water shells with stronger hydrogen bonding and more ordered structures are formed around the polymer chains. As a result, a fast transport channel to the zinc ions is provided. The PSS chains also protect the zinc electrode from directly contacting the water molecules and thus suppress water decomposition. With these merits, a Zn//Cu cell demonstrates a high coulombic efficiency of ≈99% after 1500 h cycling. Meanwhile, a record‐high cumulative Zn plating capacity of 10 000 mA h cm−2 is obtained using a Zn||Zn cell. In addition, the Zn//C@V2O5 full cell achieves almost 100% capacity retention after 1000 cycles. This work provides a new strategy for designing advanced electrolyte systems excelling in ion transport kinetics. [ABSTRACT FROM AUTHOR]

Five clinical and genetic variables proven most relevant to segregate MDS with MF-2/3 and TN-PMF subgroups, including palpable spleen, EPO levels, platelet counts, BM blast percentage and I ASXL1 i mutations, were included in this model. Distinguishing myelodysplastic syndromes with moderate-to-severe bone marrow fibrosis from triple-negative primary myelofibrosis based on clinical and genetic covariates Compared with TN-PMF cohort, the percentage of bone marrow (BM) blasts ( I p i < 0.0001) and erythropoietin (EPO) concentrations ( I p i = 0.002) were significantly higher in the MDS with MF-2/3 cohort. [Extracted from the article]

Wide‐bandgap (WBG) perovskite solar cells (PSCs) have garnered significant attention for their potential applications in tandem solar cells. However, their large open‐circuit voltage (VOC) deficit and serious photo‐induced halide segregation remain the main challenges that impede their applications. Herein, a post‐treatment strategy without thermal annealing is presented to form a 2D top layer of 2‐thiopheneethylammonium lead halide (n = 1) on WBG perovskites. This thermal annealing‐free post‐treatment method can more effectively passivate the defects of WBG methylamine (MA)‐free formamidinium/cesium lead iodide/bromide perovskite films and suppress photo‐induced perovskite phase segregation, as compared with the thermal annealing method that yields multi‐2D phases. The resulting opaque and semi‐transparent 1.66 eV‐bandgap perovskite solar cells deliver maximum power conversion efficiencies of 21.47% (a small VOC deficit of 0.43 V) and 19.11%, respectively, both of which are among the highest reports for inverted MA‐free WBG PSCs. Consequently, four‐terminal all‐perovskite tandem cells realize a remarkable efficiency of 26.64%, showing great promise for their applications in efficient multi‐junction tandem solar cells. [ABSTRACT FROM AUTHOR]

Understanding the interaction between the tropical Pacific and Atlantic Oceans has challenged the climate community for decades. Typically, boreal summer Atlantic Niño events are followed by vigorous Pacific events of opposite sign around two seasons later. However, incorporating the equatorial Atlantic information to variabilities internal to the Pacific lends no significant additional predictive skill for the subsequent El Niño‐Southern Oscillation (ENSO). Here we resolve this conundrum in a physically consistent frame, in which the nascent onset of a Pacific event rapidly induces an opposite‐signed summer equatorial Atlantic event and the lead correlation of Atlantic over Pacific is a statistical artifact of ENSO's autocorrelation. This Pacific‐to‐Atlantic impact is limited to a short window around late spring due to seasonally‐amplified Atlantic atmosphere‐ocean coupling. This new frame reconciles the discrepancies between the observed and multi‐model simulated inter‐basin relationship, providing a major advance in understanding seasonally‐modulated inter‐basin climate connections as well as their predictability. Plain Language Summary: Previous studies interpreted the observed lead/lag relationship between Atlantic Niño/Niña and Pacific Niño/Niña sea surface temperature anomalies as evidence for a precursory role of the equatorial Atlantic on the development of El Niño–Southern Oscillation (ENSO) events. This study clearly demonstrates that this statistical relationship is not related to Atlantic‐to‐Pacific causality, but can rather be explained by seasonally modulated equatorial Atlantic's response to ENSO. We find that Pacific ENSO events drive equatorial Atlantic events rather than vice versa, and reconcile the apparent discrepancies between the observed and multi‐model simulated tropical Pacific/Atlantic relationship. Key Points: The lead correlation of the equatorial Atlantic over the Pacific is not related to Atlantic‐to‐Pacific causalityThe tropical Pacific/Atlantic interaction is consistent with the nascent onset of Pacific events driving the equatorial Atlantic eventsThe discrepancies between the observed and multi‐model simulated tropical Pacific/Atlantic relationship can be reconciled in this new frame [ABSTRACT FROM AUTHOR]

Metal‐organic framework catalysts bring new opportunities for CO2 electrocatalysis. Herein, we first conduct density‐functional theory calculations and predict that Co‐based porphyrin porous organic layers (Co‐PPOLs) exhibit good activity for CO2 conversion because of the low *CO adsorption energy at Co‐N4 sites, which facilitates *CO desorption and CO formation. Then, we prepare two‐dimensional Co‐PPOLs with exclusive Co‐N4 sites through a facile surfactant‐assisted bottom‐up method. The ultrathin feature ensures the exposure of catalytic centers. Together with large specific area, high electrical conductivity and CO2 adsorption capability, Co‐PPOLs achieve a peak faradaic efficiency for CO production (FECO=94.2 %) at a moderate potential in CO2 electroreduction, accompanied with good stability. Moreover, Co‐PPOLs reach an industrial‐level current above 200 mA in a membrane electrode assembly reactor, and maintain near‐unity CO selectivity (FECO>90 %) over 20 h in CO2 electrolysis. [ABSTRACT FROM AUTHOR]

Biominerals can exhibit exceptional mechanical properties owing to their hierarchically‐ordered organic/inorganic nanocomposite structure. However, synthetic routes to oriented artificial biominerals of comparable complexity remain a formidable technical challenge. Herein we design a series of soft, deformable nanogels that are employed as particulate additives to prepare nanogel@calcite nanocomposite crystals. Remarkably, such nanogels undergo a significant morphological change—from spherical to pseudo‐hemispherical—depending on their degree of cross‐linking. This deformation occurs normal to the growth direction of the (104) face of the calcite and the underlying occlusion mechanism is revealed by in situ atomic force microscopy studies. This model system provides new mechanistic insights regarding the formation of oriented structures during biomineralization and offers new avenues for the design of synthetic nanocomposites comprising aligned anisotropic nanoparticles. [ABSTRACT FROM AUTHOR]

The delicate engineering of monovalent cations in perovskite material has led to continuous performance breakthroughs and stability improvement for the perovskite light‐emitting diodes (PeLEDs). However, the exact role of A‐site cations on the electroluminescence (EL) performance and degradation mechanism of PeLEDs has not been systematically answered yet. Herein, it is demonstrated that the most commonly used methylammonium cation (MA+) has an adverse effect on the electrochemical reaction at the interface between perovskite and metal‐oxide layer, leading to deteriorated EL performance as compared to that of the formamidinium cation (FA+)‐based perovskite. It reveals that the accelerated deprotonation process of MA+ under an electric field will aggravate the reaction between iodide and metal ion in oxide layer. The further substitution of a small portion of FA+ with inorganic cesium cation (Cs+) results in much enhanced crystallinity and enlarged crystal size, leading to an optimized peak external quantum efficiency of 21.3%. The ion migration process in the PeLEDs can be significantly suppressed with Cs+ incorporation, leading to a smaller roll‐off under large current density and an elongated half‐lifetime of 190.1 h under a current density of 20 mA cm‐2, representing one of the most stable PeLEDs based on 3D perovskite layer. [ABSTRACT FROM AUTHOR]

Comprehensive Summary: Talachalasins A—C (1—3), three new cytochalasans (CYTs), were isolated from deep‐sea‐derived fungus Talaromyces muroii sp. SCSIO 40439. The structures of 1—3, including absolute configurations, were determined based on HRESIMS, NMR spectroscopic data, ECD comparison, and single crystal X‐ray diffraction analysis. Talachalasins A—C (1—3) represented the first examples of cytochalasans possessing a unique 16β‐methyl group, distinct from >500 reported CYTs. Talachalasin C (3) was an unprecedented 20,21‐seco‐cytochalasans characterized by a 2‐oxabicyclo[3.3.1]nonan‐3‐one unit. Talachalasin A (1) displayed moderate cytotoxic activity against four tumor cell lines (IC50 3.40—10.02 μM). Talachalasin B (2) showed comparable anti‐RSV and HSV‐1 activities (IC50 12.5 μM or IC50 20.0 μM). [ABSTRACT FROM AUTHOR]

This article considers a problem of evaluating barrier option prices when the underlying dynamics are driven by stochastic elasticity of variance (SEV). We employ asymptotic expansions and Mellin transform to evaluate the option prices. The approach is able to efficiently handle barrier options in a SEV framework and produce explicitly a semi‐closed form formula for the approximate barrier option prices. The formula is an expansion of the option price in powers of the characteristic amplitude scale and variation time of the elasticity and it can be calculated easily by taking the derivatives of the Black–Scholes price for a barrier option with respect to the underlying price and computing the one‐dimensional integrals of some linear combinations of the Greeks with respect to time. We confirm the accuracy of our formula via Monte‐Carlo simulation and find the SEV effect on the Black–Scholes barrier option prices. [ABSTRACT FROM AUTHOR]

The interactions between El Niño‐Southern Oscillation (ENSO) and Indian Ocean Dipole (IOD) are known to have great implications for global climate variability and seasonal climate predictions. Observational analysis suggests that the ENSO–IOD inter‐basin connection is time‐varying and related to the Atlantic Multidecadal Oscillation (AMO) with weakened ENSO–IOD relationship corresponding to AMO warm phases. A suite of Atlantic pacemaker simulations successfully reproduces the decadal fluctuations in ENSO–IOD relationship and its link to the AMO. The warm sea surface temperature (SST) anomalies associated with the AMO drive a series of Indo‐Pacific mean climate changes through tropical‐wide teleconnections, including the La Niña‐like mean SST cooling over the central Pacific and the deepening of mean thermocline depth in the eastern Indian Ocean. By modulating ocean–atmosphere feedback strength, those mean state changes decrease both ENSO amplitude and the Indian Ocean sensitivity to ENSO forcing, therefore decoupling the IOD from ENSO. Plain Language Summary: The El Niño‐Southern Oscillation (ENSO) and Indian Ocean Dipole (IOD) are two most important interannual climate signals exciting world‐wide climate and socioeconomic impacts. Their interactions are known to have great implications for global climate variability and seasonal climate predictions. However, the ENSO–IOD relationship is time‐varying and show prominent decadal fluctuations. Such changes in ENSO–IOD relationship are associated with the decadal variation in IOD teleconnections and predictability. The prediction skill of IOD is high when the ENSO–IOD relationship is strong, and vice versa. But it remains unknown what controls the decadal modulation of Indo‐Pacific inter‐basin connection. Our findings suggest that the Atlantic Multidecadal Oscillation (AMO) may modulate the ENSO–IOD inter‐basin connection. The AMO sea surface temperature anomalies drive a series of Indo‐Pacific mean climate changes through tropical‐wide teleconnections. Those mean state changes further influence both ENSO amplitude and the Indian Ocean sensitivity to ENSO forcing, thereby modulating the ENSO–IOD relationship. This study advances our understandings on inter‐basin and cross‐scale interactions in the climate system. Key Points: The inter‐basin connection between El Niño‐Southern Oscillation (ENSO) and Indian Ocean Dipole is time‐varying and controlled by the remote Atlantic Multidecadal Oscillation (AMO)The AMO sea surface temperature anomalies drive a series of Indo‐Pacific mean climate changes through tropical‐wide teleconnectionsThe AMO induced mean state changes influence both ENSO amplitude and the Indian Ocean sensitivity to ENSO forcing [ABSTRACT FROM AUTHOR]

Tin halide perovskite solar cells (TPSCs) have attracted extensive attention because of their low toxicity and high theoretical efficiency. However, rapid crystallization, rich defects, and easy oxidation of tin‐based perovskite films seriously restrict solar cell performance. Herein, a composition and additive engineering solution by removing commonly used tin fluoride additive from formamidinium tin triiodide perovskite precursors and replacing it with excess tin (II) iodide and ethylenediamine dihydroiodide (EDAI2) is adopted. The presence of EDAI2 and excess SnI2 and the absence of SnF2 enable tin‐based perovskite films with greatly improved morphology, enhanced crystalline quality, boosted optical properties, and prolonged carrier lifetime. Therefore, the SnF2‐free non‐stoichiometric TPSCs employing the EDAI2 additive and excess SnI2 have increased built‐in potential, lowered dark currents, and reduced carrier recombination. The resulting SnF2‐free and SnI2‐rich TPSCs with EDAI2 addition realize a steady‐state efficiency of 10.0%, which is one of the highest power conversion efficiencies among the SnF2‐free TPSCs, along with considerably improved light stability. This work highlights the crucial roles of additives in TPSCs and provides an effective strategy to fabricate efficient and stable low‐toxic lead‐free perovskite solar cells. [ABSTRACT FROM AUTHOR]

Single‐atom catalysts (SACs) have received widespread interest for their high atomic efficiency, enriched active sites, excellent catalytic performance, and low cost. However, the agglomeration of single metal atoms and the use of inactive additives for affixing powdery SACs on planar electrodes may reduce the density of active sites, diminish the charge transport to active sites, and thus suppress their performance. Herein, a series of metal–nitrogen–carbon single‐atom aerogels (M‐SAAs, M: Cu, Ni, Au, Ru) are synthesized via a universal strategy, in which the merits of metal organic frameworks and carbon aerogels are perfectly combined to prevent the agglomeration of single metal atoms and overcome the problem of poor electrical conductivity. The as‐prepared M‐SAAs can be directly employed as self‐supporting electrodes for the electrochemical dechlorination of 1,2‐dichloroethane, and outstanding activity and stability are observed. Significantly, the Cu‐SAA with abundant Cu−N4 sites shows an extraordinarily high ethylene production rate of 446 µmol h−1, with a selectivity of 99% and Faradaic efficiency of 64%. Moreover, theoretical calculations are performed to demonstrate the selectivity and activity of different metal active sites. This study provides a new strategy to exploit highly effective SACs and offers an intensive insight into the mechanism of electrochemical dechlorination reactions. [ABSTRACT FROM AUTHOR]

Background: Clinical guidelines indicate that chronic highland exposure could induce pulmonary hypertension; chronic hepatic disease may affect cardiac structure and functions. However, the simultaneous impact of hepatic echinococcosis (HE) and chronic highland exposure on cardiac structure and function in Tibetan residents are under‐investigated. Methods: One hundred and twenty patients with HE, 23 healthy high‐altitude migrants with a mean residence time of 7.15 ± 1.12 years, and 46 healthy Tibetan permanent residents were enrolled in this study. All participants received comprehensive transthoracic echocardiography. Results: High‐altitude migrants have a relatively lower pulmonary artery flow velocity (PV) and a slightly higher pulmonary artery mean pressure (PAMP) than the Tibetan permanent residents. Patients with HE presented relatively smaller dimensions of the main pulmonary artery and branches and a bigger right atrium and right ventricular cavity size than the two control groups. PV, PAMP and numbers of detectable tricuspid regurgitation jet velocity (TRJV), right ventricular fractional area change (RV_FAC), tricuspid annular plane systolic excursion (TAPSE), the ratio of tricuspid inflow velocities at early diastole to tricuspid annular early diastolic excursion velocity (RV_E/e′) and right ventricular myocardial performance index (RV_MPI) were increased in patients with HE compared to the two control groups. Similarly, decreased LVEF and Impaired left ventricular diastolic function were identified in patients with HE compared to the two control groups. Conclusions: Patients with HE presented with impaired biventricular contractile performance and diastolic dysfunction. [ABSTRACT FROM AUTHOR]