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Lead halide‐based salts exhibit good photoelectric properties; however, the use, leakage, and recovery of toxic lead require careful consideration. Therefore, developing a lead‐free optoelectronic material conveniently and quickly is very important. Moreover, there is relatively little research on the salts of bismuth halides. In this study, we synthesized [PEA]3[Bi2I9] single crystals (SC) by volatilizing N,N‐dimethylformamide (DMF) solvent at 70°C. The crystal system and spatial group of [PEA]3[Bi2I9] are monoclinic and P21/n, respectively. The Tauc plot reveals the optical band gap of the [PEA]3[Bi2I9] SC at 2.048 eV. The carrier mobility of [PEA]3[Bi2I9] SC is 47.4 cm2 V−1 s−1. Steady‐state fluorescence and time‐resolved fluorescence spectrum indicate that there are four fluorescence peaks and about 7 μs lifetime, respectively. The photodetector based on [PEA]3[Bi2I9] SC under different voltages (0.5, 1, 1.5, 2, and 2.5 V) exhibits stability and regularity with turning‐on/off of the light. In addition, thermogravimetric analysis (TGA) tests indicate that [PEA]3[Bi2I9] SC has considerable thermal stability at temperatures up to 260°C, showing promise for becoming a high temperature resistant and nontoxic sensor with good application prospects. [ABSTRACT FROM AUTHOR]

To explore the curative effect of insulin external application on burn wounds of diabetic patients with different depths. A retrospective analysis of 114 diabetic burn patients in the First Hospital of Hebei Medical University from June 2019 to June 2022. According to the different treatment methods, they were divided into study group (insulin therapy) and control group (conventional therapy) with 57 cases in each. The wound healing time, dressing changes, scar healing after wound healing and adverse events were compared between two groups. Pain level, serum inflammatory factors, vascular endothelial growth factor (VEGF) and oxidative stress factors before and after treatment were compared. The wound healing time (17.23 ± 2.18 vs 20.31 ± 2.09 days) and the number of dressing changes (7.01 ± 1.23 vs 8.93 ± 1.32 times) in study group were significantly lower than those in control group (P < 0.05). Before treatment, there was no difference in pain level, VEGF, interleukin‐1 (IL‐1), tumour necrosis factor‐α (TNF‐α), malondialdehyde (MDA) and superoxide dismutase (SOD) between two groups (P > 0.05). However, the pain level, scar healing, IL‐1, TNF‐a and MDA in study group were significantly lower than those in control group after treatment (P < 0.05). And the VEGF and SOD in study group was significantly higher than that in control group (P < 0.05). External application of insulin can shorten the wound healing time of diabetic patients with different depths, reduce the number of dressing changes, promote scar healing after wound healing, relieve pain and reduce the level of inflammatory factors, which is worthy of clinical promotion. [ABSTRACT FROM AUTHOR]

The in vitro culture of unpollinated ovaries is one of the techniques used to induce gynogenesis. To explore the mechanism of lily gynogenesis and obtain haploids to shorten the breeding cycle, the in vitro effects of flower bud sampling time, exogenous plant growth regulators (PGRs), and different concentrations of picloram on embryo formation in unpollinated ovaries of Lilium L. 'Sorbonne' (oriental hybrids) were studied. The results indicated that flower buds ≥8 cm in length were most suitable. The PGRs picloram and 2,4‐dichlorophenoxyacetic acid (2,4‐D) with 6‐benzylaminopurine (6‐BA) or kinetin were useful in inducing ovule expansion in vitro. However, most ovules did not survive on the media containing 2,4‐D, whereas those grown on media containing picloram developed normally. In particular, a lower concentration of picloram (0.5 mg L−1) was found to be beneficial to the development of ovules into embryogenic shoots, whereas higher concentrations were more favorable to the development of shoots from the ovary wall. In total, 87 regenerated plants were obtained from unpollinated ovaries of Sorbonne. The chromosome ploidy of 20 of these was determined by counting root tip chromosomes, and eight of the regenerated plants were found to be haploids. Core Ideas: Longer flower bud is more appropriate for ovule development.Lower concentration of picloram promotes the development of ovule into shoots in vitro.Shoots obtained from ovules can produce more haploids.Through the ovule regeneration pathway, haploids can be obtained faster than by ovary culture.The ovary‐regenerated plantlets have different ploidy types from the mother plant. [ABSTRACT FROM AUTHOR]

Non‐small‐cell lung cancer (NSCLC) accounts for approximately 80% of lung cancer cases. TBC1D23, a member of the TBC/RABGAP family, is widely expressed in human tissues; however, its role in NSCLC is currently unknown. Immunohistochemical analysis was conducted on 173 paraffin‐embedded lung tissue sections from patients with NSCLC from 2014 to 2018 at the First Affiliated Hospital of China Medical University. MTT, colony formation assay, cell cycle assay, scratch assay, transwell assay, Western blotting and real‐time PCR were employed on multiple NSCLC cell lines modified to knock down or overexpress TBC1D23/RAB11A. Immunoprecipitation, immunoprecipitation‐mass spectrometry, immunofluorescence and flow cytometry were performed to explore the interaction between TBC1D23 and RAB11A and TBC1D23 involvement in the interaction between RAB11A and β1 integrin in the para‐nucleus. TBC1D23 was correlated with tumour size, differentiation degree, metastasis, TNM stage and poor prognosis. TBC1D23 was involved in the interaction between RAB11A and β1 integrin in the para‐nucleus, thus activating the β1 integrin/FAK/ERK signalling pathway to promote NSCLC. Furthermore, TBC1D23 promoted NSCLC progression by inducing cell proliferation, migration and invasion. This study indicated the relationship between TBC1D23 expression and the adverse clinicopathological characteristics of patients with NSCLC, suggesting that TBC1D23 may be an important target for NSCLC treatment. [ABSTRACT FROM AUTHOR]

2D all‐inorganic halide perovskites (2D AIHP) have attracted huge attention for their excellent optoelectronic properties and superior atmospheric stability for organic–inorganic halide perovskites. 2D AIHP has been fabricated by varied strategies, whereas a satisfied way to simultaneously reach good quality, dimensions, and uniformity is still far from achieved yet. Here, a direct thermal deposition method to synthesize 2D AIHP of lateral length up to ≈30 µm and uniform thickness down to ≈10 nm, which shows excellent optoelectronic performance comparable to the reported top‐level 2D AIHP, is proposed. A vertical mass transport instead of conventional horizontal mode is adopted, significantly enhancing the deposition stability. Furthermore, the morphologies of AIHP are switchable between nanowires and nanoflakes under the control of deposition temperature. This method may pave the way for uniform fabrication of 2D AIHP or AIHP‐based 2D heterostructures for various applications. [ABSTRACT FROM AUTHOR]

Electrostatic gates by ion liquid (IL) or ion gel (IG) have allowed the exploration of intriguing material properties that are related to heavy charge doping in low‐dimensional materials. However, the obtained gate modulation is usually volatile at room temperature due to the recovery of ion position when removing the gate bias, which hinders their application in practical functional devices. Herein, the electrochemical IG gate is explored, and a nonvolatile modulation of the doping polarity of MoTe2 (from n to p and reversibly to n) by exploiting the electrochemical hydrolysis of residual water in IG and the subsequent chemical ion adsorption on MoTe2 is demonstrated. Further, based on the asymmetrically coupled gate bias to source and drain terminals, a lateral pn diode is prepared with long‐term stability >5 × 104 s and a self‐powered responsivity >85 mA W−1 at the near‐infrared wavelength of 1050 nm. The performance of diode is further optimized by applying a slight gate bias that tunes the width, position of space charge region in junction, and the overall charge collection efficiency. The nonvolatile electrochemical IG gate thus offers a viable pathway toward 2D low‐power photodetectors in the infrared spectra range. [ABSTRACT FROM AUTHOR]

Although circulating tumor cells (CTCs) have shown promise as potential biomarkers for diagnostic and prognostic assessment in gastric cancer (GC), determining the predictive and prognostic value of programmed death‐ligand 1 (PD‐L1)‐positive CTCs in patients with GC is a challenge. Here, we identified that the expression of total vimentin (VIM) protein was positively correlated with PD‐L1 and inhibited CD8+ T‐cell activation in patients with GC according to bioinformatics analysis. Notably, coexpression of PD‐L1 and cell‐surface VIM (CSV) was detected by immunofluorescence and immunohistochemistry assay in locally advanced GC tumor specimens and metastatic lymph nodes. Likewise, CSV expression level was significantly decreased after transiently knocking down PD‐L1 in GC cell lines. Based on our established CTC detection platform, CTCs were isolated from peripheral blood samples collected from 70 patients (38 resectable and 32 unresectable) with GC using magnetic positive selection and a CSV‐specific monoclonal antibody, 84‐1. CSV+PD‐L1+CTCs were observed in 50 of 70 (71%) GC patient samples, ranging from 0 to 261 mL−1. A higher number of CSV+PD‐L1+CTCs were significantly associated with a short survival duration and poor therapeutic response. This study demonstrated that detection of PD‐L1+CTCs using a CSV‐enrichment method has promising value as a clinically relevant prognostic marker for GC. [ABSTRACT FROM AUTHOR]

Background: Studies have shown that E3 ubiquitin ligase CBLL1 plays multiple roles in development and tumorigenesis. CBLL1 is over‐expressed in colon cancer and associated with cancer cell proliferation. While, the overexpression of CBLL1 inhibited the estrogenic dependent cell proliferation and migration in ER alpha dependent breast cancer cell MCF‐7. Methods: We used an immunohistochemical method to detect CBLL1 expression in human NSCLC and corresponding normal lung tissues and analyzed its relationship with clinicopathological parameters. Moreover, we investigated the role of CBLL1 in NSCLC cell behavior by inhibiting its expression in A549 and H1299 cells. Results: In this study, we found that CBLL1 was frequently upregulated in non‐small lung cancer (NSCLC) tissues compared to the adjacent nontumor tissues. We found that the high expression of CBLL1 was associated with the tumor size in NSCLC tissues. It has been recently reported that CBLL1 promotes cell proliferation and invasion in A549 and H460 cells. Our results confirmed that CBLL1 promoted the proliferation by promoting G1/S cell cycle transition in NSCLCs cells. Moreover, CBLL1 knockdown inhibited cell invasion via increased E‐cadherin protein expression, and decreased expression of MMP2 and MMP9 in NSCLC cell lines. The protein expression of E‐cadherin was increased after CBLL1 depletion while the E‐cadherin mRNA was not affected after knockdown of the endogenous CBLL1. Conclusion: These results provide important insights for using CBLL1 as an oncogenic marker gene in the development and progression of non‐small cell lung cancer. [ABSTRACT FROM AUTHOR]

Lung cancer remains the leading cause of cancer‐related death worldwide. Previous studies have shown that the novel KIAA0247 gene potentially targeted by the tumor suppressor p53 may inhibit the development of several cancers. However, the exact function of KIAA0247 in non‐small‐cell lung cancer (NSCLC) is unknown. The purpose of the present study was to clarify the role of KIAA0247 in NSCLC. KIAA0247 expression was evaluated in tumors and adjacent normal tissues of 197 NSCLC patients by immunohistochemistry and real‐time PCR and analyzed for association with clinicopathological parameters. Results indicated that KIAA0247 levels positively correlated with cell differentiation (P < .001) and patient survival (P < .0001) and negatively correlated with lymph node metastasis (P < .001) and advanced p‐TNM stage (P < .001). In cultured NSCLC cell lines, KIAA0247 overexpression inhibited cell migration, invasion, and proliferation and downregulated the expression of Jagged1, Notch1 intracellular domain (NICD), Snail, cyclin D1, RhoA, RhoC, and MMP9, while upregulating that of E‐cadherin and p21. The Notch inhibitor DAPT reduced the biological effects of KIAA0247 knockdown, suggesting that KIAA0247 decreased the carcinogenic activity of NSCLC cells through downregulation of Notch signaling. Our results indicate that KIAA0247 inhibits NSCLC progression by reducing the metastatic potential of cancer cells through downregulation of the Notch pathway, which may underlie the association of KIAA0247 expression with favorable clinicopathological characteristics of NSCLC patients. These findings suggest that KIAA0247 is a candidate prognostic biomarker and potential therapeutic target in NSCLC. [ABSTRACT FROM AUTHOR]

The syntheses and structures of two new ZnII complexes, a 2D graphite-like layer {[Zn(PIA)H2O] ⋅H2O} n ( 1) and an independent 1D single-walled metal-organic nanotube (SWMONT) {[Zn2(PIA)2(bpy)2] ⋅2.5 H2O ⋅DMA} n ( 2), have been reported based on a 'Y'-shaped 5-(pyridine-4-yl)isophthalic acid ligand (H2PIA). Interestingly, the 2D graphite-like layer in 1 can transform into the independent 1D SWMONT in 2 with addition of 2,2′-bipyridine (bpy), which represents the first successfully experimental example of an independent 1D metal-organic nanotube generated from a 2D layer by a 'rolling-up' mechanism. [ABSTRACT FROM AUTHOR]

The title complex, {[Ni(C15H11N4O2S)2(C10H8N2)(H2O)2]·H2O} n, was synthesized by the reaction of nickel chloride, 4-{[(1-phenyl-1 H-tetrazol-5-yl)sulfanyl]methyl}benzoic acid (H L) and 4,4′-bipyridine (bpy) under hydrothermal conditions. The asymmetric unit contains two half NiII ions, each located on an inversion centre, two L− ligands, one bpy ligand, two coordinated water molecules and one unligated water molecule. Each NiII centre is six-coordinated by two monodentate carboxylate O atoms from two different L− ligands, two pyridine N atoms from two different bpy ligands and two terminal water molecules, displaying a nearly ideal octahedral geometry. The NiII ions are bridged by 4,4′-bipyridine ligands to afford a linear array, with an Ni...Ni separation of 11.361 (1) Å, which is further decorated by two monodentate L− ligands trans to each other, resulting in a one-dimensional fishbone-like chain structure. These one-dimensional fishbone-like chains are further linked by O-H...O, O-H...N and C-H...O hydrogen bonds and π-π stacking interactions to form a three-dimensional supramolecular architecture. The thermal stability of the title complex was investigated via thermogravimetric analysis. [ABSTRACT FROM AUTHOR]

Chain gang: A chain ‐ based 2D CoII coordination polymer was prepared by hydrothermal reaction of Co(NO3)2⋅6 H2O, H2L and bpa in the presence of sodium hydroxide. Magnetic investigation revealed canted antiferromagnetism, magnetic hysteresis, and slow magnetic relaxation. Thus, this complex could be considered as a new homospin weak ferromagnetic single ‐ chain magnet. [ABSTRACT FROM AUTHOR]

Two enantiomorphic MgII/carboxylate coordination polymers [Mg(bpda)(H2O)4] n ( 1M and 1P) have been obtained by spontaneous resolution from achiral precursors, 2,2′-bipyridyl-3,3′-dicarboxylic acid (H2bpda) and Mg(NO3)2 ·6H2O, upon crystallization without any chiral auxiliary. X-ray structural analysis shows that chiral transmission from molecular axially chiral conformations to crystal chirality is established through concerted coordination and H-bonding interactions. In addition, the CD data, and the thermal and photoluminescence properties in the solid state have also been discussed. [ABSTRACT FROM AUTHOR]

Yes-associated protein (YAP), the nuclear effector of the Hippo pathway, is a key regulator of organ size and a candidate human oncogene. This study aimed to assess the clinical significance and biological functions of YAP in non-small-cell lung cancer (NSCLC). We investigated the expression of YAP in 92 cases of NSCLC tissue by immunohistochemistry and found that YAP was expressed in 66.3% (61/92) cases and predominantly presented in the nucleus. The expression of YAP in NSCLC was significantly correlated with p-TNM stage ( P = 0.0037) and lymph node metastasis ( P = 0.0093). Importantly, YAP expression was associated with short overall survival. Further study in NSCLC cell lines in which YAP was either overexpressed or depleted confirmed that YAP markedly promoted cell proliferation and invasion. These results indicate that YAP plays an important role in NSCLC and might be a useful therapeutic target of NSCLC. ( Cancer Sci 2010; 101: 1279–1285) [ABSTRACT FROM AUTHOR]

Recent research shows that a combinatorial network optimisation problem can be approximated by adding a Shannon entropy term to its objective function. This Letter generalises it to the case of Tsallis entropy and provides the mathematical proof. [ABSTRACT FROM AUTHOR]

Emerging classes of 2D noble‐transition‐metal dichalcogenides (NTMDs) stand out for their unique structure and novel physical properties in recent years. With the nearly full occupation of the d orbitals, 2D NTMDs are expected to be more attractive due to the unique interlayer vibrational behaviors and largely tunable electronic structures compared to most transition metal dichalcogenide semiconductors. The novel properties of 2D NTMDs have stimulated various applications in electronics, optoelectronics, catalysis, and sensors. Here, the latest development of 2D NTMDs are reviewed from the perspective of structure characterization, preparation, and application. Based on the recent research, the conclusions and outlook for these rising 2D NTMDs are presented. [ABSTRACT FROM AUTHOR]

Mixed matrix membranes (MMMs) for CO2‐facilitated separation were prepared by incorporating different surface‐modified multiwalled carbon nanotubes (MWCNTs) in a fixed carrier membrane material. Polymer containing amino groups, poly(vinylalcohol‐co‐vinylamine) (VA‐co‐VAm) was synthesized as polymeric matrix. MWCNTs as well as MWCNTs surface‐modified with OH and NH2 were applied as nanofillers. The physical property, chemical structure, and membrane morphology were characterized by FT‐IR, TG, XRD, DSC, CA, XPS, and SEM. The effects of content, functional group, temperature, and pressure on gas permselectivity were studied. Results show that the incorporation of nanofillers can effectively restrict the polymer chain packing and lead to low crystallinity. The MMMs exhibited higher CO2 permselectivity than the pure polymeric membrane. For all the MMMs, the CO2 permeance and selectivity increased with MWCNTs contents to a maximum and then decreased. MWCNT‐NH2 can be regarded as the most effective nanofiller. MMMs with 2.0 wt % MWCNT‐NH2 displayed the highest CO2 permeance of 132 GPU and CO2/N2 selectivity of 74. Both CO2 permeance and selectivity were decreased with feed gas pressure and temperature. The membrane exhibited good stability in the testing with the binary gas mixtures of CO2/N2 for 110 h under 0.54 MPa. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47848. [ABSTRACT FROM AUTHOR]

In this work, ether oxide (EO)‐based multilayer composite membranes were prepared via interfacial polymerization (IP) of trimesoyl chloride (TMC) and polyetheramine (PEA) on polydimethylsiloxane precoated polysulfone support membrane. The effects of preparation parameters, such as monomer concentrations, reaction time, and heat‐treatment temperature on the membrane performance were investigated. The optimal preparation parameters have been concluded. The results showed the increasing monomers concentration of both PEA and TMC can lead to the decrease of CO2 permeance and increase of CO2/N2 selectivity. The optimal monomers concentration was found. When monomer concentrations are higher than the optimal values, the CO2 permeance decreases continually while CO2/N2 selectivity only shows a very limited improvement with the further increase of monomers concentration. The reaction time has similar effects on membrane performance as the monomers concentration. The effect of heat‐treatment temperature was also studied. With the increasing heat‐treatment temperature, the CO2 permeance shows a decrease tendency, while the CO2/N2 selectivity shows a maximum at 80 °C. When PEA is 0.013 mol L−1, TMC is 0.020 mol L−1, reaction time is 3 min, and heat‐treatment temperature is 80 °C, the optimum preparation conditions are achieved with CO2 permeance of 378.3 gas permeation unit (GPU) and CO2/N2 selectivity of 51.7 at 0.03 MPa. This work may help to design and fabricate gas separation membranes with desired performance. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47755. [ABSTRACT FROM AUTHOR]

Mixed‐dimensional heterojunction based on 1D nanowires and 2D semiconductors attracts wide interests in constructing short‐channel transistors that overcome limits in 3D semiconductors, where the gate controllability generally suffers mutual interference in multiple gate operation, e.g., in logic circuit and phototransistors. Here, the dual‐gate modulated mixed‐dimensional junction field‐effect transistor (JFET) with an inverted gate‐all‐around configuration based on 2D n‐type MoS2 onto 1D p‐type CuO nanowire is reported. Importantly, the dual‐gate transistor is made free of gate interferences by introducing self‐aligned graphene nanoribbon that screens gate coupling. It is demonstrated that the devised heterojunction could offer stabilized operation in logic NAND circuit, and in photodetection with gate enhanced detectivity of over 1010 Jones from noise measurement and fast response within 5 ms. The results may therefore shed light on the advanced design of 1D–2D mixed‐dimensional JFETs for multifunction purposes. A novel structure of mixed‐dimensional junction field effect transistor is designed for dual‐gate modulation in function devices via a rectifying 1D‐CuO/2D‐MoS2 junction and a global back gate. With a self‐aligned graphene nanoribbon introduced, the device renders excellent device gate modulated operation window for logic circuits and photodetectors. [ABSTRACT FROM AUTHOR]

Lead halide‐based salts exhibit good photoelectric properties; however, the use, leakage, and recovery of toxic lead require careful consideration. Therefore, developing a lead‐free optoelectronic material conveniently and quickly is very important. Moreover, there is relatively little research on the salts of bismuth halides. In this study, we synthesized [PEA]3[Bi2I9] single crystals (SC) by volatilizing N,N‐dimethylformamide (DMF) solvent at 70°C. The crystal system and spatial group of [PEA]3[Bi2I9] are monoclinic and P21/n, respectively. The Tauc plot reveals the optical band gap of the [PEA]3[Bi2I9] SC at 2.048 eV. The carrier mobility of [PEA]3[Bi2I9] SC is 47.4 cm2 V−1 s−1. Steady‐state fluorescence and time‐resolved fluorescence spectrum indicate that there are four fluorescence peaks and about 7 μs lifetime, respectively. The photodetector based on [PEA]3[Bi2I9] SC under different voltages (0.5, 1, 1.5, 2, and 2.5 V) exhibits stability and regularity with turning‐on/off of the light. In addition, thermogravimetric analysis (TGA) tests indicate that [PEA]3[Bi2I9] SC has considerable thermal stability at temperatures up to 260°C, showing promise for becoming a high temperature resistant and nontoxic sensor with good application prospects. [ABSTRACT FROM AUTHOR]

The tridentate Schiff base ligand of the title complex, [V(C(15)H(12)N(2)O(4))O(C(12)H(8)N(2))]·C(3)H(7)NO, was derived from the condensation of 2-hy-droxy-1-naphthaldehyde and l-asparagine. The central V(IV) atom is six-coordinated by one oxide O atom, two N atoms from 1,10-phenanthroline and one N atom and two O atoms from the Schiff base ligand in a distorted octa-hedral geometry. In the crystal structure, inter-molecular N-H⋯O hydrogen bonds connect mol-ecules into centrosymmetric dimers. The C atoms of the dimethyl-formamide solvent mol-ecule are disordered over two sites with site-occupancy factors of 0.732 (13) and 0.268 (13).