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Background: Dementia associated diseases (DAD) refer to a group of disorders clinically characterized by progressive cognitive impairment (CI). CI may reflect abnormalities across multiple cognitive domains (CD) to varying degrees and combinations and interfere with the ability to carry out activities of daily living (ADL). Determination of driving ability in routine care relies on patient, family, and clinician shared‐decision making, as availability of routine on‐road driving assessment might be limited. Incorporation of patient reported outcomes (PRO) in routine care has increased, becoming more important for patient care and treatment decisions. Neuro‐QoL Cognitive Function Questionnaire (CF) provides an opportunity to assess self‐reported cognition routinely. The relationship of CF to objective computerized multi‐domain cognitive testing and self‐reported driving has not been explored. Providing easily available objective screening might be of great value for all involved in the decision to continue or stop driving in view of the profound impact loss of driving has on independence. Method: A retrospective review of PwDAD who provided self‐reported driving status and completed both objective and subjective cognitive function (CF) measures. Subjective CF was measured by CF score which pertaining to comprehension, cognition, attention, and learning. The validated computerized cognitive assessment battery (CAB‐NT), includes 7 cognitive domains: memory(Mem), executive function(Exe), attention(Att), information processing speed(Inf), visual‐spatial(Vis), verbal function(Ver), motor skills(Mot) and a global cognitive summary score(GCS). T‐tests and regression analysis was utilized for analysis assuming both equal and unequal variances, with significance (p< 0.05). Results: 496 PwDAD, average age 73.4±8.9, 61.2% female. T‐test showed significant differences between driving status yes/no for both CF and all CAB‐NT domains. However, regression analysis showed a small effect size between CF and CAB‐NT cognitive domains scores. Conclusion: Self‐reported driving status in PwDAD corresponds to both perceived/subjective CF and objective measures of cognitive function. However, the relationship between subjective and objective cognitive function measures is problematic. With various CDs involved in the safe effective operation of a motor vehicle, it is necessary to objectively assess this risk with objective measures. Evidence of incongruent relationship between objective and subjective cognitive function enhances the importance of incorporating objective measures of cognitive ability to safely maintain an active driving status. [ABSTRACT FROM AUTHOR]

Background: Dementia associated diseases (DAD) refers to a heterogeneous group of disorders that are clinically characterized by progressive cognitive impairment (CI) that ultimately adversely influences an individual's ability to function independently. CI may reflect abnormalities across multiple cognitive domains to varying degrees and combinations across various cognitive domains (CD). Identifying treatment needs and discussing treatment options requires ongoing communication between patient and provider over the disease continuum; communication capacity may be compromised but underappreciated. Impaired verbal and episodic memory function in people with DAD (PwDAD) can adversely impact communication abilities. Maintaining an effective long‐term treatment plan requires consistent monitoring of both performance ability and patient perspective (patient reported outcomes, PRO) across a continuum of patient needs (health, safety, and QoL). Method: Retrospective review of information obtained in the course of routine care including driving status, Neuro QOL‐Anxiety Short‐Form (A‐SF); Neuro QOL‐Communication Short‐Form (C‐SF); validated multi‐domain computerized cognitive assessment battery (CAB). CAB Domain Score of Verbal Function (CAB‐V) and Memory Function (CAB‐M). CAB and PRO were completed without provider influence. Result: 530 PwDAD (62% female, average age 71.9 +/‐ 14.3 years) was used to compare patient driving status with A‐SF, C‐SF, NT‐V, NT‐M scores. T‐Tests assuming both equal and unequal variances comparing multiple PRO scores to driving status determined significance at (p<0.01). Statistically significant relationships were identified between driving status and: A‐SF, C‐SF, CAB‐V, and CAB‐M. Conclusion: Self‐reported anxiety and ability to communicate, objective impairment in verbal, and memory function are related to driving status in PwDAD. Appreciation of disease impact, whether perceived or performance ability, across a continuum should be incorporated in routine care and monitoring of dementia disorders to optimize care and outcome by identifying issues of concern that have both visible and invisible impact both patients and clinicians to design an effective plan of care to accommodate patient centric impairment and needs. Standardized methods of routine PRO collection concerning various aspects of real‐world health outside of a clinic encounter are important to building an effective holistic treatment plan. [ABSTRACT FROM AUTHOR]

Background: Dementia associated diseases (DAD) refers to clinical conditions characterized by progressive cognitive impairment (CI) that interferes with ability to function independently. However, cognitive impairments can vary in degree and combination of cognitive deficits across multiple cognitive domains. Traditional history and cognitive assessments in clinic are insufficient to identify these varied combinations. Therefore, a clinician may be unaware of these variations and impact on patient QOL and decision‐making. Effective quantitative analysis of cognitive function can be obtained in routine care by a validated, examiner‐independent, sensitive, and reliable computerized cognitive assessment battery (CAB‐NT). Patient reported outcomes (PRO) provide information regarding patient perception of ability across clinically relevant concerns. The BRIEF Health Literacy survey (BHL) PRO is used to find the degree to which one can read, understand, exchange, and use health information and resources. Comparison to computerized cognitive testing has not been explored in this population. Method: Retrospective cross‐sectional analysis of patients with DAD (PwDAD) who completed both PRO BHL and CAB in routine care on the same day. CAB‐NT included 7 cognitive domains: memory (Mem), executive function (Exe), attention (Att), information processing speed (Inf), visual‐spatial (Vis), verbal function (Ver), motor skills (Mot) and global cognitive summary score (GCS). Linear regression analysis was explored with significance (p<0.05). Result: 329 PwDaD, average age of 70±13 years, 63.2% female. Linear regression was used to analyze trends between BHL and CAB. Significant correlations (p = 0.05) were found for CAB‐NT vs: BHL: GCS‐r = 0.42, Vis‐r = 0.36, Mem‐r = 0.31, Exe‐r = 0.39, Ver‐r = 0.25, Mot‐r = 0.22, Inf‐r = 0.32, and Att‐r = 0.28. One‐way ANOVA was performed between BHL (inadequate, marginal, and adequate) and the cognitive domains of the CAB‐NT. Significant differenced (p = 0.05) were found between the three BHL groups within each cognitive domain. Conclusion: Patient centric DAD performances on CAB‐NT is related to patient‐reported health literacy. The more impaired the CAB‐NT scores, the poorer patient‐perceived health literacy reported. Patient centric recognition of CI can enhance clinician's recognition of those people who may require additional information for health‐care decisions or incorporate health‐care proxy for effective shared decision making in routine care. Incorporation of this patient centric information can potentially lead to improved outcomes and satisfaction. [ABSTRACT FROM AUTHOR]

Background: Dementia associated diseases (DAD) refers to a group of disorders characterized by progressive cognitive impairment (CI) that adversely influences ability to function independently in real world activities. CI may reflect abnormalities across multiple cognitive domains (CD) to varying degrees. Successful completion of activities of daily living (ADL) is progressively impaired DAD. Symptom recognition by family and clinicians typically present following irreversible damage, highlighting a demand for effective methods of early DAD diagnosis and treatment. Neurocognitive screening tools combined with patient reported outcomes (PRO) might provide deeper insight into the patterns and progression of DAD. Comparison of PRO across Upper Extremity Function Score (UEF), Self‐Efficacy for Managing Daily Activities (SEMDA), and cognitive performance measures with driving status in PwDAD might enhance understanding of disability across a continuum and identify the medical necessity of transportation assistance for PwDAD. Method: Retrospective review of examiner independent information collected in the course of routine care of a population of PwDAD including demographics, driving status, UEF, SEMDA, executive function (NT‐EF), and motor function, reflecting time to move and accuracy, (NT‐MF) of a multi‐domain computerized cognitive test (CTB). T‐tests were utilized for analysis with significance (p<0.05). Result: 529 PwDAD (59% female, average age 74.4 +/‐ 8.8 years) provided the data collected to compare patient driving status with UEF, SEMDA, NT‐MF, NT‐EF scores. Statistically significant (p<0.01) relationships were identified between driving status and PRO score for all domains: UEF, SEMDA, NT‐MF, and NT‐EF. Conclusion: Active driving status in PwDAD is associated with better scores on a self‐reported upper extremity ability profile, self‐efficacy for managing daily activities as well as better executive function and cognitively defined motor function planning. While effective collaboration across a cognitive network provides for driving, simultaneous monitoring of UEF and SEMDA in conjunction with both NT‐MF, and NT‐EF might provide enhanced insight into driving impairment along a continuum. Improved awareness of the multiple potential paths of impairment and real‐world impact can offer proactive opportunities for intervention as well as novel important endpoints to measure therapy efficacy. [ABSTRACT FROM AUTHOR]

Background: Dementia associated diseases (DAD) refers to clinical conditions characterized by progressive impairment of cognition that interferes with an individual's ability to function independently due to such cognitive impairment (CI). Clinically, CI can vary in degree and combination across multiple important cognitive domains (CD). Clinician and patient with DAD (PwDAD) self‐awareness/recognition of such varied types/degrees of CI might not only be sub‐optimal or inaccurate, but unable to recognize subtle change or provide quantitative information across multiple CD. Patient self‐reported outcome measures (PRO) are now often incorporated into routine care to gauge cognitive impairment, disability progression and participation in self‐management of symptoms, medications and shared decision making. Clinicians rely on patient provided information/history to treatment decisions. Incorporating PRO measures into routine care has increased and impacts care plans and decision‐making. Both accurate and reliable information is needed by clinicians to improve clinical decision‐making and outcomes as well as to avoid unanticipated/adverse outcomes. Method: Retrospective cross‐sectional analysis of PwDAD who have completed PRO on the same day for both the Self‐Efficacy for PROMIS Managing Symptom s‐SF 8a (MS‐SF) and Neuro‐QOL Cognition Function‐SF (CF‐SF) in the course of routine care. Linear regression analysis of relationship was explored with significance (p<0.05) Results: 205 PwDaD, 65% female, average age 70 +/‐ 15 years. A significant positive correlation was found between the MS‐SF and CF‐SF reflecting the patient's perceived cognition abilities and self‐reported self‐confidence in managing their symptoms (r2 = 0.5, p‐value<0.01). Conclusion: PwDaD who report higher self‐efficacy/confidence with managing medications on MS‐SF also report higher self‐perception of cognitive functioning on CF‐SF. Low perceived cognitive ability tracks with low confidence in managing symptoms. However, CF‐SF does not track with actual measures of cognitive performance suggesting that clinicians can be misled by relying on patient self‐reported confidence of symptom management. Accurate measurements of both cognitive ability and patient ability to self‐management symptoms are needed in real world care to intervene proactively and improve outcomes. [ABSTRACT FROM AUTHOR]

Background: Dementia associated diseases (DAD) are characterized by progressive impairment of cognition that interferes with an individual's ability to function independently. Clinically, cognitive impairment (CI) can vary in degree and combination across multiple cognitive domains (CD). Clinician and patient with DAD (PwDAD) recognition of such varied types/degrees of CI might not only be sub‐optimal, but also unable to recognize subtle change and progression. Patient self‐reported outcome measures (PRO) are used to gauge CI or disability progression. Traditional measures (MOCA, MMSE) include a dichotomous outcome measure and routine neuropsychological screening might not be practical. Quantitative and objective screening across multiple CD can be accomplished in routine care with validated, examiner independent, computerized multi‐domain cognitive assessment battery (CAB‐NT, NeuroTrax). NeuroQOL Cognitive Function Short‐Form (CF‐SF) is one validated disease agnostic PRO that can be incorporated to evaluate patient perception of disease impact and change on CI. The relationship of CF‐SF to multi‐domain quantitative CAB has not been explored in PwDAD. Method: Retrospective review of consecutive PwDaD who completed both CF‐SF and CAB‐NT on the same day in the course of routine care. CAB‐NT included 7 cognitive domains: memory (Mem), executive function (Exe), attention (Att), information processing speed (Inf), visual spatial (Vis), verbal function (Ver), motor skills (Mot) as well as a global cognitive summary score (GCS). Results: Linear regression analysis of relationship was explored with significance (p<0.05). 196 PwDAD, (65% female, average age 73+/‐ 9 years). "Significant" relationships (p<0.05) were identified through regression analysis for the following CD scores: GCS (r2 = 0.03), Exe (r2 = 0.04), Att (r2 = 0.06), and Mot (r2 = 0.04). Conclusion: PwDAD self‐perception of their cognitive abilities do not accurately reflect objective CAB performance measures of cognitive function. CF‐SF PRO scores do not reflect cognitive performance across multiple cognitive domains and should not be considered appropriate screening tools to incorporate into routine care to determine when to consider the need for examiner independent measures to accurately monitor disease impact or change. Objective computerized testing measures across multiple cognitive domains provides useful insight and value based information for clinicians to gauge the presence of or change in cognitive impairment. [ABSTRACT FROM AUTHOR]

Background: Dementia associated diseases (DAD) refers to several clinical conditions that are characterized by progressive cognitive impairment that interferes with an individual's ability to function independently. Cognitive impairments (CI) can vary in degree and combination across multiple cognitive domains (CD) that routine care or tests (MMSE, MOCA) might not adequately identify. Therefore, a clinician may not recognize these varied types of CI or change in CD scores effectively. Enhanced recognition of patient centric CI in routine care can be accomplished improved analytics by incorporating a validated, examiner independent computerized cognitive assessment battery (CAB‐NT). Patient self‐reported outcome measures (PRO) are concurrently incorporated with CAB‐NT to gauge associated disability progression. Ability and participation in social roles and activities and communication ability can adversely affect quality of life (QoL) for people with Dementia associated diseases (PwDAD) and are likely related to CI and other factors. Method: Retrospective review of consecutive PwDAD who completed both CAB‐NT and PRO (SSRA, APSRA, and C‐SF) on the same day in the course of routine care. CAB‐NT included 7 cognitive domains: memory (Mem), executive function (Exe), attention (Att), information processing speed (Inf), visual spatial (Vis), verbal function (Ver), motor skills (Mot) as well as a global cognitive summary score (GCS). Results: 312 PwDaD, 64.74% female, average age 66 +/‐ 17 years. Simple linear regression analyses were performed with significant correlations (p = <0.05): CAB‐NT vs SSRA: GCS r = 0.2, Exe r = 0.3, Mot r = 0.2, and Att r = 0.3. CAB‐NT vs APSRA: Exe r = 0.3, Att r = 0.2. CAB‐NT vs C‐SF: Exe r = 0.2. Conclusion: Social roles and communication in PwDAD are most impacted by CI associated with executive functioning and attention. Impairment in these domains are associated with increased difficulty for PwDaD to effectively interact with others and may lead to reduced QoL for these patients. Identifying the degree and combination of such CI precisely might allow for early and effective targeted proactive behavioral and/or medicinal intervention to improve QOL of these patients. [ABSTRACT FROM AUTHOR]

Experimental and clinical evidence suggests that N-myc downregulated gene 1 ( NDRG1) functions as a suppressor of prostate cancer metastasis. Elucidating pathways that drive survival and invasiveness of NDRG1-deficient prostate cancer cells can help in designing therapeutics to target metastatic prostate cancer cells. However, the molecular mechanisms that lead NDRG1-deficient prostate cancer cells to increased invasiveness remain largely unknown. In this study, we demonstrate that NDRG1-deficient prostate tumors have decreased integrin expression and reduced cell adhesion and motility. Our data indicate that loss of NDRG1 differentially affects Rho GTPases. Specifically, there is a downregulation of active RhoA and Rac1 GTPases with a concomitant upregulation of active Cdc42 in NDRG1-deficient cells. Live cell imaging using a fluorescent sensor that binds to polymerized actin revealed that NDRG1-deficient cells have restricted actin dynamics, thereby affecting cell migration. These cellular and molecular characteristics are in sharp contrast to what is expected after loss of a metastasis suppressor. We further demonstrate that NDRG1-deficient cells have increased resistance to anoikis and increased invasiveness which is independent of its elevated Cdc42 activity. Furthermore, NDRG1 regulates expression and glycosylation of EMMPRIN, a master regulator of matrix metalloproteases. NDRG1 deficiency leads to an increase in EMMPRIN expression with a concomitant increase in matrix metalloproteases and thus invadopodial activity. Using a three-dimensional invasion assay and an in vivo metastasis assay for human prostate xenografts, we demonstrate that NDRG1-deficient prostate cancer cells exhibit a collective invasion phenotype and are highly invasive. Thus, our findings provide novel insights suggesting that loss of NDRG1 leads to a decrease in actin-mediated cellular motility but an increase in cellular invasion, resulting in increased tumor dissemination which positively impacts metastatic outcome. [ABSTRACT FROM AUTHOR]

Background: Dementia associated disorders (DAD) refers to clinical conditions that are typically characterized by progressive cognitive impairment (CI) that interferes with an individual's ability to function independently. In routine care CI in DAD may be poorly recognized and can vary considerably in degree and combination across multiple cognitive domains. Therefore, clinical judgement may be insufficient alone to identify CI across these varied types/degrees, and how CI may directly affect both patient quality of life and decision‐making. Patient reported outcomes (PRO) are used to survey patient perception of their disease across varied real world impact. The BRIEF Health Literacy (HL) survey (BHL), Electronic health literacy (eHealth Literacy Scale, EHL) and the psychological antecedents of vaccinations (Vaccine 5C, V5C), vaccine hesitancy, have not been explored across these areas in people with DAD (PwDAD). Method: Retrospective cross‐sectional analysis of PwDAD who completed the following PRO's V5C, EHL, and BHL in routine care. Results: 146 PwDAD, average age of 72+/‐15 years. Linear regression statistics were used to analyze trends between individual V5C questions with the BHL and EHL. Significant correlations were found as follows (p<0.01): V5C‐2 (the need for vaccination)vs BHL (r =.2), V5C‐3 (everyday stress interfering with vaccination) vs BHL (r =.2), V5C‐4 (I personally weight risks/benefits of vaccination) vs BHL (r =.3), V5C‐2 vs EHL (r =.2), V5C‐3 vs EHL (r =.1), V5C‐4 vs EHL (r =.2). Conclusion: Lower perception health literacy ability (BHL) and lower ability to use electronic sources to gain information regarding their health literacy (EHL)in PwDAD impact decision and feelings regarding vaccination (i.e. the necessity of vaccination, stress as a barrier to vaccination, and risk‐benefit analysis respectively). Further investigation beyond perceptions to quantitative measures of CI across multiple cognitive domains (degrees/combinations) between the V5C, BHL, and EHL would prove useful in exploring these relationships and defining a path to enhance education to reduce vaccine hesitancy. [ABSTRACT FROM AUTHOR]

Background: Dementia associated diseases (DAD) refers to multiple clinical conditions all characterized by progressive impairment of cognition that interferes with an individual's ability to function independently due to such cognitive impairment (CI). Clinically, CI can vary in degree and combination across multiple important individual cognitive domains (CD). Depression is also reported to be an early sign of or as a potential risk factor of Alzheimer's or another DAD. Enhanced awareness of the presence of depression in people with DAD (PwDAD) and the relationship of self‐reported depression to self‐perception of cognitive function may provide insight into current screening methods incorporated in routine care and treatment options prescribed as well as the need to include further information as treatment options become more complex and time available to holistically evaluate patient needs evolves. Method: Retrospective cross‐sectional analysis of PwDAD who completed both the patient reported outcomes (PRO) Neuro QOL Cognition Function‐ Short Form (CF‐SF) and Neuro QOL Depression‐Short Form (SFD‐SF) in routine care. Linear regression analysis of relationship was explored with significance (p<0.05). Results: 213 PwDAD, 65% female, average age 70 +/‐ 15 years. A statistically significant negative relationship was identified between self‐reported depression identified by Neuro‐QOL PRO SFD‐SF and self‐perceived cognition abilities (CF‐SF) (r2 = 0.25). Conclusion: There is an inverse relationship between PRO self‐reported depression and self‐reported/self‐perceived cognitive ability in PwDAD. Incorporating PRO Cognitive Function‐Short Form as the sole measure of cognitive function or simply as a screening tool to determine when to objectively measure cognitive function in PwDAD without simultaneously screening for depression and not incorporating other objective value‐added cognitive measurement tools should not be recommended. [ABSTRACT FROM AUTHOR]

Background: Memory loss is one of the hallmark symptoms of cognitive impairment that progresses towards dementia. Different cognitive domains (CD) have been suggested to influence the performance of dual‐task (DT) activities. While there is evidence of DT effects on those with mild cognitive impairment and other dementias, the impact of DT on those with subjective memory loss is unknown. Method: Participants (n=57; mean age: 72.72±10.56 years) with memory loss but without a diagnosis of cognitive impairment, dementia, or other neurodegenerative diseases were included. They performed validated computerized cognitive assessment battery (CAB, NeuroTrax BrainCare) to obtain CD measures of executive function (EF), attention, memory, visual‐spatial processing (VSP), information processing speed (IPS), and a global cognitive score (GCS) measure. Using the Zeno Walkway Gait Analysis System (Protokinetics), measures of velocity, stride width (SW), stride time (ST), stride length, cadence, double support (DS), and gait variability were obtained for both single‐task and DT gait. Participants chose between performing the DT gait by either recalling names (n=14), counting backward by 3's (n=16), or by 7's (n=27), which were used as group assignments for analysis. A three‐group cross‐sectional mediation analysis was performed using standardized cognitive measures as mediators and the DT effect (DTE) of the gait parameters as outcomes of interest. Data analysis was conducted using SPSS 26 and SPSS AMOS 26. Result: No significant mediators of cognition on the dual‐task effect of either task were identified. However, increases in individual CD significantly predicted improvement of DTE in specific gait parameters: (1) memory significantly predicted DTE stride time (Effect size by standardized beta(ES)=0.343,p=0.022) and DTE double support (ES=0.322,p=0.033); (2) GCS (ES=0.388,p=0.028), attention (ES=0.348,p=0.007), and IPS (ES=0.290,p=0.027) significantly predicted DTE stride width; and (3) Attention (ES=0.282,p=0.047) significantly predicted DTE cadence. Furthermore, between‐group analysis showed significant differences in VSP (F(2,54)=8.820,p<0.001), IPS (F(2,54)=3.350,p=0.043) and GS (F(2,54)=5.149,p=0.009). Conclusion: Results suggest that individual CD (VSP, IPS, and/or GS) scores impact different aspects of dual tasking gait in individuals with memory loss. While there were no significant mediators, the significant cognitive predictors suggest improvement of those individual CD could improve the DTE of individual gait measures. [ABSTRACT FROM AUTHOR]

Background: Dementia is an encompassing term referring to conditions characterized by progressive cognitive impairment (CI) that impairs ability to function independently and simultaneously results in increased risk of falling. Falls are common and their consequence costly in cognitively impaired individuals. Clinical reports suggest that falls and gait performance during dual tasking (DT) are particularly related to executive function. Additional reports propose that DT gait abilities predict future fall risk and that interventions designed to improve DT will decrease future fall risk. Analysis of DT gait function to non‐DT gait function has been shown to be superior in discerning those at higher fall risk, in comparison to previous measures. Clinically, CI varies in degree and combination of cognitive deficits and gait disturbance but clinician recognition of such varied types/degrees of CI is likely problematic. Methods: Cross sectional analysis of PwDaD who underwent both validated computerized cognitive assessment battery (CAB) and digital gait analysis in the course of routine patient care and were screened for risk of falls. Results: 120 PwDaD, 57.5% female, average age 74+/‐ 10 years. T‐tests were performed between gait domains scored from PKMAS for PwDaD groups for step length, stride length, stride width, velocity and total double support. All individual gait domains showed a significant change in score for t‐tests performed between preferred walking speed (PWS) and DT gait function (p<0.01). Regression analysis of PwDaD cognitive profile against DT velocity was performed as well. CAB regressions of multiple cognitive domain scores against dual task velocity which were significant included: global summary score, executive function, visuo‐spatial and motor skills' scores (p<0.05). Conclusion: The addition of a cognitive factor to gait, i.e. dual task, demonstrates a decrease in gait parameter functions in comparison to PwDaD gait at PWS. Earlier objective patient centric identification of increased fall risk provides clinicians an opportunity to effectively and pre‐emptively intervene to reduce such increased disability consequence and costs associated with this disease related impact. [ABSTRACT FROM AUTHOR]

Background: Dementia is an encompassing term referring to multiple clinical conditions characterized by progressive cognitive impairment (CI) that interferes with an individual's ability to function independently. Clinically, CI varies in degree and combination of cognitive deficits from memory loss, verbal impairment, apraxia to impaired executive function. Clinician recognition of such varied types/degrees of CI is likely problematic. Falls are common and their consequence costly in individuals with such cognitive impairment. Effective analysis of multiple aspects of cognitive function can be provided in routine care with a validated, examiner independent, sensitive and reliable computerized cognitive assessment battery, (CAB, Neurotrax) which specifically evaluates multiple cognitive domains (CD): Memory (MEM), Executive Function (EXE), Visual Spatial (VIS), Verbal Function (VER), Attention (ATT), Information Processing (INF), and Motor Skills (MOT) and a Global Cognitive Summary Score (GCS). Method: Cross sectional analysis of PwDaD who underwent standardized CAB cognitive testing and were also screened for risk of falls based on number of falls in the past and persons fear of falling. Result: 120 PwDaD, 57.5% female, average age 74 +/‐ 10 years. T‐tests were performed between CAB CD scores grouped by risk of falling (high/low). The following CD scores were associated with increased fall risk: GCS (p=<.05) and VIS (p=<.05). A significant increased fall risk was also associated with an accumulative CDI (# of individual cognitive domains impaired) (p=<.05). Conclusion: As CAB measured cognition decreases PwDaD risk of falling increases. PwDaD at increased risk for falls had increased accumulative CI with an average of 3 CDI. PwDaD also at increased risk for falls have significantly lower GCS and Visual Spatial scores. Earlier identification of increased fall risk might allow clinicians an opportunity to effectively and pre‐emptively intervene to reduce such increased disability consequence and costs associated with this disease related impact. [ABSTRACT FROM AUTHOR]