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In this study, a cost‐effective and eco‐friendly method was developed to remediate soil contaminated by hexavalent chromium (Cr[VI]) using ferrous sulfate and biogas residue (BR). The results show that the addition of BR at mole ratio of Fe(II)/Cr(VI) = 3:1 and mass ratio of BR (dry mass)/Cr(VI) = 70:1 significantly improved the reduction of Cr(VI) and reduced its mobility. Moreover, the reduction efficiency of Cr(VI) was higher than 85% at day 1 and reached a maximum of 96.7% at day 7. The X‐ray photoelectron spectroscopy, scanning electron microscopy, and microbial diversity analyses indicated that the microbial mechanism created by the BR addition was crucial for the long‐term and stable reduction of Cr(VI). The enriched Cr(VI)‐reducing bacteria genera in the BR directly reduced Cr(VI), whereas the reducing bacteria in the BR indirectly reduced Cr(VI) to Cr(III) through the electron transport system in the reaction system. The addition of BR can lead to a high reduction efficiency and long‐term stabilization of Cr(VI)‐contaminated soils. This study provides reference values for the combined remediation technology for Cr(VI)‐contaminated soils. [ABSTRACT FROM AUTHOR]

Abstract: Wilms tumor (WT) is a genetically heterogeneous childhood kidney tumor. Several genetic mutations have been identified in WT patients, including inactivation of WTX, somatic stabilizing CTNNB1, and p53 mutations. However, the molecular mechanisms in tumorigenesis remain largely unexplored. Stat3 is a transcription factor that can promote oncogenesis. Stat3 activation is commonly viewed as crucial for multiple tumor proliferation and metastasis. We show that Stat3 is highly activated in Wilms tumor tissues compared to those in adjacent tissues. IL-6 treatment or transfection of a constitutively activated Stat3 in G401 cells promotes cell proliferation. At the molecular level, we further elucidate that Stat3 inhibits WTX expression through up-regulation of microRNA-370. Our results suggest that Stat3/miR-370/WTX regulatory axis might be a critical mechanism in Wilms tumor cells. [Copyright &y& Elsevier]