Search

To compare the efficacy and safety of silodosin and tamsulosin in patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) by a randomized crossover method. BPH patients with the complaint of LUTS were included in this study, and were randomly divided into two groups: a silodosin-preceding group (4 weeks of twice-daily administration of silodosin at 4 mg, followed by 4 weeks of once-daily administration of tamsulosin at 0.2 mg) or a tamsulosin-preceding group (4 weeks' administration of tamsulosin, followed by 4 weeks' administration of silodosin). No drug withdrawal period was provided when switching the drug. In the first treatment period, both drugs significantly improved the International Prostate Symptom Score total score, but the improvement by silodosin was significantly superior to that by tamsulosin. After crossover treatment, significant improvement was observed only with silodosin treatment. Moreover, intergroup comparison of changes revealed that silodosin showed significant improvement of straining and nocturia with first and crossover treatments, respectively, compared with tamsulosin. Silodosin also significantly improved quality of life (QOL) score in both treatment periods, while tamsulosin significantly improved QOL score only in the first treatment period. The most frequent adverse drug reaction was ejaculatory disorder with silodosin; however, the incidence of dizziness with silodosin was similar to that with tamsulosin. In BPH/LUTS patients, silodosin exhibits excellent efficacy in improving subjective symptoms in both initial and crossover treatment, and it appears to improve the QOL of patients. [ABSTRACT FROM AUTHOR]

This paper proposes a control system which improves OPU (Optical Pick Up) control performance in an optical disk system. This system can be realized by adding a correction pulse control block which is based on a position error signal onto a conventional position control loop composed of the PID control rule. Using this function, the position error resulting from a physical distortion and acceleration disturbance to the disk can be decreased sharply. Furthermore, this system can decrease the deviation caused by the shock disturbance which cannot be controlled by the PID control rule. In addition, it becomes possible to decrease the overshoot in the impulse response sharply, and realize stable capture of a target position. Since this system can be created with a simple algorithm, it is possible to use it in a wide range of applications. © 2007 Wiley Periodicals, Inc. Electr Eng Jpn, 160(2): 53–67, 2007; Published online in Wiley InterScience (www.interscience. wiley.com). DOI 10.1002/eej.20570 [ABSTRACT FROM AUTHOR]