20 results on '"Yee, Donald"'
Search Results
2. Competitive interactions with Aedes albopictus alter the nutrient content of Aedes aegypti.
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Deerman, Hunter and Yee, Donald A.
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AEDES aegypti , *COMPETITION (Biology) , *AEDES albopictus , *AQUATIC habitats , *MOSQUITOES , *FOOD chains , *DIPTERA , *DETRITUS - Abstract
Competition is often cited as a central force that affects the distribution and performance of organisms. Ecological stoichiometry is the balance of elements within animal bodies that can be affected by resource acquisition and processing, as well as by intra‐ or interspecific interactions. Though relatively underexplored for mosquitoes, stoichiometry may provide a wealth of information linking ecological interactions to body nutrient content, and potentially on to pathogen transmission. Detritus, which often varies in nutrient content, forms the base of the food web within the small aquatic habitats occupied by larval mosquitoes, and detrital nutrient content can alter mosquito growth, survival, and population growth. The invasive mosquitoes Aedes albopictus (Diptera: Culicidae) and Aedes aegypti (Diptera: Culicidae) interact as larvae in aquatic systems, often altering their adult populations. Herein, we investigated how different detritus combinations as well as how intra‐ and interspecific densities of Ae. albopictus and Ae. aegypti would affect coexistence; we also measured how nutrient composition (carbon and nitrogen) and stoichiometry (C:N) of adults would vary with those interactions. Ae. albopictus survival, population growth, and stoichiometry were not affected by intra‐ or interspecific competition; nutrient values did vary with detritus ratios. However, Ae. aegypti nutrient content and stoichiometry and survival were negatively affected within the lowest nutrient environments in the presence of Ae. albopictus, but in the highest nutrient environments, both species showed high survival rates and population growth. This is the first study to show that adult mosquito body nutrients can be altered by interspecific interactions, and as nutrient content in adults has been linked to pathogen transmission, it provides a novel role of competition in affecting disease dynamics. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
3. Influence of a simulated hurricane on aquatic insect recolonization in the phytotelma of Heliconia caribaea (Heliconiacaea).
- Author
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Everly, Jaclyn and Yee, Donald
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AQUATIC insects ,ECOLOGICAL disturbances ,HURRICANES ,INSECT communities ,ECOLOGICAL impact ,ECOSYSTEMS - Abstract
Disturbances like hurricanes can affect diversity and community composition, which may in turn affect ecosystem function. We examined how a simulated hurricane disturbance affected insect communities inhabiting the phytotelma (plant‐held waters) of Heliconia caribaea in the Luquillo Experimental Forest of eastern Puerto Rico, a tropical island that frequently experiences hurricanes. We hypothesized that disturbance would alter diversity and that larger Heliconia would attract more species following disturbance due to the area‐diversity relationship described by the Theory of Island Biogeography. Individual flower parts (bracts) of Heliconia inflorescences (racemes) were artificially disturbed via removal of existing insect communities, then after refilling with water, cohorts of Heliconia were destructively sampled biweekly for 6 weeks to assess recolonization patterns of α (bract level), β, and γ (summed across bracts; raceme level) diversity over time and across raceme sizes. Although we found no support for our hypothesis about the effect of raceme size on recolonization, our hypothesis regarding recolonization patterns over time was supported; species richness, evenness, and abundance of bracts increased directly after the disturbance and then decreased below pre‐disturbance levels, and community composition at the raceme level changed significantly over time during recolonization. β Diversity was also greater in smaller racemes compared to larger racemes, suggesting high heterogeneity across bracts of Heliconia racemes exacerbated by raceme size and age. Overall, our results highlight the importance of scale and appropriate measurements of diversity (particularly α) in experiments aiming to extrapolate conclusions about the ecological impacts of disturbances across different habitats and ecosystems. [ABSTRACT FROM AUTHOR]
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- 2023
- Full Text
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4. Population pharmacokinetics of human antithrombin concentrate in paediatric patients.
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Moffett, Brady S., Diaz, Rosa, Galati, Marianne, Mahoney, Donald, Teruya, Jun, and Yee, Donald L.
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ANTITHROMBINS ,ANTICOAGULANTS ,PHARMACOKINETICS ,DRUG dosage ,STATISTICAL bootstrapping ,PEDIATRICS ,THERAPEUTICS - Abstract
Aims Antithrombin is increasingly used in paediatric patients, yet there are few age-specific pharmacokinetic data to guide dosing. We aimed to describe the pharmacokinetic profile of human (plasma-derived) antithrombin concentrate in paediatric patients. Methods A 5-year retrospective review was performed of patients <19 years of age admitted to our institution who received antithrombin concentrate, were not on mechanical circulatory support and had baseline (predose) and postdose plasma antithrombin activity levels available for analysis. Demographic and laboratory variables, antithrombin dosing information and data on the use of continuous infusion unfractionated heparin were collected. Population pharmacokinetic analysis was performed with bootstrap analysis. The model developed was tested against a validation dataset from a cohort of similar patients, and a predictive value was calculated. Results A total 184 patients met the study criteria {46.7% male, median age [years] 0.35 [interquartile range (IQR) 0.07-3.9]}. A median of two antithrombin doses (IQR 1-4) were given to patients (at a dose of 46.3 ± 13.6 units kg
-1 ), with median of three (IQR 2-7) postdose levels per patient. Continuous infusion unfractionated heparin was administered in 87.5% of patients, at a mean dose of 34.1 ± 22.7 units kg-1 h-1 . A one-compartment exponential error model best fit the data, and significant covariates included allometrically scaled weight on clearance and volume of distribution, unfractionated heparin dose on clearance, and baseline antithrombin activity level on volume of distribution. The model resulted in a median −1.75% prediction error (IQR -11.75% to 6.5%) when applied to the validation dataset ( n = 30). Conclusions Antithrombin pharmacokinetics are significantly influenced by the concurrent use of unfractionated heparin and baseline antithrombin activity. [ABSTRACT FROM AUTHOR]- Published
- 2017
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5. Association of outcomes and anti-Xa levels in the treatment of pediatric venous thromboembolism.
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Fan, Jennifer L., Roberts, Laura E., Scheurer, Michael E., Yee, Donald L., Shah, Mona D., and Lee‐Kim, YoungNa J.
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- 2017
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6. Oviposition preference and offspring performance in container breeding mosquitoes: evaluating the effects of organic compounds and laboratory colonisation.
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ALLGOOD, DAVID W. and YEE, DONALD A.
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OVIPARITY , *MOSQUITOES , *ORGANIC compounds , *CULEX quinquefasciatus , *AEDES albopictus - Abstract
1. The preference-performance hypothesis ( PPH) predicts that organisms lacking parental care should oviposit in habitats that optimise offspring performance. Preference-performance relationships were investigated for the Asian tiger mosquito ( Aedes albopictus Skuse) and the southern house mosquito ( Culex quinquefasciatus Say) ( Diptera: Culicidae), two medically important container-breeding species, in response to an organic chemical blend mimicking decaying plant matter. Additionally, the effects of long-term laboratory colonisation of Cx. quinquefasciatus using wild and laboratory strains were evaluated. 2. Oviposition bioassays were conducted by releasing gravid mosquitoes into field enclosures with automobile tires containing low and high concentrations of the chemical blend, and water controls. The offspring were then reared in water collected from the tires in which they were deposited. 3. Aedes albopictus and wild Cx. quinquefasciatus laid more eggs in the chemical blend than water controls but did not differentiate between the low and high concentrations. Conversely, laboratory Cx. quinquefasciatus only preferred the high concentration to the low concentration. No statistical associations between oviposition preference and larval survival were found, as the chemical blend did not affect survivorship of either species. 4. The oviposition preference for the chemical blend over water controls suggests that both species oviposit in the best available resource environment, but further studies are needed before conclusions regarding preference-performance relationships can be drawn. 5. It was found that long-term laboratory colonisation affects the oviposition behaviour in Cx. quinquefasciatus, suggesting that behavioural studies on laboratory strains are not always applicable to wild populations. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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7. The interactive effects of photoperiod and future climate change may have negative consequences for a wide-spread invasive insect.
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Yee, Donald A., Ezeakacha, Nnaemeka F., and Abbott, Karen C.
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PHOTOPERIODISM , *CLIMATE change , *INTRODUCED insects , *AEDES albopictus , *PREDICTION models , *INSECT physiology , *INSECTS - Abstract
Increasing global temperatures may affect many ectotherms, including insects, although increasing temperatures are thought to benefit future populations through effects on adult size, fecundity, or populations. However, the way that temperature may interact with photoperiod is not well understood. We study this problem using the Asian tiger mosquito Aedes albopictus, an important worldwide invasive whose future spread is thought to be affected by changes in climate. We investigated how mass at maturity varied with temperature (21°C, 25°C) across short and long photoperiods, using laboratory populations from the extreme ends of this species' current US range (Florida, New Jersey). These values were used to parametrize a model to predict optimal mass based on development times; the results of a second laboratory experiment under the same treatments were compared to model predictions. Warmer conditions shortened development times in females from all locations leading to either higher or lower mass depending on the photoperiod. We then used published mass-fecundity relationships to determine the consequences of mass on fecundity under our conditions. Under the majority of scenarios warming decreased predicted fecundity under long photoperiods, but proved beneficial under short photoperiods because the costs of fast development were offset by increased survival in the face of late-season freezing risk. However, fecundity was always low under short photoperiods, so the marginal benefit of warming appears negligible given its cost under long photoperiods when the majority of reproduction occurs. Thus, with northern range expansion, where colder weather currently limits this species, detrimental effects of warming on fecundity are likely, similar to those identified for mass. Unlike previous work that has shown benefits of a warming planet to insects like Aedes albopictus, our work predicts lower performance under warming conditions in summer across the current range, a prediction with implications for range expansion, disease dynamics and populations. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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8. Variation in performance of two co-occurring mosquito species across diverse resource environments: insights from nutrient and stable isotope analyses.
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WINTERS, ANNE E. and YEE, DONALD A.
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DETRITUS , *FOOD chains , *TIRES & the environment , *CULEX , *STABLE isotope analysis - Abstract
1. Inputs of animal and plant detritus are the main energy sources for food webs in a number of isolated container systems, including discarded automobile tyres and tree holes. Containers are dominated by mosquitoes in the genera Culex and Aedes, which among other differences often engage in different foraging behaviours. We hypothesised that because Aedes feed more by browsing surfaces, whereas Culex often filter the water column, these mosquitoes would show variation in performance and differentially affect detritus. Effects of different ratios of animal and plant detritus on survival, mass, and development time for two common container mosquito species, Culex restuans L. and Aedes albopictus Skuse, were examined. We also quantified detrital contribution to biomass via isotopic and nutrient analysis and the effect of larvae on detrital decay. 2. Adult male and female mass of both species was highest with some animal detritus and lowest in only leaf detritus. Aedes albopictus survival was higher than C. restuans across most detritus ratios. 3. Aedes albopictus had higher values of 15N and in some cases 13C across all detritus ratios compared with C. restuans; A. albopictus had lower nitrogen in tissue. Aedes albopictus appeared to be more efficient at obtaining potentially limiting nutrients and had a greater overall effect on detrital decay - a possible consequence of greater foraging effort. 4. Findings further support the view that mosquito performance can be influenced by detritus type, and provide a more precise hypothesis (i.e. lower need for nitrogen) that may explain the superior competitive ability of A. albopictus over other container mosquitoes. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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9. FondaKIDS: A prospective pharmacokinetic and safety study of fondaparinux in children between 1 and 18 years of age.
- Author
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Young, Guy, Yee, Donald L., O'Brien, Sarah H., Khanna, Rachna, Barbour, April, and Nugent, Diane J.
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- 2011
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10. A regional mass balance of methylmercury in San Francisco Bay, California, USA.
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Yee, Donald, McKee, Lester J., and Oram, John J.
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WATER pollution , *METHYLMERCURY & the environment , *POLLUTION - Abstract
The San Francisco Bay (California, USA) is a water body listed as impaired because of Hg contamination in sport fish for human consumption, as well as possible effects on resident wildlife. A legacy of Hg mining in local watersheds and Hg used in Au mining in the Sierra Nevada (USA) has contributed to contamination seen in the bay, with additional more recent and ongoing inputs from various sources. Methylmercury is the species of Hg most directly responsible for contamination in biota, so better understanding of its sources, loads, and processes was sought to identify the best means to reduce impacts. A regional scale model of San Francisco Bay was developed to characterize major methylmercury inputs and processes. The model was used to evaluate the potential impact of uncertainties in estimates for methylmercury loading pathways and environmental processes, identify major data gaps, and explore management prospects for reducing methylmercury contamination. External loading pathways considered in the mass balance include methylmercury loads entering via atmospheric deposition to the bay surface, and discharges from the Sacramento/San Joaquin Delta, local watersheds, municipal wastewater, and fringing wetlands. Internal processes considered include exchange between bed and suspended sediments and the water column, in situ production and demethylation, biological uptake, and losses via hydrologic transport to the ocean through the Golden Gate. In situ sediment methylation and demethylation were dominant sources and losses determining ambient steady-state concentrations in the model, with changes in external loads and export causing smaller changes. Better information on methylation and demethylation is thus most critical to improving understanding of methylmercury balances and management. Environ. Toxicol. Chem. 2011;30:88-96. © 2010 SETAC [ABSTRACT FROM AUTHOR]
- Published
- 2011
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11. Defining and managing career challenges for mid-career and senior stage pediatric hematologist/oncologists.
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Frugé, Ernest, Margolin, Judith, Horton, Terzah, Venkateswaran, Lakshmi, Lee, Dean, Yee, Donald L., and Mahoney, Donald
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- 2010
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12. Stable isotope analysis reveals detrital resource base sources of the tree hole mosquito, Aedes triseriatus.
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KAUFMAN, MICHAEL G., PELZ-STELINSKI, KIRSTEN S., YEE, DONALD A., JULIANO, STEVEN A., OSTROM, PEGGY H., and WALKER, EDWARD D.
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DETRITUS ,STABLE isotopes ,MOSQUITOES ,FOOD chains ,TISSUES - Abstract
1. Detritus that forms the basis for mosquito production in tree hole ecosystems can vary in type and timing of input. We investigated the contributions of plant- and animal-derived detritus to the biomass of Aedes triseriatus (Say) pupae and adults by using stable isotope (
15 N and13 C) techniques in laboratory experiments and field collections. 2. Laboratory-reared mosquito isotope values reflected their detrital resource base, providing a clear distinction between mosquitoes reared on plant or animal detritus. 3. Isotope values from field-collected pupae were intermediate between what would be expected if a single (either plant or animal) detrital source dominated the resource base. However, mosquito isotope values clustered most closely with plant-derived values, and a mixed feeding model analysis indicated tree floral parts contributed approximately 80% of mosquito biomass. The mixed model also indicated that animal detritus contributed approximately 30% of mosquito tissue nitrogen. 4. Pupae collected later in the season generally had isotope values that were consistent with an increased contribution from animal detritus, suggesting that this resource became more nutritionally important for mosquitoes as plant inputs declined over the summer. [ABSTRACT FROM AUTHOR]- Published
- 2010
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13. Varied opinions on thrombolysis for venous thromboembolism in infants and children: Findings from a survey of pediatric hematology-oncology specialists.
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Yee, Donald L., Chan, Anthony K.C., Williams, Suzan, Goldenberg, Neil A., Massicotte, M. Patricia, and Raffini, Leslie J.
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- 2009
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14. Colonisation of Heliconia caribaea by aquatic invertebrates: resource and microsite characteristics.
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YEE, DONALD A. and WILLIG, MICHAEL R.
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BALISIER , *INVERTEBRATES , *AQUATIC ecology , *AQUATIC invertebrates , *FORESTS & forestry , *HABITATS , *FECES , *BIOMASS , *SUGAR - Abstract
1. Colonisation of ephemeral aquatic habitats via oviposition by invertebrates may be influenced by a variety of factors, such as the quality of aquatic habitat and the characteristics of the surrounding terrestrial environment. The water-holding bracts of Heliconia caribaea, a subtropical herb that produces ephemeral aquatic habitats, are colonised by a variety of aquatic invertebrates. To date, no experiments have been conducted to identify the cues that affect colonisation patterns via oviposition selection in Heliconia. 2. Artificial bracts were used to assess the influence of two types of resources found in bracts (plant produced carbohydrates and terrestrial snail faeces) on oviposition site-selection by invertebrate taxa via a replicated factorial design at four locations in the Luquillo Experimental Forest of Puerto Rico, U.S.A. Eleven microsite characteristics thought to affect oviposition were measured for each experimental container. 3. Most taxa responded in a minor way to microsite characteristics, whereas site selection by the most numerically dominant groups (e.g. Syrphidae) were influenced principally by resources within artificial bracts. Overall, the greatest response by particular taxa was to the presence of snail faeces. At the community level, total abundance, richness, and evenness of invertebrates increased with increasing biomass of faeces. Variation in sugar produced a more complex response. 4. In general, the terrestrial matrix surrounding these aquatic habitats was only a secondary determinant of population and community attributes; the principal factor affecting site selection was the quality of the aquatic habitat. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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15. The significance of ratios of detritus types and micro-organism productivity to competitive interactions between aquatic insect detritivores.
- Author
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YEE, DONALD A., KAUFMAN, MICHAEL G., and JULIANO, STEVEN A.
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FOOD chains , *AQUATIC insects , *INSECT behavior , *DEVELOPMENTAL biology , *MOSQUITOES , *SPATIAL behavior in animals , *INSECT populations , *HABITATS , *PATH analysis (Statistics) - Abstract
1. Investigations of competitive interactions emphasize non-detrital resources, even though detritus is a major component of most food webs. Studies of competing species focus usually on single resource types, although consumers in nature are likely to encounter mixtures of resource types that may affect whether competition results in exclusion or coexistence. 2. The invasive mosquito Aedes albopictus is capable of excluding the native mosquito Ochlerotatus triseriatus in competition for single detritus types in laboratory and field microcosms. In this study, we used nine ratios of two detritus types (animal and leaf) common in natural containers to test whether detritus ratios affect the outcome of competition. 3. Under intraspecific and interspecific competition, A. albopictus attained higher survival and estimated population growth rate than did O. triseriatus. Unlike past studies, both species had positive growth and high adult survival, with little evidence of competitive effects, under one resource ratio (10 : 1 ratio of leaf : animal detritus) regardless of mosquito densities, suggesting potential coexistence. 4. Path analysis showed that densities of larvae had negative effects on population growth for O. triseriatus but not for A. albopictus, indicating competitive superiority of A. albopictus. Population growth of both species was affected strongly by the direct paths from animal (positive) and leaf (negative) detritus, and the indirect effect of leaf detritus via bacterial production (positive). 5. Field sampling established that detritus entered real tree holes in ratios similar to those in our experiment, suggesting that natural variation in detritus ratios may influence local coexistence of these species. Seasonal variation in ratios of plant and animal detritus indicated that temporal as well as spatial variation in inputs may be important for potential coexistence. [ABSTRACT FROM AUTHOR]
- Published
- 2007
- Full Text
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16. Consequences of detritus type in an aquatic microsystem: effects on water quality, micro-organisms and performance of the dominant consumer.
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Yee, Donald A. and Juliano, Steven A.
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DETRITUS , *WATER quality , *HYDROGEN-ion concentration , *BIOGEOCHEMICAL cycles , *DEVELOPMENTAL biology , *AQUATIC invertebrates , *MOSQUITOES , *MICROORGANISMS , *ECOLOGY - Abstract
1. Variation in detritus quality and quantity can have significant effects on aquatic invertebrate food webs. Allochthonous inputs of detritus are the principal energy source for organisms in aquatic tree hole microsystems. We compared the effects of two major detritus types found in tree holes, senescent leaves (Sugar Maple and White Oak) and invertebrate carcasses (dead adult fruit flies and crickets), on several water quality characteristics of laboratory microcosms as well as on mass, survival and population performance of the dominant tree hole consumer, Ochlerotatus triseriatus (Diptera: Culicidae). To date, no study has documented the effects of animal detritus in tree hole microsystems or on resident consumers. 2. Aquatic environments receiving invertebrate carcasses had significantly greater total nitrogen, total reactive phosphorus and higher pH, than leaf-based environments. Decay rate of invertebrate carcasses was greater compared to leaf material. Consumption of O2 by micro-organisms increased with increasing detritus amounts, but we detected no difference between detritus types. 3. Ochlerotatus triseriatus larvae grew faster in animal-based treatments, and mean mass of larvae was significantly greater when more animal detritus was used. The effect of animal-based treatments on larvae translated into higher performance for adults, which were three times heavier than counterparts from plant-based containers. Survivorship and estimated population growth rates were significantly greater for O. triseriatus reared on animal-based versus plant-based detritus. 4. We hypothesise two mechanisms for the pronounced effect of invertebrate carcasses on mosquito performance relative to that associated with leaf detritus: (i) invertebrate carcasses decompose more quickly and release nutrients more effectively into the aquatic environment; or (ii) O. triseriatus larvae may directly ingest nutrient-rich components of invertebrate carcasses. Because even relatively small animal detritus additions can have strong effects on O. triseriatus populations, studies need to be conducted to explore the overall role of animal detritus in tree holes in nature. [ABSTRACT FROM AUTHOR]
- Published
- 2006
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17. Age-related differences in urinary 11-dehydroxythromboxane B2 between infants, children, and adolescents: Another example of developmental hemostasis?
- Author
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Varnell, Charles D., Goldstein, Stuart L., Yee, Donald L., Teruya, Jun, Guyer, Kirk E., Siddiqui, Shakeel, and Jefferies, John L.
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- 2014
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18. In vivo substitution of zinc by cobalt in carbonic anhydrase of a marine diatom.
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Yee, Donald and Morel, François M. M.
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- 1996
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19. Ornithine transcarbamylase deficiency: A possible risk factor for thrombosis.
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Venkateswaran, Lakshmi, Scaglia, Fernando, McLin, Valerie, Hertel, Paula, Shchelochkov, Oleg A., Karpen, Saul, Mahoney, Donald, and Yee, Donald L.
- Published
- 2009
- Full Text
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20. Acquired von Willebrand syndrome and Wilms tumor: Not always benign.
- Author
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Baxter, Patricia A., Nuchtern, Jed G., Guillerman, Robert P., Mahoney, Donald H., Teruya, Jun, Chintagumpala, Murali, and Yee, Donald L.
- Published
- 2009
- Full Text
- View/download PDF
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