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To unlock the full potential of PSCs, machine learning (ML) was implemented in this research to predict the optimal combination of mesoporous‐titanium dioxide (mp‐TiO2) and weight percentage (wt%) of phenyl‐C61‐butyric acid methyl ester (PCBM), along with the current density (Jsc), open‐circuit voltage (Voc), fill factor (ff), and energy conversion efficiency (ECE). Then, the combination that yielded the highest predicted ECE was selected as a reference to fabricate PCBM‐PSCs with nanopatterned TiO2 layer. Subsequently, the PCBM‐PSCs with nanopatterned TiO2 layers were fabricated and characterized to further understand the effects of nanopatterning depth and wt% of PCBM on PSCs. Experimentally, the highest ECE of 17.338% is achieved at 127 nm nanopatterning depth and 0.10 wt% of PCBM, where the Jsc, Voc, and ff are 22.877 mA cm−2, 0.963 V, and 0.787, respectively. The measured Jsc, Voc, ff, and ECE values show consistencies with the ML prediction. Hence, these findings not only revealed the potential of ML to be used as a preliminary investigation to navigate the research of PSCs but also highlighted that nanopatterning depth has a significant impact on Jsc, and the incorporation of PCBM on perovskite layer influenced the Voc and ff, which further boosted the performance of PSCs. [ABSTRACT FROM AUTHOR]

Producing defect‐free products is one of the essential tasks of a manufacturing company. In this paper, the causes of dead pixels are analyzed and the coordinates of dead pixels are predicted using machine learning to solve problems of dead pixels. Unlike the existing method of analyzing defects using images, tabular data where each element contains significance were used, and detailed description of suggested models are depicted. Experiments ensured the consistency of the proposed method. [ABSTRACT FROM AUTHOR]

We introduce inverse design strategy utilizing machine learning (ML) models to discover efficient blue thermally activated delayed fluorescence (TADF) organic emitter materials. Here, we leverage graph neural network (GNN) to predict the characteristic intrinsic materials properties of TADF such as excited state energy levels and their transition properties. The GNN model is trained based on density‐functional theory (DFT) calculation results to meet the TADF properties. We discuss consistency between experimental observation and ML predictions, and examined conditions for improving the accuracy of DFT calculations and ML models on top of it. [ABSTRACT FROM AUTHOR]

1.3″ 4K full‐color OLED microdisplay, which is able to realize peak brightness more than 10,000 nits together with appropriate operational lifetime of OLED devices, is introduced by addressing key technologies and challenges to develop advanced OLED microdisplay panels expecting application to the high‐quality AR/VR/MR head‐mounted displays [ABSTRACT FROM AUTHOR]

This work introduces LG Display's (LGD's) 1.3″ 4K full‐color organic light‐emitting diode (OLED) microdisplay panels with a peak brightness of more than 10,000 nits, which have been newly developed for high‐quality virtual reality/mixed reality (VR/MR) head‐mounted displays. To achieve these advanced high‐luminance OLED microdisplay panels, we have developed a well‐controlled optical microcavity and outcoupling method, along with optimized multi‐stack white OLED devices and CF‐on‐encapsulation technologies tailored to the high pixel density of the panels. [ABSTRACT FROM AUTHOR]

We examined cultural specificity in how adolescents' coping strategies in response to peer victimization are associated with adjustment with a sample of 7th–8th graders from the United States (n = 292, 60% female, Mage = 13.6, SD = 0.65) and South Korea (n = 462, 50.2% female, Mage = 13.7, SD = 0.58). Participants read scenarios describing victimization and rated the likelihood of utilizing different coping strategies. US adolescents rated conflict resolution, cognitive distancing, and revenge higher than Korean adolescents, while Korean adolescents endorsed social support seeking more than US adolescents. Social support seeking was positively associated with global self‐worth in both countries; however, social support seeking was negatively related to depression and social anxiety only for Korean youth. [ABSTRACT FROM AUTHOR]

A new reactive force field based on quantum mechanical data for describing formation of the Zn electrode‐electrolyte interface (EEI) chemistry in aqueous zinc‐ion batteries (ZIBs) is developed. This is the first demonstration in which Reactive Molecular Dynamics (RMD) simulation is used to follow the Zn reduction and anode structural evolution at the EEI. It is found that under axial pressure, Zn dendrite formation is inhibited. This is associated with accelerated ion transport and reduction while increasing preference towards horizontal (002) plane growth. Pressure‐induced desolvation of Zn ions within the electric double layer, which promotes faster reduction kinetics is observed. It is found that axial pressure stabilizes adatoms on the (002) plane by decreasing axial atom stress during nucleation and by increasing favorable lateral adatom diffusion, which reduces atomic scale dendrite formation. Finally, these are confirmed results by experimental characterization and electrochemical tests. [ABSTRACT FROM AUTHOR]

We report a highly stretchable display panel capable of enduring extreme deformations including large curvature folding, fully folded deformation and stretching without any damage. We examined both uniaxial and multi‐axial stretching with the panel, and presented a method to calculate its stretchability. Our display panel exhibited areal stretchability of up to 45% strain and remained reliably functional through 10,000 repeated stretching cycles at 20% uniaxial tensile strain. By demonstrating the ability to withstand extreme deformations while maintaining structural integrity, this platform showed strong potential for use in a variety of stretchable displays. [ABSTRACT FROM AUTHOR]

Bersiporocin, a potent and selective prolyl‐tRNA synthetase inhibitor, is expected to show a synergistic effect with pirfenidone or nintedanib in patients with idiopathic pulmonary fibrosis. To validate the combination therapy of bersiporocin with pirfenidone or nintedanib, a randomized, open‐label, two‐part, one‐sequence, three‐period, three‐treatment study was designed to evaluate the effect of drug–drug interactions (DDI) regarding their pharmacokinetics, safety, and tolerability in healthy participants. In addition, the pharmacokinetic profiles of the newly formulated, enteric‐coated bersiporocin tablet were evaluated after single and multiple administrations. The potential effects of cytochrome P450 2D6 (CYP2D6) genotyping on bersiporocin pharmacokinetics and DDI were also explored. In Part 1, participants were sequentially administered a single dose of pirfenidone 600 mg, a single dose of bersiporocin 150 mg followed by multiple doses, and bersiporocin in combination with pirfenidone. In Part 2, participants were sequentially administered a single dose of nintedanib 150 mg, multiple doses of bersiporocin 150 mg, and bersiporocin in combination with nintedanib. Forty‐six participants completed the study. There was no significant pharmacokinetic DDI between bersiporocin, and pirfenidone or nintedanib. All adverse events (AEs) were mild to moderate and did not include serious AEs, suggesting bersiporocin alone or in combination therapy were well‐tolerated. The newly formulated bersiporocin 150 mg tablet showed a moderate accumulation index. There was no significant difference in the pharmacokinetic profiles after administration of bersiporocin alone or in combination therapy between CYP2D6 phenotypes. In conclusion, there are no significant DDI regarding the pharmacokinetics, safety, and tolerability of bersiporocin administration with pirfenidone or nintedanib. [ABSTRACT FROM AUTHOR]

Indium (In) in the p‐block of the periodic table has demonstrated a high Faradaic efficiency (FE) for formate production in electrochemical CO2 reduction reaction (EC CO2 RR). Therefore, In‐based alloys have been extensively employed to improve performance. However, the effects of alterations in surface elemental composition and interfacial electronic structure have not been investigated in detail. In this study, we introduced In and In‐based alloys (InGaAg, InSn, and InSnBi) electrodes for EC CO2 RR. The experimental conditions employed in the demonstrated tests encompass various factors, such as applied potentials, electrolytes and their concentrations, as well as the effects of light, including UV and infrared light radiation. Nuclear magnetic resonance spectroscopy confirmed formate production with high FE (97.7 %) and selectivity (98.5 %). Minor amounts of CO, CH4, and H2 were also detected by gas chromatography. Depth‐profiling X‐ray photoelectron spectroscopy was used to examine the effects of alloying, potential‐induced exposed surface elemental compositions, and interfacial electronic structures. The study found that the elemental distribution was substantially altered after EC CO2 RR. These unique results provide valuable information for the improvement and theoretical modeling of In‐based alloy electrocatalysts for CO2 recycling. [ABSTRACT FROM AUTHOR]

In this research, we describe a facile design of white organic light emitting diode (WOLED) displays applicable to 8K4K resolution of large‐area displays. We demonstrated a 13.3‐inch diagonal size (166 pixel‐per‐inch) of WOLED display, including a self‐aligned oxide thin‐film transistors, simple pixel driving circuit, external compensation method, fast driving integrated gate driver circuit. The narrow bezel of 3.9 mm is realized when multi‐output gate driver circuit is applied. The required function for external compensation method is realized by the integrated gate driver circuit. The external compensation improved global luminance uniformity, especially at the low gray level. [ABSTRACT FROM AUTHOR]

The display panel design consists of active area, data pad, gate pad, cell, and glass part. The design sequentially follows the process of plan, optimization, and drawing. We've developed a panel design automation platform to automatically complete all the process with AI‐based design optimization and drawing on the basis of standard panel design. [ABSTRACT FROM AUTHOR]

Various studies have been conducted to automatically inspect defective products. Those technologies already can detect defective pixels better than humans and have been improved enough to detect Mura defect, which is rarely detected by the auto detecting systems. It is as important to determine the cause of the defect as to detect it. However, efforts to automatically identify the cause of the defect have yet to show significant results. In this study, a method to determine the cause of defect with machine learning is introduced. [ABSTRACT FROM AUTHOR]

We have developed 12‐inch 100 PPI active‐matrix micro‐LED stretchable displays that can be stretched up to 20%. Our work has involved the development of key technologies such as stretchable interconnect, stretchable film, micro‐LED, and the integration process for these components. The stretchable displays exhibited various types of deformations, suggesting the potential for new applications in information display. [ABSTRACT FROM AUTHOR]

The solid electrolyte interphase (SEI) forms on electrode surfaces from decomposition of the electrolyte. However, there is almost no atomistic detail of SEI formation on Li metal anode, a major obstacle in understanding the highly complex battery electrochemistry sufficiently to design high performance batteries. Herein, a realistic atomistic model (39 000 atoms) for the SEI formation at the interface between the Li metal anode and ionic liquid electrolyte using reactive molecular dynamics simulations is provided. A ≈10 nm thick SEI composed of a dense ordered inorganic layer near the Li‐metal anode and a porous organic layer near the electrolyte is found. These results provide new insights into a deeper understanding of the complex SEI that should be useful in developing a new generation of highly efficient batteries. [ABSTRACT FROM AUTHOR]

Demand for increased scalability of oxide thin‐film transistors (TFTs) continues to rise, along with the need for ever‐higher integration densities and driving currents. However, the undesirable channel length (LCH)‐dependency renders short channels difficult. To overcome such behavior in back‐channel etched devices, back‐channel interface engineering using commercially favorable silicon oxide (SiOx) and the effects thereof on the electrical characteristics of fully integrated TFTs are investigated. Process‐dependent investigation reveals that a sequential formation of double‐layered SiOx with a defect control layer (DCL) effectively alleviates back‐channel damage. The proposed method imparts advanced functionality to conventional materials of SiOx. The DCL promotes oxygen inter‐diffusion to the oxygen‐deficient back‐channel, suppresses excess hydrogen inflow, and boosts out‐diffusion of residual copper from the back‐channel. This afforded excellent device uniformity and electrical characteristics with the proposed device, including field effect mobility of ≈14.0 ± 1.0 cm2 V−1 s−1, threshold voltage (Vth) of ≈1.22 ± 0.39 V, and subthreshold gate swing of ≈0.46 ± 0.09 V dec−1 at W/L = 4/7 µm. Furthermore, Vth variation when LCH decreased from 20 to 4 µm is dramatically suppressed from >11.39 V with the pristine device to 0.78 V with the proposed device, because of controlled back‐channel properties providing sufficient effective LCH. [ABSTRACT FROM AUTHOR]

In this paper, we have developed Z‐type Multi‐Foldable AMOLED (ZMFA) for high durability and foldability. These properties are achieved by optimized Neutral plane of module stack. We also optimized module stack and layer materials for durability. In this paper, We will show panel characteristic of 8.97inch multi‐foldable (Z type) displays which 200k in & out folding cycles with inner folding 1.5R and Outer folding 4.0R Also, dent 6H@300gf and pen tracing (1.4 km@ 200gf) [ABSTRACT FROM AUTHOR]

In this paper, we report a 13‐inch active matrix (AM) micro‐LED stretchable display, which can be stretched by up to 20% with a 72 ppi resolution. It features a unique panel de sign, including stretchable interconnects fabricated via the conventional LTPS backplane process and micro‐LED for a light emitting device. This paper will discuss methods for realizing a stretchable panel and practical problems in stretchable display engineering. [ABSTRACT FROM AUTHOR]

We report technical approaches for enhancing brightness of OLED microdisplays based on Si backplanes (OLEDoS) by changing in white OLED device architectures and incorporating the microcavity technology. In addition, effective strategies for further increasing the performances of the OLEDoS panels are suggested. [ABSTRACT FROM AUTHOR]

Grain boundaries, ubiquitous in real materials, play an important role in the mechanical properties of ceramics. Using boron carbide as a typical superhard but brittle material under hypervelocity impact, we report atomistic reactive molecular dynamics simulations using the ReaxFF reactive force field fitted to quantum mechanics to examine grain‐boundary engineering strategies aimed at improving the mechanical properties. In particular, we examine the dynamical mechanical response of two grain‐boundary models with or without doped Si as a function of finite shear deformation. Our simulations show that doping Si into the grain boundary significantly increases the shear strength and stress threshold for amorphization and failure for both grain‐boundary structures. These results provide validation of our suggestions that Si doping provides a promising approach to mitigate amorphous band formation and failure in superhard boron carbide. [ABSTRACT FROM AUTHOR]

Ionic liquids (ILs) are promising electrolytes for high‐performance Li‐ion batteries (LIBs), which can significantly improve the safety and energy storage capacity. Although extensive experimental and computational studies have reported, further exploration is needed to understand the properties of IL systems, their microscopic structures and dynamics, and the behavior of Li ions in ILs. We report here results of molecular dynamics simulations as a function of electric field for Li diffusion in two IL systems, [EMIM][TFSI] and [BMIM][TFSI] doped with various concentrations of LiTFSI. We find that the migration of each individual Li ion depends largely on its micro‐environment, leading to differences by factors of up to 100 in the diffusivity. The structural and dynamical properties indicate that Li diffusion is affected significantly by the coordination and interaction with the oxygen species in the TFSI anions. Moreover, the IL cations also contribute to the Li diffusion mechanism by attenuating the Li–TFSI interaction. [ABSTRACT FROM AUTHOR]

An imbalance of osteoclasts and osteoblasts can result in a variety of bone‐related diseases, including osteoporosis. Thus, decreasing the activity of osteoclastic bone resorption is the main therapeutic method for treating osteoporosis. 2E‐Decene‐4, 6‐diyn‐1‐ol‐acetate (DDA) is a natural bioactive compound with anti‐inflammatory and anti‐cancer properties. However, its effects on osteoclastogenesis are unknown. Murine bone marrow‐derived macrophages (BMMs) or RAW264.7 cells were treated with DDA, followed by evaluation of cell viability, RANKL‐induced osteoclast differentiation, and pit formation assay. Effects of DDA on RANKL‐induced phosphorylation of MAPKs were assayed by western blot analysis. Expression of osteoclast‐specific genes was examined with reverse transcription‐PCR (RT‐PCR) and western blot analysis. In this study, DDA significantly inhibited RANKL‐induced osteoclast differentiation in RAW264.7 cells as well as in BMMs without cytotoxicity. DDA also strongly blocked the resorbing capacity of BMM on calcium phosphate‐coated plates. DDA inhibited RANKL‐induced phosphorylation of ERK, JNK and p38 MAPKs, as well as expression of c‐Fos and NFATc1, which are essential transcription factors for osteoclastogenesis. In addition, DDA decreased expression levels of osteoclastogenesis‐specific genes, including matrix metalloproteinase‐9 (MMP‐9), tartrate‐resistant acid phosphatase (TRAP), and receptor activator of NF‐κB (RANK) in RANKL‐induced RAW264.7 cells. Collectively, these findings indicated that DDA attenuates RANKL‐induced osteoclast formation by suppressing the MAPKs‐c‐Fos‐NFATc1 signalling pathway and osteoclast‐specific genes. These results indicate that DDA may be a potential candidate for bone diseases associated with abnormal osteoclast formation and function. [ABSTRACT FROM AUTHOR]

The control of bacterial pathogens, including Edwardsiella piscicida, in the aquaculture industry has high economic importance. This study aimed to identify a potential live vaccine candidate against E. piscicida infection to minimize the side effects and elicit immunity in the host. This study evaluated the virulence factors of E. piscicida CK108, with a special focus on the flagella. E. piscicida has two important homologous flagellin genes, namely flagellin‐associated protein (fap) and flagellin domain‐containing protein (fdp). CK226 (Δfap), CK247 (Δfdp) and CK248 (Δfap, fdp) mutant strains were constructed. Both CK226 and CK247 displayed decreased length and thickness of flagellar filaments, resulting in reduced bacterial swimming motility, while CK248 was non‐motile as it lacked flagella. The loss of flagella and decreased motility was expected to decrease the pathogenicity of CK248. However, the median lethal dose (LD50) of CK248 against zebrafish was lower than those of the wild‐type, CK226 and CK247 strains. The protective immunity and cytokine gene expression levels in the CK248‐infected zebrafish were lower than those in the wild type‐infected zebrafish. In conclusion, Fap and Fdp are essential for flagella formation and motility, and for stimulating fish immune response, which can be utilized as a potential adjuvants for E. piscicida vaccination. [ABSTRACT FROM AUTHOR]

Objectives: Many interventions have been attempted to improve adenoma detection rate (ADR) and sessile serrated lesion detection rate (SDR), and one of these interventions is educational training to recognize polyp characteristics. This study aimed to investigate the change in polyp detection rates of endoscopists before and after comprehensive training through the Gangnam‐Real Time Optical Diagnosis (Gangnam‐READI) program. Methods: Fifteen gastroenterologists participated in a 1‐year comprehensive training program that consisted of ex vivo and in vivo training that encompasses knowledge and skills in endoscopic characterization of colonic polyps using the Workgroup serrAted polypS and Polyposis (WASP) classification. We evaluated the impact of the training program by comparing the overall and individual ADR and SDR 6 months before and after the training. Results: Overall, 18,280 polyps (9337 adenomas and 855 sessile serrated lesion) were collected. The optical diagnosis training had no significant impact on the difference in ADR after training compared to before training (47.7% vs. 46.5%, P = 0.608). A tendency for a decrease in ADR variance was noted among the endoscopists after training (74.9 vs. 32.7, P = 0.121). The overall pre‐training period SDR was 4.5% and showed a statistically significant increase to 5.6%, 8.0%, and 7.1% in the first and second half of the training period, and post‐training period, respectively (P = 0.003). The optical diagnosis training did not decrease variance in SDR (8.9 vs. 8.8, P = 0.985). Conclusion: Comprehensive optical diagnosis training with WASP classification has a significant impact on increasing the overall SDR of expert endoscopists. [ABSTRACT FROM AUTHOR]

Background and Aim: While many studies demonstrated an association between visceral adiposity and colorectal adenoma (CRA), the effect of longitudinal changes in body fat composition on CRA is unclear. We investigated the longitudinal association between changes in visceral adiposity and CRA occurrence. Methods: Between 2006 and 2018, 732 (62.8%) of the 1165 subjects in a prospective cohort voluntarily underwent follow‐up abdominal fat computed tomography and colonoscopy. We defined incident and recurrent CRA as adenoma detected at follow‐up colonoscopy from negative and positive adenoma at baseline colonoscopy, respectively. Multilevel survival analysis examined the longitudinal association between changes in visceral fat and CRA. Results: During a median follow‐up of 7.4 years, 400 (54.6%) subjects developed CRA. In multivariable analysis, increasing changes in visceral adipose tissue (VAT) area were associated with higher risk of incident adenoma (hazard ratio [HR] 1.21, 95% confidence interval [CI] 1.00–1.46 for change per 10 cm2 increase; HR 1.79, 95% CI 1.08–2.97 for highest vs lowest quartile, P values for trend = 0.045). Likewise, increasing changes in VAT area were independently associated with a higher risk of recurrent adenoma (HR 1.35, 95% CI 1.13–1.62 for change per 10 cm2 increase; HR 1.62, 95% CI 1.04–2.52 for highest vs lowest quartile, P values for trend = 0.001). Changes in subcutaneous adipose tissue area were not independently associated with CRA. Conclusion: Increasing changes in VAT area were longitudinally associated with a higher risk of incident and recurrent CRA, independent of risk factors, suggesting that visceral adiposity may be an important target in CRA prevention. [ABSTRACT FROM AUTHOR]

Metabolic fitness of T cells is crucial for immune responses against infections and tumorigenesis. Both the T cell receptor (TCR) signal and environmental cues contribute to the induction of T cell metabolic reprogramming, but the underlying mechanism is incompletely understood. Here, we identified the E3 ubiquitin ligase Peli1 as an important regulator of T cell metabolism and antitumor immunity. Peli1 ablation profoundly promotes tumor rejection, associated with increased tumor‐infiltrating CD4 and CD8 T cells. The Peli1‐deficient T cells display markedly stronger metabolic activities, particularly glycolysis, than wild‐type T cells. Peli1 controls the activation of a metabolic kinase, mTORC1, stimulated by both the TCR signal and growth factors, and this function of Peli1 is mediated through regulation of the mTORC1‐inhibitory proteins, TSC1 and TSC2. Peli1 mediates non‐degradative ubiquitination of TSC1, thereby promoting TSC1‐TSC2 dimerization and TSC2 stabilization. These results establish Peli1 as a novel regulator of mTORC1 and downstream mTORC1‐mediated actions on T cell metabolism and antitumor immunity. Synopsis: The mTORC1 signaling pathway mediates metabolic reprograming and effector function of activated T cells, which is important for antitumor immunity. TSC1 ubiquitination by E3 ubiquitin ligase Peli1 negatively regulates mTORC1 activation and controls glycolytic metabolism and antitumor effector function of T cells. Peli1 negatively regulates activation of the metabolic kinase mTORC1.Peli1 mediates K63 ubiquitination of mTORC1‐inhibitory protein TSC1 and promotes TSC1/TSC2 complex stability.Peli1 deletion promotes the metabolic activities of T cells.Peli1 deficiency in mice promotes antitumor immunity. [ABSTRACT FROM AUTHOR]

Background and Aim: In East Asia, colonic diverticulosis develops most commonly in the right colon and is known to have different characteristics compared with left‐sided one. This study was designed to investigate whether right‐colonic diverticulosis is associated with posteriori dietary patterns. Methods: We retrospectively reviewed medical records of prospectively collected cohort that received health check‐up in Korea between May 2011 and January 2012. Their anthropometric data, biochemical results, medication history, underlying diseases, colonoscopic findings, and dietary data obtained from semi‐quantitative food‐frequency questionnaire were analyzed. Three dietary patterns were identified using factor analysis: healthy dietary pattern (vegetables, fish, seaweed, fruits, and beans), meat dietary pattern (red meat, processed meat/fish, fried noodle, poultry, and cephalopods), and snack dietary pattern (bread, sweets, dairy products, nuts, and rice cake). Results: Out of the total 1911 patients, 203 (10.6%) had right‐colonic diverticulosis, 21 (1.1%) had pan‐colonic diverticulosis, and 12 (0.6%) had left‐colonic diverticulosis. Among the total, none of the three patterns were associated with right‐colonic diverticulosis, under adjustment with age, gender, body mass index, metabolic syndrome, and total energy intake. However, among women, meat dietary pattern was positively associated with right‐colonic diverticulosis (odds ratio 1.866, 95% confidence interval: 1.0983–3.173, P = 0.021). Conclusion: This study demonstrated that meat dietary pattern is positively associated with right‐colonic diverticulosis among women. [ABSTRACT FROM AUTHOR]

Snapdragon (Antirrhinum majus L.) flowers are one of the most frequently used edible flowers in different preparations of foods and drinks. In this study, we examined inhibitory effects of snapdragon flower extract (SFE) against distinctive properties of cancer cells, stimulated growth, and activated metastasis, using H1299 lung cancer and HCT116 colon cancer cell lines. SFE treatment at 100–1,000 μg/ml for 24–72 hr resulted in a time‐ and dose‐dependent growth inhibition in H1299 and HCT116 cells. Cell cycle analysis and Annexin V staining assay further revealed that SFE caused cell cycle arrest at G2/M phase and induction of apoptosis, indicating the growth inhibition by SFE is attributed to its G2/M cell cycle‐arresting and apoptosis‐inducing activities. SFE dose‐dependently enhanced generation of intracellular reactive oxygen species (ROS) and reduced mitochondrial membrane potential in H1299 cells but had no effect on intracellular ROS levels in HCT116 cells, suggesting that the type of apoptosis induced by SFE in H1299 cells is different to that in HCT116 cells. Furthermore, SFE alleviated invasion, levels of matrix metalloproteinases, migration, and adhesion in H1299 and HCT116 cells. These results indicate that SFE not only inhibits cell growth by cell cycle arrest at G2/M and apoptosis induction but also alleviates metastatic properties such as invasion, migration, and adhesion in lung and colon cancer cells. [ABSTRACT FROM AUTHOR]

Background: Aplasia cutis congenita (ACC) is a rare congenital malformation characterized by a localized absence of skin. which most commonly affects the scalp. We performed the present study to elucidate the basic clinical data regarding ACC in Korea, including demographics, clinical features, radiological and therapeutic results. Methods: Fifty‐nine patients (70 lesions) with ACC (35 from our department and 24 from a Koreamed database search) were enrolled. We assessed demographics, family and obstetrical histories, clinical features (multiplicity, subtype, size, shape, hair collar sign, location, and Frieden's classification), and radiologic and therapeutic results. Results: The mean age of patients was 2.62 years, with a male‐to‐female ratio of 1.03. A minority of patients had a family history (three patients), birth trauma (one patient), maternal drug use (two patients), or human immunodeficiency virus infection (one patient) during pregnancy, and fetus papyraceus of placental infarcts (two patients). Six patients (6/59, 10.17%) had multiple lesions. Scarring was the most common manifestation (39/70, 55.71%). The scalp was the most commonly affected site (50 cases, 71.43%). Thirty‐nine patients (66.10%) met Frieden's type I classification (scalp ACC without multiple anomalies). Radiological investigations were performed in 30 patients (30/59, 50.85%) with abnormal findings in eight patients. Twenty‐five patients (42.37%) were managed conservatively, and 17 patients (28.81%) were treated with local wound care. Conclusions: This is the first and largest study assessing the basic clinical data of ACC in Korea. The results of the present study could be useful for pediatricians and dermatologists who routinely manage ACC. [ABSTRACT FROM AUTHOR]

Korea has the second highest incidence of colorectal cancer in the world. Instruments that are culturally and contextually sensitive, as well as valid and reliable, for determining health beliefs regarding colorectal cancer screening are essential for obtaining accurate information. The purpose of this study was to adapt and validate the health belief model scale for Koreans regarding colorectal cancer and fecal occult blood test utilization. Individual and cognitive interviews (also known as cognitive debriefing) with 33 Koreans, expert reviews with seven nursing practitioners and professors, and a pilot test with 18 Koreans were conducted to make the existing health belief model scale culturally and contextually sensitive. Subsequently, a cross‐sectional survey with 728 Koreans aged >50 years was conducted. Exploratory and confirmatory factor analyses of the construct validity and internal consistency reliability supported the adapted health belief model scale. The adapted and validated health belief model scale in this study could contribute to the assessment of health beliefs regarding the fecal occult blood test among Koreans with a greater degree of accuracy with respect to Korean culture and context. [ABSTRACT FROM AUTHOR]

Background: Scarce data are available on the characteristics of postoperative organ failure (POF) and mortality after gastrectomy. We aimed to describe the causes of organ failure and mortality related to gastrectomy for gastric cancer and to identify patients with POF who are at a risk of failure to rescue (FTR). Methods: The study examined patients with POF or in-hospital mortality in Seoul National University Hospital between 2005 and 2014. We identified patients at a high risk of FTR by analyzing laboratory findings, complication data, intensive care unit records, and risk scoring including Acute Physiology and Chronic Health Evaluation (APACHE) IV, Sequential Organ Failure Assessment (SOFA) score, and Simplified Acute Physiology Score (SAPS) 3 at ICU admission. Results: Among the 7304 patients who underwent gastrectomy, 80 (1.1%) were identified with Clavien–Dindo classification (CDC) grade ≥ IVa. The numbers of patients with CDC grade IVa, IVb, and V were 48 (0.66%), 11 (0.15%), and 21 (0.29%), respectively. Pulmonary failure (43.8%), surgical site complication (27.5%), and cardiac failure (13.8%) were the most common causes of POF and mortality. Cancer progression (100%) and cardiac events (45.5%) showed high FTR rates. In univariate analysis, acidosis, hypoalbuminemia, SOFA, APACHE IV, and SAPS 3 were identified as risk factors for FTR (P < 0.05). Finally, SAPS 3 was identified as an independent predictive factor for FTR. Conclusions: Cancer progression and acute cardiac failure were the most lethal causes of FTR. SAPS 3 is an independent predictor of FTR among POF patients after gastrectomy. [ABSTRACT FROM AUTHOR]

Segmental nevus depigmentosus and segmental vitiligo can be difficult to differentiate from each other. Differential diagnosis of these two diseases is important because they have significantly different prognoses and psychological effects. The purpose of this study is to identify clinical clues that may be helpful in differentiating these two diseases. We enrolled 63 patients with segmental nevus depigmentosus and 149 patients with segmental vitiligo. Sex, age of onset, sites involved, dermatomal distribution, margin of lesion and presence of poliosis were evaluated in both groups. The age of onset was less than 10 years in 96.8% of segmental nevus depigmentosus and 28.9% of segmental vitiligo cases. Trunk (36.5%) and cervical (38.1%) dermatomes were the most commonly involved in segmental nevus depigmentosus and face (67.1%) and trigeminal (64.4%) dermatomes in segmental vitiligo. The average number of dermatomes involved in truncal lesions was different in segmental nevus depigmentosus and segmental vitiligo (2.71 vs 1.62, P = 0.001). Segmental vitiligo on the face, neck and trunk appeared closer to the axis than segmental nevus depigmentosus (P < 0.001). Segmental nevus depigmentosus and segmental vitiligo showed significantly different margins (90.5% and 41.6% serrated, respectively; P < 0.001). We observed clinical differences between patients with segmental nevus depigmentosus and those with segmental vitiligo. Distribution (site, distance to axis, dermatome), vertical width, margin of lesion and presence of poliosis can be helpful in differentiating segmental nevus depigmentosus and segmental vitiligo. [ABSTRACT FROM AUTHOR]

Introduction: Apples are the most consumed fruits in Korea and have played an economically important role in Korean agriculture. However, widespread viroid infection in apples had been reported in recent years. Objectives: The objective of this study was to clarify the relationships between viroid‐disease resistance and phenols content of three apple cultivars: "Fuji", "Gamhong", and "Hongro". A model for distinguishing between viroid‐free and viroid‐infected apples was also developed. Methodology: Phenolic compounds in samples were detected using high‐performance liquid chromatography photodiode array tandem mass spectrometry (HPLC‐PDA‐MS/MS) and quantified using an ultraviolet detector at 280 nm. A C18‐column and 0.5% aqueous acetic acid–methanol were used as the stationary and mobile phase. The HPLC method was validated with respect to linearity, precision, accuracy, and recovery. Multivariate analysis was performed using phenols content as variables to classify viroid‐free and viroid‐infected apples. Results: An accurate method for identifying and quantifying phenol compounds in apple samples was developed and validated. In response to viroid infection, considerable increases in the content of dihydrochalcones (in all three cultivars), hydroxycinnamic acid (in "Fuji"), and flavonols (in "Hongro") were observed. The flavonols content in "Fuji" viroid‐infected samples, however, decreased dramatically. An effective linear discriminant model, with 98.2% accuracy and 94.6% predictive ability, was achieved to discriminate between viroid‐free and viroid‐infected samples. Conclusion: The developed HPLC method is suitable to identify and quantify phenol compounds in viroid‐free and viroid‐infected apples. A hypothesis about the significance of these compounds in viroid‐disease resistance was proposed. The linear discriminant model with high predictive ability is useful for identifying viroid‐infected apples in the orchards. The effects of viroid infection on the content of phenolic compounds in apple peel were studied using HPLC. In response to disease infection, considerable increases in the content of dihydrochalcones (in all three cultivars), hydroxycinnamic acid (in "Fuji"), and flavonols (in "Hongro") were observed. The flavonols content in "Fuji" viroid‐infected samples, however, decreased dramatically. A linear discriminant model using quantitation results was proposed for identifying viroid‐infected apples in the orchards. [ABSTRACT FROM AUTHOR]

The present study aimed to assess the clinical impact of BCR‐ABL1 transcript levels determined at an earlier time point than the 3‐month early molecular response (EMR) in chronic‐phase chronic myeloid leukemia (CML‐CP) patients. BCR‐ABL1 transcript levels of CML‐CP patients (n = 258; median age, 43 [range, 18‐81] years) treated with various tyrosine kinase inhibitors (TKIs) were determined at 4 weeks (28 ± 3 days) and at every 3 months of treatment initiation. At 4 weeks, receiver operating characteristic curves revealed that cutoff values of BCR‐ABL1 transcripts for achieving major molecular responses (MMRs) by 12 and 60 months were 40.89% and 39.16%, respectively (95% CI, 0.658‐0.772 and 95% CI, 0.643‐0.758; P < 0.0001). With 40% of BCR‐ABL1 transcripts at 4 weeks (very early MR; VEMR), patients with VEMR achieved higher 3‐month EMR and 4‐week VEMR significantly associated with higher cumulative incidences of 5‐year MMR (89.1% vs 72.3%; P < 0.001) and 5‐year deep molecular response (DMR) (56.5% vs 29.4%; P = 0.001). Furthermore, event‐free survival (EFS)‐a (93.0% vs 84.8%; P = 0.068) and EFS‐b (71.1% vs 57.9%; P = 0.061) by 5 years were also marginally significant. VEMR and 3‐month EMR were achieved in 89 patients, with significantly superior outcomes. In multivariate analyses, lower leukocyte count (P = 0.008) and frontline second‐generation TKI therapy size (P < 0.001) were significantly associated with VEMR achievement, but not baseline BCR‐ABL1 level and CML duration. In conclusion, the 4‐week BCR‐ABL1 transcript levels including VEMR could be important to predict long‐term outcomes and may provide additional information about innate intrinsic sensitivity to CML among individuals. The very early molecular response assessment could be important to predict long‐term outcomes and may provide additional information about innate intrinsic sensitivity to individual CML clone. As it also allows for the prediction of DMR, VEMR can be used as one of the important tools to select candidates for treatment‐free remission. [ABSTRACT FROM AUTHOR]

Abstract: Large flexible organic light‐emitting diode (OLED) display provides various electronic applications such as curved, bendable, rollable, and commercial display, because of its thinness, light weight, and design freedom. In this work, the process flow and key technologies to fabricate the world's first large size 77‐inch transparent flexible OLED display are introduced. “White OLED on TFT + color filter” method is used to fabricate the aforementioned display. On both thin‐film transistor and color filter substrates, transparent polyimide (PI) was used as plastic substrate with multi‐barrier. In case of a transparent flexible display, the multi‐barrier is required for the additional consideration to overcome the decrease of transmittance due to the difference in refractive index of the conventional multi‐barrier. We developed the special multi‐barrier to increase transparency with superior water vapor transition rate characteristic. The optimized amorphous indium gallium zinc oxide thin‐film transistors were employed on the multi‐barrier, and it shows the highly uniform electrical performance and reliability on plastic substrate. Also, the typical panel failure mechanism during laser lift‐off process caused by a particle in PI is studied, and a sacrificial layer was suggested between PI and a carrier glass to reduce the panel failure. Finally, we successfully realized the world's first 77‐inch transparent flexible OLED display with ultra‐high‐definition resolution, which can be rolled up to a radius of 80 mm with a transmittance of 40%. [ABSTRACT FROM AUTHOR]

Abstract: We developed and fabricated the world's highest resolution (18 megapixel, 1443 ppi) OLED on glass display panel. The design uses a white OLED with color filter structure for high density pixelization and an n‐type LTPS backplane for faster response time than mobile phone displays. A custom high bandwidth driver IC was fabricated. We developed a foveated pixel pipeline appropriate for virtual reality and augmented reality applications, especially mobile systems. [ABSTRACT FROM AUTHOR]

We developed and fabricated the world's highest resolution (18 megapixel, 1443 ppi) OLED on glass display panel. The design uses a white OLED with color filter structure for high density pixelization and an n‐type LTPS backplane for faster response time than mobile phone displays. A custom high bandwidth driver IC was fabricated. We developed a foveated pixel pipeline appropriate for VR and AR applications, especially mobile systems. [ABSTRACT FROM AUTHOR]

We successfully realized world first 77‐inch transparent flexible OLED display with Ultra High Definition (UHD) resolution, which can be rolled up to a radius of 80 mm with a transmittance of 40%. The process flow and key technologies to fabricate a large size transparent flexible OLED panel will be discussed. [ABSTRACT FROM AUTHOR]

Summary: Chicken bones are mostly discarded even though they contain a considerable amount of proteins, which would allow them to be applicable as a protein film source. In this study, chicken bone gelatine (CBG) films were prepared and characterised after the addition of cinnamon bark oil (CBO) to confer antimicrobial activity. The incorporation of 1% CBO increased the tensile strength of the CBG film from 18.2 to 23.9 MPa, whereas elongation at break was decreased from 15.6% to 5.91% and water solubility from 88.9% to 62.2%. Antimicrobial activity of the CBG films against foodborne pathogens as well as their antioxidant activity increased with the increase in CBO concentration. When CBG film containing 1% CBO was used for wrapping mozzarella cheese inoculated with Listeria monocytogenes, the population of the bacterium decreased after 20 days in storage, indicating that CBG films can be applied for improving the microbiological safety of mozzarella cheese. [ABSTRACT FROM AUTHOR]

Abstract: Under endoplasmic reticulum (ER)‐stress conditions, the unfolded protein response (UPR) generates a defense mechanism in mammalian cells. The regulation of UPR signaling is important in oocyte maturation, embryo development, and female reproduction of pigs. Recent studies have shown that melatonin plays an important role as an antioxidant to improve pig oocyte maturation. However, there is no report on the role of melatonin in the regulation of UPR signaling and ER‐stress during in vitro maturation (IVM) of porcine oocytes. Therefore, the objective of this study was to investigate the antioxidative effects of melatonin on porcine oocyte maturation through the regulation of ER‐stress and UPR signaling. We investigated the changes in the mRNA/protein expression levels of three UPR signal genes (Bip/Grp78, ATF4, P90/50ATF6, sXbp1, and CHOP) on oocytes, cumulus cells, and cumulus‐oocyte complexes (COCs) during IVM (metaphase I; 22 hours and metaphase II; 44 hours) by Western blot and reverse transcription‐polymerase chain reaction analysis. Treatment with the ER‐stress inducer, tunicamycin (Tm), significantly increased expression of UPR markers. Additionally, cumulus cell expansion and meiotic maturation of oocytes were reduced in COCs of Tm‐treated groups (1, 5, and 10 μg/mL). We confirmed the reducing effects of melatonin (0.1 μmol/L) on ER‐stress after pretreatment with Tm (5 μg/mL; 22 hours) in maturing COCs. Addition of melatonin (0.1 μmol/L) to Tm‐pretreated COCs recovered meiotic maturation rates and expression of most UPR markers. In conclusion, we confirmed a role for melatonin in the modulation of UPR signal pathways and reducing ER‐stress during IVM of porcine oocytes. [ABSTRACT FROM AUTHOR]

In solution-based synthesis of colloidal nanostructures, additions of ligands, stabilizers, and redox reagents are generally required to obtain desirable structures, though ligands and stabilizers on the surface of nanostructures can substantially affect the surface-related activity. Accordingly, an extensive rinsing process is usually required to remove residual reagents and stabilizers. This study reports a spontaneous self-biomineralization of palladium (Pd) ions on a filamentous virus to form ligand-free Pd nanowires under ambient conditions. No reducing reagents or additional surface stabilizers are used; the genetically modified virus alone supports the polycrystalline Pd nanowires within the nanostructure, maintaining the clean surface even without a rinsing process. The advantage of the ligand-free Pd nanowires is found in the Suzuki-coupling reaction, in which the nanowire catalytic activity is maintained after repeated reactions, while conventional Pd colloids undergo surface contamination by the stabilizer and lose their catalytic activity during repeated uses. The ligand-free surface, high electronic connectivity, and structural stability of the Pd nanowires also allow high sensitivity and selectivity in hydrogen gas sensing analysis. This work emphasizes the importance of the ligand-free surface of biotemplated nanostructures in maintaining functionalities without surface contamination. [ABSTRACT FROM AUTHOR]

Myzus persicae is an important insect pest that reduces crop production worldwide. The use of pesticides for aphid control has generated much concern related to insect resistance and undesirable environmental effects. In an effort to discover new alternatives to counter M. persicae, we found that Pseudomonas isolate DJ15 produced insecticidal metabolites. To isolate the insecticidal metabolites, a cell-free supernatant of DJ15 was extracted and subjected to bioassay-guided chromatography. Based on the structures elucidated in instrumental analyses, the metabolites were identified as xantholysins A and B. The metabolites showed strong insecticidal activity against M. persicae with 50% mortality at levels of 13.4 and 24.6 μg/mL for xantholysins A and B, respectively. This is the first study to identify xantholysins as insecticidal metabolites against M. persicae. [ABSTRACT FROM AUTHOR]

Background: To investigate the agreement between Kupffer phase of Sonazoid contrast-enhanced sonography (CEUS) and hepatobiliary phase of gadoxetic acid-enhanced MRI in the evaluation of focal liver lesions (FLLs).Methods: One hundred fifty-four FLLs in 154 patients who underwent both Sonazoid CEUS and gadoxetic acid-enhanced liver MRI were included in this retrospective study. FLL visibility on the Kupffer-phase images was graded as one (invisible or isoenhancing), two (vaguely visible or vaguely hypoenhancing), or three (clearly visible or clearly hypoenhancing), and that on the hepatobiliary-phase images of MRI was graded as one (invisible or hyper/isointense), two (vaguely visible or weakly hypointense), or three (clearly visible or strongly hypointense). Pairwise comparison of lesion visibility between the two modalities was performed, and intermodality agreement was assessed.Results: On Kupffer-phase CEUS, 31 (20.1%) lesions were invisible, 17 (11.1%) were vaguely visible, and 106 (68.9%) were clearly visible. On the hepatobiliary-phase MRI, 9 (5.9%) lesions were invisible, 45 (29.2%) were vaguely visible, and 100 (64.9%) were clearly visible. Overall, lesion visibility scores were not significantly different between the two modalities (p = 0.121), but the visibility was significantly better on MRI in smaller lesions. Twenty-eight lesions (18.2%) showed discrepancy in the visibility on CEUS and MRI, and most of the cases (89.7%) were lesions that were invisible on CEUS but visible on MRI.Conclusions: The overall visibility of FLLs was comparable between the Kupffer phase of Sonazoid-CEUS and the hepatobiliary-phase images of gadoxetic acid-enhanced MRI, with a discrepancy between the two modalities in 18% of the cases. © 2017 Wiley Periodicals, Inc. J Clin Ultrasound 45:542-550, 2017. [ABSTRACT FROM AUTHOR]

Li-rich layered oxide materials are promising candidates for high-energy Li-ion batteries. They show high capacities of over 200 mAh g−1 with the additional occupation of Li in their transition metal layers; however, the poor cycle performance induced by an irreversible phase transition limits their use in practical applications. In recent work, an atomic-scale modified surface, in which Ni is ordered at 2 c sites in the Li layers, significantly improves the performance in terms of reversible capacity and cycling stability. The role of the incorporated Ni on this performance, however, is not yet clearly understood. Here, the effects of the ordered Ni on Li battery performance are presented, based on first-principles calculations and experimental observations. The Ni substitution suppresses the oxygen loss by moderating the oxidation of oxygen ions during the delithiation process and forms bonds with adjacent oxygen after the first deintercalation of Li ions. These NiO bonds contribute to the formation of a solid surface, resulting in the improved cycling stability. Moreover, the multivalent Ni suppresses Mn migration to the Li-sites that causes the undesired phase transition. These findings from theoretical calculations and experimental observations provide insights to enhance the electrochemical performance of Li-rich layered oxides. [ABSTRACT FROM AUTHOR]

Chromobacterium sp. strain C61 has strong biocontrol activity; however, the genetic and biochemical determinants of its plant disease suppression activity are not well understood. Here, we report the identification and characterization of two new determinants of its biocontrol activity. Transposon mutagenesis was used to identify mutants that were deficient in fungal suppression. One of these mutants had an insertion in a homologue of depD, a structural gene in the dep operon, that encodes a protein involved in non-ribosomal peptide synthesis. In the second mutant, the insertion was in a homologue of the luxI gene, which encodes a homoserine lactone synthase. The luxI- and depD- mutants had no antifungal activity in vitro and a dramatically reduced capacity to suppress various plant diseases in planta. Antifungal production and biocontrol were restored by complementation of the luxI- mutant. Other phenotypes associated with effective biological control, including motility and lytic enzyme secretion, were also affected by the luxI mutation. Biochemical analysis of ethyl acetate extracts of culture filtrates of the mutant and wild-type strains showed that a key antifungal compound, chromobactomycin, was produced by wild-type C61 and the complemented luxI- mutant, but not by the luxI- or depD- mutant. These data suggest that multiple biocontrol-related phenotypes are regulated by homoserine lactones in C61. Thus, quorum sensing plays an essential role in the biological control potential of diverse bacterial lineages. [ABSTRACT FROM AUTHOR]

Biosurfactants have been used for crop protection in integrated pest management programs, as they are generally biodegradable and environmentally friendly. While screening for insecticidal bacteria against green peach aphid, Myzus persicae, we found that a Bacillus isolate, Y9, exhibited strong surface tension activity and produced insecticidal metabolites. The insecticidal metabolites with surface tension activity were extracted from the cell-free supernatant of Y9 and subjected to repetitive column chromatography and preparative high performance liquid chromatography (HPLC). Based on data from instrumental analyses, the metabolites were identified as surfactin isomers consisting of C14[Leu7], C14[Val7] and C15[Leu7]. The isomers with leucine showed higher insecticidal activity than the isomers with valine. Y9 was capable of producing biosurfactants as insecticidal metabolites against M. persicae, and showed potential for use as a biocontrol agent in an integrated pest management program. [ABSTRACT FROM AUTHOR]

Erythromelalgia is often refractory and resistant to many forms of treatment. Numerous therapeutic options have been tried, but effective treatment remains elusive. The sympathetic nervous system has been involved in various painful conditions of neuropathic, vascular, and visceral origin. Sympathetic block is helpful in making a diagnosis and managing pain. We report a case of excellent pain relief after lumbar sympathetic pulsed radiofrequency treatment in a patient with primary erythromelalgia of the lower extremities. This case suggests the viability of pulsed radiofrequency treatment in patients with erythromelalgia. [ABSTRACT FROM AUTHOR]

We developed bottom-gate poly-Si TFTs (BGPs) using ELA for high resolution AMOLED. The BGPs based on our novel process to solve the disconnection of poly-Si during ELA crystallization have better reliability characteristics such as breakdown voltage (BV) and kink effect compared with the conventional top-gate poly-Si TFTs. [ABSTRACT FROM AUTHOR]