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Pathological cardiac hypertrophy, a common feature in various cardiovascular diseases, can be more effectively managed through combination therapies using natural compounds. Harmine, a β‐carboline alkaloid found in plants, possesses numerous pharmacological functions, including alleviating cardiac hypertrophy. Similarly, Selenomethionine (SE), a primary organic selenium source, has been shown to mitigate cardiac autophagy and alleviate injury. To explores the therapeutic potential of combining Harmine with SE to treat cardiac hypertrophy. The synergistic effects of SE and harmine against cardiac hypertrophy were assessed in vitro with angiotensin II (AngII)‐induced hypertrophy and in vivo using a Myh6R404Q mouse model. Co‐administration of SE and harmine significantly reduced hypertrophy‐related markers, outperforming monotherapies. Transcriptomic and metabolic profiling revealed substantial alterations in key metabolic and signalling pathways, particularly those involved in energy metabolism. Notably, the combination therapy led to a marked reduction in the activity of key glycolytic enzymes. Importantly, the addition of the glycolysis inhibitor 2‐deoxy‐D‐glucose (2‐DG) did not further potentiate these effects, suggesting that the antihypertrophic action is predominantly mediated through glycolytic inhibition. These findings highlight the potential of SE and harmine as a promising combination therapy for the treatment of cardiac hypertrophy. [ABSTRACT FROM AUTHOR]

Direct modulation characteristics have been investigated for a Fabry-Perot laser diode coupled with a multimode fiber Bragg grating.Large signal modulation at 2.5 Gb/s with none-return-to-zero format has been demonstrated for the 2-cm long multimode fiber Bragg grating external cavity laser. By using a short external cavity of about 7.5 mm, small-signal frequency responses larger than 8 GHz are achieved. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26083 [ABSTRACT FROM AUTHOR]

A watt level compact green laser based on an integrated Nd:YVO4 and MgO:PPLN module (i.e. mGreen module) is presented for the first time. A linearly polarized 532 nm laser light of 1.02 Watt is obtained, which corresponds to an optical-to-optical conversion efficiency of 25.5%. The mGreen module can dramatically decrease the complexity and cost of the conventional green diode pumped solid state laser. [ABSTRACT FROM AUTHOR]

Originally published Microwave Opt Technol Lett 51: 2814–2817, 2009 . © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 52: 496, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24957 [ABSTRACT FROM AUTHOR]