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Objective: Because of the high costs associated with early‐stage laryngeal carcinoma diagnosis and prognosis prediction, this study attempts to find valuable targets to establish a novel predictive model by focusing on the aldehyde dehydrogenase 2 (ALDH2) genotype and other peripheral blood markers. Study Design: Retrospective study. Setting: Tertiary comprehensive hospital. Methods: From January 2011 to January 2021, 362 cases of laryngeal carcinoma were included and divided into 2 groups in this retrospective analysis. Information on medical history, alcohol, and tobacco consumption habits, ALDH2 genotypes, and other peripheral blood markers was collected. Endpoints of the current study included disease‐free survival and overall survival. A nomogram model for overall survival was established and evaluated using receiver operating characteristic (ROC) curves. Results: A total of 236 patients were included in the training cohort, and the other 126 were included in the validation cohort. The median follow‐up of the patients was 9.6 years (interquartile range: 7.5‐12.5 years). Peripheral fibrinogen, hemoglobin, and ALDH2 genotypes were significantly associated with an increase in laryngeal carcinoma mortality rate on Kaplan‐Meier curves. The ROC curve showed that the effectiveness of overall survival prediction by the nomogram model was better than that of traditional clinical staging. Conclusion: A prognostic nomogram of laryngeal carcinoma patients involving ALDH2 and peripheral blood markers and T and N stages was constructed and validated. [ABSTRACT FROM AUTHOR]

N‐Aryl‐ and N‐alkenylhydrazides, which include a C(sp2)‐N−N motif, have attracted considerable attention not only in biologically active molecules but also because of their extensive technical applications in organic synthesis. C(sp2)−N bond construction protocols using an N‐acylhydrazine or azocarboxylic ester as the hydrazide source provide a powerful route to these compounds. These protocols exhibit different selectivity manner for the C(sp2) moiety and the regioselectivity issue of the N−N bond. This Minireview documents the available methods that have been developed based on different starting materials. The features and drawbacks of each subdivisional methodology are demonstrated. [ABSTRACT FROM AUTHOR]

Behavioral lateralization, which is associated with the functional lateralization of the two brain hemispheres, commonly exists in animals and can provide an individual with benefits such as enhanced cognition and dual tasking. Lateral bias in limb use, as a type of behavioral lateralization, occur in many species, but the reasons for the coexistence of left‐ and right‐biased individuals in a population remain poorly understood. We examined the footedness of male yellow‐bellied tits (Pardaliparus venustulus) when they used feet to clamp mealworms against a perch, and tested its association with other fitness‐related behavioral traits (i.e., feeding efficiency, exploration tendency, and escape performance). We expected differently footed individuals to have respective advantages in these behaviors and thereby coexist ("respective advantage" hypothesis). We found their footedness repeatable, and there was no population‐level bias. While no associations of feeding efficiency and exploration tendency with footedness were detected, the right‐footed individuals were found to be harder to catch than the other individuals. Future studies need to investigate the reasons for the right‐footed individuals' superior escape performance. Moreover, the escape advantage for being right‐footed and the lack of population‐level bias in footedness in male yellow‐bellied tits suggest that the benefits related to left footedness also remain to be explored. [ABSTRACT FROM AUTHOR]

Summary: This paper investigates the strictly dissipative stabilization problem for multiple‐memory Markov jump systems with network communication protocol. Firstly, for reducing data transmission, we put forward a novel mode‐dependent event‐triggered communication scheme based on aperiodically sampled data. Secondly, a Markov jump system with general transition rates is considered to make the result more applicable, where the transition rates of some jumping modes allow to be completely known, or partially known, or even completely unknown. Thirdly, a less restrictive Lyapunov‐Krasovskii functional, which is only required to be positive definite at end points of each subinterval of the holding intervals, is first introduced for event‐triggered control issue. Based on the above methods, a sufficient condition with less conservatism is obtained to ensure the stochastic stability and dissipativity of the resulting closed‐loop system. Meanwhile, an explicit design method of the desired controller is achieved. Finally, two numerical examples are presented to demonstrate the effectiveness and advantage of the proposed method. [ABSTRACT FROM AUTHOR]