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Exposure to potentially morally injurious events (PMIEs) is a pervasive threat for military service members and may be associated with symptoms of anxiety, depression, and suicidal ideation. However, coping mechanisms, such as mindfulness, may ameliorate symptoms and improve recovery. Two studies were conducted to test dispositional mindfulness as a moderator of the links between PMIEs, as assessed using the Moral Injury Events Scale (i.e., total score and Self‐Transgression, Other‐Transgression, and Betrayal subscale scores), and symptoms of anxiety, depression, and suicidal ideation among different samples of active‐duty soldiers in garrison. In Sample 1 (N = 310), mindfulness buffered the links between PMIE exposure and symptoms of both anxiety, ∆R2 =.02, and depression, ∆R2 =.03. In Sample 2 (N = 669), mindfulness moderated the link between the MIES Betrayal subscale and anxiety symptoms, ∆R2 =.01. The results suggest that dispositional mindfulness may be a protective factor against some of the negative impacts of PMIE exposure. Further implications are discussed. [ABSTRACT FROM AUTHOR]

To describe the diagnosis and successful treatment of systemic francisellosis in a dog. An 11‐year‐old female spayed Labrador retriever presented for progressive lethargy, hyporexia, and cough. The dog was febrile with a neutrophilia, nonregenerative anemia, thrombocytopenia, and had increased activity in serum of liver‐derived enzymes. Francisella philomiragia was isolated from aerobic blood culture. The dog was treated for 6 weeks with enrofloxacin orally. Repeated aerobic blood cultures after 2 and 6 weeks of antibiotic therapy were negative. The dog was clinically normal 7 months after diagnosis with no evidence of relapse. [ABSTRACT FROM AUTHOR]

Cinacalcet is an oral calcimimetic that has potential to non‐invasively treat primary hyperparathyroidism in dogs (Canis lupis familiaris). There is minimal data assessing its efficacy in dogs. This study aimed to determine whether a single dose of cinacalcet decreases serum ionized calcium (iCa), total calcium (tCa), and parathyroid hormone (PTH) concentrations. Twelve dogs received a median dose of 0.49 mg/kg (range 0.30–0.69 mg/kg) cinacalcet per os. Venous blood samples were collected at time 0 (before cinacalcet administration), 3, 8, and 24 h following cinacalcet administration. PTH, iCa, and tCa concentrations were measured at each time point and compared to 0 hour concentrations. A significant (50%) decrease in serum PTH occurred at 3 h with a median PTH of 4.6 pmol/L (range 2.7–10.8) at baseline and 1.65 pmol/L (range 0.5–14.7) at 3 h; p =.005. A significant, but not clinically relevant, decrease in serum iCa from a median baseline of 1.340 mmol/L (range 1.32–1.41) to a 3 h median of 1.325 mmol/L (range 1.26–1.39), p =.043, was also observed. tCa concentrations were not different. This study showed that a single dose of cinacalcet leads to transient decreases in iCa and PTH concentrations in healthy dogs. [ABSTRACT FROM AUTHOR]

The work of W.E.B. Du Bois highlights the significance of Christian religion in Black American life. According to Du Bois, the Black Church serves as a site of self‐formation and affirmation, and the White Church as a source of racist beliefs and justifications for inequality. In this paper, we expand Du Bois' inquiry about the influence of religion with a study of Black Americans who belong to a predominantly White religion. For those whose religious experience is almost wholly within the "white world," what role does religion play in their lives? We analyze a set of 52 public accounts by Black Americans discussing their experiences as members of the Church of Jesus Christ of Latter‐day Saints (LDS). We find that for many Black LDS, membership in the LDS Church is characterized by contrast and contradiction, yielding spiritual conviction, joy, and meaningful communion on one hand, and racism and isolation on the other. We also find that Black LDS respond to these contradictions in a variety of ways. We classify these agentic responses into five types and examine the sociological significance of the observed variation. We conclude with a discussion of implications for scholarship on race and religion. [ABSTRACT FROM AUTHOR]

Subglacial discharge emerging from the base of Greenland's marine‐terminating glaciers drives upwelling of nutrient‐rich bottom waters to the euphotic zone, which can fuel nitrate‐limited phytoplankton growth. Here, we use buoyant plume theory to quantify this subglacial discharge‐driven nutrient supply on a pan‐Greenland scale. The modeled nitrate fluxes were concentrated in a few critical systems, with half of the total modeled nitrate flux anomaly occurring at just 14% of marine‐terminating glaciers. Increasing subglacial discharge fluxes results in elevated nitrate fluxes, with the largest flux occurring at Jakobshavn Isbræ in Disko Bay, where subglacial discharge is largest. Subglacial discharge and nitrate flux anomaly also account for significant temporal variability in summer satellite chlorophyll a (Chl) within 50 km of Greenland's coast, particularly in some regions in central west and northwest Greenland. Plain Language Summary: Greenland ice‐sheet runoff is often discharged into fjords at the base of marine‐terminating glaciers as subglacial discharge, which can drive buoyant upwelling of nutrient‐rich bottom waters and fuel phytoplankton growth in the upper ocean. We combine a buoyant plume model with updated estimates of glacier depth, runoff rates, and profiles of temperature, salinity, and nitrate to estimate nutrient upwelling on a pan‐Greenland scale. The modeled nutrient upwelling is concentrated in a few major glacier systems with the largest subglacial discharge fluxes, and increasing runoff drives substantially increased modeled nutrient fluxes. We find that modeled nutrient upwelling can explain temporal variability in coastal surface chlorophyll a in some areas, particularly in west Greenland, which hosts the island's most exported fish catches by volume and value. Key Points: We use buoyant plume theory to model subglacial discharge‐driven nitrate fluxes across Greenland's largest marine‐terminating glaciersThe largest positive nitrate flux anomalies are concentrated in a few major systems with the largest subglacial discharge fluxesRunoff and modeled nitrate upwelling can explain temporal variability in surface cholorophyll in some coastal areas in west Greenland [ABSTRACT FROM AUTHOR]

The Province of Ontario in Canada illustrates contemporary water security issues, where despite perception of water abundance, water challenges arise locally. Water risks stem from biophysical dimensions of groundwater depletion, low surface water flows, and degraded quality, and, contextual dimensions of regulatory uncertainty, public concerns and perception. While academic, policy, and practitioner interest is growing, literature reveals major gaps in comprehensive assessment of multidimensional water risks at the subwatershed scale. Addressing these gaps, the study developed a locally attuned and interdisciplinary water risk assessment framework. Using secondary mixed data analysis, the study integrated quantitative and qualitative data for water quantity and quality risks, regulatory trends, water user conflicts for 38 subwatersheds in Ontario. The framework identifies subwatersheds and sectors at high, moderate, and low risk along with media and public concern themes. The study finds high and moderate risk potential in at least 50% of studied subwatersheds for all water risk indicators and challenges the myth of water abundance in Great Lakes watershed of Ontario. The study advances knowledge in water risk assessment by applying social‐ecological perspectives, interdisciplinary approaches of Risk Theory, and mixed methods to provide a comprehensive evaluation of water security and demonstrates integration of social science perspectives in the field of sociohydrology. Our framework assesses interdisciplinary water risks to inform multisector sustainable water management decisions. While spatially scoped to populous subwatersheds of Ontario, this framework can be methodologically generalized to other geographical regions by using local data. Key Points: Developed a locally attuned interdisciplinary water risk assessment framework for 38 subwatersheds in Ontario, CanadaApplied Risk Theory and assessed multidimensional risks of biophysical quantity, quality, regulatory uncertainty, and public perceptionFound high and moderate risk potential in all categories for at least 50% of studied areas hence challenging the myth of water abundance [ABSTRACT FROM AUTHOR]

Anthropogenic releases of radiation are of ongoing importance for environmental protection, but the radiation doses at which natural systems begin to show effects are controversial. More certainty is required in this area to achieve optimal regulation for radioactive substances. We recently carried out a large survey (268 sampled animals and 20 sites) of the association between environmental radiation exposures and small mammal gut‐associated microbiomes (fungal and bacterial) in the Chornobyl Exclusion zone (CEZ). Using individual measurements of total absorbed dose rates and a study design and analyses that accounted for spatial non‐independence, we found no, or only limited, association.Watts et al. have criticised our study: for not filtering candidate non‐resident components prior to our fungal microbiome analyses, for our qualified speculations on the relative merits of faecal and gut samples, and for the design of our study which they felt lacked sufficient replication.The advantage of filtering non‐resident‐fungal taxa is not clear and it would not have changed the null (spatially adjusted) association we found between radioactive dose and mycobiome composition because the most discriminatory fungal taxa with regard to dose were non‐resident taxa.We maintain that it was legitimate for us to make qualified discussion comments on the differences in results between our faecal and gut microbiome analyses and on the relative merits of these sample types.Most importantly, the criticism of our study design by Watts et al. and the designs and analysis of their recent studies in the CEZ show a misunderstanding of the true nature of independent replication in field studies. Recognising the importance of spatial non‐independence is essential in the design and analysis of radioecological field surveys. [ABSTRACT FROM AUTHOR]

Background: This study profiles ceramides extracted from visceral and subcutaneous adipose tissue of human subjects by liquid chromatography‐mass spectrometry to determine a correlation with status of diabetes and gender. Methods: Samples of visceral and abdominal wall subcutaneous adipose tissue (n = 36 and n = 31, respectively) were taken during laparoscopic surgery from 36 patients (14 nondiabetic, 22 diabetic and prediabetic) undergoing bariatric surgery with a body mass index (BMI) >35 kg/m2 with ≥1 existing comorbidity or BMI ≥40 kg/m2. Sphingolipids were extracted and analyzed using liquid chromatography‐mass spectrometry. Results: After logarithm 2 conversion, paired analysis of visceral to subcutaneous tissue showed differential accumulation of Cer(d18:1/16:0), Cer(d18:1/18:0), and Cer(d18:1/24:1) in visceral tissue of prediabetic/diabetic female subjects, but not in males. Within‐tissue analysis showed higher mean levels of ceramide species linked to insulin resistance, such as Cer(d18:1/18:0) and Cer(d18:1/16:0), in visceral tissue of prediabetic/diabetic patients compared with nondiabetic subjects and higher content of Cer(d18:1/14:0) in subcutaneous tissue of insulin‐resistant female patients compared with prediabetic/diabetic males. Statistically significant differences in mean levels of ceramide species between insulin‐resistant African American and insulin‐resistant Caucasian patients were not evident in visceral or subcutaneous tissue. Conclusions: Analysis of ceramides is important for developing a better understanding of biological processes underlying type 2 diabetes, metabolic syndrome, and obesity. Knowledge of the accumulated ceramides/dihydroceramides may reflect on the prelipolytic state that leads the lipotoxic phase of insulin resistance and may shed light on the predisposition to insulin resistance by gender. [ABSTRACT FROM AUTHOR]

Following the 1986 Chornobyl accident, an area approaching 5000 km2 surrounding the nuclear plant was abandoned, creating the Chornobyl exclusion zone (CEZ). Although this area likely contains the most radioactive terrestrial ecosystem on earth, the absence of humans and associated activities for nearly 35 years since the accident has resulted in increases in wildlife numbers. Both the Belarussian and Ukrainian components of the CEZ are now designated as nature reserves; together they form one of Europe's largest protected areas and have been described as an iconic example of rewilding. Forests and former agricultural land (now scrub) dominate the CEZ and wildfires are an annual event. In April 2020, the CEZ suffered its most widespread fires to date when greater than 800 km2 of the 2600 km2 Ukrainian portion of the CEZ was burnt. Large‐scale fires in the CEZ have implications for wildlife, as they do elsewhere, but they also pose additional radioecological and radiological protection questions. We discuss the implications of wildfires in the CEZ, considering effects on wildlife and changes in radionuclide mobility. We also demonstrate that the risk to firefighters and the wider public from the inhalation of radionuclides in smoke resulting from fires in the CEZ is likely to be low. However, further experimental and modeling work to evaluate potential doses to firefighters from inhaled radioactive particles would be valuable, not least for reassurance purposes. Integr Environ Assess Manag 2021;17:1141–1150 © 2021 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC). KEY POINTS: The approximately 5000 km2 Chernobyl Exclusion Zone contains what is likely the most radioactive terrestrial ecosystem on earth.Wildfires are an annual event in the Chernobyl Exclusion Zone.We discuss the implications of wildfires in the Chernobyl Exclusion Zone, considering effects on wildlife and changes in radionuclide mobility.We demonstrate that the risk to firefighters and the wider public from the inhalation of radionuclides in smoke resulting from fires in the CEZ is likely to be low. [ABSTRACT FROM AUTHOR]

Environmental impacts of the 1986 Chernobyl Nuclear Power Plant accident are much debated, but the effects of radiation on host microbiomes have received little attention to date.We present the first analysis of small mammal gut microbiomes from the Chernobyl Exclusion Zone in relation to total absorbed dose rate, including both caecum and faeces samples.We provide novel evidence that host species determines fungal community composition, and that associations between microbiome (both bacterial and fungal) communities and radiation exposure vary between host species. Using ambient versus total weighted absorbed dose rates in analyses produced different results, with the latter more robust for interpreting microbiome changes at the individual level. We found considerable variation between results for faecal and gut samples of bank voles, suggesting faecal samples are not an accurate indicator of gut composition.Associations between radiation exposure and microbiome composition of gut samples were not robust against geographical variation, although we identified families of bacteria (Lachnospiraceae and Muribaculaceae) and fungi (Steccherinaceae and Strophariaceae) in the guts of bank voles that may serve as biomarkers of radiation exposure.Further studies considering a range of small mammal species are needed to establish the robustness of these potential biomarkers. [ABSTRACT FROM AUTHOR]

Humboldt Gletscher is a 100‐km wide, slow‐moving glacier in north Greenland which holds a 19‐cm global sea level equivalent. Humboldt has been the fourth largest contributor to sea level rise since 1972 but the cause of its mass loss has not been elucidated. Multi‐beam echo sounding data collected in 2019 indicate a seabed 200 m deeper than previously known. Conductivity temperature depth data reveal the presence of warm water of Atlantic origin at 0°C at the glacier front and a warming of the ocean waters by 0.9 ± 0.1°C since 1962. Using an ocean model, we reconstruct grounded ice undercutting by the ocean, combine it with calculated retreat caused by ice thinning to floatation, and are able to fully explain the observed retreat. Two thirds of the retreat are caused by undercutting of grounded ice, which is a physical process not included in most ice sheet models. Plain Language Summary: Humboldt Gletscher is the widest glacier in Greenland, slow moving, and terminating in shallow waters in its southern half, but grounded 200 m deeper than previously known in its northern half, with a submarine trough extending more than 100 km inland. The glacier has been retreating at 0.6 km/year and contributing significantly to sea level rise. We attribute the retreat to undercutting of grounded ice by warmer ocean waters combined with a retreat caused by ice thinning to floatation sooner due to glacier speed up. The glacier, which hosts an ice volume equivalent to a 19‐cm global sea level, will remain a major contributor to sea level rise this Century. Key Points: The 100‐km wide Humboldt Gletscher holds a 19‐cm sea level rise equivalent, lost 161 billion tons of mass, and retreated 13 km since 1972Warm waters at 0°C flood a 350–400 m deep trough on its northern flank that remains below sea level more than 100 km inlandWe explain the glacier retreat as 70% from ocean‐induced undercutting and 30% from thinning‐induced retreat [ABSTRACT FROM AUTHOR]

High mechanical flexibility and wavelength tunability of organic semiconductor materials have propelled the development of organic semiconductor lasers (OSLs) as a complementary technology to current inorganic lasers. While excellent progress has been made across multiple aspects of OSLs, demonstration of long‐pulse operation [quasi‐continuous wave (qCW) or continuous wave (CW)] lasing has presented significant challenges due to the detrimental accumulation of triplets under long‐pulse photoexcitation and substantial quenching of singlet excitons, arising from singlet‐triplet annihilation (STA). In particular, qCW or CW lasing from solution‐processed OSL materials has not been reported, and thus remains a long‐thought objective in optoelectronic research. Using a novel bis(N‐carbazolylstyryl)‐9,9‐dihexylfluorene (BSFCz), the first solution‐processable organic laser dye demonstrating lasing oscillation in the long‐pulse photoexcitation regime (up to 10 ms pulse width) with a low threshold (420 W cm−2), which in part can be attributed to its negligible spectral overlap between triplet excited‐state absorption and laser emission, is herein reported. Temporal emission profiles below and above the lasing threshold also demonstrate that STA has a negligible effect on emission. These combined observations show BSFCz incur low losses due to triplet excited‐states, leading to extremely small changes in lasing thresholds when moving from pulsed to qCW (>1 ms) excitation. [ABSTRACT FROM AUTHOR]

Background: In humans, Enterococcus spp. urinary tract infections (UTI) are commonly associated with urinary catheter‐induced urothelial inflammation but this is not the case in dogs. Hypothesis/Objectives: To identify risk factors predisposing dogs to enterococcal bacteriuria. Animals Seventy dogs with Enterococcus spp. bacteriuria (case) and 70 dogs with Enterococcus coli bacteriuria (control). Methods: A single center retrospective case‐control study with subjects and controls identified by a medical records search for Enterococcus spp. (subject) or E coli (control) bacteriuria from January 1, 2014 to December 31, 2017. Cases and controls were balanced with respect to average age and weight. Binary logistic regression was used to estimate and test whether the odds of having Enterococcus spp. bacteriuria (instead of E coli) were associated with the presence of any given characteristic. Results: A history of recurrent bacteriuria was significantly more common in Enterococcus spp. cases than in E coli controls (odds ratio [OR]: 2.07; 95% confidence interval [CI]: 1.04‐4.16, P =.04). Comorbidities associated with the presence of Enterococcus spp. bacteriuria included lower urinary tract (LUT) anatomic abnormalities (OR: 2.94; 95% CI: 1.17‐8.10, P =.02), urolithiasis (P =.01), and the presence of LUT neoplasia (P =.04). Small frequencies (n = 12 and n = 6, respectively) compromise our ability to precisely estimate the genuine OR for the latter 2 characteristics. Conclusions and Clinical Importance: If the identified risk factors promote Enterococcus spp. colonization in dogs via induced LUT inflammation similar to people then Enterococcus spp. bacteriuria could be a sentinel for underlying LUT inflammation. [ABSTRACT FROM AUTHOR]

Organic semiconductor dyes have attracted high interest as laser gain media owing to their judicious features of solution processability, lightweight, high mechanical flexibility, high wavelength‐tunability, and low‐cost manufacture. In this work, fluorene‐carbazolylstyryl hybrids are reported, SFCz and BSTFCz, as new solution processable organic semiconductor laser dyes to show high molar extinction coefficients (up to 1.98 × 105 dm3 mol−1 cm−1), high photoluminescence quantum yields (up to 81 ± 4%), high radiative decay constants (up to 1.24 × 109 s−1), and low film amplified spontaneous emission thresholds (down to 0.70 µJ cm−2). By using mixed‐order distributed feedback laser structures, extremely low lasing threshold of 0.5 µJ cm−2 is achieved. To elucidate their electroluminescent properties, simple solution‐processed organic light‐emitting diodes based on the new materials are fabricated to show good external quantum efficiencies (2%) and high brightness (≈2800 cd m−2). The results indicate the ease in material synthesis and fabrication enabling solution‐processed low‐threshold lasing toward future injection laser. [ABSTRACT FROM AUTHOR]

Dear Editors, We read with interest the paper by Estruch et al "Utility of the combined use of 3 serologic markers in the diagnosis and monitoring of chronic enteropathies in dogs,"1 the results section of the abstract of which would suggest that an assay based on combined measurements of OmpC (ACA), canine calprotectin (ACNA), and gliadin-derived peptide (AGA) is useful to differentiate chronic enteropathy/inflammatory bowel disease (CE/IBD) and non-IBD gastrointestinal disorders.1 However, in the materials and methods section, the differentiation of dogs with primary gastrointestinal disease from those with some forms of secondary gastrointestinal disease is described, not the differentiation of dogs with CE/IBD from those with non-IBD chronic gastrointestinal disease as stated in the abstract. While the work-up mentioned did include a minimum database and fecal examination for endoparasites, a standardized diagnostic work-up, including the outcome of broad-spectrum anthelminthic therapy or dietary trials, or tissue diagnosis, all essential for a diagnosis of IBD, are missing. [Extracted from the article]

BACKGROUND: Youth violence is a significant problem affecting community health. Community–academic partnerships can advance youth nonviolence education by synergizing the strengths of collaborators while working toward a common goal. We describe a collaboration between an urban public middle school, community nonprofit, and university‐based graduate school of nursing in implementing and evaluating the Healthy Power program, a school‐based youth nonviolence program for middle‐school boys. METHODS: A participatory program evaluation approach was used to plan and implement evaluation of the Healthy Power program with a cohort of 8 students. Collaborative planning allowed for the selection of measures that reflected program objectives and were of value to community partners while also scientifically sound. A mixed‐methods approach included a focus group and a pretest–posttest with quantitative items and open‐ended questions. RESULTS: While the quantitative pre‐posttest did not show any significant change, the open‐ended questions and focus group suggested that students had advanced their understanding and application of conflict resolution skills. CONCLUSIONS: The findings support the usefulness of community–academic partnerships for peace/conflict resolution education and program evaluation. Such programs may benefit from mixed methods of evaluation. [ABSTRACT FROM AUTHOR]

Southeast Greenland has been a major participant in the ice sheet mass loss over the last several decades. Interpreting the evolution of glacier fronts requires information about their depth below sea level and ocean thermal forcing, which are incompletely known in the region. Here, we combine airborne gravity and multibeam echo sounding data from the National Aeronautics and Space Administration's Oceans Melting Greenland (OMG) mission with ocean probe and fishing boat depth data to reconstruct the bathymetry extending from the glacier margins to the edges of the continental shelf. We perform a three‐dimensional inversion of the gravity data over water and merge the solution with a mass conservation reconstruction of bed topography over land. In contrast with other parts of Greenland, we find few deep troughs connecting the glaciers to the sources of warm Atlantic Water, amidst a relatively uniform, shallow (350 m) continental shelf. The deep channels include the Kangerlugssuaq, Sermilik, Gyldenløve, and Tingmiarmiut Troughs. Key Points: A multisensor approach resolves the bathymetry on the continental shelf and glacial fjords of southeast GreenlandFew deep or complex networks of troughs connect the glaciers to the sources of warm Atlantic Water; that is, access to ocean heat is limitedThe new bathymetry helps interpret the past and recent evolution of southeast Greenland glaciers and contribution to sea level rise [ABSTRACT FROM AUTHOR]

Assessing the presence and abundance of birds is important for monitoring specific species as well as overall ecosystem health. Many birds are most readily detected by their sounds, and thus, passive acoustic monitoring is highly appropriate. Yet acoustic monitoring is often held back by practical limitations such as the need for manual configuration, reliance on example sound libraries, low accuracy, low robustness, and limited ability to generalise to novel acoustic conditions.Here, we report outcomes from a collaborative data challenge. We present new acoustic monitoring datasets, summarise the machine learning techniques proposed by challenge teams, conduct detailed performance evaluation, and discuss how such approaches to detection can be integrated into remote monitoring projects.Multiple methods were able to attain performance of around 88% area under the receiver operating characteristic (ROC) curve (AUC), much higher performance than previous general‐purpose methods.With modern machine learning, including deep learning, general‐purpose acoustic bird detection can achieve very high retrieval rates in remote monitoring data, with no manual recalibration, and no pretraining of the detector for the target species or the acoustic conditions in the target environment. [ABSTRACT FROM AUTHOR]

ABSTRACT: This article provides a reassessment of Walter Scott's period of reading and translating German drama in the years 1796–8. This encounter tends to be credited as a pivotal moment in Scott's career, when the young Scott discovered medieval motifs and the literary depiction of the historical individual in German drama, which he then went on to incorporate into his novels. However, studying the six plays Scott translated (by Iffland, Babo, Maier, Goethe, Schiller, and Lessing) within the context in which the Scottish reading public had been introduced to German drama shows that there is much more to Scott's reception of German plays. After outlining Scott's expectations of German drama, this article analyses these six plays to show that, in them, Scott saw the results of formal innovation in casting off the rules of classical drama and portraying situations in which passionate characters could be brought to life. These insights point to the sources of many of Scott's later innovations in narrative form. While aspects of the historical novel can clearly be traced back to Goethe and Maier, Scott's narrative structure owes much to the plotting, dialogue, and primacy of situation found in German drama. [ABSTRACT FROM AUTHOR]

Abstract: A novel micro‐scale photovoltaic concept, Wafer Integrated Micro‐scale Photovoltaics (WPV), is proposed, analyzed, and experimentally demonstrated. The WPV concept seamlessly integrates multijunction micro‐cells with a multi‐functional silicon platform that simultaneously provides optical concentration, hybrid PV/CPV architecture, and mechanical alignment features. Fabrication and optical performance characterization of the Si platform are described in this paper. Over 100% improvement in the concentration‐acceptance‐angle product (CAP) is demonstrated using the wafer‐embedded micro‐concentrating elements, leading to significantly reduced module material and fabrication costs, sufficient angular tolerance for low‐cost trackers, and an ultra‐compact optical architecture compatible with commercial flat panel infrastructures. The development of a prototypical module with a 400× concentration ratio is described. Outdoor optical characterization of the module shows acceptance angles of ±1.7° and ±2.5° for 90% of on‐axis power and full‐width‐half‐maximum, respectively. The projected performance of the PV/CPV hybrid architecture illustrates its potential for cost‐effective collection of both direct and diffuse sunlight, thereby extending the geographic and market domains for cost‐effective PV system deployment. Leveraging low‐cost micro‐fabrication and high‐level integration techniques, the WPV approach presents a promising route to combine the high performance of multijunction solar cells and the low costs of flat‐plate Si PV systems. [ABSTRACT FROM AUTHOR]

Abstract: Climate change represents a significant financial risk to the insurance industry, but research has yet to assess whether the industry is managing this risk. Through the application of scale as a vertically nested hierarchy of relationships, this paper seeks to evaluate whether insurers are ‘rescaling’ risk management practices to accommodate the temporal and spatial uncertainty associated with climate change. This framework is applied to a content analysis of 178 (183) firm responses to the 2012 (2015) U.S. National Association of Insurance Commissioners Climate Risk Disclosure Survey to detect evidence of rescaling through climate change risk management (CCRM). The results reveal that the majority of companies do not integrate climate change into their risk management practices, but reinsurers are rescaling in a greater proportion than primary insurers. This finding confirms that a nested spatial and temporal scale in the insurance industry creates resistance to CCRM. The use of scale contributes to emerging scholarship on organizations and climate change by offering a framework for measuring organizational responses and justifying a research agenda on rescaling strategies as a means of risk management. [ABSTRACT FROM AUTHOR]

Research on the psychology of conspiracy theories has shown recent steps towards a standardization of measures. The present article seeks to continue that trend by presenting the Flexible Inventory of Conspiracy Suspicions ( FICS), a questionnaire template that can be adapted to measure suspicions of a conspiracy around nearly any topic of public interest. Compared to conspiracy belief measures that ask about specific theories on a given topic, the FICS is worded in such a way as to provide relatively stable validity across time and cultural context. Using a hybrid approach incorporating classical test theory and Rasch scaling, three questionnaire studies on Mechanical Turk demonstrate the validity of the FICS in measuring conspiracy suspicions regarding 9/11, vaccine safety, and US elections, with good psychometric properties in most situations. However, the utility of the FICS is limited in the case of climate change due to the existence of two opposing conspiracy theories that share essentially no common assumptions ('climate change is a hoax' vs. 'there is a conspiracy to make people believe that climate change is a hoax'). The results indicate that the FICS is a reliable and valid measure of conspiracy suspicions within certain parameters, and suggest a three-level model that differentiates general conspiracist ideation, relatively vague conspiracy suspicions, and relatively specific conspiracy beliefs. [ABSTRACT FROM AUTHOR]

'Conspiracy theory' is widely acknowledged to be a loaded term. Politicians use it to mock and dismiss allegations against them, while philosophers and political scientists warn that it could be used as a rhetorical weapon to pathologize dissent. In two empirical studies conducted on Amazon Mechanical Turk, I present an initial examination of whether this concern is justified. In Experiment 1, 150 participants judged a list of historical and speculative theories to be no less likely when they were labeled 'conspiracy theories' than when they were labeled 'ideas.' In Experiment 2 (N = 802), participants who read a news article about fictitious 'corruption allegations' endorsed those allegations no more than participants who saw them labeled 'conspiracy theories.' The lack of an effect of the conspiracy-theory label in both experiments was unexpected and may be due to a romanticized image of conspiracy theories in popular media or a dilution of the term to include mundane speculation regarding corruption and political intrigue. [ABSTRACT FROM AUTHOR]

An 11-year-old, male castrated, Boston Terrier was presented to the North Carolina State University College of Veterinary Medicine Small Animal Emergency Service with a 2-day history of progressive ataxia, left-sided head tilt, and anorexia. The dog had previously been diagnosed with chronic lymphoid leukemia and suspected immune-mediated destruction of his bone marrow precursor cells, possibly due to therapy with immunosuppressive dosages of prednisone and azathioprine. During the physical examination, abnormal findings included an increased body temperature and horizontal nystagmus. Diagnostic investigations included a computed tomography ( CT) scan, which confirmed bilateral otitis media, and a blood culture, which was positive for Listeria monocytogenes serotype 4b (epidemic clone 1). Upon treatment with ampicillin/sulbactam, enrofloxacin, and minocycline, the dog became normothermic and the neurologic signs improved. L monocytogenes serotype 4b (epidemic clone 1) has been associated with outbreaks of human listeriosis originating from food contamination. Although rare case reports of Listeria spp. infection in dogs exist, an actual infection with the epidemic clone 1 strain has never before been reported in a dog. It should be included in the differential diagnoses in immunocompromised dogs with clinical signs of septicemia. [ABSTRACT FROM AUTHOR]

A closed loop system of diabetes control would minimize hyperglycemia and hypoglycemia. We therefore implanted and tested a subcutaneous amperometric glucose sensor array in alloxan-diabetic rats. Each array employed four sensing units, the outputs of which were processed in real time to yield a unified signal. We utilized a gain-scheduled insulin control algorithm which rapidly reduced insulin delivery as glucose concentration declined. Such a system was generally effective in controlling glycemia and the degree of lag between blood glucose and the sensor signal was usually 3-8 min. After prolonged implantation, this lag was sometimes longer, which led to impairment of sensor accuracy. Using a prospective two-point calibration method, sensor accuracy and closed loop control were good. A revised algorithm yielded better glycemic control than the initial algorithm did. Future research needs to further improve calibration methods and reduce foreign body fibrosis in order to avoid a time-related increase in lag duration. [ABSTRACT FROM AUTHOR]

Faced with a potentially devastating epidemic of HIV/ AIDS in Papua New Guinea ( PNG), sexuality and mobility have become a focus of national research and prevention programs. In Gogodala and Bamu communities in the Western Province, gendered mobility and sexuality intersect with ancestral narratives that form part of a wider series of Hero Tales found in the southern regions of PNG and Irian Jaya. In this paper we highlight the way these stories detail the travels and activities of female ancestors - known as Sagalu among the Bamui and Sawiya among the Gogodala. We outline the way such ancestral figures are now linked to understandings of contemporary STIs such HIV/ AIDS as well as gendered mobility and sexuality more generally. Among the Bamu such links are sometimes directly asserted, with Sagalu represented as the origin if not cause of a uniquely defined variant of HIV/ AIDS. Among the Gogodala, however, HIV/ AIDS is predominantly understood as something external to the Gogodala and unrelated to ancestors like Sawiya. To explain this difference we note that, historically, Gogodala women have been less mobile and less transactable than their Bamu counterparts who have continued to enact unique understandings of the intersection of heterosexual marriage, gendered mobility, and illness. We argue that the mobility and sexuality of gendered ancestors is salient to understanding these contemporary enactments and their potential implications in light of the HIV epidemic in PNG. [ABSTRACT FROM AUTHOR]

To build on research concerning the development of postdeployment community-based programs, we surveyed active duty soldiers from two Brigade Combat Teams (N = 693; N = 1,385) after return from a combat deployment. The Brigade Combat Teams were located on different installations in rural areas representing 2 large military communities. The survey included an assessment about a range of community services (social events, cultural integration opportunities, family, chaplain, and mental health services, etc.). We also examined whether ratings of services varied as a function of Posttraumatic Stress Disorder symptoms, deployment experiences, organizational leadership and support, and attitudinal variables related to mental health. Differences in ratings between the 2 communities suggest the measure detected perceptions of community needs that are idiosyncratic to the particular community, and may be useful for informing program planning and service needs. [ABSTRACT FROM AUTHOR]

After a myocardial infarction, thinning and expansion of the fibrotic scar contribute to progressive heart failure. The loss of elastin is a major contributor to adverse extracellular matrix remodelling of the infarcted heart, and restoration of the elastic properties of the infarct region can prevent ventricular dysfunction. We implanted cells genetically modified to overexpress elastin to re-establish the elastic properties of the infarcted myocardium and prevent cardiac failure. A full-length human elastin cDNA was cloned, subcloned into an adenoviral vector and then transduced into rat bone marrow stromal cells ( BMSCs). In vitro studies showed that BMSCs expressed the elastin protein, which was deposited into the extracellular matrix. Transduced BMSCs were injected into the infarcted myocardium of adult rats. Control groups received either BMSCs transduced with the green fluorescent protein gene or medium alone. Elastin deposition in the infarcted myocardium was associated with preservation of myocardial tissue structural integrity (by birefringence of polarized light; P < 0.05 versus controls). As a result, infarct scar thickness and diastolic compliance were maintained and infarct expansion was prevented ( P < 0.05 versus controls). Over a 9-week period, rats implanted with BMSCs demonstrated better cardiac function than medium controls; however, rats receiving BMSCs overexpressing elastin showed the greatest functional improvement ( P < 0.01). Overexpression of elastin in the infarcted heart preserved the elastic structure of the extracellular matrix, which, in turn, preserved diastolic function, prevented ventricular dilation and preserved cardiac function. This cell-based gene therapy provides a new approach to cardiac regeneration. [ABSTRACT FROM AUTHOR]

Objectives The study examined whether elevated rates of externalizing behaviors following deployment could be explained by internalizing symptoms (depression, anxiety, and PTSD symptoms), and health of the social environment (unit leadership, organizational support, and stigma/barriers to care). Design A model of combat exposure, social environment, internalizing symptoms, and externalizing behaviors was tested in a military unit following a fifteen-month deployment to Iraq. The sample included 1,397 soldiers assessed four month post-deployment; 589 of these soldiers were assessed again nine months post-deployment. Results Externalizing behaviors were highly stable over the five-month post-deployment period. Both social environment and internalizing symptoms were significantly associated with level of externalizing behaviors at four months and nine months post-deployment, but combat exposure alone significantly predicted change in externalizing behaviors over the follow-up period. Conclusions Results suggest the need to broaden the scope of interventions targeted to combat veterans and have implications for care providers and military leaders. © 2012 Wiley Periodicals, Inc. J. Clin. Psychol. 68:782-800, 2012 [ABSTRACT FROM AUTHOR]

Benefit finding, described as one's ability to find benefits from stressful situations, has been hypothesized as a buffer against the negative effects of stress on mental health outcomes. Nonetheless, many have questioned the buffering potential of benefit finding in the face of prolonged and excessive stress such as is found in the combat environment. This study suggests that the length of a combat deployment and benefit finding may impact the relationship between combat exposure and posttraumatic stress disorder (PTSD) symptoms. Surveys were distributed to U.S. enlisted soldiers ( n = 1,917), officers, and warrant officers ( n = 163) of various combat and combat support units deployed to Iraq. A significant 3-way interaction (s r2 = .004, p < .05) revealed that benefit finding buffered soldiers from increased PTSD symptoms under high levels of combat exposure early in the deployment, but not in later months. These results indicate that although benefit finding may be a useful coping approach during the early phases of deployment, prolonged exposure to stress may diminish a soldier's ability to use benefit finding as a method for coping. [ABSTRACT FROM AUTHOR]

There is no consensus among pediatric endocrinologists in using low-dose (LD) versus high-dose (HD) cosyntropin to test for secondary/tertiary adrenal insufficiency. This paper compares LD and HD cosyntropin stimulation testing in children for evaluation of hypothalamic-pituitary-adrenal axis (HPAA) and suggests a new peak cortisol cut-off value for LD stimulation testing to avoid false positivity. Data of 36 children receiving LD (1 µg) and HD (249 µg) cosyntropin consecutively during growth hormone (GH) stimulation testing were analyzed in two groups. Group A were patients who passed GH stimulation testing and were not on oral, inhaled or intranasal steroids (intact hypothalamic-pituitary axis, n= 19). Group B were patients who failed GH stimulation testing and/or were on oral, inhaled or intranasal steroids (impaired hypothalamic-pituitary axis, n= 17). In group A, the mean peak cortisol response in LD cosyntropin was 18.5 ± 2.4 µg/dL and that for the HD cosyntropin was 24.8 ± 3.1 µg/dL ( r: 0.76, P≤ 0.05). In group B, the mean peak cortisol response in LD cosyntropin was 15.7 ± 6.1 µg/dL and that for HD cosyntropin was 21.7 ± 7.9 µg/dL ( r: 0.98, P≤ 0.05). When a standard cut-off of 18 µg/dL was used, 37% of the patients with intact HPAA failed LD cosyntropin testing, but a cut-off of 14 µg/dL eliminated false positive results. LD cosyntropin stimulation testing results should be interpreted cautiously when used alone to prevent unnecessary long-term treatment. Using a lower cut-off for LD (≥14 µg/dL) seems to avoid false positive results and still detects most cases of impaired HPAA. [ABSTRACT FROM AUTHOR]

This paper outlines some of the ways early artefact collecting contributed to the definition of the Australian region now known and marketed as the 'World Heritage Wet Tropics'. While others have collected in this region, we focus on the collecting activities of Hermann Klaatsch and the work of Norman Tindale to explore some factors that contributed to their claims that certain artefacts represent a region and its history. We argue that these understandings of region and the past, along with the now widely dispersed artefacts, maintain a lively, albeit transformed, presence in current debates about Aboriginal regional culture, linking assertions of rights to lost and stolen cultural property with notions of large-scale environmental management within the 'Wet Tropics'. [ABSTRACT FROM AUTHOR]

Following cessation of growth, yeast cells remain viable in a nondividing state for a period of time known as the chronological lifespan (CLS). Autophagy is a degradative process responsible for amino acid recycling in response to nitrogen starvation and amino acid limitation. We have investigated the role of autophagy during chronological aging of yeast grown in glucose minimal media containing different supplemental essential and nonessential amino acids. Deletion of ATG1 or ATG7, both of which are required for autophagy, reduced CLS, whereas deletion of ATG11, which is required for selective targeting of cellular components to the vacuole for degradation, did not reduce CLS. The nonessential amino acids isoleucine and valine, and the essential amino acid leucine, extended CLS in autophagy-deficient as well as autophagy-competent yeast. This extension was suppressed by constitutive expression of GCN4, which encodes a transcriptional regulator of general amino acid control (GAAC). Consistent with this, GCN4 expression was reduced by isoleucine and valine. Furthermore, elimination of the leucine requirement extended CLS and prevented the effects of constitutive expression of GCN4. Interestingly, deletion of LEU3, a GAAC target gene encoding a transcriptional regulator of branched side chain amino acid synthesis, dramatically increased CLS in the absence of amino acid supplements. In general, this indicates that activation of GAAC reduces CLS whereas suppression of GAAC extends CLS in minimal medium. These findings demonstrate important roles for autophagy and amino acid homeostasis in determining CLS in yeast. [ABSTRACT FROM AUTHOR]

The Mueller matrix represents the transfer function of an optical system in its interactions with polarized light and its elements relate to specific biologically or clinically relevant properties. However, when many optical polarization effects occur simultaneously, the resulting matrix elements represent several 'lumped' effects, thus hindering their unique interpretation. Currently, no methods exist to extract these individual properties in turbid media. Here, we present a novel application of a Mueller matrix decomposition methodology that achieves this objective. The methodology is validated theoretically via a novel polarized-light propagation model, and experimentally in tissue simulating phantoms. The potential of the approach is explored for two specific biomedical applications: monitoring of changes in myocardial tissues following regenerative stem cell therapy, through birefringence-induced retardation of the light's linear and circular polarizations, and non-invasive blood glucose measurements through chirality-induced rotation of the light's linear polarization. Results demonstrate potential for both applications. (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [ABSTRACT FROM AUTHOR]

The melanocortin system has been implicated in regulating various physiological processes including pigmentation, energy homeostasis, obesity, steroidogenesis cardiovascular, and exocrine gland function. The five melanocortin receptors that belong to the super family of G protein-coupled receptors are stimulated by naturally occurring agonists. The aim of this research was focused on the design, synthesis, and pharmacological characterization of melanocortin ligands that contain the 1,2,5-trisubstituted benzimidazole scaffold. A series of benzimidazole analogues, with three points of diversity at positions 1, 2, and 5, were designed, synthesized, pharmacologically assayed at the mouse melanocortin receptors MC1R, MC3R, MC4R, and MC5R and resulted in ligands possessing a range of agonist activity from nm to no stimulation at up to 100 μM concentrations. This study demonstrates that the benzimidazole structure template can be appended with key melanocortin agonist amino acids for the design melanocortin receptor agonist ligands. [ABSTRACT FROM AUTHOR]

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The presence of an anti-bacterial T cell response and evidence of bacterial products in inflamed joints of reactive arthritis patients suggests an antigen transportation role in this disease for macrophages and dendritic cells. We have investigated the functional properties and in vivo migration of macrophages and DC after infection with Salmonella enterica serovar Typhimurium ( S. typhimurium). BM-derived macrophages and DC displayed enhanced expression of costimulatory molecules (CD40 and CD86) and increased production of pro-inflammatory cytokines (TNF-alpha, IL-6 and IL-12p40) and nitric oxide after infection. Upon adoptive transfer into mice, infected DC migrated to lymphoid tissues and induced an anti- Salmonella T cell response, whereas infected macrophages did not. Infection of DC with S. typhimurium was associated with strong up-regulation of the chemokine receptor CCR7 and acquisition of responsiveness to chemokines acting through this receptor. Moreover, S. typhimurium-infected CCR7-deficient DC were unable to migrate to lymph nodes after adoptive transfer, although they did reach the spleen. Our data demonstrate distinct roles for macrophages and DC as antigen transporters after S. typhimurium infection and a dependence on CCR7 for migration of DC to lymph nodes after bacterial infection. [ABSTRACT FROM AUTHOR]

This paper contributes to the ethnography of masculinity and the media in PNG. I outline some changes in Kamula men's understandings of masculinity as they are registered in accounts of conflicts between state security services, the Kamula, Rambo and other actors. Outlining this history shows how Kamula men are increasingly entangled in forms of state power and violence that are partially defined by new myths of masculinity expressed in Melanesian readings of Rambo. The paper describes how some of the power effects linked to Rambo are transferred to Kamula men. I argue that in their accounts of Rambo the Kamula are also exploring different models of sovereignty and state power. [ABSTRACT FROM AUTHOR]

An algorithm designed to automatically control insulin delivery was tested in rats with Type 1 diabetes. This nonlinear algorithm included a fading memory component of proportional and derivative errors in order to simulate normal insulin secretion. Error-weighting functions for the proportional and derivative terms were used with a performance index designed for error adaptation. In the first version of the algorithm, the proportional gain was adaptively varied. In the second version, a low rate of basal insulin delivery was adaptively varied. Six 6-h studies with each version were conducted using frequent blood sampling and intravenous insulin delivery. In Version 2 studies, blood glucose levels during the last two hours were well-controlled and significantly lower than in Version 1 (118 ± 2.0 vs. 130 ± 2.9 mg/dL). Neither version produced hypoglycemia. Future research using this algorithm needs to focus on automated glucose sensing in combination with insulin delivery. [ABSTRACT FROM AUTHOR]

This paper addresses a disjunction between consumer behaviour discourse about 'impulse buying' and the reality of shopper behaviour in contemporary marketing and retail environments, by revising the concept of unplanned buying. 'Discretionary unplanned buying' is distinguished from impulse buying and is argued to he part of the core meaning of a 'consumer society'. Consumers buy goods and services with discretionary income intentionally, but without prior planning. It is suggested that such purchases account for a significant portion of the excitement and the 'hedonic' satisfaction that consumers receive from their consumption purchases, both in the present day and historically. Consumer experiences as well as the historical development of retail places and consumer society are considered. [ABSTRACT FROM AUTHOR]

Explores the quality of the work of novelist John M. Coetzee. Role of the works of novelist James Joyce in understanding the works of Coetzee; Continuing travel of Joyce's novel "Ulysses" in literature; Characteristics of Elizabeth Costello, Coetzee's imaginary writer.

Burkholderia pseudomalleiis a Gram-negative facultative intracellular pathogen that enters and escapes from eukaryotic cells using the power of actin polymerization. We have identified a bacterial protein (BimA) that is required for the ability ofB. pseudomalleito induce the formation of actin tails. BimA contains proline-rich motifs and WH2-like domains and shares limited homology at the C-terminus with theYersiniaautosecreted adhesin YadA. BimA is located at the pole of the bacterial cell at which actin polymerization occurs and mutation ofbimAabolished actin-based motility of the pathogen in J774.2 cells. Transient expression of BimA in HeLa cells resulted in F-actin clustering reminiscent of that seen on WASP overexpression. Antibody-mediated clustering of a CD32 chimera in which the cytoplasmic domain was replaced with BimA resulted in localization of the chimera to the tips of F-actin enriched membrane protrusions. We report that purified truncated BimA protein binds monomeric actin in a concentration-dependent manner in cosedimentation assays and that BimA stimulates actin polymerizationin vitroin a manner independent of the cellular Arp2/3 complex. [ABSTRACT FROM AUTHOR]