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2. International opinions and national surveillance suggest insufficient consensus regarding the recognition and management practices of infants with congenital cytomegalovirus infections

Author

UMC Utrecht, MS Neonatologie, Arts-assistenten Kinderen, Infectieziekten patientenzorg, Child Health, Infection & Immunity, Brain, Gunkel, J., Nijman, J., Verboon-Maciolek, M. A., Wolfs, T. F.W., de Vries, L. S., UMC Utrecht, MS Neonatologie, Arts-assistenten Kinderen, Infectieziekten patientenzorg, Child Health, Infection & Immunity, Brain, Gunkel, J., Nijman, J., Verboon-Maciolek, M. A., Wolfs, T. F.W., and de Vries, L. S.

Published
2017

3. Virological responses to lamivudine or emtricitabine when combined with tenofovir and a protease inhibitor in treatment-naïve HIV-1-infected patients in the Dutch AIDS Therapy Evaluation in the Netherlands (ATHENA) cohort

Author

Rokx, C., Gras, L., van de Vijver, D. A M C, Verbon, A., Rijnders, B. J A, Prins, J. M., Kuijpers, T. W., Scherpbier, H. J., van der Meer, J. T M, Wit, F. W M N, Godfried, M. H., Reiss, P., van der Poll, T., Nellen, F. J B, Lange, J. M A, Geerlings, S. E., van Vugt, M., Pajkrt, D., Bos, J. C., van der Valk, M, Wiersinga, W. J., Goorhuis, A., Hovius, J. W R, Lowe, S., Oude Lashof, A., Posthouwer, D., Pronk, M. J H, Ammerlaan, H. S M, van der Ende, M. E., de Vries-Sluijs, T. E M S, Schurink, C. A M, Nouwen, J. L., van Gorp, E. C M, van der Feltz, M., Driessen, G. J A, van Rossum, A. M C, Branger, J., Schippers, E. F., van Nieuwkoop, C., van Elzakker, E. P., Groeneveld, P. H P, Bouwhuis, J. W., Soetekouw, R., ten Kate, R. W., Kroon, F. P., van Dissel, J. T., Arend, S. M., de Boer, M. G J, Jolink, H., Vollaard, A. M., Bauer, M. P., den Hollander, J. G., Pogany, K., van Twillert, G., Kortmann, W., Cohen Stuart, J. W T, Diederen, B. M W, Leyten, E. M S, Gelinck, L. B S, Kootstra, G. J., Delsing, C. E., Brinkman, K., Blok, W. L., Frissen, P. H J, Schouten, W. E M, van den Berk, G. E L, van Kasteren, M. E E, Brouwer, A.E., Veenstra, J., Lettinga, K. D., Mulder, J. W., Vrouenraets, S. M E, Lauw, F. N., van Eeden, A., Verhagen, D. W M, Sprenger, H. G., Scholvinck, E. H., van Assen, S., Bierman, W. F W, Wilting, K. R., Stienstra, Y., Koopmans, P. P., Keuter, M., van der Ven, A. J A M, ter Hofstede, H. J M, Dofferhoff, A. S M, Warris, A., van Crevel, R., Hoepelman, A. I M, Mudrikova, T., Schneider, M. M E, Ellerbroek, P. M., Oosterheert, J. J., Arends, J. E., Wassenberg, M. W M, Barth, R. E., van Agtmael, M. A., Perenboom, R. M., Claessen, F. A P, Bomers, M., Peters, E.J.G., Geelen, S. P M, Wolfs, T. F W, Bont, L. J., Richter, C., van der Berg, J. P., Gisolf, E. H., van den Berge, M., Stegeman, A., van Vonderen, M. G A, van Houte, D. P F, Weijer, S., el Moussaoui, R., Winkel, C., Muskiet, F., Durand, A., Voigt, R., Rokx, C., Gras, L., van de Vijver, D. A M C, Verbon, A., Rijnders, B. J A, Prins, J. M., Kuijpers, T. W., Scherpbier, H. J., van der Meer, J. T M, Wit, F. W M N, Godfried, M. H., Reiss, P., van der Poll, T., Nellen, F. J B, Lange, J. M A, Geerlings, S. E., van Vugt, M., Pajkrt, D., Bos, J. C., van der Valk, M, Wiersinga, W. J., Goorhuis, A., Hovius, J. W R, Lowe, S., Oude Lashof, A., Posthouwer, D., Pronk, M. J H, Ammerlaan, H. S M, van der Ende, M. E., de Vries-Sluijs, T. E M S, Schurink, C. A M, Nouwen, J. L., van Gorp, E. C M, van der Feltz, M., Driessen, G. J A, van Rossum, A. M C, Branger, J., Schippers, E. F., van Nieuwkoop, C., van Elzakker, E. P., Groeneveld, P. H P, Bouwhuis, J. W., Soetekouw, R., ten Kate, R. W., Kroon, F. P., van Dissel, J. T., Arend, S. M., de Boer, M. G J, Jolink, H., Vollaard, A. M., Bauer, M. P., den Hollander, J. G., Pogany, K., van Twillert, G., Kortmann, W., Cohen Stuart, J. W T, Diederen, B. M W, Leyten, E. M S, Gelinck, L. B S, Kootstra, G. J., Delsing, C. E., Brinkman, K., Blok, W. L., Frissen, P. H J, Schouten, W. E M, van den Berk, G. E L, van Kasteren, M. E E, Brouwer, A.E., Veenstra, J., Lettinga, K. D., Mulder, J. W., Vrouenraets, S. M E, Lauw, F. N., van Eeden, A., Verhagen, D. W M, Sprenger, H. G., Scholvinck, E. H., van Assen, S., Bierman, W. F W, Wilting, K. R., Stienstra, Y., Koopmans, P. P., Keuter, M., van der Ven, A. J A M, ter Hofstede, H. J M, Dofferhoff, A. S M, Warris, A., van Crevel, R., Hoepelman, A. I M, Mudrikova, T., Schneider, M. M E, Ellerbroek, P. M., Oosterheert, J. J., Arends, J. E., Wassenberg, M. W M, Barth, R. E., van Agtmael, M. A., Perenboom, R. M., Claessen, F. A P, Bomers, M., Peters, E.J.G., Geelen, S. P M, Wolfs, T. F W, Bont, L. J., Richter, C., van der Berg, J. P., Gisolf, E. H., van den Berge, M., Stegeman, A., van Vonderen, M. G A, van Houte, D. P F, Weijer, S., el Moussaoui, R., Winkel, C., Muskiet, F., Durand, A., and Voigt, R.

Published
2016

4. Virological responses to lamivudine or emtricitabine when combined with tenofovir and a protease inhibitor in treatment-naïve HIV-1-infected patients in the Dutch AIDS Therapy Evaluation in the Netherlands (ATHENA) cohort

Author

Epidemiology & Health Economics, MMB, MS Infectieziekten, Circulatory Health, Infection & Immunity, MS Interne Geneeskunde, Directie Raad van Bestuur, MMB Medische Staf, Infectieziekten patientenzorg, Other research (not in main researchprogram), Onderwijssecretariaat, Divisieleiding O&O, Child Health, CTI Bont, Infectieziekten onderzoek1 (Bont), Rokx, C., Gras, L., van de Vijver, D. A M C, Verbon, A., Rijnders, B. J A, Prins, J. M., Kuijpers, T. W., Scherpbier, H. J., van der Meer, J. T M, Wit, F. W M N, Godfried, M. H., Reiss, P., van der Poll, T., Nellen, F. J B, Lange, J. M A, Geerlings, S. E., van Vugt, M., Pajkrt, D., Bos, J. C., van der Valk, M, Wiersinga, W. J., Goorhuis, A., Hovius, J. W R, Lowe, S., Oude Lashof, A., Posthouwer, D., Pronk, M. J H, Ammerlaan, H. S M, van der Ende, M. E., de Vries-Sluijs, T. E M S, Schurink, C. A M, Nouwen, J. L., van Gorp, E. C M, van der Feltz, M., Driessen, G. J A, van Rossum, A. M C, Branger, J., Schippers, E. F., van Nieuwkoop, C., van Elzakker, E. P., Groeneveld, P. H P, Bouwhuis, J. W., Soetekouw, R., ten Kate, R. W., Kroon, F. P., van Dissel, J. T., Arend, S. M., de Boer, M. G J, Jolink, H., Vollaard, A. M., Bauer, M. P., den Hollander, J. G., Pogany, K., van Twillert, G., Kortmann, W., Cohen Stuart, J. W T, Diederen, B. M W, Leyten, E. M S, Gelinck, L. B S, Kootstra, G. J., Delsing, C. E., Brinkman, K., Blok, W. L., Frissen, P. H J, Schouten, W. E M, van den Berk, G. E L, van Kasteren, M. E E, Brouwer, A.E., Veenstra, J., Lettinga, K. D., Mulder, J. W., Vrouenraets, S. M E, Lauw, F. N., van Eeden, A., Verhagen, D. W M, Sprenger, H. G., Scholvinck, E. H., van Assen, S., Bierman, W. F W, Wilting, K. R., Stienstra, Y., Koopmans, P. P., Keuter, M., van der Ven, A. J A M, ter Hofstede, H. J M, Dofferhoff, A. S M, Warris, A., van Crevel, R., Hoepelman, A. I M, Mudrikova, T., Schneider, M. M E, Ellerbroek, P. M., Oosterheert, J. J., Arends, J. E., Wassenberg, M. W M, Barth, R. E., van Agtmael, M. A., Perenboom, R. M., Claessen, F. A P, Bomers, M., Peters, E.J.G., Geelen, S. P M, Wolfs, T. F W, Bont, L. J., Richter, C., van der Berg, J. P., Gisolf, E. H., van den Berge, M., Stegeman, A., van Vonderen, M. G A, van Houte, D. P F, Weijer, S., el Moussaoui, R., Winkel, C., Muskiet, F., Durand, A., Voigt, R., Epidemiology & Health Economics, MMB, MS Infectieziekten, Circulatory Health, Infection & Immunity, MS Interne Geneeskunde, Directie Raad van Bestuur, MMB Medische Staf, Infectieziekten patientenzorg, Other research (not in main researchprogram), Onderwijssecretariaat, Divisieleiding O&O, Child Health, CTI Bont, Infectieziekten onderzoek1 (Bont), Rokx, C., Gras, L., van de Vijver, D. A M C, Verbon, A., Rijnders, B. J A, Prins, J. M., Kuijpers, T. W., Scherpbier, H. J., van der Meer, J. T M, Wit, F. W M N, Godfried, M. H., Reiss, P., van der Poll, T., Nellen, F. J B, Lange, J. M A, Geerlings, S. E., van Vugt, M., Pajkrt, D., Bos, J. C., van der Valk, M, Wiersinga, W. J., Goorhuis, A., Hovius, J. W R, Lowe, S., Oude Lashof, A., Posthouwer, D., Pronk, M. J H, Ammerlaan, H. S M, van der Ende, M. E., de Vries-Sluijs, T. E M S, Schurink, C. A M, Nouwen, J. L., van Gorp, E. C M, van der Feltz, M., Driessen, G. J A, van Rossum, A. M C, Branger, J., Schippers, E. F., van Nieuwkoop, C., van Elzakker, E. P., Groeneveld, P. H P, Bouwhuis, J. W., Soetekouw, R., ten Kate, R. W., Kroon, F. P., van Dissel, J. T., Arend, S. M., de Boer, M. G J, Jolink, H., Vollaard, A. M., Bauer, M. P., den Hollander, J. G., Pogany, K., van Twillert, G., Kortmann, W., Cohen Stuart, J. W T, Diederen, B. M W, Leyten, E. M S, Gelinck, L. B S, Kootstra, G. J., Delsing, C. E., Brinkman, K., Blok, W. L., Frissen, P. H J, Schouten, W. E M, van den Berk, G. E L, van Kasteren, M. E E, Brouwer, A.E., Veenstra, J., Lettinga, K. D., Mulder, J. W., Vrouenraets, S. M E, Lauw, F. N., van Eeden, A., Verhagen, D. W M, Sprenger, H. G., Scholvinck, E. H., van Assen, S., Bierman, W. F W, Wilting, K. R., Stienstra, Y., Koopmans, P. P., Keuter, M., van der Ven, A. J A M, ter Hofstede, H. J M, Dofferhoff, A. S M, Warris, A., van Crevel, R., Hoepelman, A. I M, Mudrikova, T., Schneider, M. M E, Ellerbroek, P. M., Oosterheert, J. J., Arends, J. E., Wassenberg, M. W M, Barth, R. E., van Agtmael, M. A., Perenboom, R. M., Claessen, F. A P, Bomers, M., Peters, E.J.G., Geelen, S. P M, Wolfs, T. F W, Bont, L. J., Richter, C., van der Berg, J. P., Gisolf, E. H., van den Berge, M., Stegeman, A., van Vonderen, M. G A, van Houte, D. P F, Weijer, S., el Moussaoui, R., Winkel, C., Muskiet, F., Durand, A., and Voigt, R.

Published
2016

5. Clinical impact of a highly prevalent Pseudomonas aeruginosa clone in Dutch cystic fibrosis patients.

Author

de Vrankrijker, A. M. M., Brimicombe, R. W., Wolfs, T. F. W., Heijerman, H. G. M., van Mansfeld, R., van Berkhout, F. T., Willems, R. J. L., Bonten, M. J. M., and van der Ent, C. K.

Subjects
PSEUDOMONAS aeruginosa infections, CYSTIC fibrosis diagnosis, COLLAGEN diseases, PSEUDOMONADACEAE, LUNG diseases
Abstract

Studies suggest that infection with highly prevalent Pseudomonas aeruginosa clones in cystic fibrosis (CF) is associated with an unfavourable clinical outcome. We studied the clinical characteristics of patients infected with a recently described, highly prevalent P. aeruginosa clone (ST406) in two CF centres in The Netherlands. Multilocus sequence typing data were available for 219 patients, of whom 40 (18.3%) were infected with ST406 and 179 with other sequence types. ST406 infection was independently associated with age, having a sibling with ST406 infection and use of inhaled antibiotics, but not with unfavourable clinical outcome, suggesting that high transmissibility is not necessarily associated with high virulence. [ABSTRACT FROM AUTHOR]

Published
2015
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6. Pneumococcal immune adherence to human erythrocytes.

Author

Hament, J.-M., van Dijk, H., Fleer, A., Aerts, P. C., Schoenmakers, M., de Snoo, M. W., Th. Dekker, B. H. A., Kimpen, J. L. L., and Wolfs, T. F. W.

Subjects
CELL adhesion, SEPSIS, LECTINS, STREPTOCOCCUS pneumoniae
Abstract

Abstract Background Human red blood cells bind various C3b-coated microorganisms via their C3b/CR1 receptor, a phenomenon referred to as immune adherence. The aim of the present study was to measure pneumococcal adherence to human red blood cells by flow cytometry and to study kinetic aspects of this binding. Material and methods We quantified pneumococcal adherence to human erythrocytes by FACS analysis and tested the involvement of antibodies and complement activation in this process. Results Pneumococci are able to bind to human red blood cells in the presence of human serum. Coating with C3b/C4b appeared obligatory for pneumococcal adherence to red blood cells. The ligand on erythrocytes was confirmed to be complement receptor 1. Kinetic studies showed that innate (mannose-binding lectin) and specific immune factors (IgG antibodies) contributed to the binding of C3b-coated pneumococci to human erythrocytes. After initial binding, serum-derived factor I was found to induce bacterial detachment from the erythrocyte. Conclusions Pneumococci are able to adhere to red blood cells. Both the classical and lectin complement pathways are important for optimal C3b-coating of pneumococci for immune adherence. Bound pneumococci are detached from red blood cells by factor I. These findings are in line with the hypothesis of immune adherence in which human erythrocytes are able to bind pneumococci and target the bacteria to the reticulo-endothelial system in the spleen. [ABSTRACT FROM AUTHOR]

Published
2003
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7. International opinions and national surveillance suggest insufficient consensus regarding the recognition and management practices of infants with congenital cytomegalovirus infections.

Author

Gunkel J, Nijman J, Verboon-Maciolek MA, Wolfs T, and de Vries LS

Subjects
Antiviral Agents therapeutic use, Cytomegalovirus Infections diagnosis, Cytomegalovirus Infections epidemiology, Cytomegalovirus Infections therapy, Female, Hearing Tests, Humans, Infant, Infant, Newborn, Mass Screening, Neonatology standards, Netherlands epidemiology, Neuroimaging, Pregnancy, Surveys and Questionnaires, Cytomegalovirus Infections congenital, Neonatology statistics & numerical data
Abstract

Aim: This study evaluated the recognition and management practices with regard to congenital cytomegalovirus (cCMV) infections by a select group of experts and through a national surveillance study., Method: A questionnaire was sent to international experts involved in mother and infant care in 2014-2015. Monthly surveillance was conducted among Dutch paediatricians for cases of cCMV infections from 2013 until 2015., Results: The questionnaire was completed by 63/103 (62%) respondents, who indicated that recognition and management practices varied. Maternal screening was performed by 17/63 (27%) and infant screening by 3/61 (5%) of the respondents. Infant CMV diagnostics were most frequently initiated due to hepatosplenomegaly and/or an increase in liver transaminases. Management practices included cranial ultrasound (57/63, 91%) and audiological follow-up in symptomatic (61/63, 97%) and asymptomatic (52/63, 83%) infants. In terms of antiviral treatment, 46/63 (73%) treated symptomatic infants only and 6/63 (9%) treated all infected infants. In total, 48 cases were registered through the Dutch surveillance study and 43/48 (90%) infants were symptomatic., Conclusion: This study indicates that infants with cCMV infection were insufficiently recognised and highlights the need for consensus on management practices. Screening of infants and the development of an international management guideline are recommended., (©2017 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.)

Published
2017
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