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Start Over Author "Wiegertjes, Kim" Publisher wiley-blackwell
3 results on '"Wiegertjes, Kim"'

1. Alterations and test–retest reliability of functional connectivity network measures in cerebral small vessel disease

Author

Gesierich, Benno, Tuladhar, Anil Man, Telgte, Annemieke, Wiegertjes, Kim, Konieczny, Marek J., Finsterwalder, Sofia, Hübner, Mathias, Pirpamer, Lukas, Koini, Marisa, Abdulkadir, Ahmed, Franzmeier, Nicolai, Norris, David G., Marques, José P., Zu Eulenburg, Peter, Ewers, Michael, Schmidt, Reinhold, Leeuw, Frank‐Erik, and Duering, Marco

Subjects
610 Medicine & health
Abstract

While structural network analysis consolidated the hypothesis of cerebral small vessel disease (SVD) being a disconnection syndrome, little is known about functional changes on the level of brain networks. In patients with genetically defined SVD (CADASIL, n = 41) and sporadic SVD (n = 46), we independently tested the hypothesis that functional networks change with SVD burden and mediate the effect of disease burden on cognitive performance, in particular slowing of processing speed. We further determined test-retest reliability of functional network measures in sporadic SVD patients participating in a high-frequency (monthly) serial imaging study (RUN DMC-InTENse, median: 8 MRIs per participant). Functional networks for the whole brain and major subsystems (i.e., default mode network, DMN; fronto-parietal task control network, FPCN; visual network, VN; hand somatosensory-motor network, HSMN) were constructed based on resting-state multi-band functional MRI. In CADASIL, global efficiency (a graph metric capturing network integration) of the DMN was lower in patients with high disease burden (standardized beta = -.44; p [corrected] = .035) and mediated the negative effect of disease burden on processing speed (indirect path: std. beta = -.20, p = .047; direct path: std. beta = -.19, p = .25; total effect: std. beta = -.39, p = .02). The corresponding analyses in sporadic SVD showed no effect. Intraclass correlations in the high-frequency serial MRI dataset of the sporadic SVD patients revealed poor test-retest reliability and analysis of individual variability suggested an influence of age, but not disease burden, on global efficiency. In conclusion, our results suggest that changes in functional connectivity networks mediate the effect of SVD-related brain damage on cognitive deficits. However, limited reliability of functional network measures, possibly due to age-related comorbidities, impedes the analysis in elderly SVD patients.

Published
2020

2. Erratum to 'Contribution of acute infarcts to cerebral small vessel disease progression'

Author

Telgte, Annemieke ter, Wiegertjes, Kim, Klijn, 3 Catharina J. M., Dichgans, Martin, Tuladhar, Anil M., Duering, Marco, Leeuw, Frank-Erik de, Gesierich, Benno, Marques, José P., Huebner, Mathias, de Klerk, Jabke J., Schreuder, Floris H. B. M., Araque Caballero, Miguel Angel, Kuijf, Hugo J., and Norris, David G.

Subjects
ddc:610
Abstract

Cerebral small vessel disease (SVD) constitutes the mainvascular cause of cognitive impairment and dementia,and accounts for about one-fifth of all strokes.1,2 SVD is further associated with gait impairment, mood disturbances, andlate-life disability.3 Conventional magnetic resonance imaging (MRI) markers of SVD include white matter hyperintensities(WMH), lacunes, and cerebral microbleeds, with WMHbeing the most widely studied.2 Traditionally, WMH havebeen attributed to chronic cerebral hypoperfusion. However,evidence for this hypothesis remains inconclusive.4,5

Published
2019

3. Contribution of acute infarcts to cerebral small vessel disease progression.

Author

Telgte, Annemieke, Wiegertjes, Kim, Gesierich, Benno, Marques, José P., Huebner, Mathias, Klerk, Jabke J., Schreuder, Floris H. B. M., Araque Caballero, Miguel A., Kuijf, Hugo J., Norris, David G., Klijn, Catharina J. M., Dichgans, Martin, Tuladhar, Anil M., Duering, Marco, Leeuw, Frank‐Erik, Ter Telgte, Annemieke, de Klerk, Jabke J, and de Leeuw, Frank-Erik

Subjects
*CEREBRAL small vessel diseases, *DISEASE progression, *DIFFUSION magnetic resonance imaging, *MAGNETIC resonance imaging, *BRAIN, *CEREBRAL hemorrhage, *COMPARATIVE studies, *INFARCTION, *RESEARCH methodology, *MEDICAL cooperation, *NEURORADIOLOGY, *RESEARCH, *EVALUATION research, *DISEASE incidence, *LACUNAR stroke, *DISEASE complications
Abstract

Objective: To determine the contribution of acute infarcts, evidenced by diffusion-weighted imaging positive (DWI+) lesions, to progression of white matter hyperintensities (WMH) and other cerebral small vessel disease (SVD) markers.Methods: We performed monthly 3T magnetic resonance imaging (MRI) for 10 consecutive months in 54 elderly individuals with SVD. MRI included high-resolution multishell DWI, and 3-dimensional fluid-attenuated inversion recovery, T1, and susceptibility-weighted imaging. We determined DWI+ lesion evolution, WMH progression rate (ml/mo), and number of incident lacunes and microbleeds, and calculated for each marker the proportion of progression explained by DWI+ lesions.Results: We identified 39 DWI+ lesions on 21 of 472 DWI scans in 9 of 54 subjects. Of the 36 DWI+ lesions with follow-up MRI, 2 evolved into WMH, 4 evolved into a lacune (3 with cavity <3mm), 3 evolved into a microbleed, and 27 were not detectable on follow-up. WMH volume increased at a median rate of 0.027 ml/mo (interquartile range = 0.005-0.073), but was not significantly higher in subjects with DWI+ lesions compared to those without (p = 0.195). Of the 2 DWI+ lesions evolving into WMH on follow-up, one explained 23% of the total WMH volume increase in one subject, whereas the WMH regressed in the other subject. DWI+ lesions preceded 4 of 5 incident lacunes and 3 of 10 incident microbleeds.Interpretation: DWI+ lesions explain only a small proportion of the total WMH progression. Hence, WMH progression seems to be mostly driven by factors other than acute infarcts. DWI+ lesions explain the majority of incident lacunes and small cavities, and almost one-third of incident microbleeds, confirming that WMH, lacunes, and microbleeds, although heterogeneous on MRI, can have a common initial appearance on MRI. ANN NEUROL 2019;86:582-592. [ABSTRACT FROM AUTHOR]

Published
2019
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