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Summary: A blueberry–grape–pineapple–cantaloupe juice blend was copigmented with gallic acid (GA) firstly and treated by high‐pressure processing (HPP) at 550 MPa, 25 °C for 5 min, ultrasound (US) at 520 W, 40 °C for 10 min, or heat treatment (HT) at 90 °C for 3 min to determine their influence on its physicochemical qualities. The shelf lives of HPP‐, US‐ and HT‐juice blends were 72, 48 and 88 days, respectively. The total anthocyanins (ACs), ascorbic acid and total phenols content in juice blends treated by HPP, US and HT did not change immediately after treatment or during the first 16 days' storage. However, after the three treatments, the total ACs, ascorbic acid and total phenols content in juice blends decreased in the following order after 16 days: US > HPP > HT. The HPP‐ and US‐treated juices were superior to the HT‐treated juices regarding flavour, and in the preservation of more types and relative content of esters and aldehydes. In conclusion, GA improved the total ACs and ascorbic acid stability in the juice, while the flavour of the HPP‐ and US‐treated juices surpasses that of HT‐treated juice. Therefore, the HPP treatment was deemed to be more advantageous and had greater market potential for short‐term storage. [ABSTRACT FROM AUTHOR]

The CML patient developed myeloid blast crisis 18 months after the initial diagnosis of CML; the MPN-U patient developed accelerated phase of disease 24.1 months after initial diagnosis (Figure B S2 b ). Of the four patients alive at last follow-up, one patient had AML transforming from MDS with a follow-up time of 20.6 months and three were in complete remission including two patients who received allo-SCT. Keywords: acute myeloid leukaemia; EVI1; MECOM; MYC; myelodysplastic syndrome EN acute myeloid leukaemia EVI1 MECOM MYC myelodysplastic syndrome 604 608 5 07/27/22 20220801 NES 220801 I MYC i rearrangement can occur in various B-cell lymphomas, plasma cell neoplasm, rarely B or T cell lymphoblastic leukaemia, and blastic plasmacytoid dendritic cell neoplasm.1-6 However, the occurrence and significance of I MYC i rearrangement in other myeloid neoplasms have not been thoroughly investigated.7-13 Here, we assessed a cohort of 40 patients with 8q24/ I MYC i -rearranged myeloid neoplasms diagnosed from January 2009 through December 2020. [Extracted from the article]

Summary: This study investigated the effect of ultrafiltration (UF) combined with high‐pressure processing (HPP) at 550 MPa, 25 °C for 5 min, ultrasound (US) at 520 W, 40 °C for 10 min and heat treatment (HT) at 90 °C for 3 min on the microbial, physicochemical and sensory properties of a blueberry–grape–pineapple–cantaloupe juice blend during 104 days of storage at 4 °C. After UF, the shelf life of the HPP‐ and US‐treated clear juice blends were 104 and 72 days during the storage at 4 °C respectively. HPP, US and HT treatment minimally affected the anthocyanin and total phenol contents, while HPP better maintained the ascorbic acid levels and sensory properties in the clear juice blend during the storage. Therefore, HPP combined with UF was identified as a prospective processing technique in the fruit juice industry. [ABSTRACT FROM AUTHOR]

Summary: Effects of ultrasound combined with high hydrostatic pressure (HHP) on physicochemical properties,microorganisms and storage attributes of cold brew tea were investigated. HHP at 400 MPa/5 min/25 °C inactivated the total aerobic bacteria, yeast and mould in cold brewed tea prepared by static brewing (SB‐tea) at 13 h/4 °C, ultrasonic bath (UB‐tea) at 150 W/120 min/0 °C and ultrasonic pulveriser (UP‐tea) at 600 W/40 min/0 °C, ensuring their microbiological safety. The results showed that there was no significant difference in the concentration of tea polyphenols between hot brewed tea prepared by 7 min/100 °C and cold brewed tea under different preparation conditions, while the caffeine in cold brewed tea was significantly lower (P < 0.05) than that in hot brewed tea. During the storage period of 8 days, compared with the untreated group, the cold brewed tea after HHP treatment had better microbiological safety. In addition, HHP treatment constantly maintained the tea polyphenols, pH, colour, antioxidant capacity and turbidity in cold brewed tea. The untreated and HHP‐treated cold brew tea were evaluated by 20 trained volunteers. Results showed that UB‐tea was more close to SB‐tea than UP‐tea in sensory profile, while HHP seem to maintain a good sensory profile as well. Therefore, this particular combined technology of ultrasonic bath and HHP displayed considerable potential for application in the cold brew tea manufacturing industry. [ABSTRACT FROM AUTHOR]

The frequent occurrence of casing failure has significantly affected the development of shale gas in the Sichuan Basin. Based on engineering and geology analyses, natural fracture/fault slip leads to casing shear deformation during hydraulic fracturing. Hence, natural fracture/fault slip and casing‐cement sheath‐formation assembly finite element models were established to quantitatively examine the characteristics of natural fracture/fault slip and mechanisms of casing shear deformation. Many factors, such as formation elastic property, in situ stress, natural fracture/fault geometry property, fluid pressure, casing elastic property, cement sheath elastic property, and well trajectory, were considered. The simulated results were in good agreement with the field data. The results indicated that natural fracture/fault slip leads to a sharp increase in casing deformation and stress in the adjacent region. Furthermore, factor sensitivity analysis results showed that a higher fluid pressure, larger fracture length, larger fracture dip angle, higher in situ stress difference, lower formation Young's modulus, and shorter distance from the wellbore to the center of the slip surface lead to severe casing stress and deformation. The countermeasures for preventing casing shear deformation involve decreasing the fracturing treatment pressure, reducing the crossing angle between the wellbore and natural fracture/fault, maintaining a safe distance from the wellbore to the large fracture/fault center, and adopting "balanced stress" fracturing operation. Hence, this study proposes a reasonable method to evaluate casing shear damage under hydraulic fracturing. [ABSTRACT FROM AUTHOR]

This paper provides the first direct evidence of the impact of enforcing insider regulations on the informativeness of insider trades and stock price efficiency across 44 countries with varying levels of insider trading regulations. Results suggest that insider purchases earn abnormal profits, especially in countries with active enforcement of insider trading regulations. We further show that while insiders trade less before earnings announcements in countries with active enforcement, their stock prices react more to earnings news than those in countries without active enforcement. Overall, our results support the view that effective insider trading regulation promotes price efficiency. [ABSTRACT FROM AUTHOR]

In this article, we examine commonality in liquidity of firms headquartered in the same states and how the local liquidity commonality is influenced by firm‐ and state‐level characteristics. We document strong liquidity comovement of nearby firms. Moreover, firms that change headquarters location experience a decrease in their liquidity commonality with firms in the old states and an increase in their liquidity commonality with firms in the new states. Our findings show that both firm‐ and state‐level characteristics determine local liquidity comovement. Local liquidity commonality is stronger for firms with smaller size and lower level of institutional ownership. Our results also suggest that state‐level volatility, state personal income, state investment income, and state turnover commonality explain the local component of liquidity commonality. We further document that the four state‐level factors perform differently during volatile market periods. [ABSTRACT FROM AUTHOR]

Shale gas reservoirs contain a large number of natural fractures. When shear slip occurs during hydraulic fracturing, it will increase reservoir permeability and improve the reservoir stimulation performance. Because shale contains a large amount of clay and organic matter, its shear slip behavior differs from that of other rocks. In this study, the shear behavior of different shale blocks is experimentally studied, and the proportion of clay and organic matter in the shale dominates the shear slip behavior. Specifically, the friction coefficient and shear strength decrease with the increasing content of clay and organic matter. A microscopic support model was developed to describe the different shear slip behaviors for different contents of clay and organic matter. When the clay and organic matter content is lower than a critical threshold (~35%), shale is microscopically grain supported and brittle shear occurs and the material is prone to shear dilation. When this content is greater than a critical content (~43%), the microscopic structure is a matrix‐supported fabric and plastic shear occurs, which is prone to shear contraction. Shale with contents between these two critical thresholds has a mixed‐support fabric, which is a transition type between brittle and plastic shear. If the proportion of clay and organic matter is less than ~35%, the natural fracture tends to dilate and retain a certain degree of opening after shearing, improving stimulation performance. When the proportion is more than ~43%, shear contraction occurs on the natural fracture surface, which is not conductive and cannot increase reservoir permeability. Key Points: Friction coefficient and shear strength decrease with increasing proportion of clay and organic matterDeveloped microscopic support model to describe different shear slip behaviors for different proportions of clay and organic matterLower clay content is easy to dilate after shear slip, thus improving reservoir permeability [ABSTRACT FROM AUTHOR]

Abstract: A fundamental question in rock physics is how the coupling of confining stress and pore pressure influences geophysical properties, which is manifested by the effective stress behavior of the porous rock. We investigated the effective stress behavior of four water‐saturated limestones with porosities ranging from 13% to 30%. Unlike previous experimental studies limited to the permeability, we also characterized the effective stress coefficients for pore volume change and bulk strain. The pore spaces of three of the limestones (two allochemical oolitic and one micritic) have significant fractions of macropores and micropores. In these three limestones with dual porosity the effective stress coefficients for permeability and pore volume change were observed to be consistently greater than 1, even though that for axial strain was less than 1. In a microscopically homogeneous assemblage, the effective stress coefficients for permeability, bulk volumetric strain, and pore volume change are predicted to be equal to or less than unity. Our data therefore show that these limestones cannot be modeled as microscopically homogeneous. Berryman (1992a, https://doi.org/10.1029/92JB01593) and Berryman (1992b, https://doi.org/10.1103/PhysRevA.46.3307) analyzed theoretically a rock made up of two porous constituents, and our experimental data are in agreement with inequalities he derived for effective stress coefficients of such an assemblage. For comparison, we studied the Leitha limestone that is made up predominately of macropores. Our data showed that all three effective stress coefficients in this case were less than unity, as predicted for a microscopically homogeneous assemblage. [ABSTRACT FROM AUTHOR]

Nanoflower‐like composites have greater contact area and more redox reactive centers, which have great potential in the application of electrode materials for supercapacitors. A nonconductive polymer binder is usually used in preparation of electrodes, which causes an increase in interface resistance and a decrease in material active sites. Here, polyaniline (PANI) and ZIF‐9 are directly grown on the Ni foam (ZIF‐9@PANI/NF) by a simple solvothermal method without a nonconductive polymer binder. A nanoflower array is grown on the NF, which can be directly used as electrode material of supercapacitor. The attachment of PANI facilitates electron transfer and increases the conductivity of the material. At a current density of 1 A g−1, the specific capacitance is up to 7 times that of the ZIF‐9. The assembled asymmetric supercapacitor has a high energy density of 52 Wh kg−1 at a power density of 800 W kg−1, remaining 90.1% after 50 000 cycles. These great electrochemical properties show the material has good market development prospects for energy storage device. [ABSTRACT FROM AUTHOR]