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Chiral Ti salalen complexes catalyze the asymmetric epoxidation of terminal non-conjugated olefins with hydrogen peroxide. Modular ligands based on cis-1,2-diaminocyclohexane (cis-DACH) were developed, giving high yields and enantiomeric excesses (ee, up to 96%) at catalyst loadings as low as 0.1-0.5mol%, and even under solvent-free conditions. [ABSTRACT FROM AUTHOR]

Hilfe für schwer Epoxidierbare: Terminale nicht ‐ konjugierte Olefine wie 1 ‐ Octen sind „schwierige“ Substrate für die asymmetrische Epoxidierung. Von cis ‐ 1,2 ‐ Diaminocyclohexan (cis ‐ DACH) abgeleitete Ti ‐ Salalen ‐ Komplexe katalysieren diese anspruchsvolle Reaktion mit guten Ausbeuten und hoher Enantioselektivität (bis zu 95 % ee) und mit H2O2 als Oxidationsmittel. Röntgenstrukturanalysen der μ ‐ Oxo ‐ und Peroxokomplexe beleuchten das Koordinationsverhalten der neuen Liganden. [ABSTRACT FROM AUTHOR]

Help for the neglected: Terminal, non‐conjugated olefins, such as 1‐octene, are difficult to epoxidize asymmetrically. Ti salalen complexes based on cis‐1,2‐diaminocyclohexane catalyze this demanding reaction giving high yields and enantioselectivities (up to 95 % ee), with H2O2 as the oxidant. The X‐ray structures of the μ‐oxo and peroxo complexes shed light on the coordination behavior of this novel class of ligands. [ABSTRACT FROM AUTHOR]

The article presents a study investigating the preparation and characterization of a positive thermoresponsive hydrogel for drug loading and release with ibuprofen (IBU) as the model drug. The hydrogel was synthesized with the sequential interpenetrating polymer network (IPN) method. Results confirmed that the IPN hydrogel could improve drug loading and provide a positive drug release pattern with a rapid drug release rate at a high temperature and a slow drug release rate at a low temperature.

The article presents chemical equations related to the article "Titanium cis-1,2-Diaminocyclohexane (cis-DACH) Salalen Catalysts for the Asymmetric Epoxidation of Terminal Non-conjugated Olefins with Hydrogen Peroxide" by Q. Wang and others, published in the "Chemistry: A European Journal" in 2015.

Hilfe für schwer Epoxidierbare: Terminale nicht ‐ konjugierte Olefine wie 1 ‐ Octen sind „schwierige“ Substrate für die asymmetrische Epoxidierung. Von cis ‐ 1,2 ‐ Diaminocyclohexan (cis ‐ DACH) abgeleitete Ti ‐ Salalen ‐ Komplexe katalysieren diese anspruchsvolle Reaktion mit guten Ausbeuten und hoher Enantioselektivität (bis zu 95 % ee) und mit H2O2 als Oxidationsmittel. Röntgenstrukturanalysen der μ ‐ Oxo ‐ und Peroxokomplexe beleuchten das Koordinationsverhalten der neuen Liganden. [ABSTRACT FROM AUTHOR]

Help for the neglected: Terminal, non‐conjugated olefins, such as 1‐octene, are difficult to epoxidize asymmetrically. Ti salalen complexes based on cis‐1,2‐diaminocyclohexane catalyze this demanding reaction giving high yields and enantioselectivities (up to 95 % ee), with H2O2 as the oxidant. The X‐ray structures of the μ‐oxo and peroxo complexes shed light on the coordination behavior of this novel class of ligands. [ABSTRACT FROM AUTHOR]

This describes the first synthesis of various salalen ligands based on cis-diaminocyclohexane, the characterization of their Ti complexes, and their application in Ti-catalyzed asymmetric epoxidations. [ABSTRACT FROM AUTHOR]