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Magnetite (Fe3O4) has a large theoretical reversible capacity and rich Earth abundance, making it a promising anode material for LIBs. However, it suffers from drastic volume changes during the lithiation process, which lead to poor cycle stability and low‐rate performance. Hence, there is an urgent need for a solution to address the issue of volume expansion. Taking inspiration from how glycophyte cells mitigate excessive water uptake/loss through their cell wall to preserve the structural integrity of cells, we designed Fe3O4@PMMA multi‐core capsules by microemulsion polymerization as a kind of anode materials, also proposed a new evaluation method for real‐time repair effect of the battery capacity. The Fe3O4@PMMA anode shows a high reversible specific capacity (858.0 mAh g−1 at 0.1 C after 300 cycles) and an excellent cycle stability (450.99 mAh g−1 at 0.5 C after 450 cycles). Furthermore, the LiNi0.8Co0.1Mn0.1O2/Fe3O4@PMMA pouch cells exhibit a stable capacity (200.6 mAh) and high‐capacity retention rate (95.5 %) after 450 cycles at 0.5 C. Compared to the original battery, the capacity repair rate of this battery is as high as 93.4 %. This kind of bionic capsules provide an innovative solution for improving the electrochemical performance of Fe3O4 anodes to promote their industrial applications. [ABSTRACT FROM AUTHOR]

Nature has created various organisms with unique chemical components and multi‐scale structures (e.g., foot proteins, toe pads, suckers, setose gill lamellae) to achieve wet adhesion functions to adapt to their complex living environments. These organisms can provide inspirations for designing wet adhesives with mediated drug release behaviors in target locations of biological surfaces. They exhibit conformal and enhanced wet adhesion, addressing the bottleneck of weaker tissue interface adhesion in the presence of body fluids. Herein, it is focused on the research progress of different wet adhesion and bioinspired fabrications, including adhesive protein‐based adhesion and inspired adhesives (e.g., mussel adhesion); capillarity and Stefan adhesion and inspired adhesive surfaces (e.g., tree frog adhesion); suction‐based adhesion and inspired suckers (e.g., octopus' adhesion); interlocking and friction‐based adhesion and potential inspirations (e.g., mayfly larva and teleost adhesion). Other secreted protein‐induced wet adhesion is also reviewed and various suckers for other organisms and their inspirations. Notably, one representative application scenario of these bioinspired wet adhesives is highlighted, where they function as efficient drug delivery platforms on target tissues and/or organs with requirements of both controllable wet adhesion and optimized drug release. Finally, the challenges of these bioinspired wet drug delivery platforms in the future is presented. [ABSTRACT FROM AUTHOR]

Summary: This study aims to evaluate how β‐glucanase impacts dough characteristics, and the in vitro starch digestibility and quality of breads from mixed wheat and highland barley flour at different wheat/highland barley flour weight ratios (70/30 and 50/50). The results showed that β‐glucanase reduced the dough's viscoelasticity and enhanced its extensibility, softness, α‐helix (2.52%–16.12%), β‐sheet (11.10%–31.66%) and free sulfhydryl content (22.70%–34.49%). This helped to mitigate the negative effects of a high β‐glucan content on the wheat/highland barley dough (P < 0.05). Moreover, β‐glucanase improved the specific volume (44.67%–56.56%) and springiness (5.56%–40.41%) as well as reduced the hardness of wheat/highland barley bread (7.50%–71.32%). Furthermore, as the higher content of slowly digestible starch (20.81%–30.84%) reduced the enzymatic rate (k value), β‐glucanase‐treated wheat/highland barley bread exhibited lower starch digestibility (66.17%–71.16%) than white bread (75.37%). Therefore, this study indicated that β‐glucanase played an offsetting role on highland barley bread while maintaining relatively low starch digestibility. [ABSTRACT FROM AUTHOR]

Disease detection is critical throughout the consumer lifecycle. Effective communication not only influences consumers' motivation to participate in disease detection but also has a significant impact on prevention outcomes. While previous literature has examined the effectiveness of the gain frame versus the loss frame in motivating detection behaviors, existing studies have produced mixed results, with the underlying psychological process remaining unclear. The present research sheds light on these issues by examining the moderating role of age. Across four experiments, we demonstrate the interactive effects of age and message framing on the effectiveness of health communication advocating disease detection for prevention. We find that as age increases, gain‐framed disease detection appeals become more persuasive than loss‐framed appeals, and that information diagnosticity is one psychological mechanism driving this effect. This research contributes to the literature on framing effects, age differences in information processing, and health compliance persuasion. Our findings also provide insights into how to engage consumers of different ages in disease detection and subsequently enable better prevention and intervention. [ABSTRACT FROM AUTHOR]

Recently, metasurface‐based photodetectors (metaphotodetectors) have been developed and applied in various fields. Metasurfaces are artificial materials with unique properties that have emerged over the past decade, and photodetectors are powerful tools used to quantify incident electromagnetic wave information by measuring changes in the conductivity of irradiated materials. Through an efficient microstructural design, metasurfaces can effectively regulate numerous characteristics of electromagnetic waves and have demonstrated unique advantages in various fields, including holographic projection, stealth, biological image enhancement, biological sensing, and energy absorption applications. Photodetectors play a crucial role in military and civilian applications; therefore, efficient photodetectors are essential for optical communications, imaging technology, and spectral analysis. Metaphotodetectors have considerably improved sensitivity and noise‐equivalent power and miniaturization over conventional photodetectors. This review summarizes the advantages of metaphotodetectors based on five aspects. Furthermore, the applications of metaphotodetectors in various fields including military and civil applications, are systematically discussed. It highlights the potential future applications and developmental trends of metasurfaces in metaphotodetectors, provides systematic guidance for their development, and establishes metasurfaces as a promising technology. [ABSTRACT FROM AUTHOR]

Through evolution, biological organisms have developed ways to sense light using ion channels, which holds several advantages, such as energy efficiency and water resistance, over humanmade optoelectronic devices. Herein, a retina‐inspired nanofluidic system is presented with a Janus heterogeneous membrane (J‐HM), which can achieve underwater visual imaging through light‐driven active ion transport. The J‐HMs are obtained through sequentially assembled WS2, and a kind of metal–organic framework nanosheets via the reaction between 2,3,6,7,10,11‐hexahydroxytriphenylene hydrate (HHTP) and Cu2+ (Cu‐HHTP). Due to the formed intramembrane electric field caused by the efficient charge separation under illumination, a photovoltaic driving force is generated for active ion transport from Cu‐HHTP to WS2. Furthermore, the unidirectionally active ion transport can be enhanced by self‐diffusion under a concentration gradient. The J‐HM with a single‐pixel design shows a nearly linear response with light intensity and has enough resolution for basic object recognition as well as a long‐term memory after data processing using a defined pixelated matrix, which can pave an avenue for designing more intelligent sensing systems. [ABSTRACT FROM AUTHOR]

BACKGROUND: Enshi Yulu tea (ESYL) is the most representative of steamed green tea in China, but its aroma formation in processing is unclear. Thus, the ESYL volatiles during the whole industrial processing were investigated using headspace solid‐phase microextraction coupled with gas chromatography–mass spectrometry. RESULTS: A total of 134 volatiles were identified. Among these, 31 differential volatiles [P < 0.05 and variable importance in projection (VIP) > 1] and 25 key volatiles [relative odor activity value (rOAV) and/or the ratio of each rOAV to the maximum rOAV (ROAV) > 1.0] were screened out, wherein β‐ionone and nonanal were the most key odorants. Besides, the sensory evaluation combined with multivariate statistical analysis of volatiles pinpointed spreading, fixation, first drying, and second drying as the key processing steps that have a pronounced influence on the aroma quality of ESYL. Furthermore, the oxidative degradation of unsaturated fatty acids, synthesis of monoterpenes, and degradation of carotenoids were the main metabolic pathway for the formation of key odorants. CONCLUSION: The study provides comprehensive insights into the volatile characteristics during the industrial processing of ESYL and promote our understanding of the aroma formation in steamed green teas. © 2024 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

Repeat consumption, a common aspect of consumers' daily lives, often results in hedonic adaptation such as satiation or boredom. In line with a growing body of research exploring methods to alleviate hedonic adaptation, this research proposes and finds that creative thinking can effectively reduce hedonic adaptation. Through five experiments conducted across various consumption contexts (music listening, video watching, photograph viewing, snack eating), we show that creative thinking reduces hedonic adaptation by fostering cognitive flexibility during repeat consumption (e.g., enjoying the same photograph from different aspects across repetitions). Supporting this underlying mechanism, the mitigating effect of creative thinking on hedonic adaptation attenuates when consumers' cognitive flexibility is constrained, or when the product itself possesses sufficient complexity that naturally encourages cognitive flexibility over repetitions. Overall, this research sheds light on how creative thinking helps alleviate hedonic adaptation in repeat consumption, with implications for marketing managers and practitioners. [ABSTRACT FROM AUTHOR]

Phosphaphenalenes, extended π conjugates with the incorporation of phosphorus, are attractive avenues towards molecular materials for the applications in organic electronics, but their electron accepting ability have not been investigated. Herein we present systematic studies on the reductive behavior of a representative phosphaphenalene and its oxide by chemical and electrochemical methods. The chemical reduction of the phosphaphenalene by alkali metals reveals the facile P−C bond cleavage to form phosphaphenalenide anion, which functions as a transfer block for structure modification on the phosphorus atom. In contrast, the pentavalent P‐oxide reacts with one or two equivalents of elemental sodium to form stable radical anion and dianion salts, respectively. [ABSTRACT FROM AUTHOR]

Reactive oxygen species (ROS) play a crucial role in determining photocatalytic reaction pathways, intermediate species, and product selectivity. However, research on ROS regulation in polymer photocatalysts is still in its early stages. Herein, we successfully achieved series of modulations to the skeleton of Pyrene‐alkyne‐based (Tetraethynylpyrene (TEPY)) conjugated porous polymers (CPPs) by altering the linkers (1,4‐dibromobenzene (BE), 4,4′‐dibromobiphenyl (IP), and 3,3′‐dibromobiphenyl (BP)). Experiments combined with theoretical calculations indicate that BE‐TEPY exhibits a planar structure with minimal exciton binding energy, which favors exciton dissociation followed by charge transfer with adsorbed O2 to produce ⋅O2−. Thus BE‐TEPY shows optimal photocatalytic activity for phenylboronic acid oxidation and [3+2] cycloaddition. Conversely, the skeleton of BP‐TEPY is significantly distorted. Its planar conjugation decreases, intersystem crossing (ISC) efficiency increases, which makes it more prone for resonance energy transfer to generate 1O2. Therefore, BP‐TEPY displays best photocatalytic activity in [4+2] cycloaddition and thioanisole oxidation. Both above reactant conversion and its product selectivity exceed 99 %. This work systematically reveals the intrinsic structure–activity relationship among the skeleton structure of CPPs, excitonic behavior, and selective generation of ROS, providing new insights for the rational design of highly efficient and selective CPPs photocatalysts. [ABSTRACT FROM AUTHOR]

Intrinsic plasticity, a fundamental process enabling neurons to modify their intrinsic properties, plays a crucial role in shaping neuronal input‐output function and is implicated in various neurological and psychiatric disorders. Despite its importance, the underlying molecular mechanisms of intrinsic plasticity remain poorly understood. In this study, a new ubiquitin ligase adaptor, protein tyrosine phosphatase receptor type N (PTPRN), is identified as a regulator of intrinsic neuronal excitability in the context of temporal lobe epilepsy. PTPRN recruits the NEDD4 Like E3 Ubiquitin Protein Ligase (NEDD4L) to NaV1.2 sodium channels, facilitating NEDD4L‐mediated ubiquitination, and endocytosis of NaV1.2. Knockout of PTPRN in hippocampal granule cells leads to augmented NaV1.2‐mediated sodium currents and higher intrinsic excitability, resulting in increased seizure susceptibility in transgenic mice. Conversely, adeno‐associated virus‐mediated delivery of PTPRN in the dentate gyrus region decreases intrinsic excitability and reduces seizure susceptibility. Moreover, the present findings indicate that PTPRN exerts a selective modulation effect on voltage‐gated sodium channels. Collectively, PTPRN plays a significant role in regulating intrinsic excitability and seizure susceptibility, suggesting a potential strategy for precise modulation of NaV1.2 channels' function. [ABSTRACT FROM AUTHOR]

Global attention is riveted on neurodegenerative diseases due to their unresolved aetiologies and lack of efficacious therapies. Two key factors implicated include mitochondrial impairment and microglial ageing. Several viral infections, including Herpes simplex virus‐1 (HSV‐1), human immunodeficiency virus (HIV) and Epstein‐Barr virus, are linked to heightened risk of these disorders. Surprisingly, numerous studies indicate viruses induce these aforementioned precipitating events. Epstein‐Barr virus, Hepatitis C Virus, HIV, respiratory syncytial virus, HSV‐1, Japanese Encephalitis Virus, Zika virus and Enterovirus 71 specifically impact mitochondrial function, leading to mitochondrial malfunction. These vital organelles govern various cell activities and, under specific circumstances, trigger microglial ageing. This article explores the role of viral infections in elucidating the pathogenesis of neurodegenerative ailments. Various viruses instigate microglial ageing via mitochondrial destruction, causing senescent microglia to exhibit activated behaviour, thereby inducing neuroinflammation and contributing to neurodegeneration. [ABSTRACT FROM AUTHOR]

Obstructive hypertrophic cardiomyopathy (oHCM) is a subtype of HCM characterized by left ventricular outflow tract obstruction resulting from cardiac muscle hypertrophy and anatomic alterations in the mitral valve and apparatus. Mavacamten, a cardiac myosin inhibitor metabolized primarily by CYP2C19 in the liver, is the first and only targeted medication approved for the treatment of symptomatic New York Heart Association (NYHA) class II–III oHCM. Previous pharmacokinetic (PK) results of mavacamten in healthy Caucasian, Japanese, and Asian participants demonstrated that mavacamten exposure was affected by CYP2C19 metabolism status. This open‐label, parallel‐group, phase I trial aimed to determine the PK and safety of mavacamten in healthy Chinese participants with different CYP2C19 genotypes. The primary outcome was to define the PK of mavacamten in healthy Chinese participants; the secondary outcome was to examine safety and tolerability. After a single oral dose of 15 or 25 mg mavacamten in fasted healthy adult Chinese individuals, Cmax was reached within a median Tmax of 0.6–1.5 h, indicating rapid absorption. Inter‐individual variability was moderate, and individuals carrying non‐functional CYP2C19 alleles (*2/*2, *3/*3, or *2/*3) exhibited longer half‐life and increased total exposure. After stratification of CYP2C19 genotypes, total mavacamten exposures were similar among different ethnic groups when compared with prior PK studies. No significant adverse events were observed in this study. Single oral administration of mavacamten at 15 mg was well tolerated across all CYP2C19 genotypes, and 25 mg dose was well tolerated in healthy participants with CYP2C19 genotypes UM/RM/NM. The PK profile of mavacamten in the healthy Chinese population was consistent with that in other healthy populations. [ABSTRACT FROM AUTHOR]

Differences in visual comfort between comfortable and uncomfortable luminance were explored on a smartphone. The results revealed that tiny changes in CFF and microsaccade parameters (pupil diameter, amplitude, and peak velocity) were presented at the comfortable luminance, inducing less eye discomfort. Particularly, CFF is an effective indicator of visual comfort and fatigue. [ABSTRACT FROM AUTHOR]

In this paper, the influence of parallax and image shape type on stereo vision perception is quantitatively explored by using RDS stimuli based on AR equipment through subjective scoring. Results show that an angular parallax amplitude between 0.6 ° and 1.2 ° can bring the best stereo sense. When amplitude ranged between 0 ° and 1.2°, the best visual comfort and the fastest image fusion speed could be achieved. [ABSTRACT FROM AUTHOR]

Facial expressions in infants have been noted to create a spatial attention bias when compared with adult faces. Yet, there is limited understanding of how adults perceive the timing of infant facial expressions. To investigate this, we used both infant and adult facial expressions in a temporal bisection task. In Experiment 1, we compared duration judgments of neutral infant and adult faces. The results revealed that participants felt that neutral infant faces lasted for a shorter time than neutral adult faces, independent of participant sex. Experiment 2 employed sad (crying) facial expressions. Here, the female participants perceived that the infants' faces were displayed for a longer duration than the adults' faces, whereas this distinction was not evident among the male participants. These findings highlight the influence of the babyface schema on time perception, nuanced by emotional context and sex‐based individual variances. [ABSTRACT FROM AUTHOR]

Pneumocystis jirovecii pneumonia and invasive pulmonary aspergillosis are both life‐threatening opportunistic fungal infections. There are only few reports of coinfection by these two fungi in the literature, and Aspergillus fumigatus is the predominant Aspergillus species in the coinfection. We report here the first case of coinfection by Aspergillus terreus and P. jirovecii pneumonia and caspofungin can be an appropriate choice for salvage treatment of the coinfection. A 51‐year‐old man with a history of immune thrombocytopenia treated with prednisone over 2 months was admitted to emergency intensive care unit for acute respiratory failure and a cavity was found on chest computed tomography. Therefore, his trachea was immediately intubated. The patient was treated with a large spectrum of antibiotic regimen, consisting initially of imipenem/cilastatin, moxifloxacin and fluconazole followed by fluconazole, imipenem/cilastatin, vancomycin, trimethoprim–sulphamethoxazole (TMP‐SMZ) and azithromycin. When the polymerase chain reaction analysis of the bronchoalveolar lavage sample revealed P. jirovecii and A. terreus, all the antibiotics were stopped except TMP‐SMZ, and voriconazole was added. Two weeks later, the patient showed clinical improvement but radiological deterioration. Consequently, caspofungin was started for salvage therapy, then the patient showed gradual clinical improvement. He was discharged with oral voriconazole and TMP‐SMZ. The antifungal treatment was continued for 6 months until complete radiological absorption. In conclusion, early bronchoscopy with bronchoalveolar lavage fluid should be considered in order to diagnose and treat promptly in those treated with corticosteroids combined with immunocompromised and caspofungin could be an appropriate choice for salvage treatment of coinfection by P. jirovecii and A. terreus. [ABSTRACT FROM AUTHOR]

Natural organisms have developed various biological ion channels/transporters to maintain normal life activities to adapt to changing environments. Significantly, ion transporters with active ion transport property show much more controllability on these activities due to a variety of external stimuli, giving guidance to construct artificial counterparts for overcoming the issues in simple nanofluidic systems restricted by self‐diffusive ion transport. Herein, a 2D nanofluidic system based on a Janus membrane (i.e., JM) is constructed, which can achieve light‐driven active ion transport and do favor for ionic power harvesting in electrolyte systems with equal concentrations. The JM is obtained through sequentially assembled montmorillonite (MMT) decorated with photoelectric molecules (i.e., PMMT) and MXene nanosheets. Due to the formed intramembrane electric field and temperature gradient caused by the efficient charge separation and localized thermal excitation under light illumination, a photovoltaic‐driven force and thermo‐osmotic are generated for preferential ion transport. In addition, the unidirectional active transport is employed to harvest ionic power, showing an output power density of 2.0 mW m−2 and a high‐performance energy conversion efficiency of 8.3 × 10−4%. The effects of the light intensity, electrolyte concentration and species on energy conversion performance are investigated, showing the university for ionic power harvesting. [ABSTRACT FROM AUTHOR]

Background and Objectives: Although both drugs and negative emotions can trigger drug craving or relapse in individuals with methamphetamine‐use disorder (MUD), it remains unclear whether individuals with MUD have attentional biases toward both drug and negative emotional cues and whether this bias involves attention orientation or difficulty in attention disengagement. This study aimed to measure different components of attentional bias toward drug‐related and negative emotional cues in individuals with MUD. Methods: Two dot‐probe tasks were used to investigate attentional bias toward drug (drug task) and negative emotional cues (emotion task) in individuals with MUD. Forty‐three males with MUD (average age of 43.44 ± 11.91 years, average drug‐use duration of 11.35 ± 8.39 years) participated in the study voluntarily. Results: There was a significant interaction between the task type and location (p =.01). Specifically, for drug cues, participants showed significant difficulty in attention disengagement toward drug cues (p =.01); however, no attention orientation (p =.46). For negative emotional cues, neither significant attention orientation (p =.07) nor significant difficulty in attention disengagement (p =.50) was found. Conclusions and Scientific Significance: Attentional bias in individuals with MUD was highly selective for drug cues; thus, difficulty in attention disengagement from drug cues can be considered a potential mediating mechanism for attentional bias modification interventions for individuals with MUD. This study served to generate hypotheses or suggest future experiments on interventions for individuals with MUD. [ABSTRACT FROM AUTHOR]

Severe pneumonia caused by respiratory viruses has become a major threat to humans, especially with the SARS‐CoV‐2 outbreak and epidemic. The aim of this study was to investigate the universal molecular mechanism of severe pneumonia induced by multiple respiratory viruses and to search for therapeutic strategies targeting this universal molecular mechanism. The common differential genes of four respiratory viruses, including respiratory syncytial virus (RSV), rhinovirus, influenza, and SARS‐CoV‐2, were screened by GEO database, and the hub gene was obtained by Sytohubba in Cytoscape. Then, the effect of hub genes on inflammasome and pyrodeath was investigated in the model of RSV infection in vitro and in vivo. Finally, through virtual screening, drugs targeting the hub gene were obtained, which could alleviate severe viral pneumonia in vitro and in vivo. The results showed that CMPK2 is one of the hub genes after infection by four respiratory viruses. CMPK2 activates the inflammasome by activating NLRP3, and promotes the releases of inflammatory factors interleukin (IL)‐1β and IL‐18 to induce severe viral pneumonia. Z25 and Z08 can reduce the expression level of CMPK2 mRNA and protein, thereby inhibiting NLRP3 and alleviating the development of severe viral pneumonia. In conclusion, the inflammatory response mediated by CMPK2 is the common molecular mechanism of severe pneumonia induced by viral infection, and Z25 and Z08 can effectively alleviate viral infection and severe pneumonia through this mechanism. [ABSTRACT FROM AUTHOR]

The image degradation owing to the absorption and scattering of optical propagation medium makes the non‐visualization and anamorphose in real image. The complex algorithms based on highly integrated hardware can restore degraded image while it causes inefficient serial operation and storage redundancy. One improved strategy is to parallel functional integration in front‐end visual perceptron. Here, a parallel photoelectron storage and visual preprocessing in nanowire perceptron to synchronously achieve image perception, visual memory, and in‐sensor preprocessing are demonstrated. This functional integration is originated from charge‐resolved storage in temporal or frequency domain under optical pulsed excitation due to cascaded defect engineering. The proposed system enhances the peak signal‐to‐noise ratio (PSNR) of degraded image from 152 to 181 dB by feature decompression and also has 7.2% of PSNR improvement by noise filtration. This system is validated to improved train accuracy of back‐end artificial neural network (ANN) by 32.8% and shorten its iteration period by 77.4%. [ABSTRACT FROM AUTHOR]

Background: Colon cancer is one of the most common digestive tract malignancies. Although immunotherapy has brought new hope to colon cancer patients, there is still a large proportion of patients who do not benefit from immunotherapy. Studies have shown that neutrophils can interact with immune cells and immune factors to affect the prognosis of patients. Methods: We first determined the infiltration level of neutrophils in tumors using the CIBERSORT algorithm and identified key genes in the final risk model by Spearman correlation analysis and subsequent Cox analysis. The risk score of each patient was obtained by multiplying the Cox regression coefficient and the gene expression level, and patients were divided into two groups based on the median of risk score. Differences in overall survival (OS) and progression‐free survival (PFS) were assessed by Kaplan–Meier survival analysis, and model accuracy was validated in independent dataset. Differences in immune infiltration and immunotherapy were evaluated by immunoassay. Finally, immunohistochemistry and western blotting were performed to verify the expression of the three genes in the colon normal and tumor tissues. Results: We established and validated a risk scoring model based on neutrophil‐related genes in two independent datasets, The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) database, with SLC11A1 and SLC2A3 as risk factors and MMP3 as a protective factor. A new nomogram was constructed and validated by combining clinical characteristics and the risk score model to better predict patients OS and PFS. Immune analysis showed that patients in the high‐risk group had immune cell infiltration level, immune checkpoint level and tumor mutational burden, and were more likely to benefit from immunotherapy. Conclusions: The low‐risk group showed better OS and PFS than the high‐risk group in the neutrophil‐related gene‐based risk model. Patients in the high‐risk group presented higher immune infiltration levels and tumor mutational burden and thus may be more responsive to immunotherapy. [ABSTRACT FROM AUTHOR]

In this study, a prediction model for visual fatigue is developed. As input, frequential and nonlinear features are extracted from multichannel EEG, and then dimensionally reduced. In the model, bidirectional LSTM and attention layers are combined for effective learning. As a result, 82.90% accuracy, 85.26% weighted precision, 82.90% weighted recall, and 84.02% weighted F1‐score were obtained. [ABSTRACT FROM AUTHOR]

Citrobacter braakii (C. braakii) is an anaerobic, gram‐negative bacterium that has been isolated from the environment, food, and humans. Infection by C. braakii has been associated with acute mucosal inflammation in the intestine, respiratory tract, and urinary tract. However, the pathogenesis of C. braakii in the gastric mucosa has not yet been clarified. In this study, the bacterium was detected in 35.5% (61/172) of patients with chronic gastritis (CG) and was closely associated with the severity of mucosal inflammation. Citrobacter braakii P1 isolated from a patient with CG exhibited urease activity and acid resistance. It contained multiple secretion systems, including a complete type I secretion system (T1SS), T5aSS and T6SS. We then predicted the potential pilus‐related adhesins. Citrobacter braakii P1 diffusely adhered to AGS cells and significantly increased lactate dehydrogenase (LDH) release; the adhesion rate and LDH release were much lower in HEp‐2 cells. Strain P1 also induced markedly increased mRNA and protein expression of IL‐8 and TNF‐α in AGS cells, and the fold increase was much higher than that in HEp‐2 cells. Our results demonstrate proinflammatory and cytotoxic role of C. braakii in gastric epithelial cells, indicating the bacterium is potentially involved in inducing gastric mucosa inflammation. [ABSTRACT FROM AUTHOR]

The molecular mechanisms of glioblastoma (GBM) are unclear, and the prognosis is poor. Spinster homolog 2 (SPNS2) is reportedly involved in pathological processes such as immune response, vascular development, and cancer. However, the biological function and molecular role of SPNS2 in GBM are unclear. SPNS2 is aberrantly low expressed in glioma. Survival curves, risk scores, prognostic nomograms, and univariate and multifactorial Cox regression analyses showed that SPNS2 is an independent prognostic indicator significantly associated with glioma progression and prognosis. Cell function assays and in vivo xenograft transplantation were performed that downregulation of SPNS2 promoted GBM cell growth, migration, invasion, epithelial–mesenchymal transition (EMT), anti‐apoptosis, drug resistance, and stemness, while overexpression of SPNS2 had the opposite effect. Meanwhile, the functional enrichment and signaling pathways of SPNS2 in the Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), and RNA sequencing were analyzed by Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene set enrichment analysis (GSEA). The above results were related to the inhibition of the PTEN/PI3K/AKT pathway by SPNS2. In addition, we predicted that SPNS2 is closely associated with immune infiltration in the tumor microenvironment by four immune algorithms, ESTIMATE, TIMER, CIBERSORT, and QUANTISEQ. In particular, SPNS2 was negatively correlated with the infiltration of most immune cells, immunomodulators, and chemokines. Finally, single‐cell sequencing analysis also revealed that SPNS2 was remarkably correlated with macrophages, and downregulation of SPNS2 promotes the expression of M2‐like macrophages. This study provides new evidence that SPNS2 inhibits malignant progression, stemness, and immune infiltration of GBM cells through PTEN/PI3K/AKT pathway. SPNS2 may become a new diagnostic indicator and potential immunotherapeutic target for glioma. [ABSTRACT FROM AUTHOR]

In order to better understand the impact of trade openness and foreign direct investment (FDI) on carbon neutrality (economic growth without increasing carbon emissions), linear fully modified ordinary least squares model and non‐linear panel threshold regression model are applied to explore the impact of trade openness and FDI on economic growth and carbon emissions in 114 countries. The results of the Tapio decoupling model showed that the decoupling between economic growth and carbon emissions is an M‐shaped from 2002‐2015, and a strong decoupling exists between them after 2015. The results from the linear model showed that FDI promotes both economic growth and carbon emissions. Trade openness promotes economic growth, but curbs the increase in carbon emissions. In other word, trade openness contributes to economic without increasing carbon emissions, which is conducive to achieving carbon neutrality. The results of the non‐linear model showed that when FDI crosses the threshold, the effect of FDI on economic growth first promotes and then inhibits and then promotes, the effect of FDI on promoting carbon emissions first increases and then decreases. When trade openness crosses the threshold, the promotion effect of trade openness on economic growth increases, while the inhibitory effect of trade openness on carbon emissions decreases. Finally, the policy implications are proposed. [ABSTRACT FROM AUTHOR]

Background: The ratio of nonhigh‐density lipoprotein cholesterol (non‐HDL‐C) to high‐density lipoprotein cholesterol (HDL‐C) has been shown associated with various metabolic diseases and atherosclerosis in primary prevention. However, there is limited evidence on the relationship between the non‐HDL‐C/HDL‐C ratio and progression of nonculprit coronary lesion (NCCL) after percutaneous coronary intervention (PCI). Hypothesis: Our study aimed to investigate the potential association between the non‐HDL‐C/HDL‐C ratio and NCCL progression in patients with acute coronary syndrome (ACS) undergoing PCI. Methods: We conducted a retrospective analysis of ACS patients who underwent coronary angiography twice at a single center from 2016 to 2022. Lipid measurements, demographic, clinical, and other laboratory data were collected from electronic medical records. NCCLs were evaluated using quantitative coronary angiography. The primary outcome was the progression of NCCL. Patients were categorized based on NCCL progression and tertiles of the non‐HDL‐C/HDL‐C ratio. Associations were analyzed using univariate and multivariate logistic regression analysis. Results: The study included 329 ACS patients who underwent PCI, with a median follow‐up angiography of 1.09 years. We found NCCL progression in 95 (28.9%) patients with acceptable low‐density lipoprotein cholesterol control (median: 1.81 mmol/L). Patients in the top tertile of the non‐HDL‐C/HDL‐C ratio had a higher risk of NCCL progression. After adjusting for potential confounding factors, the non‐HDL‐C/HDL‐C ratio remained a significant predictor for NCCL progression (adjusted odds ratio: 1.45; 95% confidence interval: 1.14–1.86; p < 0.05). Conclusions: The non‐HDL‐C/HDL‐C ratio predicts NCCL progression in ACS patients following PCI, providing a valuable tool for risk assessment and enhancing secondary prevention of atherosclerotic cardiovascular disease. [ABSTRACT FROM AUTHOR]

Sub‐surface scattering is always an important feature in translucent material rendering. When light travels through optically thick media, its transport within the medium can be approximated using diffusion theory, and is appropriately described by the bidirectional scattering‐surface reflectance distribution function (BSSRDF). BSSRDF methods rely on assumptions about object geometry and light distribution in the medium, which limits their applicability to general participating media problems. However, despite the high computational cost of path tracing, BSSRDF methods are often favoured due to their suitability for real‐time applications. We review these methods and discuss the most recent breakthroughs in this field. We begin by summarizing various BSSRDF models and then implement most of them in a 2D searchlight problem to demonstrate their differences. We focus on acceleration methods using BSSRDF, which we categorize into two primary groups: pre‐computation and texture methods. Then we go through some related topics, including applications and advanced areas where BSSRDF is used, as well as problems that are sometimes important yet are ignored in sub‐surface scattering estimation. In the end of this survey, we point out remaining constraints and challenges, which may motivate future work to facilitate sub‐surface scattering. [ABSTRACT FROM AUTHOR]

Harvesting renewable water energy in various formats such as raindrops, waves, and evaporation is one of the key strategies for achieving global carbon neutrality. The recent decade has witnessed rapid advancement of the droplet‐based electricity generator (DEG) with a continuous leap in the instantaneous output power density from 50 W/m2 to several kW/m2. Despite this, further pushing the upper limit of the output performance of DEG is still constrained by low surface charge density and long precharging time. Here, we report a DEG incorporating the Kelvin water dropper (K‐DEG) that can generate an ultrahigh instantaneous power density of 105 W/m2 upon one droplet impinging. In this design, the Kelvin water dropper continuously replenishes the high density of surface charges on DEG, while DEG fully releases these surface charges into electric output. K‐DEG with such a high output can directly light five 6‐W commercial lamps and even charge a cellphone by using falling droplets. [ABSTRACT FROM AUTHOR]

Concerns exist regarding the impact on our lives of the rise of artificial intelligence (AI). Using a large dataset of 137 countries over the period 2005–2018 from multiple sources, we estimate the causal effect of AI on individual‐level subjective wellbeing. Our identification strategy is inferred from the gravity framework and uses merely the variation in exogenous drivers of a country's AI development. We find a significant negative effect of AI on an individual's wellbeing, in terms of current levels or expectations of future wellbeing. The results are robust to alternative measures of AI, identification strategies, and sampling. Moreover, we find evidence of significant heterogeneity in the impact of AI on individual wellbeing. Further, this dampening effect on individual wellbeing resulting from the use of AI is more prominent among young people, men, high‐income groups, high‐skilled groups, and manufacturing workers. [ABSTRACT FROM AUTHOR]

Donor lymphocyte infusion (DLI) cures relapsed hematologic malignancies after allogeneic hematopoietic stem cell transplantation through the graft‐versus‐tumor (GVT) effect. Although the important role of magnesium in enhancing immunity has been mentioned in studies, limited clinical data have explored how magnesium affects the efficacy of DLI. Besides, although laboratory data demonstrate that magnesium can enhance CD8+ T cells effector function, whether magnesium regulates the tumor killing effect of peripheral blood mononuclear cells (PBMCs) remains to be explored. Here, for the retrospective study, we collected clinical data of relapsed patients receiving DLI and explored the relationship between different serum magnesium levels and patient outcomes. For in vitro studies, we investigated the effect of magnesium on the cytotoxicity of DLI cells which were PBMCs and preliminarily explored the mechanism. Eighty‐one patients were enrolled in this study. It was found that the high post‐DLI magnesium level was significantly associated with a higher incidence of complete remission (CR) or partial remission (CR/PR) and a higher possibility of survival. The magnesium level after DLI was an independent risk factor of overall survival. In vitro studies proved that increased magnesium enhanced the cytotoxic function of PBMCs on hematologic malignancies. Besides, magnesium modulated LFA‐1 headpiece opening. When blocking the integrin‐ligand interaction between LFA‐1 and ICAM‐1, the regulation effect of magnesium on PBMCs was weakened. Therefore, it was possible that magnesium regulated PBMCs effector function by stimulating LFA‐1. These results show that serum magnesium levels affect immunological responses mediated by donor lymphocytes in hematologic malignancies. [ABSTRACT FROM AUTHOR]

Trichocyte keratins hold significant promise in accelerating wound healing. Yet it is difficult to discriminate characteristics and mechanisms from their subtypes because of the high sequence homology. Here, the distinct wound healing properties in terms of wound closure rate, epidermal regeneration and angiogenesis of 17 kinds of human hair keratins is reported. Each trichocyte keratin shows distinct behaviors with unique advantages. Amongst all, recombinant keratin (RK) 33B, RK34, RK39 and RK84 show the highest efficiency in wound closure acceleration, and RK34, RK37 and RK81 presented the strongest angiogenic performance. Furthermore, transcriptomic analysis revealed the regulatory mechanisms of trichocyte keratins in the proliferation and migration of keratinocyte and blood vessel generation. Finally, the keratins with strong re-epithelialization and angiogenic performances significantly accelerate wound closure in a diabetic rat model established in-house. The findings provide a panorama view of trichocyte keratin performance in wound healing and that may harbor potential for finely tailored keratin development and precision applications. [ABSTRACT FROM AUTHOR]

Background and Objectives: Rail logistics transmission systems (RLTSs) are commonly used for the transportation of blood samples, pathological specimens and other medical materials in many hospitals, as they are rapid, secure, cost‐effective and intelligent. However, few studies have evaluated blood component transportation from blood banks to the patient care areas of hospitals using RLTS. In this study, we evaluate the RLTS used for the transportation of blood components within a medical centre. Materials and Methods: The dispatch of blood components, including packed red blood cells (pRBCs), fresh frozen plasma (FFP), cryoprecipitate and platelet units, from a blood bank to critical care areas or general wards was done using RLTS. Parameters such as the delivery time, temperature, physical integrity and blood component quality were evaluated via analytical testing using specimens obtained before and after transportation by RLTS. Results: The turnaround time and temperature of all tested blood units via RLTS transportation were able to meet the clinical demands of blood component delivery (median time: 323 s [118–668 s]; temperature variation: 4.5–8.9°C for pRBCs and FFP and 21.5–23.5°C for cryoprecipitate and platelet units). Furthermore, parameters of pRBC quality, including the haemolysis index and potassium and lactate dehydrogenase levels in plasma, were not significantly different before and after transportation through RLTS. Similarly, RLTS transportation affected neither the basic coagulation test results in FFP and cryoprecipitate specimens nor platelet aggregation and activation markers in apheresis platelet specimens. Conclusion: Hospital‐wide delivery of blood components via RLTS seems to be safe, reliable and cost‐effective and does not have any negative impact on blood quality. Therefore, the establishment of standard criteria, protocols and guidelines based on further studies is needed. [ABSTRACT FROM AUTHOR]

As water‐saturated polymer networks, hydrogels are a growing family of soft materials that have recently become promising candidates for flexible electronics application. However, it remains still difficult for hydrogel‐based strain sensors to achieve the organic unity of mechanical properties, electrical conductivity, and water retention. To address this challenge, based on the template, the excellent properties of MXene nanoflakes (rich surface functional groups, high specific surface area, hydrophilicity, and conductivity) are fully utilized in this study to prepare the P(AA‐co‐AM)/MXene@PDADMAC semi‐interpenetrating network (semi‐IPN) hydrogel. The proposed hydrogel continues to exhibit excellent strain response and flexibility after 30 days of storage at room temperature, and its performance do not decrease after 1100 cycles. Considering these characteristics, a hydrogel‐based device for converting sign language into Chinese characters is successfully developed and optimized using machine learning. Therefore, this study provides novel insight and application directions for hydrogel families. [ABSTRACT FROM AUTHOR]

Choulingdan mixture (CLDM) is an empirical clinical prescription for the adjuvant treatment of acute lung injury (ALI). CLDM has been used for almost 30 years in the clinic. However, its mechanism for improving ALI still needs to be investigated. In this study, high‐performance liquid chromatography–quadrupole/time‐of‐flight mass spectrometry (HPLC–Q‐TOF–MS/MS) was applied to characterize the overall chemical composition of CLDM. A total of 93 ingredients were characterized, including 25 flavonoids, 20 organic acids, 11 saponins, nine terpenoids, seven tannins and 21 other compounds. Then network pharmacology was applied to predict the potential bioactive components, target genes and signaling pathways of CLDM in improving ALI. Additionally, molecular docking was performed to demonstrate the interaction between the active ingredients and the disease targets. Finally, animal experiments further confirmed that CLDM significantly inhibits pulmonary inflammation, pulmonary edema and oxidative stress in lipopolysaccharide‐induced ALI mice by inhibiting the PI3K–AKT signaling pathway. This study enhanced the amount and accuracy of compounds of CLDM and provided new insights into CLDM preventing and treating ALI. [ABSTRACT FROM AUTHOR]