1. Role of DHEA and Growth Factors in Chromaffin Cell Proliferation.
- Author
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SICARD, F., KRUG, A.W., ZIEGLER, C.G., SPERBER, S., EHRHART‐BORNSTEIN, M., and BORNSTEIN, S.R.
- Subjects
DEHYDROEPIANDROSTERONE ,CHROMAFFIN cells ,CELL proliferation ,STEROIDS ,SOMATOMEDIN - Abstract
Dehydroepiandrostreone (DHEA) is a neuroactive steroid produced by the inner layer of the adrenal cortex close to the adrenomedullary cells. Chromaffin cell growth and proliferation are under the control of insulin-like growth factor II (IGF-II) and basic fibroblast growth factor (bFGF). The aim of the present study was to examine the role of DHEA on chromaffin cell proliferation induced by IGF-II and bFGF. In our model, DHEA significantly decreased IGF-II-induced proliferation by 48.7%, whereas it did not affect the proliferation induced by bFGF. These data suggest that DHEA exerts a paracrine function in the control of chromaffin cell growth. [ABSTRACT FROM AUTHOR]
- Published
- 2006
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