Search

Background. Non-Hodgkin lymphomas (NHLs) comprise a group of haematologic malignancies with different histologic subtypes. The clinical picture varies from indolent to aggressive presentation and nodal (lymphadenopathy) to extranodal (central nervous system, gastrointestinal, cutaneous plaque, or ulcer) involvement. Digital gangrene is seldom reported. Here, we describe a patient with pain and blackening of all fingers and toes as presenting symptoms of NHL. Case Presentation. A 32-year-old male weaver had been smoking three to five cannabis-containing cigarettes daily for about ten years and methamphetamine four to five tablets daily for five years. He had no history of Raynaud's phenomenon, fever, cough, weight loss, skin rash, joint pain, and atherogenic or thrombogenic risk factors. We found normal blood pressure and absent peripheral pulses in arms and legs, dry gangrene of all fingers and toes, generalized lymphadenopathy, and hepatomegaly with ascites. The chest X-ray was normal, as were blood sugar, lipid profile, and hepatic and renal function. Rheumatoid factor, antinuclear and antiphospholipid antibodies, C-ANCA and P-ANCA, hepatitis B and C, and HIV were negative. CT abdomen revealed hepatosplenomegaly with multiple intra-abdominal lymphadenopathies. The peripheral angiogram showed 90-99% stenosis of radial and dorsalis pedis arteries with normal proximal vessels. Diagnosis of non-Hodgkin lymphoma was confirmed by histopathology of cervical lymph node (diffuse type), immunohistochemically subtyped as peripheral T cell lymphoma (not otherwise specified). The digital ischemia worsened despite cessation of cannabis and methamphetamine and starting CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) treatment, making amputation necessary. Conclusion. We present, to our knowledge, the first report of peripheral T cell lymphoma, NOS presenting with gangrene in all digits complicated by methamphetamine and cannabis abuse. This uncommon vascular manifestation of non-Hodgkin lymphoma may cause a diagnostic dilemma and delayed initiation of treatment. [ABSTRACT FROM AUTHOR]

Background: The Community‐Oriented Program for Control of Rheumatic Diseases (COPCORD) is intended to reduce the information deficit about the epidemiology of rheumatic diseases, particularly in rural communities in high‐income countries. Multiple studies have been conducted using the WHO‐International League of Associations for Rheumatology (ILAR)‐COPCORD core questionnaire in Bangladesh using the translated version in the Bangla language. Cross‐cultural adaptation and validation of the questionnaire are important to achieve better outcomes. Aim: To develop a culturally adapted, valid, and reliable Bangla version of the WHO‐ILAR‐COPCORD Core English Questionnaire to use as a rheumatic screening instrument among Bangla‐speaking people. Methods: The original English WHO‐ILAR‐COPCORD questionnaire was translated into Bangla and adapted in the local socio‐cultural context maintaining idiomatic, semantic, experiential, and conceptual equivalence between the English and Bangla versions. Pretesting was carried out among 30 patients and healthy attendants, following standard international recommendations. Content validity of the adapted Bangla version was assessed by the item‐ and scale‐level content validity indices (I‐CVI and S‐CVI). The adapted Bangla version of the WHO‐ILAR‐COPCORD questionnaire was used to assess 120 patients with rheumatic problems and healthy individuals. Test‐retest reliability was assessed using intraclass correlation coefficients. Results: The Bangla version of the WHO‐ILAR‐COPCORD questionnaire showed excellent content validity (I‐CVI = 1, S‐CVI = 1). The test‐retest reliability was also acceptable (intraclass correlation coefficient > 0.7). Conclusion: The adapted Bangla version of the WHO‐ILAR‐COPCORD questionnaire demonstrated acceptable psychometric properties, in terms of content validity and test‐retest reliability, for evaluating rheumatic problems in Bangladeshi patients. [ABSTRACT FROM AUTHOR]

Aim: Development of a Bangla version of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the Bath Ankylosing Spondylitis Functional Index (BASFI). Methods: This biphasic observational study performed the translation and adaptation of the questionnaires carried out in 5 steps with pre‐testing in 30 AS patients followed by the psychometric validation of the pre‐final Bangla version utilizing content and construct validity in 115 AS patients. The reliability was examined through internal consistency and test–retest reliability involving 23 AS patients. Results: After pre‐testing of the pre‐final Bangla version of both indices, the psychometric validation found that the convergent validity of Bangla version of BASDAI showed strong correlation with C‐reactive protein (r =.75) and the Maastricht Ankylosing Spondylitis Enthesitis (r =.64), and moderate correlation with erythrocyte sedimentation rate (r =.49). Again, the Bangla BASFI showed significant correlation with occiput‐to‐wall distance (OWD) (r =.50), mentum‐to‐sternum distance (MSD) (r =.50), chest expansion (CE) (r = −.40), finger‐to‐floor (FFD) (r =.55), number of swollen joints (r =.69), and number of enthesitis (r =.68). The divergent validity demonstrated weak correlations between BASDAI and OWD (r =.43), MSD (r =.34), CE (r = −.44), FFD (r =.47). The divergent validity of BASFI could not be assessed due to lack of a suitable comparing parameter. The instruments revealed acceptable internal consistency as Cronbach's alpha was 0.86 for BASDAI and 0.93 for BASFI. A 7‐day test–retest reliability measured by the intraclass correlation coefficient were 0.80 (CI at 95% = 0.58‐0.90) for BASDAI and 0.83 (CI at 95% = 95% 0.64‐0.92) for BASFI respectively. Conclusions: Bangla version of BASDAI and BASFI may be useful in disease activity and functional ability assessment in AS patients. [ABSTRACT FROM AUTHOR]

Objective: To study the prevalence of musculoskeletal (MSK) symptoms and disorders among garment workers in Bangladesh, to look for possible relationships between pain location and type of work performed and to estimate the prevalence of rheumatological diagnoses. Methods: A cross‐sectional pilot study among 350 garment workers using the COPCORD (Community Oriented Program for Control of Rheumatic Disorders) methodology. Subjects with musculoskeletal pain were examined by rheumatologists for rheumatological diagnosis. The workers were classified into cutting, sewing, finishing and quality control operators. Results: Most of the workers were aged below 35 years (88%) and females (82.9%) and the majority had only primary education (74.6%). The prevalence of MSK pain within 7 days of the interview was 77.1%, a much higher figure than in the general population. The most affected sites were: shoulder (17.9%), lower back (15.2%), neck (13.8%) and knee (10.8%). Multiple regional pain was the commonest finding in 173 of 350 workers. In this pilot study rheumatoid arthritis was diagnosed in 0.9%, undifferentiated arthritis in 1.1%, nonspecific low back pain in 4.6%, soft tissue rheumatism in 3.7%, osteoarthritis in 0.9% and lumbar spondylosis in 1.1%, figures comparable with those observed in the general population; spondyloarthropathy was seen more often, in 1.42%, possibly explained by the small numbers. Conclusions: Musculoskeletal pains are common among garment workers of Bangladesh and may cause morbidity, disability, and work loss. Our findings may be important to plan ergonomic measures preventing complaints and may be of interest for international companies ordering garments in Bangladesh. [ABSTRACT FROM AUTHOR]

Aim: Inflammatory back pain (IBP) is the earliest symptom of axial and other forms of spondyloarthritis (SpA). However, there are no published data on prevalence of IBP among patients suffering from chronic low back pain (CLBP) in Bangladesh. In this study, we estimated the prevalence of IBP and the subtypes of SpA in a tertiary hospital in Bangladesh. Methods: This 1 year cross-sectional study was conducted among 240 CLBP patients in a rheumatology outpatient clinic. Assessment of Spondyloarthritis International Society classification criteria of IBP and predefined recognized classification criteria were followed to define different subtypes of SpA. Means and standard deviations were reported for continuous variables. Descriptive and bi-variate analyses were accordingly performed. Results: Of 240 CLBP patients, 60 (25%) had IBP and 180 (75%) had mechanical back pain (MBP). Among the 60 IBP patients, 52 (86.6%) had predominantly axial SpA (axSpA) and eight (13.4%) had predominantly peripheral spondyloarthritis. In the axSpA group, 49 (94.2%) had radiographic axSpA (rd-axSpA) also known as AS and three (5.8%) had non-radiographic axSpA (nr-axspA). AxSpA patients could be divided into eight (15.35%) with psoriasis, two (3.8%) with reactive arthritis and one patient (1.9%) had arthritis associated with inflammatory bowel disease. Fifty (83.3%) IBP and 73 (40.6%) MBP patients had age at onset of back pain < 40 years. Forty-two (70%) of the IBP and 100 (55.6%) of the MBP patients had normal body mass index. All these differences were statistically significant (P ≤ 0.0001). Conclusions: Inflammatory back pain is common among patients presenting with CLBP. The commonest cause of IBP is AS, followed by PsA and nr-axSpA. [ABSTRACT FROM AUTHOR]