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Menhaden oil (MO), whose polyunsaturated fatty acids consist mainly of (n−3) fatty acids, was fed to spontaneously hypertensive rats to determine the effect of (n−3) fatty acid on the in vitro production of prostaglandins produced from arachidonic acid (20∶4[n−6]). Capacity to form PGE and PGF was impaired in homogenates of kidney medullae and cortices from rats fed the MO diet compared to rats fed the control diet. The lower amounts of diene prostaglandins produced corresponded to the decrease in the amount of 20∶4 (n−6) in the tissue. Possibly changes produced in tissue lipids by dietary fatty acids affect prostaglandin production by reducing the availability of substrate in tissue lipids. [ABSTRACT FROM AUTHOR]

An abstract of the article "Activity of Radical Scavenger Enzymes in Skeletal Muscle of Patients With Chronic Heart Failure: Impact of a Metoprolol or Carvedilol Therapy," by A. Linke and colleagues is presented.