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4. Therapy for systemic juvenile rheumatoid arthritis with gamma-interferon: a pilot study of nine patients.

Author

Pernice W, Schuchmann L, Dippell J, Suschke J, Vogel P, Truckenbrodt H, Schindera F, Humburg C, and Brzoska J

Subjects
Arthritis, Juvenile pathology, Child, Child, Preschool, Humans, Pilot Projects, Recombinant Proteins, Arthritis, Juvenile therapy, Interferon-gamma therapeutic use
Abstract

Nine severely ill patients with a confirmed diagnosis of systemic juvenile rheumatoid arthritis were treated with recombinant gamma-interferon (gamma-IFN) in addition to the therapy they were previously receiving for their disease. Improvements in clinical symptoms were noted in 7 of the patients, and median laboratory values also showed a marked improvement after gamma-IFN treatment. A relapse occurred in 1 patient. The results of this study should stimulate further research on the use of gamma-IFN in systemic juvenile rheumatoid arthritis, particularly in determining the appropriate effective dosage.

Published
1989
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