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In recent years, the sociology of culture has turned its gaze to future aspirations. This gaze is in line with contemporary future‐oriented culture, which encourages young people to aspire to fulfill their dreams. A leading carrier of future orientation is the aspirational discourse, which has become prominent in the educational field and among youth. Sociological inquiry is conflicted regarding the outcomes of this discourse. While it is criticized for increasing inequality, it has also been shown that aspirations are means for higher achievements. In this article, we shift from a focus on outcomes to a focus on interpretation and ask: How do social actors make sense of aspiring selves despite social limitations and inequality? Based on a qualitative study that tracks the aspirational discourse among school educators and recent high school graduates in Israel, we introduce the concept of "glitches" as articulated detours that rise in response to a mismatch between the discourse and lived experience. We identify three main glitches: deviating from the message "the sky is the limit" by lowering the aspirational sky, pausing future orientation by taking time out and limiting individual accountability by yielding to force majeure. We discuss how each glitch serves a different role in the construction of individuals' life narratives and argue that the intermittent use of glitches enables individuals to sustain the mythical aspirational discourse, even in moments of mismatch and doubt. [ABSTRACT FROM AUTHOR]

In recent years, the sociology of culture has turned its gaze to future aspirations. This gaze is in line with contemporary future‐oriented culture, which encourages young people to aspire to fulfill their dreams. A leading carrier of future orientation is the aspirational discourse, which has become prominent in the educational field and among youth. Sociological inquiry is conflicted regarding the outcomes of this discourse. While it is criticized for increasing inequality, it has also been shown that aspirations are means for higher achievements. In this article, we shift from a focus on outcomes to a focus on interpretation and ask: How do social actors make sense of aspiring selves despite social limitations and inequality? Based on a qualitative study that tracks the aspirational discourse among school educators and recent high school graduates in Israel, we introduce the concept of "glitches" as articulated detours that rise in response to a mismatch between the discourse and lived experience. We identify three main glitches: deviating from the message "the sky is the limit" by lowering the aspirational sky, pausing future orientation by taking time out and limiting individual accountability by yielding to force majeure. We discuss how each glitch serves a different role in the construction of individuals' life narratives and argue that the intermittent use of glitches enables individuals to sustain the mythical aspirational discourse, even in moments of mismatch and doubt. [ABSTRACT FROM AUTHOR]

Introduction: Advanced liver disease or cirrhosis is associated with an increased risk of infections; however, the impact of high pretransplant model for end‐stage liver disease (MELD) score on cytomegalovirus (CMV) viremia after liver transplantation is unknown. Methods: This single‐center, retrospective, cohort study evaluated CMV high‐risk (CMV immunoglobulin G D+/R−) liver transplant recipients who received valganciclovir prophylaxis for 3 months between 2009 and 2019. Patients were stratified by pretransplant MELD score of <35 (low MELD) and ≥35 (high MELD). The primary outcome was 12‐month CMV viremia, and secondary outcomes included CMV resistance and tissue invasive disease, mortality, biopsy‐proven acute rejection (BPAR), leukopenia, and thrombocytopenia. Multivariable Cox proportional‐hazards modeling was used to assess the association of MELD score with the time to CMV viremia. Results: There were 162 and 79 patients in the low and high MELD groups, respectively. Pretransplant MELD score ≥35 was associated with an increased risk of CMV viremia (hazard ratio [HR] 1.73; confidence interval 1.06–2.82, p =.03). CMV viremia occurred at 162 ± 61 days in the low MELD group and 139 ± 62 days in the high MELD group. Although BPAR occurred early at 30 days (13–59) in the low‐MELD group and at 18 days (11–66) in the high‐MELD group (p =.56), BPAR was not associated with an increased risk of CMV viremia (HR 1.55 [0.93–2.60], p =.1). Discussion: MELD scores ≥35 were associated with an increased hazards of CMV viremia. In liver transplant recipients with MELD scores ≥35 who are CMV high‐risk, additional CMV intervention may be warranted. [ABSTRACT FROM AUTHOR]

Despite efforts to create dedicated smoking areas and no‐smoking signs, many smokers continue to light their cigarettes in front of public building entrances—leading to concerns over health consequences for non‐smokers passing by. To increase compliance with no‐smoking requests, behavioral interventions that tap into habitual and automatic processes seem promising. A pseudo‐randomized controlled trial was conducted to assess the differential impact of seven behavioral interventions based on Cialdini's principles of persuasion. Over a period of 9 weeks, the number of smokers was counted (total n = 17,930 observations) in front of a German University Medical Center. Relative to a baseline and a control condition, interventions based on the principles of reciprocity, scarcity, and authority were most effective in reducing the number of observed smokers in front of the building entrance (41.5%, 45.7%, and 52.1% reduction rates, respectively). Having observed smokers' behavior in vivo, this study provides substantial evidence for the impact of persuasive strategies on outdoor smoking. In the future, this knowledge should be used to protect non‐smokers from second‐hand smoke by increasing the use of designated smoking areas, leave to another place to smoke, or not smoke at all. [ABSTRACT FROM AUTHOR]

To establish dosage recommendations in patients with end-stage renal disease undergoing chronic haemodialysis, nifedipine kinetics were studied between and during haemodialysis sessions. In eight patients, during the interdialytic period, peak plasma concentrations of nifedipine (29-332 ng/ml) were reached 0.5-1.0 h after administration of a single 10 mg oral dose. Elimination half-life and oral plasma clearance were respectively 2.6 +/- 0.5 h and 1 176 +/- 412 ml/min. Nifedipine plasma protein binding was decreased in uraemic patients (88.8 +/- 0.3% vs 94.4 +/- 0.1%) but not affected by haemodialysis. Removal by haemodialysis was low: the dialyser extraction ratio and the dialysis clearance were respectively 2.3 +/- 0.8% and 2.8 +/- 0.9 ml/min. [ABSTRACT FROM AUTHOR]

Background: Cytomegalovirus (CMV) outcomes with valganciclovir prophylaxis in renal transplant recipients experiencing delayed graft function (DGF) are unclear. Methods: This single center, retrospective, cohort study of CMV high‐risk (D+/R− with alemtuzumab induction) deceased donor renal transplant recipients receiving valganciclovir prophylaxis assessed CMV outcomes in patients experiencing DGF (n = 72) versus those with immediate graft function (IGF; n = 66). Results: Cytomegalovirus viremia by 12 months occurred at similar rates in the IGF and DGF groups (30.3% vs 26.4%, respectively, P = 0.71) with 89.7% (35/39) of all cases classified as CMV disease. The median time to CMV viremia post transplant was day 141 and 138 in the IGF and DGF groups, respectively (P = 0.30). The incidence of biopsy‐proven acute rejection (BPAR) was higher in the DGF group (18.1% vs 4.6%, P = 0.02) with BPAR preceding CMV in only 1 patient. There was no significant difference in graft loss (1.5% vs 4.2%, P = 0.62) or patient survival (98.5% vs 95.8%, P = 0.62) at 1 year between the IGF and DGF groups, respectively. Conclusion: Valganciclovir prophylaxis in patients experiencing DGF yielded similar CMV outcomes up to 1‐year post transplant when compared to use in patients with IGF. [ABSTRACT FROM AUTHOR]

Summary. A case of rhinocerebral zygomycosis treated with liposomal amphotericin B is described. [ABSTRACT FROM AUTHOR]

An abstract of the study "The Effect of Continuous Versus Intermittent Treatment With Transdermal Nitroglycerin on Pacing-Induced Heart Failure in Conscious Rabbits," by Z. Szilvassy and colleagues is presented.

An abstract of the study "Predominant role of insulin resistance in the development of heart failure induced by global ischaemia in conscious rabbits with aortic regurgitation," by B. Peitl and colleagues, is presented.

Background: The basic histopathological finding in gastric mucosa is chronic atrophic gastritis in patients with pernicious anemia., Materials and Methods: We evaluated the frequency of Helicobacter pylori and pathological examinations of gastric mucosa in pernicious anemia (n = 30) by endoscopical findings and biopsy. The results were compared with gastric mucosa specimens of patients with H. pylori-positive nonulcer dyspepsia (n = 36) and H. pylori-negative nonulcer dyspepsia (n = 21)., Results: H. pylori was diagnosed in 12 patients (40%) with pernicious anemia. Fundal biopsy examinations showed atrophic gastritis in 30 patients (100%), intestinal metaplasia in 13 patients (43.3%), lymphoid follicle in 15 patients (50%), and dysplasia in 6 patients (20%). Antral biopsy examinations showed atrophic gastritis in 8 patients (26.6%), intestinal metaplasia in 8 patients (26.6%), lymphoid follicle in 8 patients (26.6%), and dysplasia in 3 patients (10%). The frequency of fundal inflammation, atrophy, intestinal metaplasia, lymphoid follicle, and dysplasia and antral intestinal metaplasia and mild antral dysplasia were found to be higher in those in the pernicious anemia group than in the nonulcer dyspeptic patients. Antral inflammation, atrophy, and moderate and severe antral dysplasia were found to be higher in those in the nonulcer dyspeptic group., Conclusions: Particularly, fundal precancerous lesions were found to be more frequent in patients with pernicious anemia independent of H. pylori.