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Abstract: The generalization use of therapeutic and illicit drugs are introducing new several chemical pollutants in water. They have been detected in water and sewage samples worldwide, hence they are considered as emerging pollutants. The increase of water threats has a negative impact on the life quality and human health. Among the illicit drugs, cocaine and derivatives are increasingly present, making efficient detection and elimination of wastewater highly prioritaire. In that sense, the main core of this work is the assessment of a novel cost‐efficient electrochemical method based on substrate electro‐oxidation (EO) using low‐cost anodes based on common graphite modified with TiO2 nanosized particles incorporated on the surface by assisted microwave deposition. Two different diameters (2 and 5 nm) of nanostructured TiO2@C anodes were tested for cocaine EO reaction using three different electrolytic solutions (NaCl 50 mM, Na2SO4 50 mM or Na2SO4 100 mM). In all cases, the electrochemical oxidation of cocaine appears to be a combination of hypsochromic and hyperchromic processes. Reaching ca. 90 % degradation after 10 minutes for all electrodes, an enhanced efficiency was especially observed for the system with higher cylindrical diameter and NaCl salt medium. The differential pulse (DP) voltammogram, carried out with all assay solutions after 10 minutes of anodic remediation at both electrodes, exhibited an anodic peak consistent with catechol like compounds. [ABSTRACT FROM AUTHOR]

In this study, we proposed the design, synthesis of a new compound 2-(4-((1-phenyl-1 H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol ( LQFM032), and pharmacological evaluation of its anxiolytic-like effect. This new compound was subjected to pharmacological screening referred to as Irwin test, prior to sodium pentobarbital-induced sleep, open-field and wire tests. The anxiolytic-like effect of this compound was evaluated using elevated plus maze and light-dark box tests. In addition, the mnemonic activity was evaluated through step-down test. In sodium pentobarbital-induced sleep test, LQFM032 decreased latency and increased duration of sleep. In the open-field test, LQFM032 altered behavioral parameter, that suggested anxiolytic-like activity, as increased in crossings and time spent at the center of open field. In the plus maze test and light-dark box test, the LQFM032 showed anxiolytic-like activity, increased entries and time spent on open arms, and increased in number of transitions and time spent on light area, respectively. Those effects was antagonized by flumazenil but not with 1-(2-Methoxyphenyl)-4-(4-phthalimidobutyl)piperazine ( NAN-190). The LQFM032 did not alter mnemonic activity. Moreover, the anxiolytic-like activity of LQFM032 was antagonized by mecamylamine. In summary, LQFM032 showed benzodiazepine and nicotinic pathways mediated anxiolytic-like activity without altering the mnemonic activity. [ABSTRACT FROM AUTHOR]