Search

The unique structure of [2.2]paracyclophane (PCP) with its rigidity, stability, and planar chirality has gained significant attention in polymer and material research. In this work, the incorporation of amino‐functionalized PCPs within polymers of intrinsic microporosity (PIMs) is reported for the first time. Three different PCP‐PIMs were prepared via a Tröger's base formation mechanism, and their structures characterized via solid‐state NMR, MALDI‐TOF, and SEM. Their porosity was evaluated using gas adsorption (N2 and CO2) based on theoretical calculations such as Brunauer–Emmett–Teller (BET), NLDFT pore size distribution (PSD) and ideal IAST CO2/N2 selectivity (15/85), a crucial separation when considering the capture of CO2 from flue gas. The surface areas were found to be between 200–230 m2 g−1 while the selectivity for CO2/N2 ranged from 46 to 70. [ABSTRACT FROM AUTHOR]

Saudi Arabia has implemented ambitious environmental protection programs by creating numerous nature reserves throughout the country. Establishment of the latter nature reserves has led to farm abandonment and the initiation of ecosystem recovery processes. Agricultural practices are known to impact the structure and physicochemical properties of soils while also often markedly affecting natural ecosystem restoration processes. Moreover, weed proliferation in crop fields may modify soil seed banks (SSB), thereby impacting subsequent vegetation recovery. Therefore, it is essential to assess SSB compositions in degraded sites, such as abandoned farms (AF), so as to identify weed species and design efficient restoration strategies in hyperarid ecosystems. In this study, SSB compositions in upper and deep soil layers, standing vegetation compositions, and soil chemical properties were analyzed and compared for two natural ecosystems (NE), two abandoned orchards (AO), two AF, and two natural evaporite basins (EB). NE, AO, AF, and EB all exhibited similar chemical properties, suggesting that former agricultural activities have been guided by a fine understanding of the local environments. Agriculture had impacted the species composition of the observed standing vegetation and germinable SSBs, which could be partly explained by soil property modifications. The findings highlighted that SSBs would warrant detailed study prior to designing ecological restoration strategies, and that the drivers of horizontal and vertical weed dissemination in hyperarid ecosystems should also be explored to gain further insight into weed proliferation patterns and to adapt restoration strategies accordingly. [ABSTRACT FROM AUTHOR]

Background: Over 768 million cases of COVID‐19 infection have been reported worldwide, with pregnant women being the most vulnerable members of society during such an infectious disease outbreak. In the United Arab Emirates, there are limited studies explaining the effects of COVID‐19 on pregnant women and their fetuses. In this study, the maternal and fetal outcomes in pregnant women with COVID‐19 in a tertiary maternal hospital, United Arab Emirates, were examined. Materials and Methods: A descriptive study was conducted in a tertiary hospital for Obstetrics and Gynecology in Ras Al Khaimah, UAE. The study included all pregnant women who tested positive for COVID‐19 infection from April 2020 to September 2021. Results: The study revealed that a higher number of COVID‐19‐infected pregnant patients presented in their third trimester (69.1%). The comorbidity of body mass index (BMI) had the most effect on the severity/hospitalization status of the patients (p = 0.018). In the nonhospitalized group, fever was the most common symptom (26%), whereas in the hospitalized group, cough was the most common symptom (94%). Emergency cesarean delivery was found to be significant (p = 0.0007) in hospitalized patients. COVID‐19 pneumonia was the prevailing adverse maternal outcome. NICU admission and prematurity were the most frequent neonatal outcomes. Conclusions: In conclusion, our findings show that adverse maternal outcomes, obesity, and mode of delivery were related to COVID‐19 severity in pregnant patients. However, there was no effect generally on the adverse fetal outcomes except for jaundice and birth weight. [ABSTRACT FROM AUTHOR]

The low sensitivity of liquid‐state nuclear magnetic resonance (NMR) can be overcome by hyperpolarizing nuclear spins by dissolution dynamic nuclear polarization (dDNP). It consists of transferring the near‐unity polarization of unpaired electron spins of stable radicals to the nuclear spins of interest at liquid helium temperatures, below 2 K, before melting the sample in view of hyperpolarized liquid‐state magnetic resonance experiments. Reaching such a temperature is challenging and requires complex instrumentation, which impedes the deployment of dDNP. Here, we propose organic conductive polymers such as polyaniline (PANI) as a new class of polarizing matrices and report 1H polarizations of up to 5 %. We also show that 13C spins of a host solution impregnated in porous conductive polymers can be hyperpolarized by relayed DNP. Such conductive polymers can be synthesized as chiral and display current induced spin selectivity leading to electron spin hyperpolarization close to unity without the need for low temperatures nor high magnetic fields. Our results show the feasibility of solid‐state DNP in conductive polymers that are known to exhibit chirality‐induced spin selectivity. [ABSTRACT FROM AUTHOR]

The Grey‐Scott model is a prominent reaction–diffusion system that has sustain consequential recent research about patterning creation in the reaction–diffusion systems. The present research work, explore the stability analysis of a proposed stochastic Grey‐Scott model, which recommend the randomness or unpredictability into the complex system. To take into account the different variations in reactant concentrations profiles, the stochasticity is modeled using the additive white noise terms. To investigate the stability characteristics of the stochastic Grey‐Scott model, we use the spectral collocation technique. Such mathematical perspective sheds light on the different system's behavior in the addition of white noise, and also it may have significance for comprehending processes in the real world that are controlled by comparable dynamics. [ABSTRACT FROM AUTHOR]

Cardiovascular disorders (CVDs) are a major global health concern, but their underlying molecular mechanisms are not fully understood. Recent research highlights the role of long noncoding RNAs (lncRNAs), particularly ANRIL, in cardiovascular development and disease. ANRIL, located in the human genome's 9p21 region, significantly regulates cardiovascular pathogenesis. It controls nearby tumor suppressor genes CDKN2A/B through epigenetic pathways, influencing cell growth and senescence. ANRIL interacts with epigenetic modifiers, leading to altered histone modifications and gene expression changes. It also acts as a transcriptional regulator, impacting key genes in CVD development. ANRIL's involvement in cardiovascular epigenetic regulation suggests potential therapeutic strategies. Manipulating ANRIL and its associated epigenetic modifiers could offer new approaches to managing CVDs and preventing their progression. Dysregulation of ANRIL has been linked to various cardiovascular conditions, including coronary artery disease, atherosclerosis, ischemic stroke, and myocardial infarction. This abstract provides insights from recent research, emphasizing ANRIL's significance in the epigenetic landscape of cardiovascular disorders. By shedding light on ANRIL's role in cellular processes and disease development, the abstract highlights its potential as a therapeutic target for addressing CVDs. [ABSTRACT FROM AUTHOR]

Forensic chemists frequently employ statistical profiling approaches to assess the degree of similarity between samples of illicit drugs. Such profiling information can help reveal connections between nodes in distribution networks and manufacturing laboratories. For amphetamine, the routine method of comparing a pair of samples includes the use of a dissimilarity measure based on the Pearson correlation coefficient calculated between their chemical profiles obtained through gas chromatography–mass spectrometry. This simple measure of (dis)similarity has been shown distinguish pairs sharing a common origin (e.g., same production batch) to a reasonable level of accuracy. However, Pearson correlation fails to capture all the relevant notions of similarity between chemical profiles of amphetamine. We present a new statistical method for forensic drug comparison that uses a more sophisticated statistical modelling approach to determine similarity between samples. We show that this leads to improved performance over the correlation‐based approach. The proposed method is easily extendable and has an intuitive interpretation both from chemistry and forensic perspectives, which supports wide applicability to illicit drug profiling in practice. [ABSTRACT FROM AUTHOR]

There is increasing interest in using specialized circuits based on emerging technologies to develop a new generation of smart devices. The process and device variability exhibited by such materials, however, can present substantial challenges for designing circuits. Three models are considered here: a physical compact model, an empirical look‐up table, and an empirical surrogate model based on a multilayer perceptron (MLP) regression. Each one is fit to measurements of discrete organic thin film transistors in the low voltage regime. It is shown that the models provide consistent results when designing artificial neuron circuits, but that the MLP regression provides the highest accuracy and is much simpler to fit compared to the compact model. The targeted technology exhibits non‐ideal behavior such as variable threshold voltage and hysteresis. Using the MLP regression model, the effect of such variability on the performance of an artificial neuron circuit is compared. It is found that these effects alter the neuron firing rate and change the time spent in the on/off states but do not change the basic operation. [ABSTRACT FROM AUTHOR]

Purpose: The concept of interposing double dorsal preputial flaps to cover the urethroplasty was introduced in 2005 to reduce the risk of urethrocutaneous fistula (UCF). Our study aims to compare the postoperative outcomes of urethroplasty for distal hypospadias between two groups: one receiving single preputial flap coverage and another receiving double flap coverage. Materials and methods: We conducted a retrospective analysis study of boys with primary distal hypospadias who underwent surgery by the same experienced surgeon, at our department between 2010 and 2021. The study population was divided into two groups: Group A, which underwent urethroplasty coverage with single dorsal preputial flap, and Group B, which underwent coverage with double flap. Postoperative complications were compared between the two groups. Results: We collected 105 cases, comprising 51 in Group A and 54 cases in Group B. The mean age at surgery was 29 months in Group A and 24 months in Group B. Post‐operative follow‐up period ranged from 6 months to 8 years. Functional and cosmetic outcomes were judged excellent in 88.7%. Only 10 boys experienced complications requiring reoperation. UCF occurred in 5 patients from Group A, while no cases were reported in Group B (p = 0.024). Meatal stenosis was identified in three patients in Group A and in two patients in Group B (p = 1). No other complications, such as glans dehiscence or penile torsion, were noted. Conclusion: Double dorsal dartos flap is an effective method for covering the new urethra and can be recommended in the treatment of patients with virgin distal hypospadias. [ABSTRACT FROM AUTHOR]

This study uses machine learning techniques to investigate the bond strength between steel and concrete under various elevated temperature scenarios. Five distinct machine learning algorithms, including Random Forest (RF), XGBoost, AdaBoost, Decision Tree, Linear Regression, and hyperparameteric optimisations, were used to predict changes in bond strength. The models underwent rigorous optimisation using GridSearchCV to achieve optimal performance. In this study, we evaluated several metrics such as Mean Squared Error, Root Mean Squared Error, Mean Absolute Error, and coefficient of determination (R2) Score to compare and assess the models' prediction capabilities. After optimisation, results indicate that the RF model exhibited exceptional performance in estimating bond strength across different temperature conditions, demonstrating minimal errors and a high R2 Score. Visual comparisons of actual and predicted values further confirmed the efficacy of the RF model in capturing complex fluctuations in bond strength. The findings of this study underscore the potential of machine learning models, particularly the optimized RF method, in accurately predicting bond strength under varying thermal conditions, with promising implications for engineering and construction practices. [ABSTRACT FROM AUTHOR]

In this research, we investigate mixed convection transport of mass and heat transfer in the unsteady boundary layer flow of the Eyring‐Powell fluid around a rotating cone in the presence of Brownian and thermophoresis effects. Rotating cones are widely used in conical diffusers, medical devices, Aerospace Engineering and a variety of rheometric and viscosimetry applications. Specifically, we focus on the flow of the Eyring‐Powell fluid around the cone in the presence of magnetohydrodynamics and nanofluid. The modeled momentum, energy, and concentration equations of the problem are transformed into nonlinear dimensionless, nonlinear ordinary equations by utilizing the similarity variables. These nonlinear coupled ordinary differential equations are solved numerically via Bvp4c, and the outcomes for important physical parameters on momentum, energy, and concentration equations are presented graphically. The computational outcomes of physical parameters for skin friction coefficient, local Nusselt number, and Sherwood are also presented in tabular form. [ABSTRACT FROM AUTHOR]

Chironomids are keystone primary benthic consumers with semi‐aquatic life cycles. They support aquatic and terrestrial consumers at higher trophic levels by conveying dietary nutrients, such as fatty acids. In this study, we combined field sampling and laboratory experiments to examine the effects of environmental parameters, including diet, on fatty acid composition and metabolism in chironomid larvae and imagines. Results from 53 lakes showed that lake size, depth, dissolved organic carbon (DOC) concentrations, and trophic state had only marginal effects on the content of long‐chain polyunsaturated fatty acids (LC‐PUFA) in chironomids. Compound‐specific stable hydrogen isotope analyses confirmed that chironomids actively bioconvert dietary fatty acid precursors to LC‐PUFA in all lake types, independent of nutrient or DOC concentrations. Moreover, fatty acid‐specific stable carbon isotope data indicated that the diet of chironomids was subsidized, particularly in oligotrophic lakes in spring, by terrestrial C18 fatty acid precursors that were converted to LC‐PUFA. Data from feeding experiments further confirmed that decreased dietary availability of LC‐PUFA enhanced the conversion of dietary short‐chain precursors to LC‐PUFA. These results suggest that chironomids are PUFA regulators that can sustain LC‐PUFA levels under varying environmental conditions. Furthermore, our results indicate that they bioconvert terrestrial low‐quality material to high‐quality resources, which, via chironomid emergence, support terrestrial food webs. Chironomids are abundant and widespread, and thus, the trophic transfer of LC‐PUFA can have significant implications for the fitness and production of upper trophic level consumers in both aquatic and terrestrial ecosystems. [ABSTRACT FROM AUTHOR]

Background: Obesity is a significant risk factor for osteoarthritis (OA). The most effective treatment for morbid obesity is bariatric surgery. Purpose: To study the effects of potential surgically induced weight loss on knee articular cartilage and OA symptoms of obese patients over a 12‐month follow‐up. Study Type: Prospective longitudinal cohort study. Subjects: 45 obese patients (38 female, BMI = 42.3 ± 6.5 kg/m2) who underwent gastric bypass (intervention group), and 46 age‐matched conservative‐care controls (37 female, BMI = 39.8 ± 4.6 kg/m2). Field Strength/Sequence: Multiecho spin echo sequence at 3 T. Assessment: Knee cartilage T2 measurements and WOMAC Indices were measured presurgery and after 12 months. The intervention group was split into successful (≥20% total weight loss (TWL)) and unsuccessful (<20% TWL) weight loss groups. T2 and WOMAC indices were also measured in controls at baseline and after 12 months. Changes among the three groups were analyzed. Statistical Tests: Analysis of variance (significance level 0.05). Results: Twenty‐six (58%) intervention patients achieved ≥20% TWL. The <20% TWL group demonstrated significantly more T2 reduction in the deep lateral femur over 12 months compared with the ≥20% TWL group (−3.83 ± 8.18 msec vs. 2.47 ± 6.54 msec, respectively), whereas no significant differences were observed on the medial femoral compartment (P = 0.385, P = 0.551, and P = 0.511 for bulk, superficial and deep regions, respectively). Changes in WOMAC indices over 12 months were significantly greater in the ≥20% TWL group compared with controls. In the <20% TWL group, pain significantly improved over 12 months compared with controls, while stiffness and function changes were not statistically significant (P = 0.063 and P = 0.051, respectively). Data Conclusion: Cartilage matrix, measured by T2, showed improvement on lateral femoral cartilage with <20% TWL compared with ≥20% TWL. Bariatric surgery provided significant improvements in knee symptoms with ≥20% TWL compared with conservative WL. This effect is also seen to some extent with <20% TWL compared with conservative WL. Level of Evidence: 2 Technical Efficacy: Stage 4 [ABSTRACT FROM AUTHOR]

Aims: Women may experience unique mental disorders due to hormone shifts. Rates of schizophrenia and bipolar disorder are similar between genders, but onset and symptoms may differ. Women tend to use more psychotropic drugs due to limited therapeutic options. This study was aimed to estimate the prevalence of psychotropic polypharmacy among females of childbearing potential and factors impacting prescribing patterns. Methods: This was a quantitative retrospective chart review for patients admitted to inpatient units at the Mental Health Hospital in Qatar. SPSS® Statistics was used for data analysis. In addition to descriptive statistics applied, linear regression and binary logistic regression models were used to examine the clinical and sociodemographic factors associated with polypharmacy and full therapeutic response upon discharge, respectively. An alpha value of 0.05 was used. Results: Of the 347 patients, 52.7% of the patients received a prescription of at least two psychotropic drugs upon discharge. Around two‐thirds (63.1%) were prescribed at least one antipsychotic. Potential predictors of polypharmacy were age (p = 0.027), longer hospital stay (p = 0.003), family history (p < 0.001), absence of suicidal history (p = 0.005), and a diagnosis of a mood disorder (p = 0.009), or a diagnosis of a psychotic disorder (p = 0.015). A full response upon discharge was less likely to occur in patients with a longer stay (OR = 0.940; p = 0.029) and in those with a substance use disorder (OR = 0.166; p = 0.035). Conclusion: There is a notably high prevalence of total polypharmacy upon discharge. Some identified factors are modifiable. Evidence‐based prescription practices through hospital guidelines and education should be emphasized to avoid unreasonable polypharmacy. [ABSTRACT FROM AUTHOR]

Copyright of World Medical & Health Policy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Reconfigurable antennas (RAs) are the key component in the modern wireless communication applications as these antennas have the ability of multifunctional and altered radiating properties in the form of radiation patterns and polarizations. The need for multiple antennas in a single device is becoming more prominent these days due to the increasing applications and user demands in daily life. Consequently, these antennas cover the maximum space in the devices; therefore, to mitigate this problem, RAs are the best solution. This article discusses the various types of RA along with the reconfigurable methods in detail. These types include the frequency, radiation pattern, polarization, and compound RAs, and methods include the electrical (with switches), mechanical, optical, and material change. Based on the requirement and application, proper methods have been chosen by the authors to achieve the reconfigurability in the antennas. The RAs find applications in various sectors including terrestrial and satellite communications, vehicular communication due its movement in rural and urban areas, and cognitive radio. [ABSTRACT FROM AUTHOR]

ABSTRACT This article introduces a third‐order super‐twisting sliding mode control (Gen‐STSMC) algorithm designed for the secure operation of a grid‐connected photovoltaic (PV) system. The improved method changes the traditional super‐twisting sliding mode control (STSMC) technique by incorporating both a linear term and a higher power term to reduce convergence time and chattering effects. This strategy generates the optimal control signals to regulate the output power of the PV system by compensating the state‐dependent uncertainties using the linear and growing term. The controller's stability analysis is conducted to demonstrate its rapid convergence compared to PI and conventional STSMC scheme. A comparative simulation study against PI and STSMC is conducted to showcase the controller's rapid convergence and robust performance in various grid‐connected PV system scenarios. Experimental tests are also performed to validate the controller's effectiveness in maintaining stable power generation in the presence of environmental fluctuations and DC link voltage variations. [ABSTRACT FROM AUTHOR]

Almost 85% of companies polled said they were looking into anomaly detection (AD) technologies for their industrial image anomalies. The present problem concerns detecting anomalies often occupied by redundant data. It can be either in images or in videos. Finding a correct pattern is a challenging task. AD is crucial for various applications, including network security, fraud detection, predictive maintenance, fault diagnosis, and industrial and healthcare monitoring. Many researchers have proposed numerous methods and worked in the area of AD. Multiple anomalies and considerable intraclass variation make industrial datasets tough. Further, research is needed to create robust, efficient techniques that generalize datasets and detect anomalies in complex industrial images. The outcome of this study focuses on various AD methods from 2019 to 2023. These techniques are categorized further into machine learning (ML), deep learning (DL), and federated learning (FL). It explores AD approaches, datasets, technologies, complexities, and obstacles, emphasizing the requirement for effective detection across domains. It explores the results achieved in various ML, DL, and FL AD methods, which helps researchers explore these techniques further. Future research directions include improving model performance, leveraging multiple validation techniques, optimizing resource utilization, generating high‐quality datasets, and focusing on real‐world applications. The paper addresses the changing environment of AD methods and emphasizes the importance of continuing research and innovation. Each ML and DL AD model has strengths and shortcomings, concentrating on accuracy and performance while applying quality parameters for evaluation. FL provides a collaborative way to improve AD using distributed data sources and data privacy. [ABSTRACT FROM AUTHOR]

Additive manufacturing (AM) is a well‐established technique that allows for the development of complex geometries and structures with multiple applications. While considered a more environmentally‐friendly method than traditional manufacturing, a significant challenge lies in the availability and ease of synthesis of bio‐based alternative resins. In our endeavor to valorize biomass, this work proposes the synthesis of new α,ω‐dienes derived from cellulose‐derived levoglucosenone (LGO). These dienes are not only straightforward to synthesize but also offer a tunable synthesis approach. Specifically, LGO is first converted into diol precursor, which is subsequently esterified using various carboxylic acids (in this case, 3‐butenoic, and 4‐pentenoic acids) through a straightforward chemical pathway. The resulting monomers were then employed in UV‐activated thiol‐ene chemistry for digital light process (DLP). A comprehensive study of the UV‐curing process was carried out by Design of Experiment (DoE) to evaluate the influence of light intensity and photoinitiator to find the optimal curing conditions. Subsequently, a thorough thermo‐mechanical characterization highlighted the influence of the chemical structure on material properties. 3D printing was performed, enabling the fabrication of complex and self‐stain structures with remarkable accuracy and precision. Lastly, a chemical degradation study revealed the potential for end‐of‐use recycling of the bio‐based thermosets. [ABSTRACT FROM AUTHOR]

Summary: As temperature rises, net carbon uptake in tropical forests decreases, but the underlying mechanisms are not well understood. High temperatures can limit photosynthesis directly, for example by reducing biochemical capacity, or indirectly through rising vapor pressure deficit (VPD) causing stomatal closure.To explore the independent effects of temperature and VPD on photosynthesis we analyzed photosynthesis data from the upper canopies of two tropical forests in Panama with Generalized Additive Models.Stomatal conductance and photosynthesis consistently decreased with increasing VPD, and statistically accounting for VPD increased the optimum temperature of photosynthesis (Topt) of trees from a VPD‐confounded apparent Topt of c. 30–31°C to a VPD‐independent Topt of c. 33–36°C, while for lianas no VPD‐independent Topt was reached within the measured temperature range. Trees and lianas exhibited similar temperature and VPD responses in both forests, despite 1500 mm difference in mean annual rainfall.Over ecologically relevant temperature ranges, photosynthesis in tropical forests is largely limited by indirect effects of warming, through changes in VPD, not by direct warming effects of photosynthetic biochemistry. Failing to account for VPD when determining Topt misattributes the underlying causal mechanism and thereby hinders the advancement of mechanistic understanding of global warming effects on tropical forest carbon dynamics. See also the Commentary on this article by Gauthey & Gardner, 244: 1119–1121. [ABSTRACT FROM AUTHOR]

The current study investigated how contact experiences may be associated with attitudes towards the ingroup and the outgroup using a three‐wave longitudinal study. We assessed Turkish native children's contact with Syrian refugees (N = 487, Mage = 10.60, SDage = 0.90) and explored relationships between initial contact and later ingroup and outgroup attitudes testing alternative mediation models. We also examined whether negative contact with outgroup members may directly or indirectly predict more positive ingroup attitudes. Findings demonstrated that positive contact was associated with both reduced ingroup positivity and increased outgroup positivity over time. However, unlike the traditionally suggested mediational pathway in contact‐deprovincialization literature, initial positive contact (T1) was associated with less positive ingroup attitudes (T3) through more positive outgroup attitudes at T2. There was no evidence for the role of negative intergroup contact on ingroup or outgroup attitudes. Findings are discussed within the broader scope of contact theory and the recently growing deprovincialization literature. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement. [ABSTRACT FROM AUTHOR]

Background: There is a paucity of research on the effects of commonly used substances, such as cannabis and other drugs, on quality of life as a contributor to head and neck cancer (HNC) prognosis. We examined associations between non‐alcohol or tobacco substance use (cannabis and other illicit drug) and self‐reported quality of life in patients with HNC prior to starting treatment. Methods: This was a cross‐sectional study of patients who presented for routine psych‐oncologevaluation prior to treatment between 11/2015 and 9/2022. Primary exposures were cannabis use (never, past, or current users) and current illicit drug use (yes/no). The primary outcome measure was the Functional Assessment of Cancer Therapy—Head and Neck (FACT‐HN) subscales (physical, social/family, functional and emotional). Linear regression models examined associations between pretreatment substance use and FACT‐HN subscales adjusting for demographic, socioeconomic, and clinical factors. Results: Of 570 patients, 13.9% endorsed current cannabis and 13.9% current illicit drug use. The mean (SD) scores for FACT‐HN subscales were physical well‐being = 22.8 (5.0), social well‐being = 22.7 (5.5), emotional well‐being = 17.5 (4.5), and functional well‐being = 18.7 (6.9). In the adjusted models, cannabis use was not independently associated with any FACT‐HN subscales. However, patients who currently used illicit drugs reported worse emotional well‐being (β = −1.32; 95% CI −2.45 to −0.20). No independent association was found between current illicit drug use and other subscales (physical, social, and functional). Conclusions: Illicit drug use, but not cannabis use, is negatively associated with pretreatment emotional well‐being in patients with HNC. Further research exploring the relationships between longitudinal cannabis and illicit drug use and methods of consumption on QoL and cancer outcomes in patients with head and neck cancer is warranted. [ABSTRACT FROM AUTHOR]

The increasing concerns about climate change demand a more profound understanding of the elements influencing carbon dioxide (CO2) emissions, particularly in nations with high carbon footprints. This study embarks on a quantitative exploration of how renewable energy consumption, economic growth, and environmental technologies impact CO2 emissions across eight nations with the highest carbon emission levels. Leveraging annual data from the period 1990–2019, we undertake a meticulous empirical analysis to unearth the factors shaping the environmental quality in these countries. Our findings reveal that per capita income and environmental technologies wield a significant influence on CO2 emission levels. Delving further into causality relationships, we discern a fascinating bidirectional causal link between CO2 emissions and renewable energy consumption. In parallel, a similar bidirectional causality is spotted between renewable energy consumption and environmental technology. From CO2 emissions to environmental technology and GDP per capita to CO2 emissions and environmental technology, unidirectional causal links are also perceived. In light of these compelling results, we propose several policy recommendations aimed at promoting sustainability and fostering a healthier environmental future. Our research underscores the potential of renewable energy consumption and environmental technologies in mitigating carbon emissions and spurring a greener economy. [ABSTRACT FROM AUTHOR]

Effective conservation practices require addressing the divide between research and implementation. Co‐production, which emphasizes collaboration and diverse knowledge exchange, is increasingly recognized as valuable in conservation to address this challenge, yet empirical insights remain limited. This case study explores using a Community of Practice (CoP) as an avenue for facilitating co‐production in shorebird conservation. Centering researchers and practitioners within implementation initiatives, we evaluate factors enabling a successful CoP and barriers hindering members' experiences. Capacity emerged as the predominant barrier, while the leading factors contributing to CoP success were having a dedicated space to support labor division, relationship building, and informal learning among CoP members. Leveraging our evaluation insights, we offer practical recommendations for structuring a CoP to optimize these benefits and advance the integration of CoPs and co‐production principles in conservation practice. [ABSTRACT FROM AUTHOR]

Quinoa (Chenopodium quinoa Willd.), a high‐value halophytic crop, is a promising candidate to ensure food security in the scenario of increasing soil salinization due to climate change. In a 2‐year field study (during 2018–2019 and 2019–2020), 18 quinoa genotypes of different origins (Q‐4, Q‐6, Q‐9, Q‐7, Q11, Q‐15, Q‐22, Q‐24, Q‐27, Q‐45, Q‐50, Q‐51, Q‐52, Q‐76, Q‐81, Q82, Q‐124, and Q‐126) were grown at two different locations (salt‐affected and normal soil having electrical conductivity (EC) of 16.24 and 1.76 dS m−1, respectively). Morphological, physiological, and yield parameters were recorded to assess the impact of salinity on different genotypes of quinoa. All the tested genotypes performed better in normal soil (37% more yield) than salt‐affected soils. Under salt‐affected conditions, differential salt tolerance responses of quinoa genotypes were observed. Among tested genotypes, Q‐7 achieved the highest chlorophyll content index, biological mass (7905 kg ha−1), and seed yield (1916 kg ha−1) under salt‐affected conditions, it was followed by Q‐81. Salt stress caused up to 94% reduction of seed yield in the salt‐sensitive genotype (Q‐11), while the salt‐tolerant genotype (Q‐81) showed only 15% reduction in seed yield. Morphological characteristics of quinoa genotypes were differently influenced by salt stress. The salt‐tolerant accessions Q‐7 and Q‐81 exhibited similar morphological characteristics. Based on the findings of this study, salt‐tolerant quinoa genotypes can be successfully grown in salt‐degraded soils (with EC ≤ 16.24 dS m−1) in extreme winter seasons with arid climatic conditions. Core Ideas: Salt‐tolerant quinoa genotypes can be successfully grown in strongly salt‐degraded soils (electrical conductivity [EC] ≤ 16.24 dS m−1).Morphological characters (growth habit and main stem shape) of quinoa are associated with salt tolerance potential.Salt‐sensitive genotypes showed significantly higher yield losses (up to 94%) than salt‐tolerant genotypes (15%–45%).Quinoa genotypes show differential salt tolerance responses based on their origin and morphological characters. Plain Language Summary: Quinoa, a high‐value halophytic crop, emerges as a promising candidate to ensure food security amidst increasing soil salinization caused by climate change. In a 2‐year field study, 18 quinoa genotypes of diverse origins were cultivated in both normal and salt‐affected soils to evaluate the impact of salinity on different quinoa genotypes. Under salt‐affected conditions, distinct salt tolerance responses were observed among the quinoa genotypes. Morphological, physiological, and yield parameters of the quinoa genotypes were variably affected by salt stress. The salt‐tolerant accessions Q‐7 and Q‐81 exhibited robust responses, showing minimal yield reduction. Based on the findings of this study, salt‐tolerant quinoa genotypes can be successfully cultivated in salt‐degraded soils (with electrical conductivity ≤ 16.24 dS m−1) during extreme winter seasons characterized by arid climatic conditions. [ABSTRACT FROM AUTHOR]

Summary: The aim of this study was to provide a quantitative synthesis of the effects of randomized controlled pediatric lifestyle interventions in treating obesity among 11–17‐year‐old children. We conducted a systematic review and meta‐analysis on the randomized controlled trials, consisting of actual exercise training and nutrition education, published between January 2000 and August 2022. The initial search yielded 2598 articles, with eight articles meeting the inclusion criteria. The articles were analyzed using a multivariate random effects model. The primary outcome variables were body mass index (BMI), standardized BMI (BMIz), and waist circumference (WC). Our analyses showed that lifestyle interventions were efficacious in improving BMI (−1.77 kg/m2, 95% CI [−2.70, −0.83], p < 0.001), BMIz (−0.30, 95% CI [−0.45, −0.16], p < 0.001), and WC (−3.32 cm, 95% CI [−5.35, −1.29], p < 0.001) in children with overweight and obesity. In addition, moderation analyses suggested that the efficacy of the lifestyle interventions correlated positively with participants' weight status and was enhanced when an intervention was boosted with a longer intervention duration and higher frequency. In conclusion, the current evidence suggests that lifestyle interventions are efficacious in treating children with obesity. The available evidence further indicates that duration, frequency, along weight status, were moderating the effectiveness of these lifestyle interventions. [ABSTRACT FROM AUTHOR]

Objective: Rarefaction of blood and lymphatic vessels in the skin has been reported in systemic sclerosis (SSc) (scleroderma). E26 transformation–specific–related factor (ERG) and Friend leukemia virus–induced erythroleukemia 1 (FLI‐1) are important regulators of angiogenesis, but their role in lymphatic vasculature is lesser known. The goal of this study was to determine the role of ERG and FLI‐1 in postnatal lymphangiogenesis and SSc lymphatic system defects. Methods: Immunofluorescence was used to detect ERG and FLI‐1 in skin biopsy samples from patients with SSc and healthy controls. Transcriptional analysis of ERG or FLI‐1–silenced human dermal lymphatic endothelial cells (LECs) was performed using microarrays. Effects of ERG and FLI‐1 deficiency on in vitro tubulogenesis in human dermal LECs were examined using a Matrigel assay. ERG and FLI‐1 endothelial–specific knockouts and ERG lymphatic–specific knockouts were generated to examine vessel regeneration in mice. Results: ERG and FLI‐1 protein levels were reduced in the blood and lymphatic vasculature in SSc skin biopsy samples. ERG levels were shown to regulate genes involved in lymphatic vessel specification, including vascular endothelial growth factor receptor 3/FLT‐4, lymphatic vessel endothelial hyaluronan receptor 1, SOX‐18, and prospero homeobox 1 (PROX‐1), whereas FLI‐1 enhanced the function of ERG. The ERG–FLT‐4 pathway regulated in vitro tubulogenesis in human LECs. Deficiency of ERG or FLI‐1 similarly impaired the function of blood vessels in mice. However, only ERG deficiency affected the regeneration of lymphatic vessels during wound healing. Conclusion: ERG and FLI‐1 are essential regulators of blood and lymphatic vessel regeneration. Deficiency of ERG and FLI‐1 in SSc endothelial cells may contribute to the impairment of blood and lymphatic vasculature in patients with SSc. [ABSTRACT FROM AUTHOR]

Hybrid planar‐Si/organic heterojunction solar cells have garnered substantial interest due to their potential for producing cost‐effective, high‐efficiency devices. This study investigates the photophysical properties and application of dibenzothiophene‐spirobifluorene‐dithienothiophene (DBBT‐mCbz‐DBT) in enhancing the efficiency of photovoltaic devices. Utilizing ultraviolet–visible and fluorescence spectroscopy, DBBT‐mCbz‐DBT is analyzed in solutions and doped films, showing maximum absorption at 380 nm and emission at 440 nm. Notably, the photoluminescence intensity in 4,4′‐di(9H‐carbazol‐9‐yl)‐1,1′‐biphenyl films peaks at 40–50% DBBT‐mCbz‐DBT concentrations, which are selected for solar cell fabrication. Enhanced light absorption and charge transport are observed with a DBBT‐mCbz‐DBT layer on silicon, significantly improving device performance. The planar silicon/poly(3,4‐ethylene dioxythiophene):poly(styrene sulfonate) (Si/PEDOT:PSS) heterojunction solar cells with DBBT‐mCbz‐DBT exhibit a power conversion efficiency of 14.75%, demonstrating substantial gains over baseline structures. The DBBT‐mCbz‐DBT layer optimizes energy band alignment, reduces recombination losses, and enhances electron transport, improving overall device efficiency. This research underscores the potential of integrating DBBT‐mCbz‐DBT in solar cells to achieve higher performance through simple, scalable fabrication methods. [ABSTRACT FROM AUTHOR]

Background: xCT, also known as SLC7A11 (solute carrier Family 7 Member 11), is a cystine/glutamate antiporter protein that mediates regulated cell death and antioxidant defense. The aim of this study was to investigate the effect of xCT on the outcome of patients diagnosed with new head and neck squamous cell carcinoma (HNSCC). Methods: This retrospective cohort study utilized a population‐based dataset, comprising all patients (n = 1033) diagnosed with new HNSCC during 2005–2015 in a population of 697,000 people. All patients (n = 585) with a tumor tissue sample available for immunohistochemical (IHC) staining were included. The follow‐up rates were 97% and 81% at 3 and 5 years, respectively. Also, the specificity of the anti‐xCT antibody was validated. Results: The expression level and prognostic significance of xCT were strongly dependent on tumor location. In oropharyngeal squamous cell carcinoma (OPSCC) patients, xCT expression was a significant prognostic factor for 5‐year overall survival (OAS) (HR: 2.71; 95% CI 1.67–4.39; p < 0.001), disease‐specific survival (DSS) (HR: 2.58; 95% CI 1.47–4.54; p = 0.001), and disease‐free survival (DFS) (HR: 2.69; 95% CI 1.55–4.64; p < 0.001). Five‐year survival rates for OPSCC patients with high and low levels of xCT were OAS 34% versus 62%; DSS 51% versus 73%; DFS 43% versus 73%, respectively. According to a multivariate model adjusted for age, T‐class, nodal positivity, and tobacco consumption, xCT was an independent prognostic factor for 3‐year survival, in which it outperformed p16 IHC. Similar associations were not observed in squamous cell carcinomas of oral cavity or larynx. Regarding treatment modalities, xCT was most predictive in HNSCC patients who received radiotherapy. Conclusions: High xCT expression was associated with poor prognosis in OPSCC. Our findings suggest that joint analysis of xCT and p16 may add significant value in OPSCC treatment stratification. [ABSTRACT FROM AUTHOR]

Aims: Anal cancer, despite its rarity, is a matter of serious concern in the United States, with an uptrend in recent years and marked racial disparities in mortality rates. The aim of this work was to investigate anal cancer mortality trends and sex race disparities in the United States from 1999 to 2020. Method: This is a retrospective study using data from the CDC WONDER database (1999–2020). We investigated deaths attributed to anal cancer, identified by the ICD‐10 code C21.1, and excluded individuals aged 14 years and under. The Mann–Kendall trend test was used to investigate temporal trends and a t‐test was used to compare continuous variables. Results: Both male and female age‐adjusted mortality attributed to anal cancer increased significantly during the study period across all subgroups, including race (Black and White), US Census region (Northeast, Midwest, South and West) and age (15–64 and ≥65 years) (p < 0.001 for all comparisons). For each subgroup, women demonstrated significantly higher rates of mortality than men, except in the Black population, where Black men had higher rates than Black women (0.40 vs. 0.29, p < 0.001). Additionally, Black men had significantly higher mean mortality rates than White men (0.40 vs. 0.27, p < 0.001). The highest rates of anal cancer mortality were among geriatric individuals, especially women aged ≥65 years, at 1.18 per 100 000. Conclusion: The rise in anal cancer mortality and racial and sex disparities present a significant challenge for healthcare providers and policy makers. Further studies are required to devise evidence‐based strategies to effectively tackle this challenge. [ABSTRACT FROM AUTHOR]

Packaging plastics are being substituted by more sustainable materials to satisfy modern‐life requirements. For example, utilisation of biocoated paperboards for packaging is one of the options; however, certain challenges exist in maintaining the integrity of the coated surface. In this study, the barrier formation and convertibility properties of a novel suberin dispersion coating were examined and compared with those of six commercial coatings by measuring their oil and grease resistance and using scanning electron microscopy (SEM) before and after creasing. Even before creasing, SEM revealed deep cavities on the coated surfaces, with the potential to impair the material barrier properties. Furthermore, finite element modelling provided evidence that creasing stresses emerged under the rules and in nearby areas. These outer stresses with internal fibre structure realignment caused the formation of surface defects such as grazes, microcracks and coating ruptures. The deepest defects, which critically reduce the barrier properties, were oriented parallel to the machine direction of the materials. In contrast, the cross‐machine direction‐oriented defects were bridged by the substrate fibres and did not penetrate that deeply into the coating thickness. The amount and severity of the surface damage revealed by SEM were correlated with the actual oil resistance measured for each material. The results indicate that the suberin dispersion exhibits promising barrier performance as a paperboard coating but requires further development to enhance its resistance to the conversion stresses. [ABSTRACT FROM AUTHOR]

Current analysis presents the unsteady two‐dimensional flow of Williamson nanofluid with suspension of microorganisms due to stretched Riga surface with porous medium. The applications of external heat source/sink with non‐uniform relations are suggested. Furthermore, activation energy and nonlinear radiative effects are encountered. The extension in energy equation is subject to the implications of famous Cattaneo–Christov model. The problem is simplified with help of dimensionless quantities. The analytical simulations of formulated problem have been performed with help of built‐in bvp4c numerical scheme. The physical aspects of problem are presented for various flow parameters. It is claimed that velocity profile boosted due to modified Hartmann parameter while declining change in velocity profile is noted for Williamson fluid constant. The temperature field enhances for non‐uniform heat source constants. Current results convey applications in heat transfer enhancement, solar energy, extrusion processes, automobile industries, fertilizers, and so forth. [ABSTRACT FROM AUTHOR]

We examine how the effects of government spending shocks depend on the balance sheet position of households. Employing U.S. household survey data, we find a large, positive consumption response for households with mortgage debt, smaller response for renters, and an insignificant response for outright homeowners, in response to a positive government spending shock. We consider a model with three types of households and show that it can successfully account for these findings. Liquidity constraints and wealth effects play a crucial role in shock propagation. Our findings suggest the importance of household mortgage debt position in the transmission mechanism of fiscal policy. [ABSTRACT FROM AUTHOR]

In the past decade, insect meal has gained popularity in the animal feed industry, particularly in aquafeed, due to rising costs and decreased availability of fish meal (FM) and fish oil. Initially met with skepticism, insect meal is now seen as a promising ingredient because of its high nutrient profile. Research worldwide is exploring its potential as a FM replacement. Insects are abundant, nutritious, and environmentally friendly, as they can be reared on organic waste, minimizing the need for land, water, and energy. This research aims at obtaining a comprehensive and in‐depth understanding of the current status and research trend patterns in this research field. To achieve this goal, this study conducts a mini systematic review and scientometric analysis of the global research published from 2013 to 2022 on the usage of insect meal in aquaculture. In the scientometric analysis, a total of 354 papers published by 1800 authors in 124 different journals from the Web of Science (WoS) core collection were analyzed, evaluating the number of publications, most relevant authors, organizations, top cited countries, most globally cited publications, and trending research themes in this field. The result showed that the University of Turin was the leading organization in insect meal research, whereas aquaculture was the leading journal, and author Laura Gasco was the prominent researcher in this field in the studied time frame (2013–2022). Italy was the leading country in Europe, while China dominated Asia in terms of the number of publications. The annual growth rate in insect meal research was found to be positive (23.11%), with 36.95 average citations per document. This study helps practitioners and scholars understand the current state of insect meal in aquaculture and identifies research requirements that can benefit both academia and industry. [ABSTRACT FROM AUTHOR]

A new image encryption algorithm based on the triple chaotic maps is proposed to deal with the issues of inadequate security and low encryption efficiency. Coloured images consist of three linked channels used in the scheme. This method uses different keys to break the correlations between adjacent pixels in each channel. The triple chaotic maps are Lorenz, 2D‐Logistic, and Henon. First, the plain image is split into RGB channels to encrypt each channel separately. Second, the triple chaotic maps generate two groups of keys. The first group of keys performs a pixel permutation, resulting in scrambled channels used as input for the following step. Finally, the second group of keys is used to diffuse the scrambled channels independently, resulting in diffused channels, which are then merged to obtain a cipher image. The triple chaotic maps of different orders generate the cipher image with great unpredictability and security. The security is evaluated using various measures. The results demonstrated a high level of security attained by successfully encrypting coloured images. Recent encryption algorithms are compared in terms of entropy, correlation coefficients, and attack robustness. The proposed method provided outstanding security and outperformed existing image encryption algorithms. [ABSTRACT FROM AUTHOR]

Lithium‐ion batteries (LIBs) are increasingly encouraged to enhance their environmental friendliness and safety while maintaining optimal energy density and cost‐effectiveness. Although various electrolytes using greener and safer glyme solvents have been reported, the low charge voltage (usually lower than 4.0 V vs Li/Li+) restricts the energy density of LIBs. Herein, tetraglyme, a less‐toxic, non‐volatile, and non‐flammable ether solvent, is exploited to build safer and greener LIBs. It is demonstrated that ether electrolytes, at a standard salt concentration (1 m), can be reversibly cycled to 4.5 V vs Li/Li+. Anchored with Boron‐rich cathode‐electrolyte interphase (CEI) and mitigated current collector corrosion, the LiNi0.8Mn0.1Co0.1O2 (NMC811) cathode delivers competitive cyclability versus commercial carbonate electrolytes when charged to 4.5 V. Synchrotron spectroscopic and imaging analyses show that the tetraglyme electrolyte can sufficiently suppress the overcharge behavior associated with the high‐voltage electrolyte decomposition, which is advantageous over previously reported glyme electrolytes. The new electrolyte also enables minimal transition metal dissolution and deposition. NMC811||hard carbon full cell delivers excellent cycling stability at C/3 with a high average Coulombic efficiency of 99.77%. This work reports an oxidation‐resilient tetraglyme electrolyte with record‐high 4.5 V stability and enlightens further applications of glyme solvents for sustainable LIBs by designing Boron‐rich interphases. [ABSTRACT FROM AUTHOR]

Nickel oxide (NiO) nanoparticles were synthesized using a green method involving Pterolobium hexapetalum flower extract as the reducing agent. Synthesized nickel oxide nanoparticles (NiO NPs) were thoroughly characterized using X‐ray diffraction, UV–vis spectroscopy, Fourier‐transform infrared spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and Brunauer–Emmett–Teller (BET) surface area analysis. The XRD analysis confirmed the pure formation of NiO NPs. TEM and SEM images revealed the size, shape, and surface morphology of the nanoparticles. BET analysis indicated a high surface area, making these nanoparticles suitable for various applications. The NiO NPs were further investigated for their potential in supercapacitor applications, demonstrating excellent electrochemical performance. NiO@rGO electrode with graphene proportion showed a maximum specific capacity of 1266 Fg−1 at 1 Ag−1. Moreover, following the 3000‐cycle assessment, the specific retention of 98.2% confirmed that the electrode had high cyclic stability. Additionally, their effectiveness in dye degradation was evaluated, showing promising results in removing organic dyes from wastewater. The antibacterial activity of the NiO nanoparticles was also assessed, indicating significant inhibition against various bacterial strains. These multifaceted studies suggest that NiO NPs synthesized from plant extract hold great promise for applications in energy storage, environmental remediation, and antimicrobial treatments. [ABSTRACT FROM AUTHOR]

The use of nanoparticles as drug‐carrying systems in medicine has received much attention, and on the other hand, the use of plants with medicinal properties has advantages over synthetic drugs. This study aims to improve the antibacterial and anti‐biofilm properties of Euphorbia hebecarpa plant extract using chitosan nanoparticles. Extraction were performed using the modified maceration and methanol solvent. The agar disc diffusion method was carried out to investigate the antimicrobial effects and MIC at an optical density (OD) of 630 nm. The anti‐biofilm agent's influence was measured at OD 570 nm, and the metabolic activity of bacteria in the damaged biofilm was determined using triphenyl tetrazolium chloride (TTC) staining. The nanoparticles were obtained by following the ionic gelation method and its characteristics were evaluated. Chitosan nanoparticles loaded with plant extract were found to be spherical shape with hydrodynamic diameter of 142 nm, a polydispersity index (PDI) of 0.184, a zeta potential of +28.6 mV. It was determined that the loading capacity (% LC) and encapsulation efficiency (% EE) percentages were 33% and 40%, respectively. The diameter of the inhibition zone in the agar disc diffusion test for both bacteria using nanoparticles loaded with the extract increased compared with control groups. Also, at a concentration of 4 mg/mL of loaded nanoparticles, 49.33% of Escherichia coli biofilm and 62.7% of Staphylococcus aureus biofilm were destroyed. The data obtained from the tests performed in this study show that the use of Euphorbia plant extract in the form of chitosan nanoparticles can have more antimicrobial and anti‐biofilm effects. [ABSTRACT FROM AUTHOR]

Foetal cells are detectable in women decades postpartum, a state termed foetal microchimerism. The interplay between these semi‐allogeneic foetal cells and the mother could be affected by genetic mismatches in the HLA loci. Here, we relate HLA allele and molecular mismatch values to the presence and quantity of foetal microchimerism in the maternal circulation during pregnancy and postpartum. A total of 76 pregnant women were included, of which 59 were followed up 1–8 years postpartum. Maternal and foetal DNA was genotyped for HLA class I and II loci. Foetal cells in maternal buffy coat were detected by qPCR, targeting inherited paternal alleles. Antibody‐verified eplet mismatch and Predicted Indirectly Recognisable HLA Epitopes (PIRCHE) scores were calculated to quantify foetal‐maternal histocompatibility from the mother's perspective. Circulating foetal cells were detected in 50.0% (38/76) of women during pregnancy, and 25.4% (15/59) postpartum. During pregnancy, HLA class II antibody‐verified eplet mismatch load and PIRCHE scores correlated negatively with the presence and quantity of foetal cells in the maternal circulation. Postpartum, HLA class I allele mismatches correlated negatively with foetal microchimerism presence, while HLA class II allele mismatches, HLA class I and II antibody‐verified eplet mismatch load, and PIRCHE‐I and PIRCHE‐II scores correlated negatively with both microchimerism presence and quantity. The correlation between mismatch parameters aimed at evaluating the risk of humoral and T cell‐mediated allorecognition and foetal microchimerism was more evident postpartum than during pregnancy. The observed predictive effect of foetal‐maternal histocompatibility on foetal microchimerism suggests that circulating foetal cells are subject to clearance by the maternal immune system. We propose that allorecognition of foetal cells in the maternal circulation and tissues influences any long‐term effect that foetal microchimerism may have on maternal health. [ABSTRACT FROM AUTHOR]

Background: Open offers (OOs) in liver transplantation (LT) result from bypassing the traditional allocation system. Little is known about the trends of OOs or the differences in donor/recipient characteristics compared to traditionally placed organs. We aim to quantify modern practices regarding OOs and understand NMP's impact, focusing on social determinants of health (SDH), cost, and graft‐associated risk. Methods: LTs from 1/1/2018 to 12/31/2023 at a single center were included. NMP was implemented on 10/1/2022. The CDC (centers for disease control)‐validated social vulnerability index (SVI) and donor risk index (DRI) were calculated. Comprehensive complications index (CCI), Clavien‐Dindo grades, patient and graft survival, and costs of transplantation were included. Results: 1162 LTs were performed; 193 (16.8%) from OOs. OOs were more common in the post‐NMP era (26.5% vs. 13.3%, p < 0.001). Pre‐NMP, patients receiving OOs had longer waitlist times (118 vs. 69 days, p < 0.001), lower MELDs (17 vs. 25 points, p < 0.001), and riskier grafts (DRI = 1.8 vs. 1.6, p = 0.004) compared to standard offers. Post‐NMP, recipients receiving OOs demonstrated no difference in waitlist time (27 vs. 20 days, p = 0.21) or graft risk (DRI = 2.03 vs. 2.23, p = 0.17). OO recipient MELD remained lower (16 vs. 22, p < 0.001). OO recipients were more socially vulnerable (SVI), pre‐NMP (0.41 vs. 0.36, p = 0.004), but less vulnerable after NMP (0.23 vs. 0.36, p = 0.019). Despite increased graft risk, pre‐NMP OO‐LTs were less expensive in the 90‐day global period ($154 939 vs. $178 970, p = 0.002) and the 180‐days pre‐/post‐LT ($208 807 vs. $228 091, p = 0.021). Cost trends remained similar with NMP. Conclusion: OOs are increasingly utilized and may be appealing due to demonstrated cost reductions even with NMP. Although most OO‐related metrics in our center remain similar before and after machine perfusion, programs should take caution that increasing use does not worsen organ access for socially vulnerable populations. [ABSTRACT FROM AUTHOR]

Huntington's disease (HD) is a devastating neurodegenerative disease that is manifested by a gradual loss of physical, cognitive, and mental abilities. As the disease advances, age has a major impact on the pathogenic signature of mutant huntingtin (mHTT) protein aggregation. This review aims to explore the intricate relationship between aging, mHTT toxicity, and cellular senescence in HD. Scientific data on the interplay between aging, mHTT, and cellular senescence in HD were collected from several academic databases, including PubMed, Google Scholar, Google, and ScienceDirect. The search terms employed were "AGING," "HUNTINGTON'S DISEASE," "MUTANT HUNTINGTIN," and "CELLULAR SENESCENCE." Additionally, to gather information on the molecular mechanisms and potential therapeutic targets, the search was extended to include relevant terms such as "DNA DAMAGE," "OXIDATIVE STRESS," and "AUTOPHAGY." According to research, aging leads to worsening HD pathophysiology through some processes. As a result of the mHTT accumulation, cellular senescence is promoted, which causes DNA damage, oxidative stress, decreased autophagy, and increased inflammatory responses. Pro‐inflammatory cytokines and other substances are released by senescent cells, which may worsen the neuronal damage and the course of the disease. It has been shown that treatments directed at these pathways reduce some of the HD symptoms and enhance longevity in experimental animals, pointing to a new possibility of treating the condition. Through their amplification of the harmful effects of mHTT, aging and cellular senescence play crucial roles in the development of HD. Comprehending these interplays creates novel opportunities for therapeutic measures targeted at alleviating cellular aging and enhancing HD patients' quality of life. [ABSTRACT FROM AUTHOR]

Background: The application of nanoparticles (NPs) in horticultural crops is in a tremendous increase. NPs help in the overcoming of stresses with positive impacts on plant growth and development. Silver NPs (AgNPs) have numerous pre‐ and postharvest applications in agriculture. Aims and methods: This study aimed to evaluate the effect of AgNPs application (0, 50, 100, 150, and 200 ppm) at three spray intervals (5, 10, and 15 days) on the morphological and compositional traits, and defense system of strawberry. Results: Results showed that AgNPs application enhanced the growth, yield, quality, and nutritional aspects of strawberry grown under field conditions. Shoot fresh weight (20.20 g) and leaf number/plant (41.53) were enhanced at 100 ppm AgNPs and 15 days interval. A stunted growth of strawberry plants was recorded at 200 ppm AgNPs. Moreover, a 15‐day‐spray interval was found optimum for the improvement of major morphological traits. Fruit size, yield, total soluble solids, acidity, and antioxidant capacity were improved at 50 and 100 ppm AgNPs. The activation of plant defense system, that is, superoxide dismutase, peroxidase, catalase, total soluble protein, and ascorbic acid was improved under AgNPs foliar application. The activation of stress indicating marker malondialdehyde outlined a high defense response of strawberry at 150 ppm AgNPs. Conclusions: Conclusively, AgNPs application at 50, 100, and 150 ppm can be considered effective for sustainable strawberry production. [ABSTRACT FROM AUTHOR]

Copyright of Irrigation & Drainage is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)