Search

Background. This study aims to analyze the effect of Semelil, an herbal selenium-based medicine, on osteogenesis in rabbit calvarium defects. Methods. Four identical bony defects (8 mm) were created in the calvarium of 16 New Zealand male rabbits and filled randomly with xenogenic bone substitute material (Bio-Oss®) and semelil herbal drug (ANGIPARS™). One site was filled with Bio-Oss (B); the second site was treated with ANGIPARS (A); the third site was treated with ANGIPARS + Bio-Oss (AB); and the fourth site was left as untreated control (C) and defects were left unfilled. Rabbits were randomly divided into two groups (n=8) and sacrificed at four and eight weeks. Percentage of new bone formation, type of the newly formed bone, percentage of the remaining xenograft biomaterial, and foreign body reaction (FBR) were evaluated via histological and histomorphometric analyses. Results. The percentage of new bone formation was significantly different among four groups. The highest effect was observed in AB, followed by A, B, and C groups, respectively. The difference in the mean percentage of new bone formation between four and eight weeks was significant for all four groups (P<0.001). Regarding bone formation, the interaction effect of A and B was significant at four (P<0.001) and eight weeks (P=0.002). ANGIPARS alone and in presence of Bio-Oss enhanced new bone formation at both four and eight weeks (P<0.001). The mean amount of new bone formation was significantly different at four and eight weeks in groups C (P=0.008), A (P<0.001), B (P<0.001), and AB (P=0.003). FBR was not observed in any group. Conclusion. Semelil may be useful as an adjunct to conventional osteoconductive materials in order to enhance osteogenesis. [ABSTRACT FROM AUTHOR]

Objectives This retrospective cross-sectional study aimed to evaluate the prevalence of biologic complications of implants in patients treated by fixed implant supported prosthesis without regular maintenance program. Materials and methods One hundred thirty-four patients with 478 implants, installed during a 10-year period (2001-2010), were recruited for clinical and radiographic follow-up examinations. The periodontal and implant health status were assessed to determine the prevalence of peri-implant diseases. Results The mean ± SD loading time for implants was 4.43 ± 2.25 years. Fifty-five percentage of the implants were tissue-level implants. Peri-implantitis was diagnosed in 20% of patients and 8.8% of implants. Subject-based and implant-based prevalence of mucositis amounted to 48.5% and 40%, respectively. Mean crestal bone loss in tissue-level and bone-level implants were 0.28 ± 0.53 mm and 1.37 ± 1.5 mm, respectively. Smoking and lack of keratinized mucosa was associated with peri-implantitis at an odds ratio of OR = 2.57 and 3.89, respectively. Conclusions After a 5-year period of loading without any regular maintenance program, one out of five patients would experience peri-implantitis. Tissue-level implants had lower values of peri-implantitis prevalence and crestal bone loss. [ABSTRACT FROM AUTHOR]