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Start Over Author "Quinlivan L" Publisher wiley-blackwell
3 results on '"Quinlivan L"'

1. Genetic variation indnmt3band increased global dna methylation is associated with suicide attempts in psychiatric patients

Author

Murphy, T. M., Mullins, N., Ryan, M., Foster, T., Kelly, C., McClelland, R., O'Grady, J., Corcoran, E., Brady, J., Reilly, M., Jeffers, A., Brown, K., Maher, A., Bannan, N., Casement, A., Lynch, D., Bolger, S., Buckley, A., Quinlivan, L., Daly, L., Kelleher, C., and Malone, K. M.

Subjects
DNA methylation, epigenetics, behavior, methyltransferases, receptor, life stress, childhood abuse, DNA methyltransferases, psychiatry, slc1a3, polymorphisms, major depression, protein, suicide, risk
Abstract

Recently, a significant epigenetic component in the pathology of suicide has been realized. Here we investigate candidate functional SNPs in epigenetic-regulatory genes, DNMT1 and DNMT3B, for association with suicide attempt (SA) among patients with co-existing psychiatric illness. In addition, global DNA methylation levels [5-methyl cytosine (5-mC%)] between SA and psychiatric controls were quantified using the Methylflash Methylated DNA Quantification Kit. DNA was obtained from blood of 79 suicide attempters and 80 non-attempters, assessed for DSM-IV Axis I disorders. Functional SNPs were selected for each gene (DNMT1; n?=?7, DNMT3B; n?=?10), and genotyped. A SNP (rs2424932) residing in the 3' UTR of the DNMT3B gene was associated with SA compared with a non-attempter control group (P?=?0.001; Chi-squared test, Bonferroni adjusted P value?=?0.02). Moreover, haplotype analysis identified a DNMT3B haplotype which differed between cases and controls, however this association did not hold after Bonferroni correction (P?=?0.01, Bonferroni adjusted P value?=?0.56). Global methylation analysis showed that psychiatric patients with a history of SA had significantly higher levels of global DNA methylation compared with controls (P?=?0.018, Student's t-test). In conclusion, this is the first report investigating polymorphisms in DNMT genes and global DNA methylation quantification in SA risk. Preliminary findings suggest that allelic variability in DNMT3B may be relevant to the underlying diathesis for suicidal acts and our findings support the hypothesis that aberrant DNA methylation profiles may contribute to the biology of suicidal acts. Thus, analysis of global DNA hypermethylation in blood may represent a biomarker for increased SA risk in psychiatric patients.

Published
2012

2. Genetic variation in DNMT3B and increased global DNA methylation is associated with suicide attempts in psychiatric patients.

Author

Murphy, T. M., Mullins, N., Ryan, M., Foster, T., Kelly, C., McClelland, R., O'Grady, J., Corcoran, E., Brady, J., Reilly, M., Jeffers, A., Brown, K., Maher, A., Bannan, N., Casement, A., Lynch, D., Bolger, S., Buckley, A., Quinlivan, L., and Daly, L.

Subjects
SUICIDAL behavior, PSYCHOTHERAPY patients, DNA methylation, GENETIC polymorphisms, PATHOLOGICAL psychology, EPIGENETICS, METHYLTRANSFERASES
Abstract

Recently, a significant epigenetic component in the pathology of suicide has been realized. Here we investigate candidate functional SNPs in epigenetic-regulatory genes, DNMT1 and DNMT3B, for association with suicide attempt ( SA) among patients with co-existing psychiatric illness. In addition, global DNA methylation levels [5-methyl cytosine (5- mC%)] between SA and psychiatric controls were quantified using the Methylflash Methylated DNA Quantification Kit. DNA was obtained from blood of 79 suicide attempters and 80 non-attempters, assessed for DSM-IV Axis I disorders. Functional SNPs were selected for each gene ( DNMT1; n = 7, DNMT3B; n = 10), and genotyped. A SNP (rs2424932) residing in the 3′ UTR of the DNMT3B gene was associated with SA compared with a non-attempter control group ( P = 0.001; Chi-squared test, Bonferroni adjusted P value = 0.02). Moreover, haplotype analysis identified a DNMT3B haplotype which differed between cases and controls, however this association did not hold after Bonferroni correction ( P = 0.01, Bonferroni adjusted P value = 0.56). Global methylation analysis showed that psychiatric patients with a history of SA had significantly higher levels of global DNA methylation compared with controls ( P = 0.018, Student's t-test). In conclusion, this is the first report investigating polymorphisms in DNMT genes and global DNA methylation quantification in SA risk. Preliminary findings suggest that allelic variability in DNMT3B may be relevant to the underlying diathesis for suicidal acts and our findings support the hypothesis that aberrant DNA methylation profiles may contribute to the biology of suicidal acts. Thus, analysis of global DNA hypermethylation in blood may represent a biomarker for increased SA risk in psychiatric patients. [ABSTRACT FROM AUTHOR]

Published
2013
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3. Oral health self-care behaviours in serious mental illness: A systematic review and meta-analysis.

Author

Turner E, Berry K, Aggarwal VR, Quinlivan L, Villanueva T, and Palmier-Claus J

Subjects
Health Behavior, Humans, Self Care, Mental Disorders epidemiology, Oral Health
Abstract

Aim: To understand the relationship between serious mental illness and oral health self-care behaviours using meta-analytic methods and a narrative synthesis of available literature., Method: The review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines [PROSPERO reference: CRD42020176779]. Search terms pertaining to serious mental illness and oral health were entered into EMBASE, PsycINFO, Medline and CINAHL. Eligible studies included a sample of people with a serious mental illness and a quantitative measure of an oral health self-care behaviour (eg dental visits, toothbrushing). The Effective Public Health Practice Project tool was utilised to appraise the quality of the literature. Studies in the meta-analysis contained a non-clinical or general population comparator sample., Results: People with a serious mental illness were significantly less likely to visit the dentist (OR 0.46, 95% CI 0.32-0.065, p > 0.001) or brush their teeth (OR 0.19, 95% CI 0.08-0.42, p < 0.001) when compared to non-clinical comparator samples. Few studies explored other oral health self-care behaviours (eg flossing and mouth washing), but uptake was generally low in people with a serious mental illness. The study quality of included studies was variable., Conclusions: The research showed a reduced uptake of oral health self-care behaviours in people with a serious mental illness. Suboptimal oral health can negatively impact on physical, social and psychological functioning. Further research is needed to understand the reasons for low rates of oral health self-care behaviours in this population., (© 2021 The Authors. Acta Psychiatrica Scandinavica published by John Wiley & Sons Ltd.)

Published
2022
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