1. Lidocaine aerosol preoperative application for improving the comfort of pediatric patients undergoing tonsillectomy and adenoidectomy: A prospective randomized controlled trial.
- Author
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Cheng, Lixia, Zhang, Fazhong, Ma, Guifen, Peng, Qingcai, Zhang, Mingyue, Sun, Yuanming, Xia, Xiaoqiong, and Li, Yuanhai
- Subjects
TONSILLECTOMY ,ADENOIDECTOMY ,CHILD patients ,RANDOMIZED controlled trials ,AEROSOLS ,LIDOCAINE ,MANN Whitney U Test - Abstract
Background and Aims: The use of lidocaine aerosol for pediatric tonsil and adenoidectomy has been reported less frequently. We hope to improve the perioperative comfort of pediatric patients undergoing these procedures by applying lidocaine aerosol. Methods: A total of 122 pediatric patients receiving tonsil and adenoidectomy were randomly divided into a lidocaine aerosol group (Group L) and a saline group (Group C), with 61 patients in each group; 2.4% alkaline lidocaine aerosol and saline were sprayed in the pharynx before induction. Our primary outcome were the incidence and rate ratio (RR) of postoperative pharyngeal complications (oropharyngeal dryness, dysphagia, hoarseness, and sore throat) and the pharyngeal comfort score, the latter of which was assessed by the occurrence of the above complications (yes = 0 point, none = 1 point). The secondary outcomes included preoperative and intraoperative blood pressure and heart rate, the incidence of choking during the induction period, the intraoperative opioid dosage, and the pain level and depth of sedation at 2, 6, and 24 h postoperatively. Statistical software used in this study included PASS15.0, SPSS 26.0, and GraphPad Prism 9.3.1, and statistical methods used included the t‐test, the χ² test, the Mann–Whitney U test, and the repeated measures analysis of variance. Results: The incidence and RR of postoperative pharyngeal complications such as oropharyngeal dryness (RR: 0.667, 95% confidence interval [CI]: 0.458–0.970, p = 0.03), dysphagia (RR: 0.333, 95% CI: 0.114–0.976, p = 0.03), hoarseness (RR: 0.647, 95% CI: 0.433–0.967, p = 0.03), and sore throat (RR: 0.727, 95% CI: 0.547–0.967, p = 0.03) were significantly lower in Group L than in Group C at 2 h postoperatively, and the incidence and RR of postoperative sore throat was significantly lower in Group L than in Group C at 6 h postoperatively (RR: 0.717, 95% CI: 0.547–0.942, p = 0.01). The postoperative pharyngeal comfort scores were significantly higher in Group L than in Group C at all postoperative time points (p < 0.05). The Ramsay sedation score was significantly higher (p < 0.01) and FLACC (face, legs, activity, crying, and consolability) score was significantly lower (p < 0.01) in Group L than in Group C at 2 h postoperatively. In Group C, the blood pressure and heart rate significantly faster at all time points immediately after intubation and afterward, except at the end of surgery (p < 0.05). Conclusions: In pediatric tonsil and adenoidectomy, the application of lidocaine aerosol before induction can reduce the incidence of postoperative pharyngeal complications, improve the child's postoperative pharyngeal comfort, and better realize perioperative "comfort medical treatment." Key points: The main results: In pediatric tonsil and adenoidectomy, the application of lidocaine aerosol before induction can reduce the incidence of postoperative pharyngeal complications, improve the child's postoperative pharyngeal comfort, and better realize perioperative "comfort medical treatment."The main limitations of the study: First, there may be a certain selection bias in this study. Second, the degree of response to surrounding environmental stimuli varies among pediatric patients and we could not control. Finally, the potential clinical relevance of 2.4% alkaline lidocaine aerosol is poorly studied.The prospect of research and clinical use: In pediatric tonsil and adenoidectomy, factors such as pharyngeal complications greatly reduce perioperative comfort in pediatric patients. The results of this study show that the application of lidocaine aerosol before induction of general anesthesia can reduce the postoperative pharyngeal complications of this type of surgery, alleviate the postoperative pain, maintain hemodynamic stability, and improve the degree of perioperative comfort of pediatric patients. It can be seen that this study has good clinical significance and application prospects, and is worth promoting and applying. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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