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Background: Cancer patients are increasingly affected by chemotherapy‐related cardiac dysfunction. The reported incidence of this condition vary significantly across different studies. Hypothesis: A better comprehensive understanding of chemotherapy‐related cardiac dysfunction incidence in cancer patients is imperative. Therefore, we performed a meta‐analysis to establish the overall incidence of chemotherapy‐related cardiac dysfunction in cancer patients. Methods: We searched articles in PubMed and EMBASE from database inception to May 1, 2023. Studies that reported the incidence of chemotherapy‐related cardiac dysfunction in cancer patients were included. Results: A total of 53 studies involving 35 651 individuals were finally included in the meta‐analysis. The overall pooled incidence of chemotherapy‐related cardiac dysfunction in cancer patients was 63.21 per 1000 person‐years (95% CI: 57.28−69.14). The chemotherapy‐related cardiac dysfunction incidence increased steeply within half a year of cancer chemotherapy. Also, the trend of chemotherapy‐related cardiac dysfunction incidence appeared to have plateaued after a longer duration of follow‐up. In addition, chemotherapy‐related cardiac dysfunction incidence rates are significantly higher among patients with age ≥50 years versus patients with age <50 years (99.96 vs. 34.48 per 1000 person‐years). The incidence rate of cardiac dysfunction was higher among breast cancer patients (72.97 per 1000 person‐years), leukemia patients (65.21 per 1000 person‐years), and lymphoma patients (55.43 per 1000 person‐years). Conclusion: Our meta‐analysis unveiled a definitive overall incidence rate of chemotherapy‐related cardiac dysfunction in cancer patients. In addition, it was found that the risk of developing this condition escalates within the initial 6 months postchemotherapy, subsequently tapering off to become statistically insignificant after a duration of 6 years. [ABSTRACT FROM AUTHOR]

Aims: The current evidence demonstrates that mesenchymal stem cells (MSCs) hold therapeutic potential for ischemic stroke. However, it remains unclear how changes in the secretion of MSC cytokines following the overexpression of heme oxygenase‐1 (HO‐1) impact excessive inflammatory activation in a mouse ischemic stroke model. This study investigated this aspect and provided further insights. Methods: The middle cerebral artery occlusion (MCAO) mouse model was established, and subsequent injections of MSC, MSCHO‐1, or PBS solutions of equal volume were administered via the mice's tail vein. Histopathological analysis was conducted on Days 3 and 28 post‐MCAO to observe morphological changes in brain slices. mRNA expression levels of various factors, including IL‐1β, IL‐6, IL‐17, TNF‐α, IL‐1Ra, IL‐4, IL‐10, TGF‐β, were quantified. The effects of MSCHO‐1 treatment on neurons, microglia, and astrocytes were observed using immunofluorescence after transplantation. The polarization direction of macrophages/microglia was also detected using flow cytometry. Results: The results showed that the expression of anti‐inflammatory factors in the MSCHO‐1 group increased while that of pro‐inflammatory factors decreased. Small animal fluorescence studies and immunofluorescence assays showed that the homing function of MSCsHO‐1 was unaffected, leading to a substantial accumulation of MSCsHO‐1 in the cerebral ischemic region within 24 h. Neurons were less damaged, activation and proliferation of microglia were reduced, and polarization of microglia to the M2 type increased after MSCHO‐1 transplantation. Furthermore, after transplantation of MSCsHO‐1, the mortality of mice decreased, and motor function improved significantly. Conclusion: The findings indicate that MSCs overexpressing HO‐1 exhibited significant therapeutic effects against hyper‐inflammatory injury after stroke in mice, ultimately promoting recovery after ischemic stroke. [ABSTRACT FROM AUTHOR]

HLA‐A*26:206:02N differs from A*26:01:01:01 by a single nucleotide exchange in exon 3. [ABSTRACT FROM AUTHOR]

Progressive peritoneal fibrosis and the loss of peritoneal function often emerged in patients undergoing long‐term peritoneal dialysis (PD), resulting in PD therapy failure. Varieties of cell‐cell communications among peritoneal cells play a significant role in peritoneal fibrogenesis. Extracellular vesicles (EVs) have been confirmed to involve in intercellular communication by transmitting proteins, nucleic acids or lipids. However, their roles and functional mechanisms in peritoneal fibrosis remain to be determined. Using integrative analysis of EV proteomics and single‐cell RNA sequencing, we characterized the EVs isolated from PD patient's effluent and revealed that mesothelial cells are the main source of EVs in PD effluent. We demonstrated that transforming growth factor‐β1 (TGF‐β1) can substitute for PD fluid to stimulate mesothelial cells releasing EVs, which in turn promoted fibroblast activation and peritoneal fibrogenesis. Blockade of EVs secretion by GW4869 or Rab27a knockdown markedly suppressed PD‐induced fibroblast activation and peritoneal fibrosis. Mechanistically, injured mesothelial cells produced EVs containing high level of integrin‐linked kinase (ILK), which was delivered to fibroblast and activated them via p38 MAPK signalling pathway. Clinically, the expression of ILK was up‐regulated in fibrotic peritoneum of patients undergoing long‐term PD. The percentage of ILK positive EVs in PD effluent correlated with peritoneal dysfunction and the degree of peritoneal damage. Our study highlights that peritoneal EVs mediate communications between mesothelial cells and fibroblasts to initiate peritoneal fibrogenesis. Targeting EVs or ILK could provide a novel therapeutic strategy to combat peritoneal fibrosis. [ABSTRACT FROM AUTHOR]

Epilepsy is a common chronic neurological disorder characterized by widespread neuronal death. The purpose of this study was to investigate the role of nuclear factor erythroid 2‐related factor 2 (Nrf2) m6A methylation in epilepsy. To create epileptic models, the rats were given Lithium chloride and pilocarpine, and isolated primary rat hippocampal neurons were cultured in an Mg2+‐free medium. The frequency of seizures was recorded in the epilepsy group of rats. The functional tests included TUNEL, MTT, and flow cytometry. Mechanistically, RNA degradation assay, RNA immunoprecipitation, and methylated RNA immunoprecipitation were performed. In epileptic models, Nrf2 and fat mass and obesity‐associated (FTO) levels were downregulated, whereas YT521‐B homology (YTH) domain family protein 2 (YTHDF2) was upregulated. Additionally, in epileptic models, there was a rise in the m6A methylation level of Nrf2 mRNA. Overexpressing FTO increased cell viability and reduced apoptosis, but Nrf2 interference reversed these effects. Meanwhile, FTO overexpression decreased the m6A methylation of Nrf2 mRNA. Moreover, YTHDF2 bound to Nrf2 mRNA and decreased its stability. Furthermore, FTO overexpression reduced seizure frequency in rats and inhibited hippocampal neuron apoptosis via lowering the m6A methylation level of Nrf2 mRNA. Overexpressing FTO reduced m6A methylation of Nrf2 mRNA, increased cell viability, suppressed apoptosis, and slowed the progression of epileptic diseases, which is linked to YTHDF2 binding to m6A‐modified Nrf2 and promoting its degradation, as well as downregulating Nrf2 expression in hippocampal neurons. [ABSTRACT FROM AUTHOR]

Objective: Adipogenesis has been recognized as an attractive avenue for maintaining systemic homeostasis, with peroxisome proliferator‐activated receptor γ (PPARγ) showing predominant roles in this process. This study aims to identify promising drug candidates by targeting PPARγ for adipogenesis‐based metabolic homeostasis and to clarify the detailed mechanisms. Methods: Molecular events contributing to adipogenesis were screened, which identified PPARγ as having the predominant role. Promising agents of adipogenesis agonism were screened using a PPARγ‐based luciferase reporter assay. The functional capacity and molecular mechanisms of magnolol were intensively examined using 3T3‐L1 preadipocytes and dietary models. Results: This study found that F‐box only protein 9 (FBXO9)‐mediated lysine 11 (K11)‐linked ubiquitination and proteasomal degradation of PPARγ are critically required during adipogenesis and systemic homeostasis. Notably, magnolol was identified as a potent adipogenesis activator by stabilizing PPARγ. The pharmacological mechanisms investigations clarified that magnolol directly binds to PPARγ and markedly interrupts its interaction with FBXO9, leading to a decline in K11‐linked ubiquitination and proteasomal degradation of PPARγ. Clinically important, magnolol treatment significantly facilitates adipogenesis in vitro and in vivo. Conclusions: The downregulation of K11‐linked ubiquitination of PPARγ caused by FBOX9 is essentially required for adipogenesis, while targeting PPARγ‐FBXO9 interaction provides a new avenue for the therapy of adipogenesis‐related metabolic disorder. [ABSTRACT FROM AUTHOR]

Purpose: Genotype‐phenotypic correlation of KCNH1 variant remains elusive. This study aimed to expand the phenotypic spectrum of KCNH1 and explore the correlations between epilepsy and molecular sub‐regional locations. Methods: We performed whole‐exome sequencing in a cohort of 98 patients with familiar febrile seizure (FS) or epilepsy with unexplained etiologies. The damaging effects of variants were predicted by protein modeling and multiple in silico tools. All reported patients with KCNH1 pathogenic variants with detailed neurological phenotypes were analyzed to evaluate the genotype‐phenotype correlation. Results: Two novel KCNH1 variants were identified in three cases, including two patients with FS with inherited variant (p.Ile113Thr) and one boy with epilepsy with de novo variant (p.Arg357Trp). Variant Ile113Thr was located within the eag domain, and variant p.Arg357Trp was located in transmembrane domain 4 of KCNH1, respectively. Two patients experienced refractory status epilepticus (SE), of which one patient died of acute encephalopathy induced by SE. Further analysis of 30 variants in 51 patients demonstrated that de novo variants were associated with epileptic encephalopathy, while mosaic/somatic or germline variants cause isolated epilepsy/FS. All hotspot variants associated with epileptic encephalopathy clustered in transmembrane domain (S4 and S6), while those with isolated epilepsy/seizures or TBS/ZLS without epilepsy were scattered in the KCNH1. Conclusions: We found two novel missense variants of KCNH1 in three individuals with isolated FS/epilepsy. Variants in the KCNH1 cause a spectrum of epileptic disorders ranging from a benign form of genetic isolated epilepsy/FS to intractable form of epileptic encephalopathy. The genotypes and variant locations help explaining the phenotypic variation of patients with KCNH1 variant. [ABSTRACT FROM AUTHOR]

Background: The null phenotype in P1PK blood group, known as "p," is extremely rare in the whole world. Individuals of p phenotype spontaneously form anti‐PP1PK isoantibody. Here, we report a case of p phenotype with naturally occurring anti‐PP1PK isoantibodies in a Chinese individual. Study Design and Methods: Serology tests, containing alloantibodies screening and identification, were conducted to demonstrate the phenotype in P1PK blood group. The genotype of A4GALT gene was identified by haplotypes separation and sequencing. Results: The serological assay demonstrated the p phenotype of the proband, presenting with 1:64 titer of anti‐PP1PK. The sequencing data revealed a compound heterozygote consisting of A4GALT*P1.01 with c.343A>T and a novel allele based on A4GALT*01N.05 with an addition polymorphism c.100G>A. The sequence of the novel allele has been submitted to GenBank and the accession number OM912503 was assigned. Conclusion: Our study demonstrates a case of naturally occurring anti‐PP1Pk in a Chinese individual with p phenotype, which is based on compound heterozygosity including one novel allele. As the proband is a young lady, monitoring the titer of anti‐PP1PK and early initiation of medical intervention are essential after her pregnancy. [ABSTRACT FROM AUTHOR]

HLA‐B*58:01:40 differs from HLA‐B*58:01:01 by a single nucleotide change in exon 3, 507 C‐ > T (codon 145.3 CGC‐ > CGT). [ABSTRACT FROM AUTHOR]

HLA‐A*11:452N differs from A*11:01:01:01 by a single nucleotide exchange in exon 1. [ABSTRACT FROM AUTHOR]

Several species of soil free‐living saprotrophs can sometimes establish biotrophic symbiosis with plants, but the basic biology of this association remains largely unknown. Here, we investigate the symbiotic interaction between a common soil saprotroph, Clitopilus hobsonii (Agaricomycetes), and the American sweetgum (Liquidambar styraciflua). The colonized root cortical cells were found to contain numerous microsclerotia‐like structures. Fungal colonization led to increased plant growth and facilitated potassium uptake, particularly under potassium limitation (0.05 mM K+). The expression of plant genes related to potassium uptake was not altered by the symbiosis, but colonized roots contained the transcripts of three fungal genes with homology to K+ transporters (ACU and HAK) and channel (SKC). Heterologously expressed ChACU and ChSKC restored the growth of a yeast K+‐uptake‐defective mutant. Upregulation of ChACU transcript under low K+ conditions (0 and 0.05 mM K+) compared to control (5 mM K+) was demonstrated in planta and in vitro. Colonized plants displayed a larger accumulation of soluble sugars under 0.05 mM K+ than non‐colonized plants. The present study suggests reciprocal benefits of this novel tree‐fungus symbiosis under potassium limitation mainly through an exchange of additional carbon and potassium between both partners. The anatomic and nutritional aspects of the facultative biotrophic interaction between the Clitopilus hobsonii and American sweetgum tree are revealed. The mode of action of fungal contribution to plant K+ acquisition under the K+ limitation condition is proposed. This work represents a distinct mechanism underlying a novel root—fungal symbiosis. [ABSTRACT FROM AUTHOR]

Common I RHD i variants and zygosity were assessed by sequence-specific primer PCR (PCR-SSP) method, including I RHD i positive and whole I RHD i exon deletion genotypes, I RHD*weak partial 15 i , I RHD*01 N.03 i , I RHD*DEL1 i homozygous. Keywords: hematology - red cells; immunohematology (RBC serology, blood groups); molecular biology EN hematology - red cells immunohematology (RBC serology, blood groups) molecular biology E40 E42 3 08/09/22 20220801 NES 220801 INTRODUCTION The Rhesus (Rh) blood group system is one of the most complex blood group systems, comprising 56 antigens. A novel RHD allele caused by RHD c.710 713dup associated with a negative phenotype in a Chinese Han blood donor. [Extracted from the article]

There have been some conflicting claims whether larger prostate weight (PW) reduces the risk of positive surgical margins (PSMs). This study aims to examine the associations between PW and PSMs. PubMed, Web of Science and Cochrane library were systematically retrieved. Relative risks (RRs) and the corresponding 95% confidence intervals (CIs) were synthesised utilising random‐effect models. Ultimately, 22 cohort studies met criteria were enrolled in this meta‐analysis, of which 18 studies reporting the RR of the highest VS lowest category of PW yielded the combined RR of PSMs of 0.61 (95% CI 0.50–0.74). Subgroup analysis showed that geographic region and surgical modalities were considered as potential confounders of influence of PW on PSMs. The nonlinear dose–response relationship demonstrated that PSM risk decreased by 1% (RR = 0.99, 95% CI, 0.98–0.99) for every one gram increment in PW. This study suggests PW has a negative association with risk of PSMs, and having a appropriate PW is very important. [ABSTRACT FROM AUTHOR]

In recent years, large-capacity high-voltage direct currents (HVDCs) have been employed to transfer electricity from the west to the east of China. However, the frequent frequency drops due to HVDC blockings seriously threaten the short-term frequency stability of receiving-end power systems. The existing emergency frequency control strategy is not adaptive to the varying operation conditions and may cause excessive or deficient actions, which could result in inefficient control or high risk of frequency instability. Therefore, a real-time coordinated control strategy is proposed in this study based on the online-updated frequency response model. The model is designed to incorporate multiple types of generators and to reflect the dynamic frequency response of loads. The new control strategy combines multiple control resources, including the emergency demand response and HVDC power modulation, to improve the short-term frequency stability after HVDC failures. By online data preparation and cubic fitting, the nadir of the frequency is expressed as an analytic function of the control variables. A real-time optimisation of emergency controls is achieved to improve the short-term frequency dynamics. Case studies show that the proposed scheme is robust to the varying operation conditions and has lower control cost than the existing control strategy. [ABSTRACT FROM AUTHOR]

An unprecedented arylboration of unactivated terminal alkenes, featuring 1,n‐regioselectivity, has been achieved by nickel catalysis. The nitrogen‐based ligand plays an essential role in the success of this three‐component reaction. This transformation displays good regioselectivity and excellent functional‐group tolerance. In addition, the incorporation of a boron group into the products provides substantial opportunities for further transformations. Also demonstrated is that the products can be readily transformed into pharmaceutically relevant molecules. Unexpectedly, preliminary mechanistic studies indicate that although the metal migration favors the α‐position of boron, selective and decisive bond formation is favored at the benzylic position. An unprecedented arylboration of unactivated terminal alkenes, featuring 1,n‐regioselectivity (n>2), has been achieved by nickel catalysis. An array of valuable alkylboronic esters are prepared with this method. Mechanism studies indicate that a nickel migration and a selective bond‐formation step are involved in this reaction. [ABSTRACT FROM AUTHOR]

Background The aim of this prospective study was to assess the diagnosis value of four-dimensional echocardiography area strain (AS) combined with exercise stress echocardiography to evaluate left ventricular regional systolic function in patients with mild single vessel coronary artery stenosis. Methods Based on treadmill exercise load status, two-dimensional conventional echocardiography and four-dimensional echocardiography area strain were performed on patients suspected coronary artery disease before coronary angiogram. Thirty patients (case group) with mild left anterior descending coronary artery stenosis (stenosis <50%) and thirty gender- and age-matched patients (control group) without coronary artery stenosis according to the coronary angiogram results were prospectively enrolled. Results All the patients had no left ventricular regional wall motion abnormality in two-dimensional echocardiography at rest and exercise stress. There was no significant difference in the 16 segmental systolic peak AS at rest between two groups. After exercise stress, the peak systolic ASrest-stress at mid anterior wall (−7.00%±10.90% vs 2.80%±23.69%) and mid anterolateral wall (−4.40%±18.81% vs 8.80%±19.16%) were decreased, while increased at basal inferolateral wall (14.00%±19.27% vs −5.60%±15.94%) in case group compared with control group ( P<.05). Conclusions In patients with mild single vessel coronary artery stenosis, the area strain was decreased at involved segments, while compensatory increased at noninvolved segments after exercise stress. Four-dimensional echocardiography area strain combined with exercise stress echocardiography could sensitively find left ventricular regional systolic function abnormality in patients with mild single vessel coronary artery stenosis, and locate stenosis coronary artery accordingly. [ABSTRACT FROM AUTHOR]

Homogeneous gold catalysts are interesting as they can act as potent carbophilic Lewis acids to activate the π bonds of alkynes, allenes, and alkenes. Many impressive applications for the formation of C−C or C−heteroatom bonds have been found due to the excellent functional group compatibility of these catalysts and the air and moisture tolerance of their reactions. Here, we have developed gold-catalyzed novel intramolecular cycloisomerizations of nitrogen or oxygen-tethered cyclopropenes with propargylic esters. The reaction proceeded through different pathways according to different substituent styles, affording 5-azaspiro[2.5]oct-7-enes and bicyclo[4.1.0]heptanes. [ABSTRACT FROM AUTHOR]

The 36-39delA/A, (Figure S1) 297A/G, 467C/T, 646T/A, 681G/A, 771C/T, 829G/A heterozygous sites were found in the proband by direct genomic sequencing, which did not completely match any I ABO i allele combination. In conclusion, one novel allele with a I c.36-39delA i mutation in I ABO*A1.02 i was identified, which was predicted to be responsible for the weak A antigen in a Chinese individual. ABO blood group is the most important blood group system in both transfusion and transplantation.1 However, discrepancies in the forward and reverse typing results in serologic tests occur occasionally, which might be caused by the genetic variation. [Extracted from the article]

Common I RHD i variants and zygosity were assessed by sequence-specific primer PCR (PCR-SSP), as previously reported.4 DNA sequencing of I RHD i exons 1-10 and flanking intron regions was performed using in-house primers. Moreover, the I c.1228-1G>C i mutation from the proband was then passed to the daughter, who typed an I RHD c.1228-1G>C i allele and a normal I RHD i gene. Currently, 336 I RHD i alleles have been identified according to ISBT allele nomenclature version v5.0 (http://www.isbtweb.org/working-parties/red-cell-immunogenetics-and-blood-groug-terminology). [Extracted from the article]

Gold- and silver-catalyzed novel intramolecular cycloisomerizations of nitrogen or carbon-tethered indolylcyclopropenes to furnish biologically and pharmaceutically valuable azepino-[4,5- b]indole and spiro[indoline-3,4′-piperidine] derivatives have been developed. Both reactions exhibit high chemoselectivity and stereospecificity through completely different reaction pathways. Based on mechanistic studies, it is well demonstrated that gold and silver catalysts act differently to promote the anti- and syn-addition and the steric effect of the catalysts play an important role to switch the addition mode, affording the catalyst-controlled-divergent synthesis. [ABSTRACT FROM AUTHOR]

ABSTRACT Qingkailing (QKL) injection, a modified modern Chinese medicine preparation, is widely used in the clinic for its significant antipyretic and anti-inflammatory effects, but its serious adverse drug reactions have attracted more and more attention. Series of caffeoylquinic acids in QKL are widely suspected to be the allergens responsible for these adverse drug reactions. Therefore, pharmacokinetic studies of the caffeoylquinic acids are needed. In this paper, a simple, rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometry method was developed for the simultaneous determination of chlorogenic acid, neochlorogenic acid, baicalin, geniposide, cholic acid and hyodeoxycholic acid in rat plasma. Chromatographic separation was achieved on a BEH C18 column by a gradient elution at a flow rate of 0.40 mL/min in only 6.0 min. All analytes were monitored by multiple reaction monitoring mode with negative electrospray ionization. The calibration curves of these analytes were all linear ( r > 0.9978) over wide concentration ranges. The intra- and inter- day precisions (relative standard deviations) were within 14.3% and accuracy (relative error) ranged from −6.8 to 4.8%. The mean recoveries ranged from 74.5 to 105.6%. This validated method was successfully applied to the pharmacokinetic study of the six analytes in rats following an intravenous administration of QKL injection. Copyright © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Here, we describe a novel mutation, c.125G > C, on the I GYPA*01 i allele in a 28-year-old Chinese male, which caused absence of M antigen in red blood cells (RBCs). The polymorphism of MNS blood group antigens is determined by the amino acid sequences of glycophorin A (GPA) and glycophorin B (GPB). A novel GYPA*01 allele with a c.125C > G (p.Thr42Ser) mutation identified in a Chinese individual. [Extracted from the article]

Identification of a novel B allele with a c.917 T > C mutation on the ABO*B.01 allele The accurate typing of ABO blood group, which is the most important blood group system, is essential to ensure safe transfusion and transplantation. We prefer to define this novel allele to be a B allele due to the lack of anti-B in plasma and its high similarity with I ABO*B.01 i allele. [Extracted from the article]

This study offers a description and analysis of consonant voicing and devoicing in the L2 English of Cantonese speakers from Hong Kong. Focusing on stem-final voiced obstruents in distinct structural environments, we find that the rates of voicing and devoicing vary with the environment. Stem-final obstruents are more likely to devoice in prevoiceless and word-final positions than in prevocalic and pre-sonorant positions. Our analysis reveals a systematic pattern, expressible by three ranked constraints: IdOn(Lar)»*Lar» Id(Lar). This ranking retains to a large extent the ranking relations of the constraints in Cantonese. Our finding suggests that transfer plays a significant role in shaping the L2 English ranking. The comparison with L1 English shows that the two varieties are distinct, providing further evidence for a distinct Hong Kong English accent() and for the emergence of a distinct variety of English with unique sound structures(). [ABSTRACT FROM AUTHOR]

This paper investigates stress placement in the English of Spanish speakers, Nigerian English and Singapore English. This investigation reveals that they have in common several patterns of stress placement that are distinct from British or American English. We show that these patterns cannot be accounted for by transfer. A different explanation is suggested, one that explains the recurrent patterns in terms of English vowel duration. It is proposed that in determining stress in multisyllabic words, L2 speakers assess the duration of syllable nuclei and assign stress to the syllable containing the longest vowel. In contrast with transfer, which holds L2 speakers' first languages responsible, this proposal attributes the distinct patterns of stress placement to the target language, making possible a unified account of the shared patterns in the three varieties of English. As L2 speakers, regardless of their first languages, grapple with the same target language, it should have a similar effect, giving rise to the common patterns of stress placement in the three varieties of English. [ABSTRACT FROM AUTHOR]

This work raises questions about the omission of Cunningham Slip Correction Factor (Cc(D)) in geometric equivalent diameter (Dp) conversions from the electric mobility diameter (Dm) and the aerodynamic diameter (Da) in relation to the calculation of effective density (ρe) as defined by Li et al. (2018; https://doi.org/10.1029/2018JD028956). They reported that ρe could be calculated using the formula "(Da/Dm)2," in which Cc(D) was not introduced into the conversion between two diameters involving Dm and Dp or Da and Dp. However, these conversions, which ignored Cc(D) in the transition regime, are not supported by current studies; nor did the group demonstrate their rationality. This comment shows that an error of up to 24.7% could be caused by ignoring the Cc(D) during conversions between the Dp and Dm for particles with a dynamic shape factor of 2.50 and a Dm of 550 nm; an error of 5.6% could be caused by ignoring the Cc(D) during conversions between Dp and Da for particles having a dynamic shape factor of 1.12, a density of 2.20 g/cm3, and a Da of 550 nm. The deviation of ρe could be amplified by 55.5% and 11.2% due to the squared term in the formula. Therefore, this comment argues that it is irrational to ignore Cc(D) when calculating Dp and ρe by using Dm and Da. Key Points: Cunningham Slip Correction Factor must be introduced in the conversion of geometric equivalent diameter in the transition regime [ABSTRACT FROM AUTHOR]

The growing demand for advanced energy storage devices with high energy density and high safety has continuously driven the technical upgrades of cell architectures as well as electroactive materials. Designing thick electrodes with more electroactive materials is a promising strategy to improve the energy density of lithium‐ion batteries (LIBs) without alternating the underlying chemistry. However, the progress toward thick, high areal capacity electrodes is severely limited by the sluggish electronic/ionic transport and easy deformability of conventional electrodes. A self‐supported ultrahigh‐capacity and fire‐resistant LiFePO4 (UCFR‐LFP)‐based nanocomposite cathode is demonstrated here. Benefiting from the structural and chemical uniqueness, the UCFR‐LFP electrodes demonstrate exceptional improvements in electrochemical performance and mass loading of active materials, and thermal stability. Notably, an ultrathick UCFR‐LFP electrode (1.35 mm) with remarkably high mass loading of active materials (108 mg cm−2) and areal capacity (16.4 mAh cm−2) is successfully achieved. Moreover, the 1D inorganic binder‐like ultralong hydroxyapatite nanowires (HAP NWs) enable the UCFR‐LFP electrode with excellent thermal stability (structural integrity up to 1000 °C and electrochemical activity up to 750 °C), fire‐resistance, and wide‐temperature operability. Such a unique UCFR‐LFP electrode offers a promising solution for next‐generation LIBs with high energy density, high safety, and wide operating‐temperature window. An ultrahigh‐areal‐capacity, thermally stable (up to 750 °C), and fire‐resistant LiFePO4‐based nanocomposite cathode is fabricated through a facile bottom‐up self‐assembly strategy, which is a promising candidate for advanced high‐performance and safe batteries. [ABSTRACT FROM AUTHOR]

The article presents a case study of a 48-year-old male patient with a history of an unremitting odynophagia and pharyngeal foreign body sensation, which were aggravated gradually. He had no history of endotracheal intubation or cervical manipulation and also denied any history of cervical or craniofacial trauma and other discomfort in the throat. He was not on any medications. A three dimensional reconstruction of thyroid cartilage showed a medial displacement of the right superior cornu.

The TFA-mediated intramolecular cycloisomerization of substrates (I) gives rise to azocino[5,4-b]indoles (II), whilst the reaction of aryl-substituted cyclopropenes (III) does not stop at the stage of azocino[5,4-b]indoles, but affords tetracyclic products (IV). [ABSTRACT FROM AUTHOR]

An abstract of the article "Visible Light Mediated Aerobic Radical C-H Phosphorization Toward Arylphosphonates" by Pan Peng and colleagues is presented.

A gold-catalyzed intramolecular cycloisomerization of cyclopropenes, N- or O-tethered, affords 5-azaspiro[2.5]oct-7-enes and bicyclo[4.1.0]heptanes depending on the substitution pattern. [ABSTRACT FROM AUTHOR]

A diagram is presented which explains the chemical process of Gold- and Silver-Catalyzed Intramolecular Cyclizations of Indolylcyclopropenes for the Divergent Synthesis of Azepinoindoles and Spiroindoline Piperidines.

Review: 122 refs. [ABSTRACT FROM AUTHOR]