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1. Cyclic nucleotides and calcium transport in cultured dermal fibroblasts from progressive systemic sclerosis and rheumatoid arthritis patients.

Author

Grozdova MD, Khokhlova JV, Panasyuk AF, Guseva NG, and Trofimova TM

Subjects
Adolescent, Adult, Arthritis, Rheumatoid pathology, Biological Transport drug effects, Cells, Cultured, Collagen biosynthesis, Epinephrine pharmacology, Female, Fibroblasts metabolism, Humans, Male, Middle Aged, Propranolol pharmacology, Scleroderma, Systemic pathology, Skin pathology, Arthritis, Rheumatoid metabolism, Calcium metabolism, Cyclic AMP metabolism, Cyclic GMP metabolism, Scleroderma, Systemic metabolism, Skin metabolism
Abstract

Levels of cAMP were decreased and cGMP increased in progressive systemic sclerosis (PSS) fibroblasts compared with normal fibroblasts. PSS cells took up unusually large quantities of Ca++. The epinephrine-induced increases in cAMP were diminished sixfold and epinephrine-induced Ca++ uptake was abnormal in PSS cells. Considerable heterogeneity was observed in rheumatoid arthritis fibroblasts. Membrane-bound abnormalities in (PSS) cells may be of importance in the defective control of collagen production in progressive systemic sclerosis.

Published
1984
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