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The lithium–sulfur (Li–S) battery system has attracted considerable attention due to its ultrahigh theoretical energy density and promising applications. However, with the increasing demands on S loading and electrolyte content, practical Li–S batteries still face several serious challenges, such as slow reaction kinetics at the cathode interface, unstable anode interface reactions, and undesirable crosstalk effects between the cathode and anode. Traditional electrolyte systems often struggle to address these challenges under practical conditions, thereby rendering it imperative to establish a new electrolyte system for practical Li–S batteries. This review first discusses the necessity of establishing a new electrolyte and propose specific parameter requirements, such as the electrolyte‐to‐sulfur mass ratio (Em/S). Subsequently, some electrolyte modification strategies proposed by researchers are summarized to address the different challenges associated with practical Li–S batteries. Finally, the combination of different strategies is reviewed, aiming to reveal more effective design approaches that simultaneously address multiple challenges, while providing guidance for establishing a new balanced electrolyte for practical Li–S batteries. This article promotes the development of new electrolytes for practical Li–S batteries and can act as a reference for the development of electrolytes for other secondary batteries. [ABSTRACT FROM AUTHOR]

Summary: The development of lightweight networks makes neural networks more efficient to be widely applied to various tasks. Considering the deployment of hardware like edge devices and mobile phones, we prioritize lightweight networks. However, their accuracy has always lagged far behind SOTA networks. In this article, we present a simple yet effective activation function, called WReLU, to improve the performance of lightweight networks significantly by adding a residual spatial condition. Moreover, we use a strategy to switch activation functions after determining which convolutional layer to use. We perform experiments on ImageNet 2012 classification dataset in CPU, GPU, and edge devices. Experiments demonstrate that WReLU improves the accuracy of classification significantly. Meanwhile, our strategy balances the effect of additional parameters and multiply accumulate. Our method improves the accuracy of SqueezeNet and SqueezeNext by more than 5% without increasing extensive parameters and computation. For the lightweight network with a large number of parameters, such as MobileNet and ShuffleNet, there is also a significant improvement. Additionally, the inference speed of most lightweight networks using our WReLU strategy is almost the same as the baseline model on different platforms. Our approach not only ensures the practicability of the lightweight network but also improves its performance. [ABSTRACT FROM AUTHOR]

A challenge in the pandemic era is to implement effective but flexible practical teaching for biological sciences courses. Such teaching needs to deliver conceptual, analytical and practical skills training while having the option to rapidly respond to health and safety issues, local regulations, staff and student concerns. In this paper, we describe a set of cell biology practicals (mini‐project) that meets many of these requirements and provides flexibility in providing skills training both through online and in practical laboratory environments. We have used a human adenocarcinoma cell line A431 stably transfected with a fluorescent cell cycle reporter as a biological model to deliver training through discrete work packages encompassing cell culture, fluorescence microscopy, biochemistry and statistics. How such work packages can be modified to, an online format either partially or completely is also described. Furthermore, the activities can be adapted for teaching both undergraduate and postgraduate level courses to ensure effective skills training which is applicable to a wide range of biological degree programs and levels of study. [ABSTRACT FROM AUTHOR]

Developing meaningful in‐course exercises for university‐level marine ecology students can be challenging due to the constraints imposed by time, logistics, and/or safety. Here, I describe three exercises that exploit the explanatory power of body size to provide context for field‐, laboratory‐, and desktop‐based projects done by students at varying stages of their university education. The exercises collectively help to develop a range of research skills including data acquisition, analysis, interpretation, and communication. [ABSTRACT FROM AUTHOR]

Diarrhoea is a leading cause of morbidity and mortality world-wide. Most diarrhoeal episodes are acute and infectious in origin. Diarrhoea lasting for longer than 4 weeks with no discernible infectious aetiology warrants thorough evaluation. The aim of this review is to elucidate an approach to evaluation of diarrhoea based on its pathophysiologic mechanisms with focus on aetiology, investigation and management of chronic diarrhoea. It includes a brief description of normal fluid homeostasis in the gut and pathophysiology of diarrhoea. Further, diarrhoea is classified as 'watery', 'fatty' and 'bloody' based on stool characteristics. Relevant history, physical examination findings, first and second-line investigations which help in differentiating the different types of diarrhoea are listed and an algorithmic approach to individual types of diarrhoea has been devised. Principles of management and recent advances in diagnostics and therapeutics of diarrhoea are briefly discussed. [ABSTRACT FROM AUTHOR]

A practical and user-friendly strategy for the chain-end reduction of halogen terminated polymers that employs hydrogen gas and heterogeneous catalysis (palladium on carbon) is reported. Quantitative dehalogenation of a wide variety of monomer families (polystyrenes, polyacrylates, and polymethacrylates) with either chlorine or bromine chain-ends is observed. The utility of this chain-end reduction is further highlighted by mild reaction conditions, simple purification, and compatibility with a wide range of solvents. [ABSTRACT FROM AUTHOR]

N,N-Dimethylaminophenyl moiety is a common fragment in medicinal chemistry as several pharmaceuticals bearing this privileged motif are on the market and under clinical evaluation. Oxidative N-demethylation is generally regarded as the major metabolic pathway. However, pharmacokinetics, metabolites studies as well as the further structural modification are precluded by the impracticality of chemical synthesis. Here we report that acetic acid can significantly accelerate visible-light photoredox catalyzed N-demethylation of N,N-dimethylaminophenyl derivatives. This approach is easy for large scale reaction and even for potential industrial manufacture. [ABSTRACT FROM AUTHOR]

Circulating insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are associated with prostate cancer. Using genetic variants as instruments for IGF peptides, we investigated whether these associations are likely to be causal. We identified from the literature 56 single nucleotide polymorphisms (SNPs) in the IGF axis previously associated with biomarker levels (8 from a genome-wide association study [GWAS] and 48 in reported candidate genes). In ∼700 men without prostate cancer and two replication cohorts ( N ∼ 900 and ∼9,000), we examined the properties of these SNPS as instrumental variables (IVs) for IGF-I, IGF-II, IGFBP-2 and IGFBP-3. Those confirmed as strong IVs were tested for association with prostate cancer risk, low (< 7) vs. high (≥ 7) Gleason grade, localised vs. advanced stage, and mortality, in 22,936 controls and 22,992 cases. IV analysis was used in an attempt to estimate the causal effect of circulating IGF peptides on prostate cancer. Published SNPs in the IGFBP1/IGFBP3 gene region, particularly rs11977526, were strong instruments for IGF-II and IGFBP-3, less so for IGF-I. Rs11977526 was associated with high ( vs. low) Gleason grade (OR per IGF-II/IGFBP-3 level-raising allele 1.05; 95% CI: 1.00, 1.10). Using rs11977526 as an IV we estimated the causal effect of a one SD increase in IGF-II (∼265 ng/mL) on risk of high vs. low grade disease as 1.14 (95% CI: 1.00, 1.31). Because of the potential for pleiotropy of the genetic instruments, these findings can only causally implicate the IGF pathway in general, not any one specific biomarker. [ABSTRACT FROM AUTHOR]

A pedagogic intervention, in the form of an inquiry-based peer-assisted learning project (as a practical student-led bioinformatics module), was assessed for its ability to increase students' engagement, practical bioinformatic skills and process-specific knowledge. Elements assessed were process-specific knowledge following module completion, qualitative student-based module evaluation and the novelty, scientific validity and quality of written student reports. Bioinformatics is often the starting point for laboratory-based research projects, therefore high importance was placed on allowing students to individually develop and apply processes and methods of scientific research. Students led a bioinformatic inquiry-based project (within a framework of inquiry), discovering, justifying and exploring individually discovered research targets. Detailed assessable reports were produced, displaying data generated and the resources used. Mimicking research settings, undergraduates were divided into small collaborative groups, with distinctive central themes. The module was evaluated by assessing the quality and originality of the students' targets through reports, reflecting students' use and understanding of concepts and tools required to generate their data. Furthermore, evaluation of the bioinformatic module was assessed semi-quantitatively using pre- and post-module quizzes (a non-assessable activity, not contributing to their grade), which incorporated process- and content-specific questions (indicative of their use of the online tools). Qualitative assessment of the teaching intervention was performed using post-module surveys, exploring student satisfaction and other module specific elements. Overall, a positive experience was found, as was a post module increase in correct process-specific answers. In conclusion, an inquiry-based peer-assisted learning module increased students' engagement, practical bioinformatic skills and process-specific knowledge. © 2016 by The International Union of Biochemistry and Molecular Biology, 44:304-313 2016. [ABSTRACT FROM AUTHOR]

Anatomy learned by active exploration through dissection has many proven benefits including improvement of anatomic knowledge. Decreased laboratory time may affect the quality of dissection and ultimately lower student performance in anatomy translating to lower knowledge acquisition. The aim of this study was to determine whether the quality of students' dissection in teams correlates with their performance in the gross anatomy course. Quality of dissections for each team enrolled in a gross anatomy course at Mayo Medical School was evaluated biweekly using a five-point rubric based on course learning objectives. Assessment of anatomic knowledge was based on sequential laboratory practice practical examination scores, achievements on daily audience response system (ARS) quizzes, and final practical, written, and National Board of Medical Examiners® (NBME®) Gross Anatomy and Embryology Subject Examinations. Twelve teams comprising 48 students were included in the study. There was a positive correlation between dissection quality and practice practical examination score ( R = 0.83) and a negative correlation between dissection quality and ARS quizzes ( R = −0.985). Dissection teams with a passing score on their dissection evaluations (>70%) performed better on their final examinations. Based on an end of course survey, students agreed that dissection evaluations should continue to be a part of the course. This study showed that better quality of dissection was associated with higher scores on practice practical examinations, final practical, written, and NBME examinations. The study demonstrated a positive correlation between dissection evaluations, accompanied by formative feedback during the course, and higher scores on final course assessments. Anat Sci Educ 8: 45-52. © 2014 American Association of Anatomists. [ABSTRACT FROM AUTHOR]

The article offers the authors' insights on the need of chemical engineers to focus on practical and technological solutions to solve problems related to energy supply and environmental impact. They discuss the effort made by chemical engineers to minimize the required energy to meet the growing populations' demand. They consider the importance of chemical engineering in addressing energy challenges. They also explain the addiction to fossil fuel in human history.

ABSTRACT The aim of this essay is to provide a philosophical discussion of Frederick Douglass's thought in relation to Christianity. I expand upon the work of Bill E. Lawson and Frank M. Kirkland-who both argue that there are Kantian features present in Douglass as it relates to his conception of the individual-by arguing that there are similarities between Douglass and Kant not only concerning the relationship between morality and Christianity, but also concerning the nature of the soul. Specifically, I try to show that the moral weakness of slaveholding Christianity that Douglass attacked is found in the ecclesial formation of the slaveholding Christian church; it is a formation that begins with epistemology, but ignores ethics. I conclude, in part, that both Douglass and Kant reject a Cartesian psychological dualism in favor of a conception of the soul that is more attentive to one's moral development. [ABSTRACT FROM AUTHOR]

To cite this article: Meyer R, Venter C, Fox AT, Shah N. Practical dietary management of protein energy malnutrition in young children with cow's milk protein allergy. Pediatric Allergy Immunology 2012: 23: 307-314. Abstract Cow's milk protein allergy (CMPA) affects between 1.9 and 4.9% of infants and young children. This food allergy requires the complete elimination of cow's milk and its derivatives, impacting on nutritional status. The risk of having protein energy malnutrition (PEM) in children with CMPA has been well documented. In 2007, the World Health Organisation published guidelines on the dietary management of PEM, which has impacted on the recommendations and composition on specialist feeds for many chronic diseases, but not on CMPA. The main change in management of the child with PEM is the protein energy ratio and energy requirements. The ideal protein energy ratio lies between 8.9 and 11.5%, which would ensure a deposition of about 70% lean and 30% fat mass. In addition, for optimal catch-up growth between 5 and 10 g/kg/day, energy requirements should be between 105 and 126 kcal/kg/day. Although most current hypoallergenic formulas fall well within the recommendation for protein, there is a problem in achieving energy requirements. As a result, modular additions are often made, disturbing the protein energy ratio or feeds are concentrated, which impacts on osmolality. We therefore aimed to review current guidelines on PEM and how these can be applied in the management of the malnourished child with CMPA. [ABSTRACT FROM AUTHOR]