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Objectives: To evaluate and compare the diagnostic test accuracy (DTA) of three-dimensional transvaginal ultrasound (3D-TVS) and magnetic resonance imaging (MRI) for deep myometrial infiltration (DMI) and cervical invasion for preoperative staging and surgery planning in patients with endometrial cancer (EC).Methods: This systematic review and meta-analysis investigated the DTA of MRI and 3D-TVS for DMI and cervical invasion in patients with EC. A literature search was performed using MEDLINE, Scopus, EMBASE, ScienceDirect, The Cochrane library, ClinicalTrials.gov, Cochrane Central Register of Controlled Trials, EU Clinical Trials Register and World Health Organization International Clinical Trials Registry Platform to identify relevant studies published between January 2000 and December 2021. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool.Results: Five studies, including a total of 450 patients, were included in the systematic review. All five studies compared the DTA of 3D-TVS vs MRI for DMI, and three studies compared the DTA of 3D-TVS vs MRI for cervical invasion. Pooled sensitivity, positive likelihood ratio and negative likelihood ratio for detecting DMI using 3D-TVS were 77% (95% CI, 66-85%), 4.57 and 0.31, respectively. The respective values for detecting DMI on MRI were 80% (95% CI, 73-86%), 4.22 and 0.24. Bivariate metaregression indicated a similar DTA of 3D-TVS and MRI (P = 0.80) for the correct identification of DMI. Pooled ln diagnostic odds ratio for detecting cervical invasion was 3.11 (95% CI, 2.09-4.14) for 3D-TVS and 2.36 (95% CI, 0.90-3.83) for MRI. The risk of bias was low for most of the four domains assessed in QUADAS-2.Conclusion: 3D-TVS demonstrated good diagnostic accuracy in terms of sensitivity and specificity for the evaluation of DMI and cervical invasion, with results comparable with those of MRI. Thus, we confirmed the potential role of 3D-TVS in the preoperative staging and surgery planning in patients with EC. © 2022 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. [ABSTRACT FROM AUTHOR]

Background: Several randomised controlled trials (RCTs) have investigated the usefulness of pituitary block with gonadotrophin-releasing hormone (GnRH) antagonists during intrauterine insemination (IUI) cycles, with conflicting results.Objective: The aim of the present systematic review and meta-analysis of RCTs was to evaluate the effectiveness of GnRH antagonist administration as an intervention to improve the success of IUI cycles.Search Strategy: Electronic databases (MEDLINE, Scopus, EMBASE, Sciencedirect) and clinical registers were searched from their inception until October 2017.Selection Criteria: Randomised controlled trials of infertile women undergoing one or more IUI stimulated cycles with GnRH antagonists compared with a control group.Data Collection and Analysis: The primary outcomes were ongoing pregnancy/live birth rate (OPR/LBR) and clinical pregnancy rate (CPR). Pooled results were expressed as odds ratio (OR) or mean differences with 95% confidence interval (95% CI). Sources of heterogeneity were investigated through sensitivity and subgroups analysis. The body of evidence was rated using GRADE methodology. Publication bias was assessed with funnel plot, Begg's and Egger's tests.Main Results: Fifteen RCTs were included (3253 IUI cycles, 2345 participants). No differences in OPR/LBR (OR 1.14, 95% CI 0.82-1.57, P = 0.44) and CPR (OR 1.28, 95% CI 0.97-1.69, P = 0.08) were found. Sensitivity and subgroup analyses did not provide statistical changes in pooled results. The body of evidence was rated as low (GRADE 2/4). No publication bias was detected.Conclusion: Pituitary block with GnRH antagonists does not improve OPR/LBR and CPR in women undergoing IUI cycles.Tweetable Abstract: Pituitary block with GnRH antagonists does not improve the success of IUI cycles. [ABSTRACT FROM AUTHOR]

(d,e) Second scan showed multilocular-solid mass of 127 × 77 × 107 mm, with low-level echogenicity of cyst content and irregular solid component (d), which had moderate vascularization (color score, 3) on color Doppler (e). gl GLO:F0Y/01may20:uog21875-fig-0002.jpg PHOTO (COLOR): Histological examination of endometrioid borderline tumor arising from endometriotic cyst. GRAPH: Videoclip S1 Grayscale and color Doppler ultrasound imaging of endometrioid borderline ovarian tumor arising from endometriotic cyst at second scan, showing multilocular-solid cyst with low-level echogenicity of content and irregular vascularized solid component. [Extracted from the article]

In most countries, national health services offer cancer screening programmes for breast, colon and cervical cancer. I Sir, i We have found that the COVID-19 pandemic has had a significant negative effect on oncology screenings. Effect of the COVID-19 pandemic on oncology screenings: it is time to change course. [Extracted from the article]

An abstract of the article "Endometrial surveillance in tamoxifen users: accuracy of ultrasound versus hysteroscopic investigation-observational longitudinal cohort study" by S. Gizzo and others is presented.

An abstract of the article "Old and new protagonists on the ultrasound scene for the diagnosis of deep pelvic endometriosis: a systematic literature review and meta-analysis" by S. Gizzo is presented.

An abstract of the article "Effective anatomical and functional status of the lower uterine segment at term pregnancy: ultrasound estimation of the risk of uterine dehiscence" by S. Gizzo is presented.

An abstract of the article "Update on hydration strategies for amniotic fluid improvement in isolated oligohydramnios and normohydramnios: a systematic review and meta-analysis" by R. Venturella and others is presented.

An abstract of the article "Borderline ovarian tumors and frozen section: role of preoperative He4 and ROMA score to increase frozen section accuracy" by S. Gizzo is presented.

An abstract for the article "How age influences ovarian vascular three dimensional ultrasound parameters in a large population of Italian fertile women" by R. Venturella and others, is presented.

The objectives of this study were to investigate the implications of human papillomavirus ( HPV) sperm infection on male fertility, impairment of sperm parameters, and possible alteration of sperm nuclear status and to identify a possible effective management of infertile men with HPV sperm infection. We employed a systematic review and clinical management proposal at the Centers for Reproductive and Health care for treating infertile male patients with HPV infection. Literature search was carried out in electronic databases in the last two decades. We focused our attention on: (i) HPV sperm prevalence (ii) HPV-related alteration of sperm parameters; (iii) molecular mechanisms of HPV semen infection and infertility. The main outcome measures were HPV prevalence in infertile male patients and semen parameters. The prevalence of HPV sperm infection ranges between 2 and 31% in men from general population and between 10 and 35.7% in men affected by unexplained infertility. The presence of HPV in semen is associated with an impairment of sperm motility and the presence of anti-sperm antibodies. The molecular mechanisms underlying impairment of sperm motility apparatus need further evaluations. A greater attention should be applied to assess HPV sperm infection, particularly in men undergoing assisted reproduction techniques cycle for male infertility or sperm banking. It would be useful to perform HPV test and fluorescent in situ hybridization analysis for HPV in semen from these patients both at first admission, to define the possible presence and localization of semen infection, and after 6 months, to assess the possible virus clearance retrieval on normal sperm parameters. [ABSTRACT FROM AUTHOR]

A letter to the editor is presented in response to the article "Office gel sonovaginography for the prediction of posterior deep infiltrating endometriosis: a multicenter prospective observational study" that was published in the March 2015 issue is presented.

Background: Several randomised controlled trials (RCTs) have investigated the usefulness of pituitary block with gonadotrophin-releasing hormone (GnRH) antagonists during intrauterine insemination (IUI) cycles, with conflicting results., Objective: The aim of the present systematic review and meta-analysis of RCTs was to evaluate the effectiveness of GnRH antagonist administration as an intervention to improve the success of IUI cycles., Search Strategy: Electronic databases (MEDLINE, Scopus, EMBASE, Sciencedirect) and clinical registers were searched from their inception until October 2017., Selection Criteria: Randomised controlled trials of infertile women undergoing one or more IUI stimulated cycles with GnRH antagonists compared with a control group., Data Collection and Analysis: The primary outcomes were ongoing pregnancy/live birth rate (OPR/LBR) and clinical pregnancy rate (CPR). Pooled results were expressed as odds ratio (OR) or mean differences with 95% confidence interval (95% CI). Sources of heterogeneity were investigated through sensitivity and subgroups analysis. The body of evidence was rated using GRADE methodology. Publication bias was assessed with funnel plot, Begg's and Egger's tests., Main Results: Fifteen RCTs were included (3253 IUI cycles, 2345 participants). No differences in OPR/LBR (OR 1.14, 95% CI 0.82-1.57, P = 0.44) and CPR (OR 1.28, 95% CI 0.97-1.69, P = 0.08) were found. Sensitivity and subgroup analyses did not provide statistical changes in pooled results. The body of evidence was rated as low (GRADE 2/4). No publication bias was detected., Conclusion: Pituitary block with GnRH antagonists does not improve OPR/LBR and CPR in women undergoing IUI cycles., Tweetable Abstract: Pituitary block with GnRH antagonists does not improve the success of IUI cycles., (© 2018 Royal College of Obstetricians and Gynaecologists.)